ライフサイエンスコーパス: intestine

1 with a focus on the esophagus, stomach, and intestine.

2 high-mannose-type (HM-type) N-glycans in the intestine.

3 ipids in vesicles as it enters the mammalian intestine.

4 tion in wild-type and Apc(Min/+) mouse small intestine.

5 that results from extensive resection of the intestine.

6 is GPCR, such as the lung, testes, and small intestine.

7 s that migrate from the spinal cord into the intestine.

8 el disease, within the context of the murine intestine.

9 issecting cis regulation of cell fate in the intestine.

10 IR-induced tissue injury than the male small intestine.

11 eading from the small intestine to the large intestine.

12 d host defense against microorganisms in the intestine.

13 ctive effect against oxidative stress in the intestine.

14 amplify anti-helminth immunity in the small intestine.

15 using conditions that mimic the human small intestine.

16 tating lipid digestion and absorption in the intestine.

17 immune responses in the mucosal cells of the intestine.

18 ey niche cells and signals of the developing intestine.

19 l to probe the biology and immunology of the intestine.

20 ell out of favor due to high toxicity of the intestine.

21 s depends on mitochondrial uncoupling in the intestine.

22 th a triple-lumen sampling tube in the small intestine.

23 pose tissue around the inflamed and fibrotic intestine.

24 istone deacetylase 3 (HDAC3) activity in the intestine.

25 lastic debris, which is then released in the intestine.

26 r this SPM to promote mucosal healing in the intestine.

27 rstanding the complex pathophysiology of the intestine.

28 ation of tuft-ILC2 circuits within the small intestine.

29 Escherichia coli colonization of the host's intestine.

30 alterations in microbiota communities in the intestine.

31 salt concentrations in the stomach and upper intestine.

32 nd, but this has not been established in the intestine.

33 educed mast cell infiltration into the small intestine.

34 d on the absorptive enterocytes of the small intestine.

35 hat meningeal IgA(+) cells originated in the intestine.

36 entiation into infectious particles in small intestine.

37 ions within the complex milieu of the animal intestine.

38 ion of the bacterial population in the small intestine.

39 lls, but not epithelial cells (IECs), in the intestine.

40 imicrobial resistance biogeography along the intestine.

41 in Adenomatous polyposis coli (APC)-mutated intestine.

42 of polyphenol could be absorbed by the small intestine.

43 1,25(OH)(2)D(3) in both proximal and distal intestine.

44 of acute GVHD involving the skin, liver, and intestines.

45 MPRSS2 receptor expression in the uninflamed intestines.

46 -21 in memory IgA(+) B cell responses in the intestines.

47 neys, and liver, but high in the stomach and intestines.

48 Moreover, the virus was also detected in the intestines.

49 is a stem cell marker in hair follicles and intestines.

50 h deleterious effects to the small and large intestines.

51 tions in the liver, serum, skin, spleen, and intestines.

52 ally differentiated cells in bone marrow and intestines.

53 o the right colon (0.167 +/- 0.04) and small intestine (0.153 +/- 0.03).

54 ), 10.2-14.9]; 3 h: 11.0 [95%CI, 8.7-13.4]), intestines (1 h: 24.2 [95%CI, 14.9-33.4]; 3 h: 28.2 [95%

55 In adult Drosophila intestine, a well-studied model of homeostatic cell turn

56 d that leptin-mediated MTP regulation in the intestine affects plasma lipid levels.

57 , is required for tissue repair in the mouse intestine after experimental damage.

58 xpression of Treg-cell-inducing genes in the intestine after PA intake.

59 eroidetes, and lower Firmicutes in the large intestine, along with lower levels of circulating short-

60 The intestine also harbors a large and diverse microbial pop

61 ar response at single-cell resolution in the intestine altered transcriptional cell state, leading to

62 led to produce infectious progenies in small intestine, although infectious progenies were eventually

63 hlamydia sp. still failed to reach the large intestine, although similarly inoculated plasmid-free Ch

64 ns and unfractionated IEL derived from human intestines, an effect mediated by CD44, a known osteopon

65 ine muscular organs: heart, skeletal muscle, intestine and bladder.

