ライフサイエンスコーパス: intracellular

1 rom control (CD44, cell surface; and MARCKS, intracellular).

2 ployed mycobacteria DNA, either extracted or intracellular.

3 TDP-43 oligomers mostly colocalized with intracellular Abeta in the brain of AD patients.

4 ession of many of the key genes required for intracellular accommodation of arbuscular mycorrhizal fu

5 e development, autoregulation of nodulation, intracellular accommodation of bacteria, nodule oxygen h

6 Internalization studies strongly correlate intracellular accumulation and anticancer activity in te

7 In parallel to its intracellular accumulation in AD, tau is also released i

8 rapid clearance and only slight increases in intracellular accumulation in myocytes.

9 wo-dimensional (2D) neuronal cultures causes intracellular accumulation of Abeta42 peptide, but these

10 To prevent toxic intracellular accumulation of amyloid precipitate, secre

11 gene, in conjunction with quantification of intracellular accumulation of compound 1 and cell viabil

12 Intracellular acetyl-CoA concentrations are associated w

13 ide analogues is strongly dependent on their intracellular activation by host cellular kinases to yie

14 We observed unexpected intracellular activity profiles for a number of CDKi's,

15 ual in its poor secretion from cells and its intracellular activity; it interacts, directly or indire

16 Increased intracellular adenosine triphosphate levels activate the

17 Apoptosis was preceded by an increase of intracellular aggregates, which was not linked to increa

18 mbrane RET tyrosine kinase to signal through intracellular Akt/Erk pathways.

19 echanistically, we found that ABHD5 elevates intracellular AMP content, which activates AMPK, leading

20 ps, but not mock-infected qHA-sps, contained intracellular amylin, APP, and/or Abeta, and amyloid.

21 odel that describes how tumor cells regulate intracellular and extracellular acidity while they grow

22 roach the problem analyzing the evolution of intracellular and extracellular calcium fluxes during a

23 uiring tools that can bridge the gap between intracellular and population-level coordination.

24 in how internal and external protons control intracellular and selectivity filter gates to modulate T

25 Surprisingly, intracellular application of IBMX or of the second messe

26 develop effective approaches for monitoring intracellular autophagy dynamics, as a comprehensive acc

27 surfactant levels, a significant fraction of intracellular bacteria are non-growing.

28 Many intracellular bacteria can establish chronic infection a

29 and accumulate to high enough levels to kill intracellular bacteria.

30 This leads to more productive intracellular bacterial infections but is protective aga

31 herapeutic and prevention strategies against intracellular bacterial infections such as brucellosis.

32 esponse during macrophage infection with the intracellular bacterial pathogen Salmonella enterica Typ

33 ydia trachomatis and Chlamydia muridarum are intracellular bacterial pathogens of mucosal epithelial

34 n the pathogenesis of persistence induced by intracellular bacterial pathogens, including B. abortus

35 Therefore, immune lymphocytes directly limit intracellular bacterial replication within the cytoplasm

36 Burkholderia pseudomallei is an intracellular bacterium and the causative agent of melio

37 For infections with the obligate intracellular bacterium Chlamydia trachomatis, variation

38 rancisella tularensis is a highly infectious intracellular bacterium that causes tularemia by invadin

39 w comparably large NCs infiltrate this vital intracellular barrier to enter the nuclear interior.

40 Intracellular binding partners were determined by ligand

41 ibition of FAAH bidirectionally dysregulates intracellular, but not circulating, N-acyl amino acids.

42 mediated by resident calmodulin bound to the intracellular C-terminal segment of the GluN1 subunit of

43 Increased or decreased intracellular C3 results in autoimmunity and infections,

44 P(2) ), the substrate hydrolysed by PLC, and intracellular Ca(2+) .

45 nd CaMKII inhibition prevents both increased intracellular Ca(2+) and neurotoxicity in Drosophila and

46 emains uncertain but it can follow increased intracellular Ca(2+) concentration ([Ca(2+)](i)).

47 A sustained increase in intracellular Ca(2+) concentration (referred to hereafte

48 ddition to the impact of such discoveries on intracellular Ca(2+) dynamics and biophysical properties

49 simultaneously monitoring ionomycin-induced intracellular Ca(2+) elevations with fluorometry.

