ライフサイエンスコーパス: interstitium

1 n the immune cells that infiltrate the renal interstitium.

2 collecting ducts, nephrons, vasculature and interstitium.

3 of infection, injury, and stress within the interstitium.

4 transport through the vasculature and tumor interstitium.

5 n of ammonium in the medullary and papillary interstitium.

6 lar total volume exclusion properties in the interstitium.

7 ogens and reside in both the airways and the interstitium.

8 ge of the contrast agent into the islet cell interstitium.

9 of amyloid-beta peptide (Abeta) in the brain interstitium.

10 oth muscle actin-positive cells in the renal interstitium.

11 olar lavage (BAL) fluid, but not in the lung interstitium.

12 sion-dependent albumin shifts from plasma to interstitium.

13 cs and were significantly faster than in the interstitium.

14 t can permit passive accumulation into tumor interstitium.

15 ctor CD8(+) T cells within the infected lung interstitium.

16 regulating Abeta fibril growth in the brain interstitium.

17 cells and promote inflammation in the renal interstitium.

18 tween the urinary space and the hyperosmotic interstitium.

19 eas HeV initiated infection primarily in the interstitium.

20 d, small molecules, and cells from the renal interstitium.

21 tments are defined: the testis cords and the interstitium.

22 individuals and can gain access to the brain interstitium.

23 sors and LHX9 to the coelomic epithelium and interstitium.

24 or secreted ligands that traffic through the interstitium.

25 ewer F4/80 positive cells in the peritubular interstitium.

26 n of lipid conjugated ASO is isolated to the interstitium.

27 the accumulation of scar tissue in the lung interstitium.

28 P (positional isomer of 3',5'-cAMP) into the interstitium.

29 aces at the same time limiting flow into the interstitium.

30 RESUS + VH favors fluid flux into the interstitium.

31 yaluronan on diffusive hindrance through the interstitium.

32 hways between connected cells and within the interstitium.

33 rs is limited by diffusion through the tumor interstitium.

34 iderable leakage of the probe into the islet interstitium.

35 e examples of stromal cells within the renal interstitium.

36 net fatty acid flow between the cell and the interstitium.

37 lin may promote its own movement into muscle interstitium.

38 the reduced tonicity of the renal medullary interstitium.

39 AM cells, that form nodules in the pulmonary interstitium.

40 was mainly scattered in damaged tubules and interstitium.

41 eases the concentration of NEi in the muscle interstitium.

42 on of tubular cells through the TBM into the interstitium.

43 the tubular epithelium and excluded from the interstitium.

44 of potential tubular stem cells in the renal interstitium.

45 sonance (CMR) can assess abnormal myocardial interstitium.

46 r compartment into the noninflamed pulmonary interstitium.

47 Sertoli cells and to a lesser extent in the interstitium.

48 MP-9 were concomitantly induced in the renal interstitium.

49 ycocalyx was significantly lower than in the interstitium.

50 st likely due to increased mixing within the interstitium.

51 y located within the mesangium and the renal interstitium.

52 esting activation of eosinophils in the lung interstitium.

53 s found between endothelial cells and in the interstitium.

54 oping coronary vasculature in the myocardial interstitium.

55 vessels and colocalized with vimentin in the interstitium.

56 with calcium, cross the endothelium into the interstitium.

57 ule and remains below detection level in the interstitium.

58 ion of toxic materials from the lumen to the interstitium.

59 vement and/or activation within the inflamed interstitium.

60 ed by persistence of thickened intersaccular interstitium.

61 mplex II-positive macrophages in the ovarian interstitium.

62 e is little accumulation of potassium in the interstitium.

63 olve both the cardiomyocytes and the cardiac interstitium.

64 as myofibroblasts accumulate in the tubular interstitium.

65 es were unable to extravasate into the tumor interstitium.

66 allowed access of the 160 kD Crry-Ig to the interstitium.

67 ore biopsies had lymphocytes in 5-30% of the interstitium.

68 plugs, as well as in thickened perialveolar interstitium.

69 blast cells (LBCs) into lung parenchyma and interstitium.