66 PS-NPs were mainly detected in the intestine and brood chamber in F0 and transferred to F1

67 Microbial communities in the intestine and cecum displayed characteristic GH profiles

68 nalogous biochemical profiles of human small intestine and colon scaffolds, indicating that they can

69 nificantly elevated neutrophils in the small intestine and colon, but LPS was not detected in serum a

70 sult in the development of adenomas in small intestine and colon.

71 he microbial community residing in the small intestine and colon.

72 age-related regenerative decline in the fly intestine and discusses recent findings that start to es

73 important for E. coli survival in the mouse intestine and for production of higher level of 3-hydrox

74 sual forward genetic screen in the zebrafish intestine and identified mutants with defective apical t

75 y inhibiting sugar transporters in the small intestine and improving insulin sensitivity.

76 patterning roles during organogenesis of the intestine and in the regulation of adult intestinal home

77 we found along the length of the mouse small intestine and in tumours contrast with previous reports

78 cause disease, naturally living in the lower intestine and is expelled into the environment within fa

79 ogically relevant model to examine the human intestine and its functions.

80 a gut-on-a-chip platform to model the human intestine and key aspects of IBD.

81 he genes targeted by the siRNA in the liver, intestine and kidney glomeruli of mice at siRNA doses th

82 nt mechanism of substrate drug uptake in the intestine and liver and therefore a determinant of clini

83 peripheral tissues originate mostly from the intestine and liver via synthesis and secretion of apoli

84 -T3/TL and H2-Q10 is restricted to the small intestine and liver, respectively, yet CD8alphaalpha-con

85 l cells; and malignant transformation in the intestine and liver.

86 e effects of leptin on MTP expression in the intestine and liver.

87 tor of macronutrient absorption in the small intestine and may be a viable therapeutic option to trea

88 yme transits through the length of the small intestine and measured in the terminal ileum, and can be

89 , neoplastic, and infectious diseases of the intestine and mitigate the particular health risks faced

90 r, kidney, heart, and blood, cholestanone in intestine and muscle, and beta-sitosterol in spleen.

91 C therapy reduced crypt dropout in the small intestine and promoted elevated expression of growth fac

92 ed effects of food and drug additives in the intestine and provide a framework for the data-driven se

93 heir S1P-receptor-1 mediated egress from the intestine and recruitment to the bone marrow (BM) that c

94 Pic in MUC2 barrier disruption in the human intestine and shows that colonoids are a reliable system

95 1)C]biotin was rapidly absorbed in the small intestine and swiftly distributed to the same organs.

96 nizes mainly the medial portion of the small intestine and that both the abundance and localization p

97 ssion increasing predominantly in the distal intestine and the kidney.

98 d in the diminished production of IgA in the intestine and the nAg reactivity of these antibodies.

99 eatic islets, vascularize decellularized rat intestines and arborize healthy or cancerous human colon

100 d effector capacity populate lymph nodes and intestines and exhibit tissue-resident signatures and si

101 ding esophagus, stomach, and small and large intestine) and nerves projecting to the GIT and supporti

102 tissue classes (nervous system, muscle, and intestine) and two neuronal subtypes (dopaminergic and s

103 required to turn on TRA-1 expression in the intestine, and environmental stressors shut off TRA-1 ex

104 the duodenum, jejunum and ileum of the small intestine, and in human intestinal tumours from those re

105 tanding of the interactions among the liver, intestine, and its flora.

106 TP2) is highly expressed in the liver, small intestine, and kidney, where it functions in both the tr

107 istopathologic changes in the trachea, large intestine, and pancreas, and abnormalities in the develo

108 tive hubs for regional immunity in the human intestine, and the methods presented will allow future a

109 rent ventral skin through which their bones, intestines, and beating hearts can be seen.

