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1 that are functionally incapable of draining interstitial fluid.
2 n the steady-state Abeta levels in the brain interstitial fluid.
3 iologically relevant analytes present in the interstitial fluid.
4 y readily gain access to and function within interstitial fluid.
5 thin extracellular matrix under perfusion of interstitial fluid.
6 es between the cerebrospinal fluid (CSF) and interstitial fluid.
7 llowed by excessive entry of Ca(2+) from the interstitial fluid.
8 specific tissues, including lymph nodes, and interstitial fluid.
9 vective exchange of cerebrospinal fluid with interstitial fluid.
10 n are enveloped in their microenvironment by interstitial fluid.
11 the cells followed by Ca(2+) entry from the interstitial fluid.
12 y), resulting in the release of ATP into the interstitial fluid.
13 ation by altering Abeta clearance from brain interstitial fluid.
14 rgeting tumor cells based on the cues in the interstitial fluid.
15 high soluble Hsp27 levels in patients' tumor interstitial fluid.
16 tween models of different cell types via the interstitial fluid.
17 s present at significant levels in blood and interstitial fluid.
18 for non-invasive lithium drug monitoring in interstitial fluid.
19 ed on the optical quantitation of glucose in interstitial fluid.
20 greater than that measured between lumen and interstitial fluid.
21 ral cells under conditions characteristic of interstitial fluid.
22 n a CGM is substantially delayed relative to interstitial fluid.
23 attoos can be used to monitor metabolites in interstitial fluid.
24 biofluids, such as sweat, tears, saliva and interstitial fluid.
25 hat can simultaneously sample skin cells and interstitial fluid.
26 essures that is related to the volume of the interstitial fluid.
27 ar clearance of fluorescent dextran from the interstitial fluid.
28 y cellular lipids, relative to cytosolic and interstitial fluids.
29 As, messenger RNAs, or DNA between cells via interstitial fluids.
30 of APP were reduced, resulting in decreased interstitial fluid Abeta levels and attenuated amyloid d
31 tophan methylamide (GM 6001) increased brain interstitial fluid Abeta levels and elimination of half-
33 differences in the elimination half-life of interstitial fluid Abeta measured by in vivo microdialys
34 usterin(-/-) mice had elevated CSF and brain interstitial fluid Abeta, as well as significant differe
35 nic controls and the significant decrease of interstitial fluid Abeta, but not the effects on amyloid
38 space into brain parenchyma to exchange with interstitial fluid (also known as the glymphatic system)
39 ered a significant and transient increase in interstitial fluid amyloid-beta40 levels in old plaque-b
41 s in a buffer that mimics the composition of interstitial fluid and blood plasma, LJM-3064 rapidly sw
42 leared in part through the exchange of brain interstitial fluid and cerebrospinal fluid along a brain
43 el accounts for vascular, transvascular, and interstitial fluid and drug transport as well as the dia
44 are a promising technique to probe the brain interstitial fluid and estimate the extracellular concen
45 lactate detection was assessed in artificial interstitial fluid and in human serum, both spiked with
46 tion of a pro-inflammatory cytokine in mouse interstitial fluid and of urinary biomarkers in patient
47 Abeta generation, its circulation within the interstitial fluid and perivascular drainage pathways an
49 iquely adapted for the continuous removal of interstitial fluid and proteins and is an important entr
50 levels and shortened half-life in the brain interstitial fluid and reduced amyloid plaque load in th
51 s of CED in enhancing the convective flow of interstitial fluid and reducing the drug concentration d
52 tem comprises blind-ended tubes that collect interstitial fluid and return it to the circulatory syst
53 method was successfully used for analysis of interstitial fluid and serum samples after a subcutaneou
54 lymph nodes, conduits are known to transport interstitial fluid and small molecules from afferent lym
56 the hypothesis that perivascular drainage of interstitial fluid and solutes out of brain tissue is dr
57 bservations in the human brain indicate that interstitial fluid and solutes, such as amyloid-beta (Ab
60 show that osmolarity differences between the interstitial fluid and the external environment trigger
61 ngiva is supplied with lymphatics that drain interstitial fluid and transport immune cells to the lym
62 in knowledge of their roles in clearance of interstitial fluid and waste from the brain, particularl
63 c vessel function with decreased drainage of interstitial fluids and reduced dietary fat absorption.
64 vant samples including breath, urine, blood, interstitial fluid, and biopsy samples are summarized.
