ライフサイエンスコーパス: intoxicate

1 nsport chain within target cells in order to intoxicate.

2 vercome the inhibition of caspases and still intoxicate.

3 tic brain-injured (TBI) patients are alcohol intoxicated.

4 iders (91.3%) and 86 bicyclists (69.4%) were intoxicated.

5 milarly intoxicated than if tested while not intoxicated.

6 grade memory task of alcohol impairment when intoxicated.

7 nly apparent if the animals are tested while intoxicated.

8 lls are not able to take up TpeL and are not intoxicated.

9 on produced by a moderate (0.75 g/kg) and an intoxicating (1.25 g/kg) EtOH dose was investigated in t

10 e-Scooter riders were more often intoxicated (336 [39.5%] vs 180 [7.7%]) and had a lower

11 Finally, apoptosis was observed in CNF1-intoxicated 5637 cells.

12 .1% vs 7.1%) or conviction for driving while intoxicated (7.9% vs 1.2%).

13 onsistent with the hypothesis that ethanol's intoxicating actions in the brain include reducing synch

14 in a large sample of young adults, using an intoxicating alcohol dose and more ecologically valid ta

15 We also exposed Wistar rats to air or intoxicating alcohol levels in vapor chambers for 14-h/d

16 Intoxicated AM remained fully capable of B. anthracis sp

17 nflammasome activation and apoptosis of LeTx-intoxicated and B. anthracis-infected macrophages.

18 For this, thioacetamide (TAA)-intoxicated and bile-duct-ligated (BDL) rats were used a

19 Fibroblasts that were intoxicated and later stimulated to proliferate failed t

20 By contrast, cannabidiol, which is a non-intoxicating and potentially therapeutic component of ca

21 ry 24 h by gastric intubation, with repeated intoxicating and withdrawal episodes leading to a kindli

22 e drinking, physical fighting, driving while intoxicated, and alcohol-related health problems and wer

23 or driver age, sex, history of driving while intoxicated, and survival status, implementation of the

24 fects and clinical presentation if abused or intoxicated, and to know what anesthetic options would b

25 clists, did not use helmets, were more often intoxicated, and were more often injured during nighttim

26 MPTP-intoxicated animals that received Cop-1 immune cells sho

27 f-function mutants resemble those of ethanol-intoxicated animals.

28 n intoxication allowed the rescue of 100% of intoxicated animals.

29 om agonist-treated mice administered to MPTP-intoxicated animals.

30 stry values from buffer-treated versus ricin-intoxicated animals.

31 ects on vulnerable neurons or mediated by GA-intoxicated astrocytes that fail to support neuron funct

32 unable to communicate clearly, and who were intoxicated at the time of screening.

33 However, intoxicated bees were as willing to engage in trophallax

34 ively bred (from the HS/Npt line) to achieve intoxicating blood alcohol levels (BALs) after binge-lik

35 0 adults who had blood alcohol measured were intoxicated (blood alcohol content >22 mmol/L [100 mg/dL

36 Intoxicated burned mice demonstrated a two-fold (p < 0.0

37 and sciatic nerves was reduced in galactose-intoxicated, but not streptozotocin-diabetic rats.

38 at the time of injury, and 516 (16.2%) were intoxicated by alcohol or other drugs.

39 ouse diaphragm neuromuscular junctions fully intoxicated by BoNT serotype A.

40 In contrast, synapses fully intoxicated by BoNT serotypes D or E were refractory to

41 ndplate potentials in mouse diaphragms fully intoxicated by BoNT/A.

42 tantial redistribution in human airway cells intoxicated by ExoS, -T, and -Y.

43 We find that DeltacpgA cells are intoxicated by glucose or other carbon sources that feed

44 in the evaluation of all patients who may be intoxicated by natural substances.

45 Senescence is transmitted to non-intoxicated bystander cells by an unidentified senescenc

46 lta9-tetrahydrocannabinol (THC), the primary intoxicating cannabinoid in cannabis, are densely locali

47 Dermonecrotic lesions of supernatant intoxicated CD36(-/-) mice are significantly larger, wit

48 ical membranes, resulting in an inability to intoxicate cells through either apoptotic or necrotic pa

49 To intoxicate cells, ACT binds to the cell surface, translo

50 oxin exploits DRMs for oligomer formation to intoxicate cells.