110 d during growth and after injury, the larval intestine appears to lack resident neurogenic precursors

111 id not detect viral RNA in the wall of small intestine, appendix, gallbladder, bile, liver, and urine

112 V replication and IFN induction in the small intestine are accompanied by significant decreases in IF

113 he selective pressures acting on CVB3 in the intestine are not well characterized.

114 standing of the microbial flora of the human intestine, as well as dissection of their interactions w

115 higher levels of UPR activation than female intestine, as well as higher number of apoptotic Paneth

116 (OH)(2)D(3)]-activated genes in the proximal intestine associated with active calcium transport (Trpv

117 gnificantly upregulated gene networks in the intestine associated with helper T cells' (Th1, Th2, and

118 epth single-cell map of the developing human intestine at 6-10 weeks post-conception.

119 ble bacteria are highly limited in the fetal intestine at mid-gestation, although strains with immuno

120 We also obtained small and large intestine biopsies from 8 adults and 10 newborn infants

121 ly to facilitate its absorption in the small intestine, both citrate cleavage in hepatocytes and micr

122 m (ENS) coordinates diverse functions in the intestine but has eluded comprehensive molecular charact

123 mydia produced infectious progenies in small intestine but was 530-fold less infectious than plasmid-

124 Mucosal immunity develops in the human fetal intestine by 11-14 weeks of gestation, yet whether viabl

125 When the remaining absorption surface of the intestine cannot absorb enough macronutrients, micronutr

126 In the small intestine, chemosensing by epithelial tuft cells results

127 Duodenum Intestine-Chip demonstrates the polarized cell architect

128 -Chips technology to create a human Duodenum Intestine-Chip that emulates intestinal tissue architect

129 n microengineered fluidic-based Organ-Chips (Intestine-Chips) exposed to enterotoxigenic Escherichia

130 ere present in higher abundance in the small intestine compared to the colon.

131 wed significantly higher accumulation in the intestines compared to the free model drug, as well as 1

132 The intestine contains some of the most diverse and complex

133 ing the protease/antiprotease balance in the intestine, contributing to epithelial damage and increas

134 How the intestine coordinates physiological and immune responses

135 The microbiome-intestine cross-talk includes a dynamic exchange of gase

136 (Delta/Delta) mice died rapidly due to small intestine damage, which was not rescued by p53 codeletio

137 In the intestine, DC are found in organized lymphoid tissues, s

138 In turn, NRF2 mitigates lethal intestine degeneration upon autophagy loss.

139 Pancreas, large and small intestines demonstrated lower segmentation accuracy and

140 Immune protection in the intestine depends on the development of Bacteroidetes, i

141 Enteropathy of the small intestine developed in gnotobiotic mice that had been co

142 Older intestines did not convincingly demonstrate a faster IPI

143 Msi1-overexpressing mice had shortened intestines, diminished intestinal epithelial cell (IEC)

144 Fetal intestines dominated by Micrococcaceae exhibited distinc

145 Finally, we identified two intestine-enriched transcription factors that specifical

146 transcriptional signature is shared in small intestine enterocytes among coronavirus receptors (ACE2,

147 In developing intestine enteroid cultures, NRG1, but not EGF, permitte

148 The critical role of Bccip in intestine epithelial renewal was verified with a Villin-

149 ient Chlamydia sp. failed to reach the large intestine, explaining the lack of live pGP3-deficient Ch

150 n in vitro digestion model using a Rat Small Intestine Extract (RSIE).

151 Together, our results suggest that the young intestine facilitates CD8alphaalpha IEL establishment an

152 istered polymers that bind bile acids in the intestine, forming nonabsorbable complexes.

153 g the probe into the lumen of small or large intestine fragments, robust phosphorescence intensity an

154 o be used in functional foods to protect the intestine from oxidative stress.

155 ingly demonstrate a faster IPI compared with intestines from adult and young donors.

156 Intestines from Apc(+/+) mice injected with the vector e

157 on enhances IL-22 production, which protects intestines from inflammation.