65 ire mouse CNS--brain and spinal cord tissue, interstitial fluid, and CSF--while having no effect on b
66 dwelling sensor needle to measure glucose in interstitial fluid, and device-integrated sweat stimulat
67 These two ions are key components of the interstitial fluid, and their concentrations change in a
68 system to account for its permeation by the interstitial fluid, and we include fluid pumping as well
69 e demonstrate that Abeta levels in the brain interstitial fluid are dynamically and directly influenc
70 der physiological condition using artificial interstitial fluid at pH 7.4, whereas the one with wildt
71 hatic system is responsible for transporting interstitial fluid back to the bloodstream, but unlike t
73 ss of the lymph pump system impacts not only interstitial fluid balance but other aspects of overall
74 molecular analysis in sweat, tears, saliva, interstitial fluid, blood, wound exudate as well as exha
76 microfluidic system enhanced the exchange of interstitial fluids by 567-fold, which increased the rat
77 im through viscous fluids, such as blood and interstitial fluid, by undulating their bodies as travel
79 kling EV molecular alterations secreted into interstitial fluids can provide an alternative, non-inva
80 changes that report on acidification of the interstitial fluid caused by an accelerated glycolysis.
81 ure of the physiological environment (blood, interstitial fluid, cell cytoplasm, etc.), and the durat
82 whether the glymphatic system, a brain-wide interstitial fluid-cerebrospinal fluid exchange describe
84 il has been developed, and it shows that (1) interstitial fluid channels form before lymphatic endoth
85 zed barrier organ that must tightly regulate interstitial fluid clearance and prevent infection in or
86 suggest that the skin contains a hypertonic interstitial fluid compartment in which MPS cells exert
88 gned to serve this need by collecting dermal interstitial fluid containing biomarkers without the dan
89 t such that the glucose concentration of the interstitial fluid could be measured by spectroscopicall
93 glycocalyx and that the oncotic pressure of interstitial fluid does not directly determine fluid bal
95 sel stiffening, dysfunctional blood flow and interstitial fluid drainage, white matter rarefaction, i
96 could potentially be used to monitor how the interstitial fluid dynamics affect cancer microenvironme
98 to regulate the movement of immune cells and interstitial fluid, facilitate immune crosstalk, and ult
100 mphatic regeneration by uniquely correlating interstitial fluid flow and lymphatic endothelial cell m
101 mor growth is characterized by both abnormal interstitial fluid flow and the associated interstitial
102 ferential sprouting toward paths of draining interstitial fluid flow as might occur to connect capill
106 ding is critical for skeletal integrity, and interstitial fluid flow is an important stimulus for ost
107 medium, the physical property that dictates interstitial fluid flow is the hydraulic permeability.
108 e explants showed that intermediate level of interstitial fluid flow selectively decreased cytokine-i
109 ocity, we used a simple model of peritumoral interstitial fluid flow to calculate the fluid flow velo
116 creted by maternal intestinal cells into the interstitial fluid for transport of heme to extraintesti
119 from arteries and veins that serves to drain interstitial fluid from surrounding tissues and plays a
120 pothesized to represent impaired drainage of interstitial fluid from the brain and may reflect underl
122 individual microneedle shafts melted away by interstitial fluid from the epidermis and upper dermis,
123 egrated Lab-on-PCB wearable patch extracting interstitial fluid from the patient via integrated micro
127 m is the preferred route for the drainage of interstitial fluid from tissues and also serves as a con
129 range and limit of detection compatible with interstitial fluid glucose levels of diabetic patients a
130 under continuous flow proved compatible with interstitial fluid glucose levels of diabetic patients.
