ライフサイエンスコーパス: intersubunit

1 proteasome subunits, more than half of them intersubunit.

2 t high glutamate concentrations, the initial intersubunit activation of mGluR1 proceeds with millisec

3 ciation with p55 was unperturbed, suggesting intersubunit affinities similar to WT.

4 The effect of intersubunit allosteric pocket "signature mutants" F88A,

5 vestibule of the receptor in addition to the intersubunit allosteric pocket.

6 ties that depend on multimerization, such as intersubunit allostery or the capacity to do mechanical

7 lay a large role in establishing such strong intersubunit anchoring.

8 hexameric architecture that is stabilized by intersubunit and interdomain interactions of LRRNT and L

9 Here we investigate both intersubunit and intrasubunit interactions between TM he

10 tructural studies have provided evidence for intersubunit and intrasubunit steroid-binding sites in t

11 These maturation factors act on both the intersubunit and the solvent sides of the LSU, where the

12 ol slowed the rate of modification of L240C (intersubunit) and increased the rate of modification of

13 ogs and other drugs that bind selectively to intersubunit anesthetic sites.

14 tive allosteric modulators by binding to the intersubunit anesthetic-binding sites in the GABAAR tran

15 romosomal instability, cancer, and decreased intersubunit association.

16 the extracellular domain that provides three intersubunit ATP binding sites.

17 genesis studies, has provided a model of the intersubunit ATP-binding sites and identified an extrace

18 imulations to demonstrate a coupling between intersubunit bending and the degree of flattening of eac

19 at changes in subunit dihedral angle lead to intersubunit bending or twist, suggesting a conserved me

20 reB filaments exhibited nucleotide-dependent intersubunit bending, with hydrolyzed polymers favoring

21 ly, the FNIII-like domain forms a continuous intersubunit beta-sheet dimer, previously unobserved for

22 nd in all apicomplexan PBGS enzymes forms an intersubunit beta-sheet, stabilizing a pro-octamer dimer

23 panded capsid are reinforced by formation of intersubunit beta-sheets with N-terminal segments of aux

24 s may have been compensated for by increased intersubunit beta-strand interactions at the icosahedral

25 pinwheel with elastic deformation modes and intersubunit binding interactions.

26 ed that S-mTFD-MPPB binds to the same GABAAR intersubunit binding site as R-mTFD-MPAB, but with negat

27 subunit interface site similar to its GABAAR intersubunit binding site.

28 ChR ion channel, but it does not bind to the intersubunit binding site.

29 otentiator, has identified a second class of intersubunit binding sites for general anesthetics in th

30 high selectivity to distinct but homologous intersubunit binding sites in the transmembrane domain o

31 tophans were within reach of both intra- and intersubunit binding sites.

32 on and provide a first demonstration that an intersubunit-binding site in the GABAAR transmembrane do

33 us but pharmacologically distinct classes of intersubunit-binding sites for general anesthetics in th

34 local shear force that accelerates filament intersubunit bond rupture.

35 ovirus-like human endogenous retrovirus--for intersubunit bonding and found that, as in the lentiviru

36 ed us to show that antibodies binding at the intersubunit boundary inhibit uncoating of the virion ou

37 tein uL2 to with rProtein bS6, forming a new intersubunit bridge 'B9'.

38 Dynamic remodelling of intersubunit bridge B2, a conserved RNA domain of the ba

39 iological role in establishing the ribosomal intersubunit bridge B2a and mediating translational fide

40 the 50S subunit and disassembles the central intersubunit bridge B2a, resulting in RF2 departure.

41 ture, the 30S shoulder is rotated inward and intersubunit bridge B8 is disrupted.

42 t, whereas G347U is located 77 A distant, at intersubunit bridge B8, close to where EF-Tu engages the

43 wn to be necessary for mitoribosome-specific intersubunit bridge formation and 15S rRNA H44 stabiliza

44 htly coupled to its ability to form a strong intersubunit bridge linking the primary and complementar

45 NS3920, the corresponding histidine forms an intersubunit bridge that reinforces the ligand-mediated

46 ional change of rRNA helix H69, an essential intersubunit bridge, and a secondary binding site of the

47 nd Lsg1 together embrace helix 69 of the B2a intersubunit bridge, inducing base flipping that we sugg

48 alyses of the cryo-EM maps reveal that eight intersubunit bridges (bridges B1a, B1b, B2a, B2b, B3, B7