158 We sorted cells from Lgr5-GFP knockin intestines from mice and characterized gene expression p

159 Intestines from old rats fared similarly to their younge

160 We compared the development of IPI in intestines from young (3 mo), adult (14 mo), and old (20

161 Intestine graft viability compromises retrieval in most

162 > kidney > heart > blood > spleen > muscle > intestine > blubber > fur, and in both sexes coprostanol

163 MTG8- and MTG16-knockout intestines had increased crypt hyperproliferation and ex

164 cell isolation from helminth-infected murine intestines has been notoriously difficult, due to the st

165 nsive anatomical or functional loss of small intestine, has debilitating long-term consequences for c

166 of epithelial/mesenchymal cross talk in the intestine, has meant that work in many diverse model sys

167 -alpha-tocopherol doses shows both liver and intestine have roles in alpha-tocopherol catabolism.

168 nimals showed lower muscle mass of the small intestine, higher abundance of Bacteroidetes, and lower

169 ats can modulate EtOH-induced changes in the intestine; however, mechanisms underlying these effects

170 a and adenocarcinomas in the small and large intestines; however, no differences were noted in the ad

171 ually targeted by IgA1 and IgA2 in the small intestine, IgA1+IgA2+ and IgA1-IgA2+ bacteria coexist in

172 es' compositions of terminal ileum and large intestine in 5 healthy individuals.

173 ll expansion and mast cell activation in the intestine in a model of food allergy.

174 e effects of radiation-induced damage to the intestine in adults and have identified msi as a potenti

175 d autophagy-related gene expression in small intestine in mice.

176 e show by imaging the murine small and large intestines in steady-state that intestinal CX3CR1(+) mac

177 melanoma lesions (skin) and distant organs (intestine) in tert mutants exhibited higher levels of se

178 y as a therapeutic target in diseases of the intestine, including inflammatory bowel disease (IBD), g

179 -fed WT mice decreased MTP expression in the intestine, increased it in the liver, and lowered plasma

180 termediate filaments (IFs) in the C. elegans intestine indicate important contributions to intestinal

181 progenies were eventually detected in large intestine, indicating a critical role of the plasmid in

182 The intestine interacts with many factors, including dietary

183 ggested that calcium transport in the distal intestine involves a paracellular process, we found that

184 The mammalian intestine is a complex environment that is constantly ex

185 The intestine is a highly dynamic environment that requires

186 The intestine is an essential physical and immunological bar

187 The mammalian intestine is colonized by trillions of microorganisms th

188 ens and Caenorhabditis elegans show that the intestine is the major site of expression but individual

189 in expression levels in blood, brain, heart, intestine, kidney, liver, lung, muscle and spleen were d

190 d ideas about the development of stomach and intestine laterality.

191 disrupt the microbial ecosystem in our large intestine leading to disease.

192 on-autonomously activates the UPR(ER) in the intestine, leading to enhanced proteostasis and lifespan

193 7.9% (7/39), and 11.9% (29/243) for isolated intestine, LI, modified MV, and MV allografts, and 2.7%

194 ted an increase in the length of their small intestines, likely to compensate for challenges in absor

195 In particular, the highly radiosensitive intestine limits the use of radiation for patients with

196 eight vascularized, two-channel organ chips (intestine, liver, kidney, heart, lung, skin, blood-brain

197 ost of energy expenditure, creating a futile intestine-liver cycle.

198 cRNA-seq to interrogate the developing human intestine, lung, and kidney in order to identify organ-e

199 ces throughout the body, including the skin, intestine, lung, gingiva, and uterus.

200 Microbes in the intestine maintain liver homeostasis but can also serve

201 nocarcinoma (Caco-2) and human non-malignant intestine microvascular endothelial cells (HIMEC) was as

202 Specifically, in the inflamed intestine, monocyte ablation was shown to ameliorate col

203 itamin D is critical for the function of the intestine, most studies have focused on the duodenum.

204 cts of diet on each taxon in stool and small-intestine mucosa samples.

205 ecessary for doxorubicin (DXR)-induced small intestine mucosal damage.