51 ating that BFT did not injure HT29/C1 cells, intoxicated cells exhibited regulatory volume decrease,

52 capacity of Stxs to alter gene expression in intoxicated cells have been limited to individual genes.

53 p1-induced mitochondrial fission within VacA-intoxicated cells inhibited the activation of the proapo

54 uction of lethal mitochondrial damage in TNF-intoxicated cells is discussed.

55 e the mammalian cell, ExoU rapidly lyses the intoxicated cells via its phospholipase A(2) (PLA(2)) ac

56 In Stx-intoxicated cells, the NLRP3 inflammasome triggered the

57 sing depolarisation of the inner membrane in intoxicated cells, together with increased outer membran

58 Within intoxicated cells, vacuolation precedes cytochrome c rel

59 ading to cell cycle arrest and distension of intoxicated cells.

60 ng distinct ion selectivities and impacts on intoxicated cells.

61 to quantify the cytosolic pool of PTS1 from intoxicated cells.

62 xoS trafficking to the perinuclear region of intoxicated cells.

63 Cholera toxin (CT) intoxicates cells by trafficking from the cell surface t

64 BoNT intoxicates cells in a highly programmed fashion initiat

65 esults suggest that the process by which ETA intoxicates cells requires a low vacuolar pH for another

66 Helicobacter pylori vacuolating toxin (VacA) intoxicates cells.

67 that is devoid of the CROP domain but still intoxicates cells.

68 ileukin diftitox fusion toxin-targeting and -intoxicating cells expressing high-affinity IL-2R.

69 est in the use of cannabis and its major non-intoxicating component cannabidiol (CBD) as a treatment

70 We sought to determine whether a mildly intoxicating concentration of ethanol could alter morphi

71 Many studies have demonstrated that intoxicating concentrations of ethanol (10-100 mM) can s

72 Interestingly, exposure to intoxicating concentrations of ethanol induces GIRK2 exp

73 unction of all GIRK channels was enhanced by intoxicating concentrations of ethanol, but other, relat

74 iposomes and demonstrate that cholesterol or intoxicating concentrations of ethanol, i.e., >20 mM, ea

75 ion renders these receptors sensitive to low intoxicating concentrations of ethanol.

76 At intoxicating concentrations, ethanol activation of DAerg

77 Delta(9)-tetrahydrocannabinol (THC) is the intoxicating constituent of cannabis and is responsible

78 (9)-tetrahydrocannabinol (THC) is the intoxicating constituent of cannabis and is responsible

79 These two toxins intoxicate cultured cells by similar mechanisms, and Tcd

80 cannot be further stimulated by ARF6 fail to intoxicate cultured cells.

81 , which inhibits the accumulation of cAMP in intoxicated cultured cells, significantly decreases the

82 1-556) plus anthrax toxin protective antigen intoxicated cultured mammalian cells and caused actin re

83 re significantly reduced or abolished in Stx-intoxicated D-THP-1 cells in which the expression of NLR

84 ntoxication over 5-fold, lowered the minimal intoxicating dose by over 100-fold, and allowed complete

85 tive responses before and after receiving an intoxicating dose of alcohol (.8 g/kg) or a placebo beve

86 er a single or repeated administration of an intoxicating dose of alcohol (3 g/kg).

87 ic injections of the vehicle or a moderately intoxicating dose of alcohol (3.0 gm/kg) daily for 3 d.

88 mice following repeated administration of an intoxicating dose of alcohol.

89 /kg) was reduced 87% by pretreatment with an intoxicating dose of ethanol (3.5 g/kg).

90 vioral changes in rats treated with a single intoxicating dose of ethanol (EtOH).

91 Following administration of an intoxicating dose of ethanol, Adh1 -/- mice, and to a le

92 der (AUD), particularly in terms of relevant intoxicating doses and measurement of stimulating and re

93 e GlyR with the sedative effects produced by intoxicating doses of ethanol.