49 lude rRNA segments in contact with the tRNA, intersubunit bridges and helices 28, 32 and 34 of the sm

50 Many intersubunit bridges are specific to the mitoribosome, w

51 S rRNA residues involved in the formation of intersubunit bridges B3, B5, B6, B7b and B8.

52 (i) the bulk transfer of energy through the intersubunit bridges from the large to the small subunit

53 In this study, the contribution of intersubunit bridges to the energy barrier of translocat

54 work propagating motion from the tRNA to the intersubunit bridges to the head swivel or along the sam

55 ribosomal subunit protein bL31, which forms intersubunit bridges to the small ribosomal subunit, ass

56 osomal subunits remain associated through 17 intersubunit bridges, five of which are eukaryote specif

57 ere, we review the molecular nature of these intersubunit bridges, how they change conformation durin

58 tions between the ribosomal subunits, termed intersubunit bridges, keep the ribosome intact and at th

59 d directly in the formation of six of the 15 intersubunit bridges.

60 ably, the TnrA sensor domains insert into GS intersubunit catalytic pores, destabilizing the TnrA dim

61 odels, we investigate cholesterol binding to intersubunit cavities of the GABAAR transmembrane domain

62 tive of binding stability; the extracellular intersubunit cavity expanded and intersubunit electrosta

63 Propofol-induced motions in the intersubunit cavity were distinct from motions associate

64 C shows R-ketamine bound to an extracellular intersubunit cavity.

65 of CeFIGL-1-AAA has adapted to establish an intersubunit charge interaction, which contributes to it

66 hes, whereas the G4941I mutation resulted in intersubunit clashes among the mutated isoleucines.

67 mechanism of activation, and the role of the intersubunit cleavage.

68 ried ligand-binding pocket at interdomain or intersubunit clefts, facilitating proper solvent shieldi

69 sp104 hexamers adapt different mechanisms of intersubunit collaboration to disaggregate stress-induce

70 aggregates but employ distinct mechanisms of intersubunit collaboration.

71 hus, the dynamic response of mTORC1 requires intersubunit communication by the Rag GTPases, providing

72 Importantly, Hsp104 variants with impaired intersubunit communication dissolve disordered aggregate

73 onvenient format for assessing mechanisms of intersubunit communication from a variety of NMR measure

74 tinct roles of intrasubunit interactions and intersubunit communication in allostery.

75 This intersubunit communication pushes the Rag GTPases into e

76 drolysis, to study allosteric regulation and intersubunit communication.

77 ved residues for roles in ATP hydrolysis and intersubunit communication.

78 critical for its functionality in alpha/beta intersubunit communication.

79 ing of individual subunits as well as of the intersubunit communications.

80 Bacillus subtilis enzyme undergoes dramatic intersubunit conformational alterations during formation

81 ions demonstrated that IM-CKV063 binds to an intersubunit conformational epitope on domain A, a funct

82 to induce signaling in T cells via intra- or intersubunit conformational rearrangements within the ex

83 Comparison of intersubunit conformations among five classes obtained a

84 ally aromatic compounds devoid of long-range intersubunit conjugation.

85 de a wealth of data on the stoichiometry and intersubunit connectivity of endogenous protein assembli

86 knowledge of their subunit stoichiometry and intersubunit connectivity.

87 from crosslinking experiments identifying an intersubunit contact most consistent with that number; s

88 turn influences the formation of stabilizing intersubunit contacts and thus the reaction's degree of

89 op, which was hypothesized to make important intersubunit contacts between coat proteins in adjacent

90 along the entire length of S1, and also have intersubunit contacts between S1 and S4.

91 t only provides further understanding of the intersubunit contacts in allosteric coupling in the HCN

92 (HCN) channel as a model system to study the intersubunit contacts in cAMP-dependent gating.

93 t from steric hindrance of the W domain with intersubunit contacts in the actin filament.

94 te receptors, NMDA receptors have additional intersubunit contacts in the ligand binding domain that

95 talytic-right subunits, which make extensive intersubunit contacts in the tetramer.

96 Extensive intersubunit contacts stabilize a bent filament-like arr

97 We identified intra- and intersubunit contacts that formed with the LA loops; the

98 main are critical for stabilizing intra- and intersubunit contacts that guide proper capsid assembly.