70 vascular leak allowed ATX to enter the renal interstitium.

71 port across endothelial barriers into tissue interstitium.

72 units, the nephrons, surrounded by the renal interstitium.

73 f amyloid-beta (Abeta) peptides in the brain interstitium.

74 inant involvement of glomeruli and medullary interstitium.

75 idney development require signaling from the interstitium.

76 iseases involving the airways, including the interstitium.

77 contribute to progenitor cells in the testis interstitium.

78 0 to 700 kDa or 10 to 200 nm into the kidney interstitium.

79 within lymph nodes (LNs) draining the tumor interstitium.

80 profile intermediate between epithelium and interstitium.

81 onal migration through cell barriers and the interstitium.

82 CXCL1 chemotactic gradient accurately in the interstitium.

83 ught to be too slow for an adaptation to the interstitium [3], is an important second route allowing

84 y, DPP4+ progenitors reside in the reticular interstitium, a recently appreciated fluid-filled space

85 route to modulate solute transport from the interstitium according to biomechanical cues.

86 for the fluid exchange between the blood and interstitium across the capillary membrane, allowing the

87 n that neural stem cells can penetrate tumor interstitium, actively migrating even to hypoxic tumor c

88 In murine renal interstitium after obstructive injury, tPA and alpha-SMA

89 n the nuclei of renal tubular epithelium and interstitium after obstructive injury.

90 d cells collectively accumulated in the lung interstitium along with the successful metastatic cells

91 (PMNs) from the vascular space into the lung interstitium and airspace is an early step in the host i

92 uited from the circulation and patrolled the interstitium and airspaces of the lung.

93 to the bronchoalveolar lavage fluid and lung interstitium and airway goblet cell metaplasia, smooth m

94 infiltration of inflammatory cells into the interstitium and airways, and production of inflammatory

95 lar TG2 colocalized with Sdc4 in the tubular interstitium and basement membrane, where TG2 also coloc

96 ts that non-satellite cell types from muscle interstitium and bone marrow also give rise to myonuclei

97 our locations (i.e. intracellular, membrane, interstitium and circulation) are similar: opsonization,

98 P is also released basolaterally, toward the interstitium and circulation, to inhibit tubular inflamm

99 hondrial metabolite succinate into the local interstitium and circulation.

100 chains or transthyretin (TTR) in the cardiac interstitium and conducting system, represent an importa

101 rease in the number of myofibroblasts in the interstitium and degradation of the accumulated extracel

102 renal fibrosis, ATX accumulates in the renal interstitium and drives fibroblast accumulation and prom

103 hog readout) in postnatal Six2creFrs2alphaKO interstitium and ectopic sonic hedgehog (Shh) in subsets

104 rier proteins Cp, like albumin in plasma and interstitium and Fatty Acid-Binding Proteins within endo

105 ve discovered molecular heterogeneity in the interstitium and have characterized new markers of disti

106 tes that were spatially confined to the lung interstitium and heterogenous in their expression of CD1

107 effect accompanied by a hypotonic medullary interstitium and impaired countercurrent multiplication.

108 fficking of T lymphocytes from the pulmonary interstitium and into the large airways, during the onse

109 activity exists within the human myocardial interstitium and is a dynamic process under conditions s

110 n with amber light acidified the surrounding interstitium and led to activation of endogenous ASIC1a

111 expansion of alpha-SMA-positive cells in the interstitium and loss of tubular area occur via encroach

112 in the extravascular compartment, within the interstitium and lymph, in health and disease, and we he

113 TR-dextran remained confined by surrounding interstitium and myofibroblasts.

114 When present, they are limited to the tubulo-interstitium and often subtle despite profound dysfuncti

115 , on both T-cell number in the glomeruli and interstitium and on cytokine expression characteristic o

116 uced T cell responses in the airway and lung interstitium and protection in B cell-depleted wild-type

117 ble clinicians and researchers to assess the interstitium and quantify ECM expansion using extracellu

118 semipermeable barrier between blood and the interstitium and regulates various critical biochemical

119 nsplanted into host rat testes, colonize the interstitium and subsequently differentiate in vivo.

