ライフサイエンスコーパス: intracellular localization

1 oth the phototherapeutic activity as well as intracellular localization.

2 minus of the prodomain are required for this intracellular localization.

3 hereas SHH absence caused CXCR4 to assume an intracellular localization.

4 heir structural classification, topology and intracellular localization.

5 ring substrate specificity or in determining intracellular localization.

6 asmic tail of TLR9 important for appropriate intracellular localization.

7 on their content of viral genomes and their intracellular localization.

8 es were surrounded by F-actin, demonstrating intracellular localization.

9 ane, whereas endogenous receptors exhibit an intracellular localization.

10 idues also play a crucial role in beta(1)Pix intracellular localization.

11 al features of the TLR9 molecule control its intracellular localization.

12 eas phosphorylation at Thr-299 regulates its intracellular localization.

13 as the transmembrane domain plays no role in intracellular localization.

14 motherapeutic drugs and in regulating FADD's intracellular localization.

15 effects of zinc on ZIP7 gene expression and intracellular localization.

16 king, its interaction with adaptors, and its intracellular localization.

17 However, each isozyme displays a distinctive intracellular localization.

18 y and negatively regulated by control of its intracellular localization.

19 lls, in addition to the previously described intracellular localization.

20 NADP(H) levels in a manner dependent on its intracellular localization.

21 sic luminescence properties to determine its intracellular localization.

22 active oxygen species and their preferential intracellular localization.

23 cellular properties, such as DNA content and intracellular localization.

24 TREX1 interacted with ORF1p and altered its intracellular localization.

25 ing PI-binding sites that may regulate their intracellular localization.

26 reas glycan type affects the cell uptake and intracellular localization.

27 ito midgut oocyst sporozoites, exhibiting an intracellular localization.

28 ightly controls autophagy by modulating p300 intracellular localization, affecting the accessibility

29 To assess intracellular localization, Alexa Fluor 546-conjugated D

30 es were performed to assess their pattern of intracellular localization and ability to oligomerize, r

31 These may play an important role in the intracellular localization and activity of H(+)-ATPases.

32 rt virus generation exhibited an aberrant M1 intracellular localization and affected protein incorpor

33 sequence-specific signals as determinants of intracellular localization and as a basis for the differ

34 Intracellular localization and biochemical studies on in

35 Here, we report a rational approach to study intracellular localization and biological activity of th

36 st response, and the correlation between Rep intracellular localization and biological functions coul

37 mutants were generated for investigation of intracellular localization and cell biology.

38 tizer protoporphyrin IX (PpIX) fluorescence, intracellular localization and cell response to photodyn

39 versatile, label-free assay to determine the intracellular localization and concentration of a given

40 tivity, the molecular mechanisms controlling intracellular localization and cytoprotective activity a

41 lates adhesion and TJ function by regulating intracellular localization and degradation of selected c

42 green fluorescent protein and studied their intracellular localization and diffusional mobilities us

43 We have observed previously that both its intracellular localization and expression levels are sen

44 ancer development, we have characterized its intracellular localization and function in the prostate

45 The intracellular localization and function of APOL1 in podo

46 This SnapShot summarizes the intracellular localization and function of proteins impl

47 Our data suggest that RPGR modulates intracellular localization and function of RAB8A.

48 the contribution of Cys-2 and Cys-12 to the intracellular localization and function of RGS4.

49 However, very little is known about the intracellular localization and function of TXNIP, and al

50 ng and upstream of Gsk3beta and beta-catenin intracellular localization and function.

51 IP6K1 deletion disrupts alpha-actinin's intracellular localization and function.

52 ncy and rapamycin treatment lead to aberrant intracellular localization and functional impairment of

53 In the present study, we investigated the intracellular localization and G protein-dependent and -

54 y identifies IE1 as a new regulator of STAT3 intracellular localization and IL-6 signaling and points

55 ciated with viral replication complexes, the intracellular localization and interactions of p28 with

56 vitro GST pull-down techniques for detecting intracellular localization and interactions of PNGase, H

57 ing regions of nucleostemin altered both its intracellular localization and its stability.

58 DIS3L2 has a different intracellular localization and lacks the PIN domain foun

59 Events directly regulating Gln3 intracellular localization and nitrogen catabolite repre

60 rtant function of the C terminus for correct intracellular localization and protein stability, and it

61 ort the development of a reporter to examine intracellular localization and regulation by growth fact

62 Control over peptide intracellular localization and retention is possible by

63 d in biological traits of protein synthesis, intracellular localization and ribosome biogenesis, whic

64 Intracellular localization and secretion of wild-type an

65 ) motif resulted in both altered patterns of intracellular localization and self-assembly compared to

66 nvasion of human-RPEs, begin to characterize intracellular localization and survival of Pg within the

67 iate endosomal fusion affect M. tuberculosis intracellular localization and survival.

68 By using this mutant, we found that intracellular localization and trafficking of AnkG into

69 caffolding protein NHERF1, which affects the intracellular localization and trafficking of NHERF1 ass

70 ion between these mutants that altered their intracellular localization and trafficking under both lo

71 its interaction with 14-3-3beta protein and intracellular localization and uncover a mechanism by wh

72 edges of amino acid sequence 138-168 invoke intracellular localization and/or degradation.

73 ine or threonine residues and changing their intracellular localization and/or stability.

74 We investigated the uptake, intracellular localization, and antitumor activity of tw

75 these mutants were examined for VLP budding, intracellular localization, and oligomerization.