50 doplasmic reticulum (ER) acts as the largest intracellular Ca(2+) store that maintains Ca(2+) homeost

51 TRPV4(R269C) triggers increased intracellular Ca(2+) through a Ca(2+)/calmodulin-depende

52 ined by an in vitro assay, and the levels of intracellular Ca(2+) uptake and Na, K-ATPase mRNA were d

53 ependently activated by membrane voltage and intracellular Ca(2+).

54 e responses measured were an increase in the intracellular [Ca(2+)] ([Ca(2+)](i)) and high-molecular-

55 The increase in intracellular [Ca(2+)](I) with VIP and UTP was significa

56 s included effects on beating parameters and intracellular Ca2+ flux in CMs and inhibition of tubulog

57 MdxS3E cardiomyocytes displayed improved intracellular Ca2+ signaling and a reduction of NADPH ox

58 While stretch-elicited X-ROS primes intracellular calcium (Ca(2+) ) channels for synchronize

59 he release of these granules is dependent on intracellular calcium (Ca(2+)) signals.

60 In the pancreas, excessive intracellular calcium causes mitochondrial dysfunction,

61 harmacologically assessed mAChR-A to monitor intracellular calcium mobilization upon receptor activat

62 ignalling, which is linked to an increase in intracellular calcium oscillation mediated by ryanodine

63 and HFrEF to reveal distinct differences in intracellular calcium regulation and excitation-contract

64 Using cryo-soft X-ray microscopy we imaged intracellular calcium-containing particles in the PMCs a

65 ubsequent P2Y(2)R activation, and downstream intracellular calcium-dependent signal transduction.

66 events are similarly tightened by buffering intracellular calcium.

67 e signaling pathways, resulting in increased intracellular cAMP, and enhanced activation of EPAC and

68 lian neuron-specific kinesin-2 implicated in intracellular cargo transport.

69 A(+) motor that drives the transport of many intracellular cargoes towards the minus end of microtubu

70 eins, recent evidence shows that a number of intracellular "cargos" navigate the cytoplasm by hitchhi

71 receptor coupling to the downstream cAMP/PKA intracellular cascade.

72 egion, a transmembrane helix, and two tandem intracellular catalytic domains referred to as D1 and D2

73 Both intact cells (IC) and intracellular cell-free extracts (CFE) from most of the

74 under static conditions but did not enhance intracellular cGMP accumulation.

75 An intracellular chaperone, microsomal triglyceride transfe

76 which our modeling shows can be explained by intracellular chloride processing.

77 Intracellular collagen assembly begins with the oxidativ

78 e coordinated in localizing an ARF GEF to an intracellular compartment to initiate a transport pathwa

79 Histones are typically located within the intracellular compartment, and more specifically, within

80 t siRNA accumulation and stability in acidic intracellular compartments is critical for long-term act

81 t as molecular tethers, inter-connecting two intracellular compartments to enable efficient transport

82 ess abnormally synthesize hyaluronan (HA) in intracellular compartments.

83 , secreting acids to the lumen or acidifying intracellular compartments.

84 athway allowing the lysosomal degradation of intracellular components, plays a crucial role in the ma

85 d as model cell-based carriers with distinct intracellular composition and curcumin was a model encap

86 ydrolysis of phosphocreatine, increasing the intracellular concentration of inorganic phosphate (P(i)

87 PDXK disruption reduced intracellular concentrations of key metabolites needed f

88 nonical toggle switch and the opening of the intracellular crevice for G protein coupling.

89 growth of intestinal organoids by modifying intracellular crowding and elevating Wnt/beta-catenin si

90 the cNMP-dependent gating is mediated by the intracellular cyclic nucleotide-binding domain (CNBD) co

91 Intracellular Cygb concentration was estimated as 3.5 mu

92 36 viremic pediatric kidney recipients using intracellular cytokine staining and flow cytometry.

93 pecific reporter (TCSn::GFP) closely matches intracellular cytokinin content in roots, yet we also fi

94 xygen generation, which was supported by the intracellular DCFDA study.

