ライフサイエンスコーパス: intestinal organoid

1 BAs and TGR5 agonists promoted growth of intestinal organoids.

2 roliferative signal inhibition in livers and intestinal organoids.

3 gene expression in patient-derived and mouse intestinal organoids.

4 es the adherence of these pathogens to human intestinal organoids.

5 r genes to enable future research of chicken intestinal organoids.

6 They also stimulated growth in primary human intestinal organoids.

7 , and regulation of ISC function in mice and intestinal organoids.

8 ls, endothelial cells, cancer spheroids, and intestinal organoids.

9 e conversion process in mice and human adult intestinal organoids.

10 or zebrafish development and growth of mouse intestinal organoids.

11 , on the bovine intestinal barrier utilizing intestinal organoids.

12 from the small intestine of mice and derived intestinal organoids.

13 ogel systems that allow for the expansion of intestinal organoids.

14 -potentiating activity in cultured cells and intestinal organoids.

15 -knockout (CRISPR-KO) screen, and imaging of intestinal organoids.

16 ing of food allergens was conserved in human intestinal organoids.

17 nt supplementation restored function of aged intestinal organoids.

18 ophages, while TNF was a strong activator in intestinal organoids.

19 heroids were pre-organoids that matured into intestinal organoids.

20 ) reactions, to support routine passaging of intestinal organoids.

21 ablishing a robust protocol for high quality intestinal organoids.

22 ath in the intestinal epithelium of mice and intestinal organoids.

23 r stem cells (CSCs) and attenuated growth of intestinal organoids.

24 the more promiscuous transformation of small intestinal organoids.

25 t to promote maintenance of Lgr5(+) IESCs in intestinal organoids, an effect mainly mediated by Greml

26 regulates differentiation of goblet cells in intestinal organoid and enterocyte cell cultures; differ

27 this gene correction strategy is verified in intestinal organoids and airway epithelial cells derived

28 quivalent to Trikafta for F508del, corrected intestinal organoids and corrected R553X nonsense mutati

29 Consistent with this, Nlrp12-deficient intestinal organoids and CRC cells showed increased prol

30 Remarkably, inhibition of MAPK signaling in intestinal organoids and cultured cells changed the rela

31 increased L-cell density in mouse and human intestinal organoids and elevated GLP-1 secretory capaci

32 expansion and biobanking of patient-derived intestinal organoids and fibroblasts, the generation of

33 reovirus, as well as in donor-derived human intestinal organoids and human biopsy samples.

34 quently downregulated in SARS-CoV-2 infected intestinal organoids and human colon carcinoma cells. In

35 suppression of cell proliferation in murine intestinal organoids and human CRC lines.

36 gulate ACE2 in human lung, cholangiocyte and intestinal organoids and in the corresponding tissues in

37 loped a coculture system for mouse and human intestinal organoids and macrophages to explore the cros

38 ntenance and differentiation of rabbit small intestinal organoids and organoid-derived cell monolayer

39 cancer cell lines, as well as primary mouse intestinal organoids and patient-derived colorectal canc

40 GLP-2 expanded intestinal organoids and reduced expression of apoptosis

41 reproducible model of DXR-induced injury in intestinal organoids and reveal differences in in vitro

42 xploit mouse and human knock-in and knockout intestinal organoids and show that agents used as commer

43 o map subcellular transcript localization in intestinal organoids and tissue from adult mice.

44 We characterized the role of ATP7B in mouse intestinal organoids and tissues.

45 ion, was boosted in AZA-treated murine small intestinal organoids and was associated with decreased D

46 encing (RNA-seq), single-cell RNA-seq, human intestinal organoids, and cell trajectory analysis, we s

47 silencing also inhibited growth of IECs and intestinal organoids, and circHIPK3 overexpression promo

48 induced human pluripotent stem cell-derived intestinal organoids, and confirm in vivo that GH suppre

49 Using single-cell RNA sequencing, intestinal organoids, and gain- and loss-of-function exp

50 ly relevant targets of HECT E3s in cells and intestinal organoids, and in a genetic screen that ident

51 We isolated epithelial cells, generated intestinal organoids, and performed RNA sequence analyse

52 ended BME hydrogel culture method will allow intestinal organoids, and potentially other organoid typ

53 human peripheral blood mononuclear cells and intestinal organoids, and this toxicity is neutralized b

54 n defined media; (stage 2) microinjection of intestinal organoids; and (stage 3) generation of animal

55 Intestinal organoids are useful in vitro models for basi

56 rom inducible pluripotent stem cells (termed intestinal organoids) are being applied to study human i

57 Here, using intestinal organoids as a model of tissue regeneration,

58 ion as stressor and primarily murine-derived intestinal organoids as a model system, we show that MDP

59 rk states, and vulnerabilities of transgenic intestinal organoids as a novel approach to understandin

60 n datasets including Vero E6 cells, lung and intestinal organoids, as well as additional patient lung

61 n this issue of Cell Stem Cell, using murine intestinal organoids, Basak et al. (2017) induce stem ce

62 nzazepine increased the number of L cells in intestinal organoid-based mouse and human culture system

63 of Blood, Matsuzawa-Ishimoto et al report an intestinal organoid-based platform that re-creates genet

64 In mouse intestinal organoids, BBLN localizes subapically, togeth

65 inhibition of HDAC3 in adult mice and human intestinal organoids blocked tuft cell expansion.