131 ockdown produced profound suppression of VMH interstitial fluid glutamine concentrations in the basal
132 t with insulin sensitization, adipose tissue interstitial fluid glycerol concentrations fell under hy
133 nsulinemia failed to suppress adipose tissue interstitial fluid glycerol release (180 +/- 50 micromol
135 tic vasculature is essential for maintaining interstitial fluid homeostasis, and dysfunctional lympha
136 minimally invasive glucose monitoring in the interstitial fluid in the dermal region, in contrast to
137 Whereas the relatively minor role of free interstitial fluid in the fluid mechanics and perfusion
138 ) often corresponds with the accumulation of interstitial fluid in the retina [i.e., the development
139 trated ascending vasa recta (AVRs) drain the interstitial fluid in this location, but this function h
141 mg), cortisol concentrations within adipose interstitial fluid increased (4.3 +/- 1.1 vs. 14.2 +/- 2
146 acinar cells, to drive transcellular flux of interstitial fluid into the labyrinth of the salivary du
148 tivated by NMDA receptors and regulate brain interstitial fluid (ISF) Abeta levels in opposite direct
151 vity regulates the regional concentration of interstitial fluid (ISF) Abeta, which drives local Abeta
152 f this study, catecholamines from myocardial interstitial fluid (ISF) and aortic and coronary sinus p
153 ellular space by convective exchange between interstitial fluid (ISF) and cerebrospinal fluid (CSF) a
155 cellular tau from various sources, including interstitial fluid (ISF) and CSF from an AD transgenic m
156 ation increases levels of tau in mouse brain interstitial fluid (ISF) and human cerebrospinal fluid (
157 ogical insulin clamp significantly increased interstitial fluid (ISF) and plasma Abeta compared with
159 ent did not suppress Ang II levels in the LV interstitial fluid (ISF) despite marked inhibition of AC
161 ar pathway for cerebrospinal fluid (CSF) and interstitial fluid (ISF) exchange that facilitates effic
163 The physiological lag between blood and interstitial fluid (ISF) glucose is a major challenge fo
165 D uses an osmotic gradient to withdraw brain interstitial fluid (ISF) in a controlled manner via an i
168 aracterized soluble Abeta oligomers in brain interstitial fluid (ISF) of awake, freely moving APP/PS1
169 erebral microdialysis to obtain serial brain interstitial fluid (ISF) samples in 18 patients who were
170 t a novel method of quickly acquiring dermal interstitial fluid (ISF) samples using a Lorentz-force a
171 (NE) and epinephrine (Epi) into the cardiac interstitial fluid (ISF) space in experimentally induced
172 function significantly reduced the levels of interstitial fluid (ISF) tau in PS19 mice expressing P30
173 om the adjacent subarachnoid space and brain interstitial fluid (ISF) via the glymphatic system.
174 duced by neurons and released into the brain interstitial fluid (ISF), a process regulated by synapti
175 le Abeta levels and Abeta half-life in brain interstitial fluid (ISF), as measured by in vivo microdi
176 Abeta is released by neurons into the brain interstitial fluid (ISF), in which it can convert into t
177 ther tau is normally released into the brain interstitial fluid (ISF), its concentration in ISF in re
178 in 4 (AQP4) facilitated exchange of CSF with interstitial fluid (ISF), may provide a clearance pathwa
179 n vivo monitoring of glucose directly in the interstitial fluid (ISF), the continuous monitoring of k
180 o, we used microdialysis to sample the brain interstitial fluid (ISF), which contains the most solubl
190 .0001, and P<0.0001, respectively) and renal interstitial fluid levels of AT(2)R downstream signaling
191 ishes proliferative properties of myocardial interstitial fluid (MIF) by enhancing expression of matr
192 asurements were made in myocardial tissue or interstitial fluid (MIF) from dogs undergoing repetitive
193 by altering the chemical composition of the interstitial fluid near the surface of the aggregate.
195 nged the half-life of soluble Abeta in brain interstitial fluid of awake animals, 3) raised the conce
196 etabolism of sAbeta by astrocytes and in the interstitial fluid of mice that received apoE infusions
198 ical hyperinsulinemia on the response of the interstitial fluid of skeletal muscle to intravenously i
199 from postmortem cortical extracts and brain interstitial fluid of tau-transgenic mice, as well as hu
201 showed that T0 decreased Abeta levels in the interstitial fluid of the hippocampus, supporting the co
203 lexes (sIL-15 complexes) are abundant in the interstitial fluid of tumors with expression preceding t
204 oncentrations found in the cerebrospinal and interstitial fluids of the human brain, and the mechanis
206 Abeta oligomers were sequestered from brain interstitial fluid onto brain membranes much more rapidl
208 ghts a surprising and unrecognized role that interstitial fluid plays in setting the discharge rate,
209 lect the ability of ponezumab to mobilize an interstitial fluid pool of amyloid-beta40 in brain.
211 has been hypothesized that tumors with high interstitial fluid pressure (IFP) and/or hypoxia respond
212 draining lymphatic vasculature and decrease interstitial fluid pressure (IFP) by reducing vascular p
213 total tissue pressure (TTP) increasing above interstitial fluid pressure (IFP) directly with collagen
214 s can decrease tumor vessel permeability and interstitial fluid pressure (IFP) in a process of vessel
216 low of interstitial fluid and the associated interstitial fluid pressure (IFP) in solid tumors and su
219 t drug delivery is complicated by high tumor interstitial fluid pressure (IFP), irregular vascular di
222 71 with the stromal PDGFr-beta reduced tumor interstitial fluid pressure (P(IF)) by >50% and in so do
226 ion, vascular volume, microvascular density, interstitial fluid pressure and the number of viable, ci
227 of both freely mobile fluid and gel fluid to interstitial fluid pressure by performing simultaneous,
230 mph nodes by controlling edema formation and interstitial fluid pressure in the presence of LPS.