95 Autophagy is an intracellular degradation pathway crucial to maintaining

96 supramolecular polymer ensures the efficient intracellular delivery and the release of Cas9 RNP into

97 Dye-loaded particles demonstrated that intracellular delivery was achieved in all cells in 2D c

98 not reduce pain-like behavior indicating its intracellular delivery was required for behavioral effec

99 hurdles that must be overcome for effective intracellular delivery, types of nonviral nanomaterials

100 lly resistant peptide-polymer conjugates for intracellular delivery.

101 In evolving to obligate intracellular dependence, Chlamydia has significantly re

102 atase CD45(2,3), which results in the direct intracellular dephosphorylation of tyrosine residues on

103 In addition, in vitro produced intracellular-derived particles were infectious in liver

104 , and undergo capsid disassembly to reach an intracellular destination that supports infection.

105 ivation upon 365 nm UV treatment and enables intracellular deubiquitinating enzyme profiling.

106 in the subsequent ozonation and the greater intracellular diffusion of ozone after the membrane disr

107 Aergic neurons impacted baseline DAT surface:intracellular distribution in DAergic terminals from fem

108 the expression, proteolytic processing, and intracellular distribution of genetic PLD3 variants prev

109 smic Mallory-Denk bodies, and changes of the intracellular distribution of high-mobility group box 1

110 Emiliania huxleyi intracellular DMSP did not respond to metabolically imba

111 ced conditions, while Thalassiosira oceanica intracellular DMSP was significantly correlated to stres

112 nt phosphorylation of alpha3GlyRs within the intracellular domain (ICD), which decrease the GlyR-asso

113 s associated with decreased levels of Notch1 intracellular domain (N1ICD) and impaired regenerative r

114 xpression of the constitutively active NOTCH intracellular domain in CD11c-expressing cells.

115 The intracellular domain of the serotonin type 3A receptor,

116 the light-inducible homo-interaction of the intracellular domain of TrkB in the cytosol or on the pl

117 esulting in enhanced tissue distribution and intracellular drug delivery of molecules, nanoparticles,

118 By limiting unrestricted activation of intracellular effectors, compartmentalized signaling of

119 enetic circuits while accounting for spatial intracellular effects.

120 therefore uniquely poised to communicate the intracellular energy status of adipocytes to other nonad

121 uclear region that is presumably the site of intracellular envelopment.

122 dary structure elements, indicating that the intracellular environment affects LOV photoreceptor mech

123 was recapitulated in vitro by emulating the intracellular environment through the addition of the cr

124 These data include paired intracellular/extracellular recordings and state-of-the-

125 d by reverse-transcriptase quantitative PCR, intracellular flow cytometry, and ELISA.

126 he successful development of drugs targeting intracellular folate metabolism, such as methotrexate an

127 he Hippo signaling effector Yki/YAP/TAZ, how intracellular force regulates these processes remains po

128 Cell crawling requires the generation of intracellular forces by the cytoskeleton and their trans

129 itated variant FXII-W268R/S544A reveals that intracellular fragmentation is largely dependent on auto

130 Depletion of the intracellular free iron content using the membrane-perme

131 . coli cells, suggesting that Fur senses the intracellular free iron content via reversible binding o

132 RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations.

133 immunogold labeling, we identified decreased intracellular glutamate density in presynaptic terminals

134 Intracellular glutamine levels are decreased in the abse

135 otherapy-resistant tumor growth by consuming intracellular glutathione and activating apoptosis.

136 ression of Lewis X and sialyl-Lewis X in the intracellular granules and on the cell surface, respecti

137 Intracellular HA-DAT colocalized with VPS35, a subunit o

138 As a result of this transition, the intracellular halves of the S6 helices bend and rotate b

139 A with different media conditions to produce intracellular HEV cell culture-derived particles (HEVcc)

140 e interactions are essential for maintaining intracellular homeostasis.

141 The initiation of intracellular host cell colonization by symbiotic rhizob

142 MINPP1 deficiency results in an intracellular imbalance of the inositol polyphosphate me

143 at (LRR) receptor (NLR) proteins function as intracellular immune receptors that perceive the presenc

144 g of a protein that forms polymers and large intracellular inclusions.

145 refers to the brief but intense elevation of intracellular indole during stationary phase entry.

146 genes induced by diverse stimuli, including intracellular infection and proteotoxic stress.