94 alcohol dehydrogenase with ethanol, given in intoxicating doses, and adjunctive hemodialysis.

95 h physiologically relevant (i.e., moderately intoxicating) doses of ethanol inhibits clearance of 5-H

96 involvement in risky driving, riding with an intoxicated driver and being taken advantage of sexually

97 to determine probable cause and to arrest an intoxicated driver at the scene, the results are prelimi

98 e validity of this test in the conviction of intoxicated drivers.

99 astrocytes in the hippocampus of 26 lethally intoxicated drug addicts and 35 matched controls are des

100 0,+)AT-rBAT transfectants became selectively intoxicated during exposure to Cys-S-Hg-S-Cys.

101 evel results in locomotory resistance to the intoxicating effect of ethanol, equivalent to that of sl

102 oluntary ethanol consumption and some of the intoxicating effects caused by administration of ethanol

103 rther suggest that ASICs might contribute to intoxicating effects of alcohol and AUD in humans.

104 suggest a novel role for ASIC1A in the acute intoxicating effects of alcohol in mice.

105 Supporting a role for ASIC1A in the intoxicating effects of alcohol in vivo, we observed mar

106 A(A)-R) has been implicated in mediating the intoxicating effects of ethanol and the motor ataxic eff

107 tion of BK channels is responsible for acute intoxicating effects of ethanol in C. elegans.

108 The acute intoxicating effects of ethanol in the central nervous s

109 In contrast, sensitivity to the acute intoxicating effects of ethanol is reduced.

110 system lead to increased sensitivity to the intoxicating effects of ethanol.

111 ncreased or reduced sensitivity to the acute intoxicating effects of ethanol.

112 et taste, they show that alcohol's enjoyable intoxicating effects on the rising limb correspond with

113 actions of ethanol translate to its observed intoxicating effects remains poorly understood.

114 LF has mononuclear phagocyte-specific intoxicating effects that are not well understood.

115 Delta(9)-tetrahydrocannabinol (THC) and its intoxicating effects, mainly owing to the aversive respo

116 by children, adolescents, and adults for its intoxicating effects.

117 rently accepted hypothetical model that PMNs intoxicate engulfed microbes with an overwhelming influx

118 rhea by colonizing the human small bowel and intoxicating epithelial cells.

119 rats are exposed to intermittent episodes of intoxicating ethanol and withdrawal, leading to a kindli

120 M2 (MthK) or TM6 (slo1), with sensitivity to intoxicating ethanol levels.

121 ilization and impedes the ability of PAO1 to intoxicate eukaryotic cells effectively in a type III-de

122 ilizes a type III secretion system (T3SS) to intoxicate eukaryotic host cells.

123 cyclase (AC) toxin from Bordetella pertussis intoxicates eukaryotic cells by increasing intracellular

124 Here, we show that even a single intoxicating exposure to ethanol causes non-cell-autonom

125 s, and improved locomotor activities in MPTP-intoxicated Gfaf(cre) mice, but not Gdnf( astro) mice la

126 ere were 65 abnormal CT scans (10.3%) in the intoxicated group.

127 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated hemiparkinsonian monkeys.

128 Pet-intoxicated HEp-2 and HT29 cells stained with fluorescei

129 lobacter jejuni differ in their abilities to intoxicate host cells with defined defects in host facto

130 ra toxin (CT) holotoxin must be activated to intoxicate host cells.

131 Gram-negative pathogens communicate with and intoxicate host cells.

132 ilizes a type III secretion system (T3SS) to intoxicate host cells.

133 plasma membrane to the perinuclear region of intoxicated host cells.

134 Cholera toxin (CT) enters and intoxicates host cells after binding cell surface recept

135 rchers suggest that, since the toxin rapidly intoxicates HT-29 cells, it may be internalized.

136 iated with diarrhea rapidly and irreversibly intoxicates human intestinal epithelial cells (HT29/C1)

137 Alcohol-intoxicated humans have high levels of fatty acid ethyl

138 ntamicin or gamma irradiation were unable to intoxicate, illustrating that toxin delivery requires vi

139 ifetime ounces of alcohol consumed and times intoxicated in lifetime estimated at visits 1 week or mo

140 ol concentration-levels that would be mildly intoxicating in humans.