66 d new cultures can be induced to form mature intestinal organoids by exposure to Wnt3a.

67 lumetric compression regulates the growth of intestinal organoids by modifying intracellular crowding

68 lumetric compression regulates the growth of intestinal organoids by modifying intracellular crowding

69 Intestinal organoids capture essential features of the i

70 report a single cell transcriptomic atlas of intestinal organoid cells derived from embryos of broile

71 ived from two CIVMs: a stem-cell-based human intestinal organoid CIVM and a neonatal rodent testis CI

72 stem cells following differentiation in the intestinal organoid CIVM.

73 rimarily focus on recent findings enabled by intestinal organoids co-cultured with lymphocytes, we po

74 Using intestinal organoids (colonoids and enteroids) derived f

75 The resulting three-dimensional intestinal 'organoids' consisted of a polarized, columna

76 pothesized that the radiation sensitivity of intestinal organoids could predict the sensitivity of in

77 Intestinal organoid culture has widely depended on exoge

78 of budding structures found in our in-vitro intestinal organoid culture images on days 3 and 7 after

79 We used mouse and human ex vivo 3D intestinal organoid cultures and in vivo mouse models to

80 In studies of intestinal organoid cultures and mice with inducible del

81 CS administered to mice in vivo and intestinal organoid cultures ex vivo reduced epithelial

82 We generated intestinal organoid cultures from a subset of samples an

83 Intestinal organoid cultures from patient biopsies displ

84 Depletion of RIPK1 in intestinal organoid cultures sensitized them to TNF-indu

85 We improve the viability and homogeneity of intestinal organoid cultures to enable long-term time-la

86 Like a HFD, ex vivo treatment of intestinal organoid cultures with fatty acid constituent

87 In intestinal organoid cultures, the terminal web NM2C netw

88 Using intestinal organoid cultures, we found that, compared wi

89 entiation of mucin-producing goblet cells in intestinal organoid cultures.

90 d, wild-type (WT) and Pxr-null mice, primary intestinal organoids cultures, and the luciferase report

91 ermore, TNF treatment and CFTR inhibition in intestinal organoids demonstrated that TNF promotes ion

92 Infection of intestinal organoids derived from different donors with

93 thelial cells and an intestinal channel with intestinal organoids derived from human induced pluripot

94 Of note, InsP(3) also induced growth of intestinal organoids derived from human tissue, stimulat

95 fluid secretion in two complementary models: intestinal organoids derived from subjects with CF and a

96 For molecular studies, we used intestinal organoids derived from these mice.

97 In this study, we used intestinal organoid-derived cultures differentiated from

98 Using intestinal organoids developed from duodenal biopsies fr

99 YAMC cells, and mouse and human intestinal organoids, died rapidly in response to TNF.

100 Gastric and small intestinal organoids differentiated from human pluripote

101 We investigated intestinal organoid emergence, focusing on measurable pa

102 hat both pluripotent stem cell-derived human intestinal organoids engrafted into mice and patient-der

103 robials is dramatically askew in human small intestinal organoids (enteroids) as compared to that in

104 cell cycle and circadian clock in 3D murine intestinal organoids (enteroids).

105 ies spanning in vitro efferocytosis, ex vivo intestinal organoids ("enteroids"), and in vivo Cre-medi

106 for device fabrication, culture of Caco-2 or intestinal organoid epithelial cells in conventional set

107 -cell transcriptomic analysis of human small intestinal organoids explanted from mice with experiment

108 Human intestinal organoids expressing the motorless MYO5B tail

109 o track all cells in crypts of growing mouse intestinal organoids for multiple generations, allowing

110 Using intestinal organoids from a CF mouse model, we determine

111 Intestinal organoids from Atoh1 mutant mice did not grow

112 Employing intestinal organoids from healthy individuals, we demons

113 in the same spheroid to vascularize lung and intestinal organoids from induced pluripotent stem cells

114 mor-affected cats (FMT organoids) and normal intestinal organoids from mice (MI organoids) and perfus

115 We generated 3-dimensional small intestinal organoids from mice and studied the effects o

116 tured allogeneic T cells kill Atg16L1-mutant intestinal organoids from mice, which was associated wit

117 lear factor (NF) kB translocation in primary intestinal organoids from PXR-humanized mice, but not Px

118 The development of intestinal organoids from single adult intestinal stem c

119 We derived intestinal organoids from wild-type mice and Tgr5(-/-) m

120 p three-dimensional cellular forces in mouse intestinal organoids grown on soft hydrogels.