99 the AMPA receptor structure, this face forms intersubunit contacts with the transmembrane helices of

100 d by ATP hydrolysis lead to an alteration of intersubunit contacts within and across the rings, ultim

101 In non-NMDA receptors, the strength of intersubunit contacts within ligand-binding domains is i

102 Freed of intersubunit contacts, the apical domain of each subunit

103 d upon desensitization and replaced by newer intersubunit contacts.

104 utamate-gated channels for largely conserved intersubunit contacts.

105 MR titration data reveal that there is minor intersubunit cooperativity in formation of a ternary com

106 ike EcoSSB, the mtSSB does not show negative intersubunit cooperativity.

107 study the mechanisms of force generation and intersubunit coordination in the ClpXP protease from E.

108 that may functionally facilitate intra- and intersubunit coordination, including the 5.8S rRNA.

109 uld activate the Hsp104 hexamer by promoting intersubunit coordination, suggesting that Hsp70 is an a

110 e interaction, mechanochemical coupling, and intersubunit coordination.

111 al step-size of 1 nm and a certain degree of intersubunit coordination.

112 We find that long-range intersubunit correlation of amino-acid pairs is weaker i

113 Our results suggest that intersubunit crevices found in the TM domain of the ATP-

114 outh of the BchL ATP-binding pocket promotes intersubunit cross stabilization of the two subunits.

115 g to both subunits as a prerequisite for the intersubunit cross stabilization.

116 We have performed intersubunit cross-linking using glutaraldehyde of the O

117 By inducing RyR intersubunit cross-linking, ROS can increase SR Ca(2+) l

118 dine receptor (RyR) subunits, referred to as intersubunit cross-linking.

119 Intersubunit cross-talk between this domain and the DnaA

120 Remarkably, several intersubunit crosslinks abrogated membrane fusion, but b

121 ing is instead inhibited by oxidation of the intersubunit cysteine pair to a mixture of disulfide and

122 Venus flytraps leads to a compaction of the intersubunit dimer interface, thereby bringing the cyste

123 ron resonance (DEER) spectroscopy to measure intersubunit distance distributions in SthK, a bacterial

124 copy to measure a large number of intra- and intersubunit distances between spin labels attached to s

125 We found intersubunit distances to average 16 A between neighbori

126 binding zinc, but no changes are observed in intersubunit distances.

127 aliana revealed the presence of a regulatory intersubunit disulfide bond (Cys(86)-Cys(119)).

128 designated BG505 SOSIP.664, incorporates an intersubunit disulfide bond (SOS) to covalently link the

129 tivity is biochemically regulated through an intersubunit disulfide bond between Cys86 and Cys119 in

130 r this enzyme and reveals the presence of an intersubunit disulfide bond between Cys86 and Cys119.

131 odimers being trapped by the formation of an intersubunit disulfide bond between cysteine residues st

132 cysteine substitutions successfully promoted intersubunit disulfide bond formation in HeV F.

133 onship between dimer-decamer transitions and intersubunit disulfide bond formation is more complex th

134 antibodies and nearest neighbor analyses via intersubunit disulfide bond formation.

135 s 166 and 254 thus appear to be required for intersubunit disulfide bond formation.

136 es bound the enzyme in close proximity to an intersubunit disulfide bond interactions that covalently

137 n the lentiviruses, the Env subunits lack an intersubunit disulfide bond.

138 gly, Y424C-G428C monomers were associated by intersubunit disulfide bonds and were insensitive to MTS

139 utant HIV-1 particles capable of spontaneous intersubunit disulfide bonds at the interhexamer interfa

140 We now demonstrate that intersubunit disulfide bonds exist between monomeric sub

141 the spatial constraints introduced by these intersubunit disulfide bonds in the outer vestibule of t

142 47, P48, and G49 to cysteine, allowing novel intersubunit disulfide bonds to form with the free C153

143 Intersubunit disulfide bonds were detected in purified p

144 was discovered to be a homotetramer with an intersubunit disulfide bridge.

145 partial proteolysis and to reduction of its intersubunit disulfide bridges by glutathione.

146 Intersubunit disulfide bridges, Cys-206-Cys-206 and Cys-

147 the subunit interface of sfALR, close to the intersubunit disulfide bridges.

148 of excitatory amino acid transporter 1 form intersubunit disulfide cross-links within the trimer.