206 e that loss of malonyl-CoA production in the intestine negatively impacts germline development indepe

207 found that ILC3 responses are altered in the intestine of defined patient populations with chronic in

208 ollected from the proximal half of the small intestine of Hnf4alphagamma(DKO) and control mice.

209 o examine transcriptional differences in the intestine of juvenile yellow perch through RNA-sequencin

210 The bone marrow, spleen, and intestine of Kmt2d(+/betaGeo) mice contained diminished

211 lso induced by 1,25(OH)(2)D(3) in the distal intestine of KO/TG mice.

212 ein expression were greatly increased in the intestine of mice with CKD.

213 nt selectively in the spleen, but not in the intestine of Taok3 (-/-) and CD11c-cre Taok3 (fl/fl) mic

214 Moreover, the small intestine of treated animals show reduced hypoxic injury

215 vitamin D receptor (VDR) only in the distal intestine of VDR null mice (KO/TG mice) results in the n

216 responses in RAW264.7 macrophages and in the intestines of a mouse model.

217 sine modifications by LC/MS, in normal small intestines of C57BL/6J wild-type mice, and in normal and

218 obial ecosystems in nature thrive within the intestines of humans and other animals.

219 ce fed the wheat- or ATI-containing diets to intestines of mice on control diets increased the severi

220 ontaining, control diets and transplanted to intestines of mice with and without colitis on control o

221 Intestines of old rats did not show major histological a

222 The intestines of these patients are macroscopically normal,

223 ively transferred IELps parked better in the intestines of young mice than in adults.

224 ated with linear position in the mouse small intestine or intestinal tumours.

225 also undergo ITx as part of a combined liver-intestine or multivisceral transplant for a variety of i

226 fermentation of prebiotic fiber in the large intestine), or high prebiotic fiber diets.

227 fic RNA-sequencing data from pancreas, small intestine, ovary, kidney, and heart with existing p53 ch

228 es, including blood, lungs, liver, and small intestines (P < 0.001-0.05).

229 nally coinoculated into the same mouse small intestine, plasmid-free Chlamydia sp. was no longer able

230 symbionts near the epithelial surface of the intestine poses an enormous challenge to the host becaus

231 erograde tracing identify a subset of distal intestine-projecting vagal neurons that are positioned t

232 differentiation factor-15) and increased the intestine protector citrulline level in total body irrad

233 The BLP strains colonize the intestine, reduce Lm mucosal colonization and systemic d

234 Bacterial colonization of the human intestine requires firm adhesion of bacteria to insolubl

235 s (ATIs), a component of wheat, activate the intestine's innate immune response via toll-like recepto

236 The human female small intestine seems less susceptible to IR-induced tissue in

237 Tuft cells in the small intestine sense and direct the immune response against e

238 haeal, viral, and protozoal) features of the intestine separate its nearly 100 trillion microbes from

239 Male intestine showed significantly higher levels of UPR acti

240 Wild-type mouse intestines showed approximately linear, negative concent

241 Throughout a 24-h period, the small intestine (SI) is exposed to diurnally varying food- and

242 single-cell RNA-sequencing analyses on small intestine (SI) MMC9s were performed to illuminate MMC9 t

243 he development and physiologic role of small intestine (SI) vasculature is poorly studied.

244 lyzed in crude human-stomach and human-small-intestine simulations and may therefore meet the prebiot

245 etase inhibitor dibenzazepine, and mice with intestine-specific disruption of Rbpj.

246 he ovaries to the gut promotes growth of the intestine specifically in mated females, and enhances th

247 p. was no longer able to spread to the large intestine, suggesting that pGP3-deficient Chlamydia sp.

248 animals' food intake or the weight of their intestines, suggesting that PDE4 inhibition impairs gast

249 ean)) using muscle (T/M), bladder (T/B), and intestine (T/I) as background organs were determined.

250 oncentrations of metformin accumulate in the intestine than in the circulation, where it alters nutri

251 physiology that more closely resemble intact intestine than study under static conditions.