231 th Starling's hypothesis relating the higher interstitial fluid pressure in the tumor with flux acros
232 vessels through normalization decreases the interstitial fluid pressure in tumours, thus allowing sm
234 to literature, we show that reducing tumour interstitial fluid pressure is not essential to increase
236 polymerase eta-deficient mice and found that interstitial fluid pressure was already elevated in the
239 y 2.5-fold (immunohistochemistry), and tumor interstitial fluid pressure was suppressed by approximat
240 ses (compression and tension), (ii) elevated interstitial fluid pressure, (iii) altered material prop
242 ted that PDGFR-beta inhibition reduces tumor interstitial fluid pressure, and thus increases the upta
244 ve been studied including cut-off pore size, interstitial fluid pressure, and tumor tissue microstruc
245 wn to exhibit high vascular permeability and interstitial fluid pressure, but the transport pathways
246 o transport in these fibroids is likely high interstitial fluid pressure, correlating with high colla
247 the tumor reduces its compact structure and interstitial fluid pressure, increases blood perfusion,
248 ascular permeability without effecting tumor interstitial fluid pressure, leading to increased delive
249 DC101 (a VEGF-receptor-2 antibody) decreases interstitial fluid pressure, not by restoring lymphatic
250 d; increased diffusional distances, elevated interstitial fluid pressure, regions of dense extracellu
251 Compression of lymphatic vessels elevates interstitial fluid pressure, whereas compression of bloo
253 nvironment-characterized by hypoxia and high interstitial fluid pressure--fuels tumor progression and
256 plastic reaction generates inordinately high interstitial fluid pressures (IFPs), exceeding those pre
258 suggested that condylar cartilage relies on interstitial fluid pressurization to a greater extent th
260 s an increase in chymase activity in cardiac interstitial fluid, providing an alternate pathway for A
261 tercurrent exchange and efficient removal of interstitial fluid resorbed from the loop of Henle and c
263 system to the blood vasculature that returns interstitial fluid, salts, small molecules, resorbed fat
264 a metabolomic comparison of the bone marrow interstitial fluid samples from leukemia patients before
265 sharp gradient of S1P between blood and the interstitial fluids seems to be essential to ensure the
266 Pgp inhibitor, Abeta levels within the brain interstitial fluid significantly increased within hours
268 influx from the perivascular spaces into the interstitial fluid space rapidly transport solutes and c
269 uch as amyloid-beta peptide (Abeta) from the interstitial-fluid space of the brain to the bloodstream
271 pond to potential interferences found in the interstitial fluid, such as fructose, vitamin C and lact
272 deep substance of the brain, mixes with the interstitial fluid surrounding neurons and glia, and pla
273 rocess in which serotonin accumulates in the interstitial fluid surrounding the mammary secretory epi
274 and efficiently sample fluids such as sweat, interstitial fluids, tear and saliva for the electrochem
276 ould result in an accumulation of ATP in the interstitial fluid that would be related with a rise in
277 ions of >118 metabolites in plasma and tumor interstitial fluid, the extracellular fluid that perfuse
279 barrier and dissolve upon contact with skin interstitial fluid thus releasing the nanoparticles into
283 ept that neurons continuously acquire C from interstitial fluid to permit plasma membrane turnover an
284 efficiently simulate vascular blood flow and interstitial fluid transport in silico for validation ag
285 or immune surveillance and the regulation of interstitial fluid transport in the endocrine pancreas a
286 ness, to quantify and understand the role of interstitial fluid transport, lymphatic-convective drain
287 ls, combined with proteomic information from interstitial fluid, unraveling novel inflammatory player
289 monitoring of glucose concentrations in the interstitial fluid using near IR as the interrogating me
290 but little is known about how tumor IFP and interstitial fluid velocity (IFV) are affected by change
291 permeability was calculated by measuring the interstitial fluid velocity through the clots at a const
292 and a fast pulse, that is, traveling at the interstitial fluid velocity, or only a retarded shock.
296 e hyperaemia of substances released into the interstitial fluid, with emphasis on whether they are en
297 to known interfering species present in the interstitial fluid, with resolution and sensitivity (1.5
298 y, are appropriate for potassium analysis in interstitial fluid within both clinical and harmful leve
299 ference-free ethanol detection in artificial interstitial fluid without compromising its sensitivity,
300 e heart, and relieves congestion by clearing interstitial fluid without excessively reducing blood vo