147 te its life cycle, Chlamydia must evade both intracellular innate immune responses and adaptive cytot

148 ngs raise the possibility that the increased intracellular ionic strength and elevated osmolytes caus

149 mpairs mitochondrial respiration by limiting intracellular iron availability through an oxidant-based

150 ure the amount of, and variability in, their intracellular iron content.

151 Plasma islatravir pharmacokinetics and intracellular islatravir-triphosphate pharmacokinetics w

152 and axo-spinous glutamatergic synapses, and intracellular labeling on the surface of mitochondria.

153 eucine but instead facilitated the efflux of intracellular leucine pools.

154 therapy, which is partly due to reduction of intracellular levels of anticancer drugs through ATP-bin

155 Moreover, intracellular levels of caspase 3/7 were increased in HL

156 ltered sphingolipid metabolism and increased intracellular levels of ceramide, paralleled by a nonred

157 Silencing of eIF3e reduced the intracellular levels of the c, d, and l subunits of eIF3

158 rent requirements prompted by their distinct intracellular lifestyles.

159 ttering microscopy was used to probe de novo intracellular lipid content.

160 This SnapShot summarizes the intracellular localization and function of proteins impl

161 t epithelial cells(ARPE-19), their survival, intracellular localization, and the pathological effects

162 motors to transport cargoes to their correct intracellular locations.

163 sphosphate (PIP(2)) interaction profile near intracellular loop (ICL) 2/TM3 at the G-protein-coupling

164 ed mice with a mutation (KR389-390AA) in the intracellular loop of the GlyR alpha2 subunit which resu

165 ibitor or by mutating two lysine residues in intracellular loop three causes Smo to aberrantly accumu

166 le to increase cellular retention by forming intracellular macromolecule adducts.

167 Magnetosomes are intracellular magnetic nanocrystals composed of magnetit

168 However, the underlying intracellular mechanisms leading to product aggregate fo

169 However, very little is known about the intracellular mechanisms that take place during CLas cel

170 BCR signaling triggers a cascade of intracellular mediators that eventuates in transcription

171 ARF GEFs to be recruited from the cytosol to intracellular membrane compartments.

172 ompanied by the formation of phase-separated intracellular membrane domains.

173 Arfs control distinct steps in intracellular membrane traffic, and one of the Arf-activ

174 yze ATP to pump protons across the plasma or intracellular membrane, secreting acids to the lumen or

175 infection induces the massive remodeling of intracellular membranes and the development of specializ

176 the cost of growth rate and accumulation of intracellular membranes.

177 ted within both plasma membrane leaflets and intracellular membranes.

178 their environment by flexibly reprogramming intracellular metabolic pathways that subsequently alter

179 In summary, we have identified intracellular metabolic traits associated with the 1q25

180 Evaluating ATM phenotype and intracellular metabolism together may more accurately il

181 Intracellular metabolomics analysis revealed decreasing

182 ding of how metal sensor proteins respond to intracellular metal concentrations.

183 ore, maintenance of proper concentrations of intracellular metals is essential for cell fitness and p

184 derstand how the spatio-temporal dynamics of intracellular Mg(2+) ((i)Mg(2+)) are integrated into cel

185 e, pro-inflammatory cytokine production, and intracellular migration of early-stage inflammatory elem

186 ting by directly probing chemically specific intracellular molecular vibrations via ultrafast multico

187 S can be expressed in cells and used for the intracellular monitoring of biological molecules.

188 reening of a GSK-proprietary library against intracellular Mycobacterium tuberculosis identified 1, a

189 ed I(Kv1.5) increase also required an intact intracellular N terminus, which contains the binding mot

190 S1-S2 linker of Kv1.5 communicates with the intracellular N terminus.

191 Moreover, auranofin reduced the burden of intracellular N. gonorrhoeae by over 99% outperforming t

192 estigated whether expression of CD73 impacts intracellular NAD(+) content and NAD(+)-dependent DNA re

193 reatment of BMDMs with lactate increased the intracellular NADH/NAD(+) ratio and upregulated NF-kappa

194 lular lactate:pyruvate ratio, normalized the intracellular NADH:NAD(+) ratio, upregulated glycolytic

195 However, STEAP1 lacks an intracellular NADPH-binding domain and does not exhibit

196 Keratin intermediate filaments form dynamic intracellular networks, which span the entire cytoplasm

197 m of dementia, associated with deposition of intracellular neuronal tangles consisting primarily of h

198 litate Salmonella entry, establishment of an intracellular niche, and modulation of immune responses.