120 eliminated, the putative SLCs colonized the interstitium and subsequently expressed 3betaHSD, demons

121 the development of a medullary subset of the interstitium and that this non-autonomously affects the

122 GF)-beta 1, particularly within the fibrotic interstitium and the fibroblastic focus, and prominently

123 both trans-endothelial migration to the lung interstitium and trans-epithelial migration into the air

124 ed to the capillary endothelium and neuronal interstitium and, in two cases, within the nucleus of th

125 enhanced vascular permeability in the renal interstitium, and ATX protein localized to areas of vasc

126 sement membrane, were not found in the renal interstitium, and did not express alpha-smooth muscle ac

127 Phd3 were differentially expressed in renal interstitium, and heterozygous deficiency for Phd1 and P

128 ed in interacinar capillaries (IAC), islets, interstitium, and small- and medium-size vessels.

129 d, microdialysis sampling of skeletal muscle interstitium, and stable isotope methodology, to assess

130 corbate concentrations expected in the brain interstitium, and was stimulated by cobalt ions.

131 ry arteries, veins, lymphatics, and the lung interstitium are all represented at the level of the sec

132 ex cell-cell interactions among cells in the interstitium are involved in testis morphogenesis.

133 ronevironment - both the vasculature and the interstitium - are needed to maximize the effects of che

134 a) and steroidogenic cells (Leydig and theca-interstitium) are two major somatic cell types in mammal

135 the salinity/tonicity of the renal medullary interstitium as a result of inhibition of active sodium

136 Spirochetes in the cardiac interstitium associated with collagen fibers and co-loca

137 ic col(V) in bronchoalveolar lavage and lung interstitium because of MMP-mediated matrix degradation.

138 evalent mononuclear cell infiltration in the interstitium beginning at day 2 p.i. and peaking at day

139 in expression in renal tubular cells and the interstitium but not glomeruli.

140 ing Ab had suppressed Smad activation in the interstitium but not in myocytes, and noncanonical (TGF-

141 -positive cells are located within the renal interstitium, but are negative for Foxd1, an established

142 o bronchoalveolar lavage fluid and into lung interstitium, but CXCR2-/- mice reconstituted with CXCR2

143 sodium channel, and is pumped into the lung interstitium by basolaterally located Na/K-ATPase, thus

144 would be more easily cleared from the brain interstitium by diffusion than by bulk flow.

145 (+) channels (ENaC) and is extruded into the interstitium by Na,K-ATPase.

146 lular matrix (ECM) within the glomerulus and interstitium characterizes renal fibrosis, but the mecha

147 Inasmuch as myocardial interstitium contains angiotensinogen and angiotensin-co

148 oss the capillary endothelium from plasma to interstitium continues to be debated.

149 d in which the NDL tumor cells and the tumor interstitium could no longer be detected.

150 ealed that the cells that accumulated in the interstitium derived from nephron progenitor cells and e

151 ere poorly restored specifically in the lung interstitium, despite their significant restoration in t

152 presenting delivery of the contrast to tumor interstitium, determined from the kinetic curves of GdDT

153 EPDCs, which colonize the cardiac interstitium during embryogenesis, massively differentia

154 ), PGE(2) and PGI(2), also accumulate in the interstitium during exercise, and breathing 40% O(2) abo

155 ent to establish bulk flow through the brain interstitium during infusion.

156 Water accumulation in the interstitium (edema) and the peritoneum (ascites) of nep

157 neutralization of CXCL2 but not CXCL1 in the interstitium effectively reduced neutrophil recruitment.

158 cells forming a network throughout the renal interstitium expressed macrophage-specific markers.

159 l flux cause unstable oxygen levels in tumor interstitium, extravascular oxygenation of R3230Ac mamma

160 This study aimed to investigate capillary-interstitium fluid exchange in HFpEF, including lymphati

161 raction of renal cortical volume occupied by interstitium from baseline to 5 years or ESRD from IF/TA

162 ATP is released into the interstitium from muscle fibres, at least in part throug

163 ing bone spicules, which limit the amount of interstitium from which mural myofibroblasts can be recr

164 of effector T cells from the vascular to the interstitium functions through a pertussis toxin-sensiti

165 pHLIP also maps the renal cortical interstitium; however, kidney accumulation can be reduce

166 levels, fluid and protein loss in pulmonary interstitium, impaired lung expansion, and alveolar-capi

167 /around mast cells within the fibrotic renal interstitium in all samples.