121 ical Wnt/beta-catenin signalling, and induce intestinal organoid growth in vitro and Lgr5(+) ISCs in

122 Ifnlr1-/- intestinal organoid growth was significantly impaired, a

123 ase Lgr5(+) stem cell expansion, and promote intestinal organoid growth.

124 Intestinal organoids have been widely used to study cell

125 Intestinal organoids have proven useful to study crypt m

126 Human intestinal organoid (HIO)-derived tissue-engineered inte

127 Human intestinal organoids (HIOs) derived from pluripotent ste

128 tand the etiology of CCS, we generated human intestinal organoids (HIOs) from intestinal stem cells i

129 tiation of pluripotent stem cells into human intestinal organoids (HIOs) has served as a powerful mea

130 erentiation of PSCs into 3-dimensional human intestinal organoids (HIOs) in vitro.

131 Human pluripotent stem cell (hPSC)-derived intestinal organoids (HIOs) lack some cellular populatio

132 Human intestinal Organoids (HIOs) may be set up from primary h

133 Here, we generated human intestinal organoids (HIOs) produced in vitro from human

134 k human pluripotent stem cell (hPSC)-derived intestinal organoids (HIOs) under multiple culture condi

135 luripotent stem cell (PSC) technology, human intestinal organoids (HIOs) with remarkably similarity t

136 pluripotent stem cell (hiPSC)-derived human intestinal organoids (HIOs) would facilitate the develop

137 rate potential applications in imaging human intestinal organoids (HIOs), colon mucosa, and retina.

138 Here, we asked if human intestinal organoids (HIOs), which are derived from plur

139 vestigated the therapeutic capacity of human intestinal organoids (HIOs), which are generated from hu

140 em cells from this patient to generate human intestinal organoids (HIOs).

141 ural crest cells (NCCs) and developing human intestinal organoids (HIOs).

142 roscopy of murine telocytes co-cultured with intestinal organoids identified specialized telocyte ext

143 -specific deletion of CLMP (Clmp(DeltaIEC)), intestinal organoids, IECs with overexpression, or loss

144 Here we exploited intestinal "organoids" (iHOs) generated from human induc

145 a unique dataset of manually annotated human intestinal organoid images with bounding boxes and train

146 to automate crypt-like structure counting on intestinal organoids in both in-vitro and in-silico imag

147 and quantify the size distribution of human intestinal organoids in brightfield images.

148 The existing method of culturing intestinal organoids in surface-attached native extracel

149 We cultured adult stem cell-derived intestinal organoids in the chip for 7 days and tracked

150 l phenotype of NMS mice in vivo and in mouse intestinal organoids in vitro.

151 merase chain reaction and RNAscope) of small intestinal organoids incubated with the Notch inhibitor

152 t PrP(c) is required for proper formation of intestinal organoids, indicating that it contributes to

153 al regeneration and differentiation by using intestinal organoids is critical for studying both homeo

154 of human pluripotent stem-cell-derived human intestinal organoids is globally similar to the immature

155 to efficiently meet energy demands in human intestinal organoids is unclear.

156 Intestinal organoids lacking ATG16L1 reproduced this los

157 maican fruit bat (JFB, Artibeus jamaicensis) intestinal organoid model of severe acute respiratory sy

158 Using an intestinal organoid model, we demonstrate that clock dis

159 axis arises largely from animal studies, but intestinal organoid models make it possible to identify,

160 been strongly enabled by the development of intestinal organoid models.

161 pical membrane and mediates (54)Mn uptake in intestinal organoid monolayer cultures.

162 anoids, sterile faecal supernatants impacted intestinal, organoid monolayer, gene expression in a PGC

163 ell polarity in liver organoids, guide small intestinal organoid morphogenesis and control lung tip b

164 In intestine tissues of mice and human intestinal organoids, MTG8 and MTG16 repress transcripti

165 Intestinal organoids offer a model of self-organization

166 Intestinal organoids offer great promise for modeling in

167 Human intestinal organoids originating from induced pluripoten

168 To generate intestinal organoids, pluripotent stem cells are first d

169 platform could support long-term culture of intestinal organoids, potentially replacing the need for

170 Finally, we show that human intestinal organoids require higher doses of DXR to indu

171 gr5-positive stem cells, isolated from small intestinal organoids, require Cdx2 to maintain their int

172 Cultures of intestinal organoids reveal IL-38 functions as a growth

173 n >1 million single cells derived from small intestinal organoids reveals cell-type- and cell-state-s

174 sing CAG-rtTA3-CtBP2 overexpression in small intestinal organoids, shCtBP2 knockdown in LS174T cells,

175 CRTH2-deficient small intestinal organoids showed enhanced budding and termina

176 es the structural integrity of fragile small intestinal organoids (SIOs).