199 Resonance at one common level of stochastic intracellular noise across days from 6 to 36 h of light/

200 cell envelopes and interact with lipids and intracellular nucleic acids.

201 sults are partially consistent with previous intracellular observations in these synapses.SIGNIFICANC

202 at this process can serve as a mechanism for intracellular organization in prokaryotes and eukaryotes

203 has reformed our understanding of bacterial intracellular organization, cellular development, and ce

204 Concomitantly, XPR1 silencing led to intracellular P(i) accumulation and a potential impact o

205 Surprisingly, STAT6 did not enhance intracellular parasite proliferation, but rather modulat

206 A major challenge of intracellular parasite research is collection of high pa

207 varying nutrient availability, the obligate intracellular parasite Toxoplasma gondii reprograms its

208 Listeria monocytogenes is a Gram-positive, intracellular pathogen harboring the surface-associated

209 Intracellular pathogen infection leads to proteotoxic st

210 he other, but the Gram-positive, facultative intracellular pathogen Listeria monocytogenes is unusual

211 (NLRs) localize in the cytosol to recognize intracellular pathogen products and initialize the innat

212 However, we report here that the facultative intracellular pathogen Salmonella enterica serovar Typhi

213 CMV is an obligate and persistent intracellular pathogen that continually drives the produ

214 ia monocytogenes is a foodborne, facultative intracellular pathogen that secretes c-di-AMP and activa

215 s provide durable protection against diverse intracellular pathogens and can be broadly segregated in

216 ion and CD8 T cell-mediated immunity against intracellular pathogens and tumors.

217 Intracellular pathogens are responsible for an enormous

218 Intracellular pathogens mobilize host signaling pathways

219 However, for the control of intracellular pathogens, a strong Th1 response character

220 Many intracellular pathogens, such as mammalian reovirus, mim

221 orphisms with an increased susceptibility to intracellular pathogens.

222 ne responses and protective efficacy against intracellular pathogens.

223 have provided insights into the circuits and intracellular pathways in the brain reward center that a

224 Lipokines are intimately connected to intracellular pathways of fatty acid metabolism and ther

225 n complex shapes with a remarkable degree of intracellular patterning.

226 A low percentage of bihormonal cells has intracellular Pg in both humans and experimental mice.

227 However, how intracellular pH affects mammalian TRPC channels remains

228 The intracellular portion limits Pyr levels, whereas the TMD

229 lays a similar role in protrusions driven by intracellular pressure.

230 rotein (K13), a protein involved in multiple intracellular processes including endocytosis of hemoglo

231 Solenopsins also reduced the intracellular proliferation of T. cruzi amastigotes in i

232 ing magnetic fields was sufficient to induce intracellular protease release, suggesting altered membr

233 The intracellular protein SOCS1 is known to downregulate cyt

234 oss-of-function variants in AP-4 subunits on intracellular protein trafficking using patient-derived

235 cNAc transferase (OGT) modifies thousands of intracellular proteins, the human pathogen Toxoplasma go

236 interactions with plasma, cell-surface, and intracellular proteins, which facilitates their tissue d

237 Chagas disease, caused by the intracellular protozoan parasite Trypanosoma cruzi, is a

238 reating cells for 6 h with cisplatin reduced intracellular PRPP availability.

239 may result from a PBMT-mediated increase of intracellular reactive oxygen species (ROS) levels and S

240 n cycle 42 activation, as well as downstream intracellular reactive oxygen species production.

241 Intracellular recordings linked propensity to cell excit

242 e been extensively studied and modeled using intracellular recordings of postsynaptic currents and po

243 sm, which proceeds through an opening of the intracellular region allosterically elicited by the bind

244 ltiple domains in both the extracellular and intracellular regions.

245 or for any analyte has been used to quantify intracellular release.

246 ed that in addition to the inhibition of the intracellular replication of HIV by autophagy, trehalose

247 Intracellular replication of the deadly pathogen Mycobac

248 protein TBC1D5 during vacuole biogenesis and intracellular replication.