149 This suggests that the intersubunit disulfide induces a conformational change t

150 atoms (from R194 itself and from C95 of the intersubunit disulfide of the other protomer) and with t

151 ess and the possibility that both intra- and intersubunit dynamic binding (i.e., loss and restoration

152 hrough the single heme moiety rather than an intersubunit electron pathway through a potential domain

153 ate residue, which is believed to facilitate intersubunit electron transfer between the Rieske center

154 This long-range, intersubunit electron transfer occurs by a multistep "ho

155 -called bridging glutamate (E205) residue in intersubunit electron transfer.

156 zed that an arginine-119 residue was forming intersubunit electrostatic bonds with D97.

157 This intersubunit electrostatic interaction among GlyR subuni

158 tracellular intersubunit cavity expanded and intersubunit electrostatic interactions involved in chan

159 We conclude that intra- and intersubunit electrostatic networks at the extracellular

160 mation that exposes the surfaces engaging in intersubunit FliGC/FliGM contacts.

161 Intersubunit fluorescence resonance energy transfer meas

162 Although the typical S100 protein intersubunit four-helix bundle is conserved upon S-nitro

163 Specifically, we ask to what extent intersubunit geometry affects oligomerization state.

164 indirect, or allosteric mutations affecting intersubunit geometry via indirect mechanisms are as imp

165 ct changes outside the interface that affect intersubunit geometry.

166 that the synthesis of the primer proceeds by intersubunit glucosylation of dimeric glycogenin, even t

167 The MSAE produced by heterodimer intersubunit glucosylation was 60% of that produced by t

168 and critical role for this centrally located intersubunit helix (H69) in accurate and efficient subst

169 n sites for sensory adaptation that lie near intersubunit helix interfaces of the Tsr homodimer.

170 thereby properly position a backbone NH for intersubunit hydrogen bonding to the key Asp.

171 rs at the dimer interface and enhancement of intersubunit hydrogen bonds in the presence of bt10, whi

172 tional changes that lead to disruption of an intersubunit interaction between a "hot-spot" loop in th

173 nterface and designed mutants to perturb the intersubunit interaction.

174 Our results suggest that 4 intersubunit interactions (Arg11-Asp343, Lys113-Asp367,

175 brium toward particle formation by promoting intersubunit interactions and stabilizing assembly inter

176 eucine zipper region of UL6 is important for intersubunit interactions and stable ring formation.

177 cture of the open state that has stabilizing intersubunit interactions and that is compatible with av

178 the role of residues involved in intra- and intersubunit interactions and their link with the channe

179 We identified numerous intersubunit interactions and up to six Rab-binding site

180 mechanism of the complex RbsABC2, we probed intersubunit interactions by varying the presence of the

181 s and modeling to probe these class-specific intersubunit interactions for their role in glutamate bi

182 as crystallized as a pentamer, revealing the intersubunit interactions in a wild type neuronal nAChR

183 C-linker is the site of virtually all of the intersubunit interactions in the C-terminal region.

184 Glu(42), an amino acid that participates in intersubunit interactions in the CRP pentamer and is bur

185 Intersubunit interactions involving 11 hydrogen bonds an

186 In the unliganded Env, intersubunit interactions maintain the gp41 ectodomain h

187 t phosphorylation-induced destabilization of intersubunit interactions mediated by the N-terminal dom

188 We have identified one of the key intersubunit interactions that controls pH-induced monom

189 important sites of dynamic intrasubunit and intersubunit interactions that regulate assembly of the

190 g short range and long range interdomain and intersubunit interactions that uniquely regulate the act

191 s did not, suggesting the inhibitors enhance intersubunit interactions to overcome channel biogenesis

192 uggest that the tethering arm contributes to intersubunit interactions within the EGF receptor dimer.

193 identified two regions involved in critical intersubunit interactions.

194 interactions and 2) trans-allostery requires intersubunit interactions.