252 s validated with a multiphysics model of the intestine that autonomously learns how to coordinate its

253 and maintains the hypoxic environment of the intestine that is critical for nutrient absorption, inte

254 (EED) is an enigmatic disorder of the small intestine that is postulated to play a role in childhood

255 promotes a pro-inflammatory state within the intestine that may be treated by SBA restoration.

256 regulated dynamic neuroimmune circuit in the intestine that promotes a trade-off between innate immun

257 with the developing microbiome of the small intestine, the major site for nutrient metabolism and ab

258 ly elicited more IgA production in the large intestine through the T cell-dependent B cell-activation

259 ids incubated with the Notch inhibitor DAPT, intestine tissues from mice given injections of the gamm

260 We analyzed intestine tissues from mice with disruption of the RUNX1

261 y Notch signaling via ATOH1 in organoids and intestine tissues from mice.

262 Intestine tissues from patients with ulcerative colitis

263 In intestine tissues of mice and human intestinal organoids

264 nd levels of CX3CR1 protein and Il10 mRNA in intestine tissues, and reduced body weight and death fro

265 es in the functional response of human small intestine to a virulence factor of a pathogenic intestin

266 ated insulin-like peptide, which acts in the intestine to determine lifespan.

267 ibute to the well-known vulnerability of the intestine to infection.

268 evirus B3 (CVB3), successfully penetrate the intestine to initiate infection and spread systemically

269 defence programmes in the upper airways and intestine to limit K. pneumoniae colonization within the

270 ind that peptide YY is required in the small intestine to maintain normal electrophysiology in the pr

271 t be prevented from spreading from the small intestine to the large intestine.

272 ng-form LEPR (ObRb), highly expressed in the intestine, to down-regulate MTP.

273 Intestines undergoing LP showed fewer histological signs

274 anced production of virulence factors in the intestine underpin the biofilm hyperinfectivity phenotyp

275 sed Ag-specific memory IgA production in the intestines upon infection with Citrobacter rodentium, th

276 dynamics of bacterial populations within the intestine using larval zebrafish and live imaging.

277 The liver communicates with the intestine via the portal vein, biliary system, and media

278 proliferation, and decreased growth of small intestine villi and colon crypts.

279 y, the elemental distribution of Zn in small intestine villi of mice subjected to a Zn-enriched diet

280 rs and (ii) chlamydial colonization in small intestine was highly dependent on plasmid.

281 The inflammatory response in male intestine was significantly higher compared to females,

282 uring infection of the skin, lung, and small intestine, we assessed the role of CGRP receptor signali

283 e of HDAC inhibitors such as butyrate in the intestine, we found that HDAC3 activity was sharply incr

284 levels of farnesoid X receptor in liver and intestine were significantly increased after intestinal

285 logical examination of the muscle, liver and intestine were similar among treatments.

286 mice, frontal cortex, liver, and small/large intestines were collected.

287 We report here that MPs in the intestines were more abundant and significantly smaller

288 erns of distribution along the length of the intestine, were linked to the systemic circulation throu

289 s before returning to the lumen of the small intestine, where adult worms dwell.

290 latter function is most evident in the large intestine, where the inner mucus layer separates the num

291 a partially intracellular niche in the large intestine, whereas A. lumbricoides larvae penetrate the

292 Lactose is mostly hydrolysed in the small intestine, whereas lactulose, recognised prebiotic carbo

293 f estrogen-mediated immune regulation in the intestine, whereby homeostatic expression of ERbeta norm

294 imulated cell proliferation in liver but not intestine (which is more responsive to non-targeted RSPO

295 ons between phages and bacteria in the human intestine, which is essential information for the develo

296 es and Verrucomicrobia compared to the small intestine, while Actinobacteria, and superphylum Patesci

297 Additionally, affl-2 mutants have herniated intestines, while worms lacking its sole paralog (affl-1

298 howed a more pronounced release in the small intestine with a vitamin bioaccessibility of 56%.

299 cted in nasal turbinate, trachea, lungs, and intestine with acute bronchiolitis present in infected l

300 The large intestine, with its array of crypts lining the epitheliu