168 e IV collagen, were reduced in glomeruli and interstitium in anti-VLA-1-treated animals (P = 0.0006).

169 ADPKD, monocytes accumulate within the renal interstitium in association with increased levels of mon

170 t, in the heart, mast cells are found in the interstitium in close proximity to nerves and myocytes,

171 S2 protein increased in the renal interstitium in diabetes and regulated TGF-beta-mediated

172 hing of the epithelium and thickening of the interstitium in embryonic lungs.

173 n the endothelial capillary walls and neural interstitium in GBCA-injected rats, but not in control r

174 beta chain protein is primarily in the renal interstitium in healthy and regenerating kidney.

175 and of fibrillar collagen I in the adjacent interstitium in the dual infection may facilitate dissem

176 e morphologic characteristics of the cardiac interstitium in the hibernating human myocardium and eva

177 y epithelial cell layer and also in the lung interstitium in the sites of leukocytic infiltration tha

178 es loss of CTSK expression in the myocardial interstitium in vivo.

179 53), Fg immunoreactivity in the tubules and interstitium increased remarkably and was able to distin

180 Renal interstitium inflammatory infiltrates were observed in 5

181 lved in the movement of neutrophils from the interstitium into alveoli.

182 ion of megakaryocytic PP extensions from the interstitium into BM sinusoids and triggering the subseq

183 gression of inflammatory cells from the lung interstitium into the airway lumen is critical for the r

184 ed from the blood vessels drains through the interstitium into the lymphatic vessel network and this

185 ux of an extracellular marker from the renal interstitium into the proximal tubule of the rat.

186 port by MCTs tends to drive lactate from the interstitium into tumor cells.

187 f CD4(+) T regulatory cells to the allograft interstitium is a final common pathway for metastable re

188 Here, we show that during development the interstitium is a highly heterogeneous patterned populat

189 of the neutralizing superoxide flow into the interstitium is associated with the activation of mitoch

190 Infiltration of immune cells into the renal interstitium is characteristic of chronic inflammatory k

191 Leukocyte infiltration of the cortico-interstitium is characteristic of many forms of progress

192 The hyperosmolality in the renal medullary interstitium is of major importance as a driving force f

193 n, the principal component of the myocardial interstitium, is hypothesized to be essential for this m

194 uman hearts, LOXL2 is upregulated in cardiac interstitium; its levels correlate with collagen crossli

195 contrast reagent transfer between plasma and interstitium (K(trans)) and interstitial space volume fr

196 ure but did not appreciably migrate into the interstitium, leading to a 56% increase in MR signal at

197 The accumulation of collagen within the lung interstitium leads to impaired respiratory function.

198 ephron cells but can switch fates into renal interstitium-like cell types.

199 mulation of fluid and cysts in the medullary interstitium, loss of medullary vascular bundles, and de

200 eposition of Fg in subendothelial matrix and interstitium making the immobilized Fg a readily accessi

201 Refocusing on the interstitium may potentially improve care through the id

202 ption of water into the hypertonic medullary interstitium mediated by collecting ducts.

203 estis cords (epithelium) and the surrounding interstitium (mesenchyme).

204 the seminiferous tubules and the testicular interstitium of busulfan-treated wild-type or c-kit muta

205 macrophages in the alveolar spaces and lung interstitium of COPD patients and controls.

206 ific T cell responses in the airway and lung interstitium of genetic B cell-deficient (Jh(-/-) knocko

207 hat the overexpression and deposition in the interstitium of high-molecular-weight hyaluronan (HA) is

208 mM to 10 mM, a level observed in the muscle interstitium of humans during exercise.

209 tubular epithelial cell damage in the renal interstitium of ICGN mice.