195 ations that reduce dimerization or alter the intersubunit interface affect both the second conformati

196 emonstrated that point mutations in the EpsE intersubunit interface also reduce ATPase activity witho

197 e non-adhesive CfaB subunit localized to the intersubunit interface and significantly reduced fimbria

198 effects whether it contributed either to an intersubunit interface containing a canonical ACh bindin

199 this is due to minor differences between the intersubunit interface formed by the NTDs and the abilit

200 Earlier we hypothesized that the intersubunit interface in CYP3A4 oligomers is similar to

201 e inhibitors act through a unique pH-sensing intersubunit interface in GPC, but atomic-level structur

202 le open conformation in which changes at the intersubunit interface in the CTD also alter the electro

203 uces the binding of a neurotransmitter at an intersubunit interface into the opening of a central ion

204 The JMJD5-PKM2 interaction resides at the intersubunit interface region of PKM2, which hinders PKM

205 transmembrane segments of the VSDs form the intersubunit interface that mediates coupling between bi

206 structural rearrangements at the cytoplasmic intersubunit interface.

207 g a third Glu-binding site at an alpha/alpha intersubunit interface.

208 ll molecules activate PKM2 by binding to its intersubunit interface.

209 with helix 44 and spans the entire ribosome intersubunit interface.

210 dentified, allowing modeling of the complete intersubunit interface.

211 lphaW493R rewires structural dynamics of the intersubunit interfaces alpha1beta and alpha2gamma.

212 Elements at the intersubunit interfaces coordinate ATP hydrolysis with t

213 mbrane-associated domains (M3 and M4) at the intersubunit interfaces form putative sites of alcohol a

214 tivated CaMKII acts as a wedge by docking at intersubunit interfaces in the hub.

215 Intersubunit interfaces play a critical role in alloster

216 GluClalphaR, we introduced mutations at the intersubunit interfaces where Glu (the neurotransmitter)

217 ogues) that are located at and stabilize the intersubunit interfaces, together with a single tightly

218 o equivalent Glu-binding sites at beta/alpha intersubunit interfaces, where the GluClbeta and GluClal

219 are near, but not in, the active site or at intersubunit interfaces.

220 formation of heterologous (i.e., asymmetric) intersubunit interfaces.

221 ting of five amino acids at the M3-M4 domain intersubunit interfaces.

222 c subunits, harboring 10 active sites at the intersubunit interfaces.

223 ncluding a more thorough characterization of intersubunit interfaces.

224 s, quantifiable manner for the heterogeneous intersubunit, intraring, noncovalent cross-links provide

225 hat the closed conformation is stabilized by intersubunit ion-ion interactions involving negative res

226 Antibodies that bind at the intersubunit junction neutralize as monovalent Fabs, whi

227 P2-binding sites in the regions close to the intersubunit junctions, suggesting that NSP2 binding cou

228 A unique 'intersubunit latch' within this transmembrane interface

229 Following cleavage, the intersubunit linker (and associated conformational chang

230 evaluation of the role of the prodomain and intersubunit linker on caspase-6 structure and function

231 s L1, L3, and L4 and in the 130s region, the intersubunit linker region, the 26-32 region as well as

232 structures of caspase-6 with and without the intersubunit linker.

233 lipid bilayers related to reorganization of intersubunit lipid binding sites demonstrate a critical

234 UGDHs where structural divergence within the intersubunit loop structure likely contributes to the Ca

235 in the C-terminal domain and another in the intersubunit MHR interface.

236 Two types of intersubunit modules formed by the large ATPase domain o

237 bonds between adjacent subunits to restrict intersubunit movements inhibited channel function.

238 inhibits InsP3R activity by restricting the intersubunit movements that initiate gating.

239 ncode both surface recognition and favorable intersubunit packing interactions.

240 nition by P-TEFb and reveal an unanticipated intersubunit pocket on the AFF4 SEC that potentially rep

241 and revealed specific binding to the 2-fold intersubunit pocket.

242 We conclude that both intrasubunit and intersubunit reaction mechanisms are necessary for the d

243 o glucosylate exclusively by intrasubunit or intersubunit reaction mechanisms.

244 with deformation of these domains as well as intersubunit rearrangements during AMPA receptor desensi

245 These results suggest that (i) the ribosomal intersubunit reorganizations upon RRF binding and subseq

246 ion, leaving the ribosome in a non-canonical intersubunit rotated state with an exposed codon in the

247 Intersubunit rotation and movement of the L1 stalk, a mo

248 Here, we use single-molecule FRET to monitor intersubunit rotation and the inward/outward movement of

249 del in which L1 stalk movement is coupled to intersubunit rotation and/or IF2 binding.