141 2 are activated in vivo in the colon of Stx2-intoxicated infant rabbits, a model in which Stx2 induce

142 SDL), information learned while an animal is intoxicated is recalled more effectively when the subjec

143 , many studies have concentrated on its less intoxicating isomer cannabidiol (CBD).

144 e receptor, entering the cell, and, finally, intoxicating it.

145 abrogates IL-1beta and IL-18 secretion by DT-intoxicated keratinocytes, while ZAKalpha deletion or in

146 (CBD) is widely used and believed to be non-intoxicating, lacking acute performance effects (e.g., n

147 CBD treatment significantly improved ethanol-intoxicated larval survival rate by 40% and also improve

148 Pre-exposure to moderate, high, or intoxicating levels of alcohol had no effect on cocaine

149 ch animals are exposed to and withdrawn from intoxicating levels of ethanol on a daily basis-produces

150 uction pathway in the behavioral response to intoxicating levels of ethanol.

151 chronic alcohol drinking, albeit at moderate intoxicating levels, induces an allostatic change in the

152 ght percent of trespassers were killed while intoxicated (median alcohol level, 56 mmol/L [260 mg/dL]

153 ary bacterial burden was observed in alcohol-intoxicated mice at 16 and 24 h and was associated with

154 Orally intoxicated mice could be rescued by MAb 11E10 6 h but n

155 etected Stx2a in kidney sections from orally intoxicated mice in the same region as the epithelial ce

156 stration 4 h after MRSA infection in alcohol-intoxicated mice rescued USA300 clearance in vivo.

157 Furthermore, kidney sections from Stx2a-intoxicated mice revealed multifocal, acute tubular necr

158 l-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice where it inhibits parkin through tyrosi

159 istopathology, and full protection of orally intoxicated mice with monoclonal antibody (MAb) 11E10 di

160 x with the enzyme, their protective index on intoxicated mice, and their pharmacokinetics.

161 s and protected dopaminergic neurons in MPTP-intoxicated mice, but at levels less than simvastatin.

162 and GGTI also protected nigrostriata in MPTP-intoxicated mice.

163 n the substantia nigra pars compacta of MPTP-intoxicated mice.

164 to non-transplanted, X-irradiated cuprizone-intoxicated mice.

165 itters, and improved motor functions in MPTP-intoxicated mice.

166 nigra pars compacta of PD patients and MPTP-intoxicated mice.

167 e nigrostriatal dopaminergic pathway in MPTP-intoxicated mice.

168 l-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice.

169 is downregulated in PD patients and in MPTP-intoxicated mice.

170 rs and improved locomotor activities in MPTP-intoxicated mice.

171 locomotor activities in SARS-CoV-2 spike S1-intoxicated mice.

172 locomotor activities in SARS-CoV-2 spike S1-intoxicated mice.

173 istent and progressive disease in acute MPTP-intoxicated mice.

174 inuous impairment of motor functions in MPTP-intoxicated mice.

175 itters, and improved motor functions in MPTP-intoxicated mice.

176 t against nigrostriatal degeneration in MPTP-intoxicated mice.

177 l-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice.

178 of neuronal cell bodies and termini in MPTP-intoxicated mice.

179 unced effects in VIPR2 agonist-treated, MPTP-intoxicated mice.

180 nd that ricin rapidly reaches the kidneys of intoxicated mice.

181 We used the progressively MPTP-intoxicated monkey model that expresses recovery from mo

182 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated monkey model to further elucidate the nature

183 l-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated monkeys (when motor symptoms are less appare

184 rior olive neurons obtained from chronically intoxicated monkeys revealed a significant up-regulation

185 xins exhibited an extremely low capacity for intoxicating mouse Y1 adrenal cells and for inducing pro

186 only used antimalarial agent, endows anthrax-intoxicated murine peritoneal macrophages with a 50% and

187 medication inhibiting cytochrome 450 3A, or intoxicated on the day of surgery were excluded.