210 l mice, neutrophils remained confined in the interstitium of injured lungs and did not advance into t

211 nkeys were concentrated in the glomeruli and interstitium of kidneys, and in the portal triads and pa

212 a rapid and substantial accumulation in the interstitium of muscle tissue followed by relatively rap

213 Although eATP is virtually absent in the interstitium of normal tissues, it can be present in the

214 Both glomeruli and interstitium of patients with SVV strongly expressed CD1

215 sion in vessels, respiratory epithelium, and interstitium of phosphatase-deficient lung.

216 , GFP-positive donor cells were found in the interstitium of recipient testes, and they expressed the

217 ence of continuous remodeling in the cardiac interstitium of the hibernating myocardium, an important

218 l fibrosis, myofibroblasts accumulate in the interstitium of the kidney, leading to massive depositio

219 lenge reduced the collagen deposition in the interstitium of the lung that usually follows challenge.

220 The exit of lymphocytes from the interstitium of the lung, across the bronchial epitheliu

221 sal of ASO from the blood compartment to the interstitium of the muscle tissues to enhance ASO functi

222 to four times more likely to migrate to the interstitium of the myocardium than AdlacZ-infected epic

223 Mamu-AG stained few cells, primarily in the interstitium of the testis, there was consistent immunos

224 r survival of fetal Leydig precursors in the interstitium of the XY gonad.

225 of administered fluid accumulate in the lung interstitium of these patients.

226 WF+, alpha-SMA+ cells and were found in the "interstitium" of the scaffold.

227 arriers, drawing particular attention to the interstitium operating as a dynamic interface for water

228 R, uric acid was associated with doubling of interstitium or ESRD from IF/TA (OR 1.83, 95% CI, 1.06-3

229 the primary composite outcome of doubling of interstitium or ESRD from interstitial fibrosis and tubu

230 ran-retaining cells did not migrate into the interstitium or express alpha-smooth muscle actin.

231 and (5) numbers of monocytes/macrophages in interstitium or glomeruli, and (6) arterial proliferatio

232 ver, little is known about the origin of the interstitium or the molecular and cellular diversity wit

233 How the interstitium orchestrates these various roles is poorly

234 is involved in tau clearance from the brain interstitium, our results suggest that regional disrupti

235 creased, while fractional volume of cortical interstitium (P <0.00001) and atrophic tubules (P <0.01)

236 a-catenin from the underlying Wnt-responsive interstitium phenocopies the medullary deficiency of Wnt

237 ted to multiple cell types within the muscle interstitium, primarily endothelial cells.

238 deposition of type I collagen in the cardiac interstitium provides a noninvasive way to quantify myoc

239 presents, fibrosis of both the glomeruli and interstitium rapidly progresses, microthrombi appear, an

240 lung development, leading to thickened lung interstitium, reduced airway branching, and perinatal de

241 was that mast cells within the inflammatory interstitium release chymase, an enzyme capable of effic

242 proliferation and resulting expansion of the interstitium remain largely unknown.

243 logy, particularly in the distal airways and interstitium, remains poorly described.

244 overgrew and translocated crystals into the interstitium, restoring the tubular luminal patency; thi

245 t from the IMCD lumen to the inner medullary interstitium, resulting in osmotic diuresis.

246 Morphometric analysis of renal tubules and interstitium revealed a marked attenuation of tubular in

247 d by tumor cells and secreted into the tumor interstitium (secreted protein acid rich in cysteine).

248 The skin interstitium sequesters excess Na+ and Cl- in salt-sensi

249 ematopoietic origin within the infected lung interstitium serve as antigen presenting cells (APC) for

250 Reuptake of neurotransmitters from the brain interstitium shapes chemical signaling processes and is

251 thin or administered directly into the tumor interstitium, such as cytokines, chemokines, proteases,

252 itically, it is ectopically expressed in the interstitium, suggesting that ectopic JAK2 may contribut

253 s in transport properties of the vessels and interstitium that are associated with antiangiogenic the

254 dle-shaped cells were seen in the testicular interstitium that differed from the precursor cells in t

255 tropism to the basement membrane (BM)-renal interstitium that enables the bacteria to cause chronic

256 ts prime biologic importance for the cardiac interstitium that may rank highly in the hierarchy of va

257 haracterized cell types differentiate in the interstitium (the space between testis cords).