250 Ribosomal intersubunit rotation destabilizes the catalytic RF2 dom

251 s long axis and orthogonal to the well-known intersubunit rotation distinguishes the posttranslocatio

252 A model is presented describing how cyclic intersubunit rotation ensures the unidirectionality of t

253 ribosomal subunit and slows down spontaneous intersubunit rotation in pretranslocation ribosomes.

254 steric interactions involved in coordinating intersubunit rotation originating from rpL10 in the core

255 gly inhibit A-site tRNA binding and ribosome intersubunit rotation that accompanies translation elong

256 iotic to predictably perturb the dynamics of intersubunit rotation, a structural rearrangement of the

257 elbow, stalk movement is directly linked to intersubunit rotation, rotation of the 30S head domain a

258 nd B4, B7a and B8 are predicted to constrain intersubunit rotation, these data provide evidence that

259 ions of the small subunit-head swiveling and intersubunit rotation-are thus coordinated via long-rang

260 ectively, impacts translation by controlling intersubunit rotation.

261 n) state involves both 30S head movement and intersubunit rotation.

262 the small subunit are maintained throughout intersubunit rotation.

263 he pivot for head swiveling with the axis of intersubunit rotation.

264 olecular ratchets, involving both intra- and intersubunit rotational movements, to drive the synchron

265 Intersubunit rotational states differ in these structure

266 translocation, characterized by intermediate intersubunit rotations, L1 stalk positions, and tRNA con

267 In R297C, this was due to disruption of intersubunit salt bridge Glu(288)-Arg(297).

268 we identified 12 amino acid residues forming intersubunit salt bridges and 21 amino acid residues for

269 ociation between the binding and breakage of intersubunit salt bridges in the EC domain.

270 in subunits, which is stabilized by multiple intersubunit salt bridges.

271 Intersubunit salt bridging between Arg(4) and Glu(53) du

272 We identify the intersubunit side of the large subunit as the binding si

273 followed by the polypeptide exit tunnel, the intersubunit side, and finally the central protuberance.

274 Coexisting nucleotide states, and correlated intersubunit signaling features, coordinate rotation of

275 it via a conserved but structurally distinct intersubunit-signaling pathway common to diverse AAA+ ma

276 An intersubunit site (labeled residues beta3-L294 and G308)

277 on of PAMs that bind selectively to a single intersubunit site in the GABA(A)R transmembrane domain,

278 A second intersubunit site partially overlaps with the GABA site

279 demonstrated to act through a transmembrane intersubunit site situated in the upper three helical tu

280 inds to the canonical beta(3)(+)-alpha(1)(-) intersubunit site that mediates receptor activation by n

281 oth the alpha1 intrasubunit and beta3-alpha1 intersubunit sites are critical for neurosteroid action.

282 subunit sites for most halothane binding and intersubunit sites for thiopental binding.

283 m as well as propofol bind to the homologous intersubunit sites in the GABAAR transmembrane domain th

284 el homology model suggests propofol binds to intersubunit sites in the TMD in the resting state.

285 size that binding at any of these homologous intersubunit sites is sufficient for anesthetic action a

286 yl) determines selectivity for intra- versus intersubunit sites, in contrast to GABAARs, where this d

287 l, a general anesthetic that binds to GABAAR intersubunit sites, inhibited [(3)H]S-mTFD-MPPB photolab

288 de that ML277 activates IKs by binding to an intersubunit space and allosterically influencing pore c

289 e than 20 angstrom and are stabilized in the intersubunit space by dimeric ArfB.

290 hape and position of this IRES domain in the intersubunit space compared to those of tRNA, supporting

291 MRP complex shows that FMRP binds within the intersubunit space of the ribosome such that it would pr

292 The spin label mobility, intersubunit spin-spin proximity, and the solvent-access

293 s of the IF2.tRNA sub-complex forming on the intersubunit surface of the 30S IC may play a significan

294 ilament bending and torsional rigidities and intersubunit torsional flexibility measured experimental

295 The linker length between P1 and P3 dictates intersubunit (trans) versus intrasubunit (cis) autophosp

296 ctivation via four biochemically established intersubunit transmembrane pockets.

297 suggests that all bind to a broadly similar intersubunit transmembrane site.

298 ternal GXY repeats of gp12 to build a stable intersubunit triple helix in a prokaryotic setting.

299 Despite this intersubunit uncoupling, both I domains remain individua

300 in the GLIC TMD that frame intrasubunit and intersubunit water-accessible cavities were individually