249 generated in pollen tubes (PTs) and affects intracellular responses through the modulation of Ca(2+)

250 hia chaffeensis, a tick-transmitted obligate intracellular rickettsial agent, causes human monocytic

251 ole, heterologous transporters to facilitate intracellular routing, and strain optimization to improv

252 Proliferating intracellular S aureus led to the expansion and eventual

253 nal cells and how aberrant extracellular and intracellular S1P signaling contributes to the pathogene

254 Consequently, GLUT4 intracellular sequestration and mobilization by insulin

255 In the absence of lysis, MAC may induce intracellular signaling and cell activation, responses i

256 r energy status and nutrient availability to intracellular signaling and metabolic pathways.

257 cellular ligand binding domain but lacks the intracellular signaling domain.

258 The fidelity of intracellular signaling hinges on the organization of dy

259 A is not a pure BCR mimic but rather rewires intracellular signaling in EBV-infected B cells that opt

260 to reduce the computational complexity of an intracellular signaling mechanistic model.

261 ggers two broad, TRAF6- and TRAF5-dependent, intracellular signaling pathways to produce representati

262 olved in resolution and tissue repair, whose intracellular signaling remains of interest.

263 nize and parse microbial elicitors and drive intracellular signaling to limit or facilitate microbial

264 o four broad categories-DNA damage response, intracellular signaling, immune engagement, and genetic

265 ns transducing the encapsulation effect into intracellular signalling cascades promoting differentiat

266 ver, this approach does not directly prevent intracellular signalling, such as through tonic or susta

267 the precise transmission and integration of intracellular signals.

268 etabolites, and it has become clear that the intracellular sphingolipid composition of renal cells is

269 (3)R] and the ability to release Ca(2+) from intracellular stores via type 1 Ins(1,4,5)P(3)Rs were in

270 or assemblies in vitro as well as in diverse intracellular structures ranging from contractile bundle

271 ed use of dynamic behaviors at the levels of intracellular structures, individual cells, and cell gro

272 stingly, DDX5 depletion specifically reduced intracellular succinate, a TCA cycle intermediate that s

273 Recent reports have shown that intracellular, (super)paramagnetic ferritin nanoparticle

274 ned mutations in vitro identified defects in intracellular survival and protection against neutrophil

275 ia dynamics and functions to influence their intracellular survival or evade host immunity.

276 resulted in enhanced autophagy and improved intracellular survival rates compared to those of wild-t

277 4(+) cells showed an increased percentage of intracellular survivin in MG patients compared with cont

278 cells and recover conjugates that bind to an intracellular target.

279 ny (antimonite), we hypothesized that common intracellular targets lead to similarities in cellular r

280 s including reversibly binding to endogenous intracellular targets, modulating signaling pathway acti

281 al therapeutic strategies aim to prevent the intracellular tau accumulation.

282 Line 66 mice express intracellular tau aggregates in multiple brain regions a

283 or evolved to target ATG16L1's engagement in intracellular traffic rather than in LC3 lipidation brin

284 ubulins play crucial roles in cell division, intracellular traffic, and cell shape.

285 sporadic human prion disease that implicate intracellular trafficking and sphingolipid metabolism as

286 These results define tools for studying the intracellular trafficking of pathogens elicited by inhib

287 Intracellular trafficking through the Golgi using the ma

288 bution and tissue delivery, cellular uptake, intracellular trafficking, potency and toxicity.

289 r-activated receptor gamma (PPARgamma) is an intracellular transcription factor whose signaling activ

290 termines the spatial scale of organelles and intracellular transport and thereby affects biosynthesis

291 axons and dendrites defines the direction of intracellular transport in neurons.

292 The intracellular transport of cholesterol from the PM to th

293 downregulated genes related to synthesis and intracellular transport of FA, synthesis of triglyceride

294 (Lis1) is a key cofactor for dynein-mediated intracellular transport towards the minus-ends of microt

295 ian TULP1-4 proteins play essential roles in intracellular transport, cell differentiation, signaling

296 , and promise new possibilities for studying intracellular transport, cell motility, and neuronal phy

297 nelles and an arborized system of tracks for intracellular transport.

298 r-alpha-helix bundle protein that acts as an intracellular transporter and buffer for fatty-acyl-CoA

299 omes, and subsequent interactions with other intracellular vesicles and organelles generate the final

300 hey play important roles in acidification of intracellular vesicles, organelles, and the extracellula