258 and 50% urea (to simulate in vivo papillary interstitium), the collected fluid osmolality was decrea

259 lood vessels or extravasates into the tumour interstitium, the overexpressed gamma-glutamyl transpept

260 Many animals permanently inhabit the marine interstitium, the space between sand grains [1, 2].

261 ctively), followed by "tubuli combined" and "interstitium." The network detected 92.7% of all glomeru

262 of Henle and spreads from there through the interstitium to beneath the urothelium.

263 fibroblast population, relays signals to the interstitium to promote myofibroblast differentiation an

264 use protein and fluid extravasation into the interstitium to reduce the vascular volume.

265 ary plasma through the endothelial cells and interstitium to the cardiomyocyte, applying standard phy

266 so facilitates the transport of ASO from the interstitium to the lymph and back into circulation.

267 re that serves to retrieve components of the interstitium to the lymph system.

268 ellular backflux of lanthanum from the renal interstitium to the proximal tubule lumen in association

269 ely), and the delivery of adenosine into the interstitium (to 290+/-80 and 299+/-143 nmol/L for the l

270 ased RIHP by 37% (Delta1.8 +/- 0.2 mmHg) and interstitium-to-lumen La backflux by 32% (Delta40.2 +/-

271 The net paracellular interstitium-to-lumen lanthanum backflux was measured be

272 rity of urinary ammonium; it is driven by an interstitium-to-lumen NH3 gradient due to the accumulati

273 blasts to express and secrete Loxl2 into the interstitium, triggering fibrosis, systolic and diastoli

274 utral macromolecules that equilibrate in the interstitium under various degrees of hydration.

275 mic changes in the metabolic profiles of the interstitium, urinary lumen, and glomerulus-areas that a

276 nce of tubular damage that exposes the renal interstitium, uromodulin becomes an endogenous danger si

277 vity was directly measured in the myocardial interstitium using a validated inline digital fluorogeni

278 um (La), was infused directly into the renal interstitium via a chronically implanted matrix.

279 rculating immune complexes "pumped" into the interstitium via trans-endothelial transport and trigger

280 on of ACE inhibitors directly into the renal interstitium, via the microdialysis probe, either did no

281 and the mean cleft path length from lumen to interstitium was 411 nm.

282 opically xenografted into the intrapulmonary interstitium was examined.

283 imilarly, staining of islets and parenchymal interstitium was not statistically associated with AMR.

284 tion in the capillary endothelium and neural interstitium was observed only in the contrast group.

285 ge trace pericyte-like cells in the alveolar interstitium, we show that this population proliferates

286 Invading cells in the lung interstitium were also quantified after immunohistochemi

287 ercise, metabolites accumulate in the muscle interstitium where they stimulate chemosensitive afferen

288 ively charged glycosaminoglycans in the skin interstitium, where sodium is bound to glycosaminoglycan

289 l Wnt signaling in the surrounding medullary interstitium, where the capillaries reside.

290 cts to dilated proximal tubules and expanded interstitium, whereas active caspase-3 was mainly scatte

291 (int) macrophages are located throughout the interstitium, whereas F4/80(lo)/CD11c(hi) dendritic cell

292 ormation, and transported these ICs into the interstitium, whereas neutrophil depletion drastically r

293 ation was a T cell infiltration in the renal interstitium, which affected some tubules.

294 ion of plasma proteins and leukocytes in the interstitium, which characterizes several vascular disea

295 ts with acute AAV had more mast cells in the interstitium, which correlated with the severity of tubu

296 of NF-kappaB-positive nuclei to cells in the interstitium, which stained positive for the pericyte ma

297 nd neutrophil-rich inflammatory areas of the interstitium, while NET-prone primed neutrophils were pr

298 he brain, suggesting that reaching the brain interstitium will be sufficient to ensure therapeutic ef

299 the atrial endothelium, penetrating into the interstitium, with increased collagen deposition.

300 Although neutrophils locomote through the interstitium without pericellular collagen degradation,