177 Intestinal organoid studies confirmed that high CIN does

178 Based on a previously described intestinal organoid swelling model, we established a 3D-

179 etabolic-labeling data, which we apply to an intestinal organoid system to delineate differentiation

180 shes their ability to form long-term growing intestinal organoids that differentiate into intestinal

181 Here, we developed respiratory and intestinal organoids that recapitulated the cellular div

182 Finally, IL-17A stimulation of human-derived intestinal organoids that were locked into a cystic imma

183 ivo experimental models of GVHD and in vitro intestinal organoids, the study authors show that glucoc

184 ric neural crest cells into developing human intestinal organoids, thereby restoring ENS cell types a

185 wth of Wnt-hypersensitive Rnf43/Znrf3-mutant intestinal organoids through stem cell exhaustion and co

186 imensional agent-based mathematical model of intestinal organoids to better describe the system physi

187 target crypt-like regions in patient-derived intestinal organoids to enrich for stem-like and activel

188 MHC-I expression, sensitizes human cells and intestinal organoids to Epx2 and Epx3 toxicity.

189 Here we used intestinal organoids to explore the effects of metformin

190 Here we expose human intestinal organoids to genotoxic pks(+) E. coli by repe

191 sions using high-resolution imaging and used intestinal organoids to identify underlying mechanisms.

192 We used intestinal organoids to quantitatively study the potency

193 experimental and computational approaches in intestinal organoids to reveal reciprocal effects of gut

194 1 infection caused differentiated C2BBe1 and intestinal organoids to secrete exosomes containing vira

195 ntroduce each of these driver mutations into intestinal organoids to show that they are modulators of

196 restored the responsiveness of Apc-deficient intestinal organoids to stimuli regulating the prolifera

197 mvent this limitation by exploiting cultured intestinal organoids together with single-cell measureme

198 Human intestinal organoid transplants were used to demonstrate

199 s exhibited an intestinal phenotype, whereas intestinal organoids underwent gastric metaplasia with s

200 Biodegradable polymer scaffolds seeded with intestinal organoid units were implanted into syngenic r

201 degradable polymers seeded with neonatal rat intestinal organoid units were implanted into the omenta

202 In differentiated human intestinal organoids, uORF protein-knockout echoviruses

203 n of six different NRs individually in human intestinal organoids using small molecules agonists.

204 ow that USP46 is essential for Wnt-dependent intestinal organoid viability, likely via its role in LR

205 nical compression, we show that expansion of intestinal organoids was facilitated through elevated Wn

206 nical compression, we show that expansion of intestinal organoids was facilitated through elevated Wn

207 ic strategy, and coculture of enteric neuron-intestinal organoid, we show that enteric neurons expres

208 Using mouse intestinal organoids, we confirmed that Suv4-20h2-mediat

209 Finally, using human intestinal organoids, we demonstrate that BTP2 significa

210 Using human embryonic stem cell-derived intestinal organoids, we demonstrate that the duration o

211 In vitro, using small intestinal organoids, we found that excretory/secretory

212 g ribosome profiling and CRISPR screening in intestinal organoids, we identify the nascent polypeptid

213 Using intestinal organoids, we show that concomitant activatio

214 Using intestinal organoids, we show that transient p53 express

215 Using human intestinal organoids, we showed that autocrine IL-1beta

216 Here, using mouse intestinal organoids, we uncover a paracrine mechanism b

217 Intestinal organoids were cultured on tissue matrices.

218 Intestinal organoids were generated from C57BL/6 and SHP

219 erived colorectal cancer organoids and mouse intestinal organoids were genetically manipulated for fu

220 When intestinal organoids were stimulated with IL-4, tuft cel

221 Murine intestinal organoids were used to evaluate embedding in

222 Intestinal organoids were used to examine P-glycoprotein

223 are used to specify the initial geometry of intestinal organoids, which in turn controls their patte

224 Co-culture of intestinal organoids with a colibactin-producing pks(+)E

225 Here, we modeled fISC activation in mouse intestinal organoids with doxorubicin (DXR) treatment, a

226 al epithelial cells (IEC) derived from human intestinal organoids with monocyte-derived macrophages,

227 em, we demonstrate accelerated production of intestinal organoids with significantly enhanced structu

228 of knockout mice and zinc supplementation of intestinal organoids with Zip14 deletion restored transc

229 We have developed a method of culturing intestinal organoids within suspended basement membrane