188 vents by increasing risk-taking behaviors in intoxicated or impaired persons.

189 SH and GSSG in rat urine and plasma samples, intoxicated or not by lead.

190 enzimidazoles, those who were acutely ill or intoxicated, or those reporting treatment within the pre

191 chemical and histological parameters in mice intoxicated orally versus intraperitoneally with Stx2a.

192 We also propose that mice intoxicated orally with ricin likely die from distributi

193 Specifically, intoxicated participants showed higher false recognition

194 In a misinformation task, intoxicated participants were more susceptible to false-

195 vidence for enhanced false-memory effects in intoxicated participants.

196 ne clearance based on a normal CT scan among intoxicated patients with no gross motor deficits appear

197 en; mean age, 40.3 years), 13 age-matched CO-intoxicated patients without parkinsonism, and 13 age-ma

198 the cervical spine should not be cleared in intoxicated patients, resulting in prolonged immobilizat

199 on reduces GCS, thus limiting its utility in intoxicated patients.

200 mal CT scans are sufficient to clear CSIs in intoxicated patients.

201 e" outbreak because of the appearance of the intoxicated persons.

202 ompare the unadjusted mortality of the total intoxicated population and for specific intoxication sub

203 tive 5-HT(2A) receptor agonists may lack the intoxicating properties of hallucinogens such as LSD.

204 ared to both control (P<0.001) and galactose-intoxicated rats (P<0.05).

205 e-mediated function in LED-treated, methanol-intoxicated rats.

206 onses were profoundly attenuated in methanol-intoxicated rats.

207 ith unchanged metallothionein-I in manganese-intoxicated rats.

208 n bile duct-ligated and carbon tetrachloride intoxicated rats.

209 3-beta-glucanase mRNA was up-regulated in Al-intoxicated roots, with highest expression after 12 h.

210 nors differ dramatically in their ability to intoxicate SN56 cells, probably because of the different

211 Neural states of impairment from intoxicating substances, including cannabis, are poorly

212 ists that rescue neurotransmission in BoNT/A-intoxicated synapses provides compelling evidence for po

213 cyclase toxin (ACT) of Bordetella pertussis intoxicates target cells by generating supraphysiologic

214 removed by trypsin, were fully competent for intoxicating target cells, demonstrating that surface-bo

215 y when the subject is tested while similarly intoxicated than if tested while not intoxicated.

216 athogens or accumulating metals in excess to intoxicate the pathogen in a process termed 'nutritional

217 gans undergoes olfactory learning (OL) while intoxicated, the learning becomes state dependent such t

218 nfection lock persisters in growth arrest by intoxicating their TCA cycle, lowering cellular respirat

219 thanol in C. elegans that directly equate to intoxicating through to supralethal blood alcohol concen

220 ocations of the individual subunits in cells intoxicated, under various conditions, with hybrid heter

221 ith toxins) and endogeneous (serum from mice intoxicated via oral, intranasal, and intravenous routes

222 mates of lifetime ounces of alcohol or times intoxicated were observed.

223 In addition, many trauma patients are also intoxicated, which generally worsens outcomes.

224 nfers significant survival benefits for mice intoxicated with alpha-toxin or wSP in both therapeutic

225 estrain violent subjects, who are frequently intoxicated with cocaine and other drugs of abuse.

226 odulate enterotoxin expression because cells intoxicated with heat-labile toxin overproduce and relea

227 Rats were intoxicated with methanol, and retinal function was asse

228 We observed similar results in aged monkeys intoxicated with MPTP: they developed severe DOPA-respon

229 We observed that Vero cells intoxicated with Stx1a behave differently than those int

230 ted with Stx1a behave differently than those intoxicated with Stx2 subtypes: cells challenged with St

231 bunit delayed the mean time to death of mice intoxicated with Stx2a and reduced the cytotoxic effect

232 WldS and wild-type mice were intoxicated with the cancer chemotherapeutic agent pacli

233 akim Hospital ED and GI clinic who were lead-intoxicated, with or without opiate use disorder.

234 K28 is a viral A/B protein toxin that intoxicates yeast and fungal cells by endocytosis and re