76 bolic activity, inflammation, GAPDH activity/intracellular localization, and poly-ADP-ribosylation of

77 h proteins that are likely to exhibit native intracellular localization, and second, it yields inform

78 o amyloidogenic processing is related to its intracellular localization, and that secretase-independe

79 t epithelial cells(ARPE-19), their survival, intracellular localization, and the pathological effects

80 orylation of beta-catenin, its stability, or intracellular localization; and (v) phosphorylation at t

81 ndent degradation of Stp1 and Stp2 and their intracellular localization are differentially regulated.

82 n to direct phosphorylation, proteolysis and intracellular localization are key mechanisms regulating

83 ation and the mechanisms regulating its dual intracellular localization are unknown.

84 oth complexes are live cells permeant, their intracellular localizations are significantly affected b

85 ve now been identified that control both the intracellular localization as well as activity of the Rt

86 Furthermore, this mutant displayed the same intracellular localization as WT SNAP25, indicating that

87 y SIRT1 and that this in turn influences its intracellular localization, association with STRAD, kina

88 Parkin mutants vary in their intracellular localization, binding to substrates and en

89 oteins, and others typically associated with intracellular localization but recently shown to be extr

90 P2BR mutations not only resulted in aberrant intracellular localization, but also attenuated AAP2 pro

91 rform diverse functions and exhibit distinct intracellular localizations, but contain similar cytopla

92 igens at different levels and with different intracellular localizations, but it is not known whether

93 We confirmed intracellular localization by generating a CD33m-specifi

94 Proteins establish and maintain a distinct intracellular localization by means of targeting, retent

95 androgen-regulated tumor suppressor and its intracellular localization can be modulated by ultraviol

96 ational arginylation of CRT can regulate its intracellular localization, cell function, and survival.

97 tivity to PI3K inside cells and suggest that intracellular localization could contribute to regulatio

98 Intracellular localization (cytosol, nucleoli, endosomes

99 In vivo intracellular localization data revealed that the H89G m

100 This intracellular localization dictates that vaccinia virus

101 Here we studied the intracellular localization, enzymatic activity, and meta

102 e chaperones in plants we investigated their intracellular localization, evolutionary relationships,

103 of this study demonstrate the importance of intracellular localization for CTLA-4 protein function a

104 opeophorbide-a (HPPH) altered the uptake and intracellular localization from mitochondria to lysosome

105 ractionation, CALR mutants exhibit different intracellular localization from that of wild-type CALR.

106 Aberrant PTK6 expression and intracellular localization have been detected in human p

107 The purpose for this intracellular localization, however, is not clear.

108 epressed AKT phosphorylation by altering its intracellular localization, immediately followed by prom

109 amond syndrome (SBDS) protein expression and intracellular localization in 7 patients with SDS and he

110 ntrinsic antibiotic resistance and protected intracellular localization in alveolar macrophages.

111 o probe the effect of glycan presentation in intracellular localization in HeLa and SV40 epithelial c

112 n proteins, respectively, and analyzed their intracellular localization in HeLa cells by immunofluore

113 us to assay Gln3-Myc(13) phosphorylation and intracellular localization in isogenic wild type, sit4,

114 YopE-MLD) were necessary and sufficient for intracellular localization in mammalian cells.

115 Immunohistochemistry confirmed intracellular localization in maturation-stage ameloblas

116 BDNF levels and intracellular localization in neurons are regulated by m

117 at one of these, Vph2, undergoes a change in intracellular localization in response to ER stress and,

118 r the regulation of Gln3 phosphorylation and intracellular localization in response to the nature of

119 pseudophosphorylation mutant showed aberrant intracellular localization in vivo and accumulated prima

120 , microscopic analyses show a defective Myo2 intracellular localization in ypt31Delta/32ts and in Ypt

121 and cell surface distributions and enhanced intracellular localizations in striatal neurons of AChE-

122 the CaR active intracellularly but also its intracellular localization includes both the ER, traditi

123 It also increased the level of ATF6 and intracellular localization into the nuclei in the neuron

124 This Mirk-dependent change in p21 intracellular localization is a natural part of myoblast

125 lum in Chinese hamster ovary cells, and this intracellular localization is also observed in neurons.

126 lr1 binds to polyadenylated RNA and that its intracellular localization is modulated by phosphorylati

127 egments in the dark, proving that the normal intracellular localization is not due the size exclusion

128 dge about their detailed characteristics and intracellular localization is relatively limited.

129 ndence, and endolysis (subfamily 1) and with intracellular localization, Mn(2+) dependence, and exoly

130 -targeting domains, but differences in their intracellular localization modulated specificity for hos

131 Despite its intracellular localization, NOD2 participates in sensing

132 leukocytes is thought to be achieved through intracellular localization of 5-lipoxygenase (5-LOX): nu

133 wed by protein level changes including their intracellular localization of a subset is subject to lig

134 Fluorescent imaging revealed intracellular localization of A-NK but weak A-NK-amide l

135 Changes in intracellular localization of activated FYN and LYN were

136 o, but the cell-type expression patterns and intracellular localization of activated, ie, phosphoryla

137 Domain-swapping experiments revealed that intracellular localization of AICL is determined by its

138 Herein, we show a predominantly intracellular localization of APOL1 G0 and the renal ris

139 The activity and intracellular localization of ATP7B are regulated by cop

140 nd the effect of CRP on binding, uptake, and intracellular localization of autoantibody snRNP complex

141 issue distribution, we have established that intracellular localization of autoantigen predisposes fo

142 alysis studies, the NMR spectra revealed the intracellular localization of BA.

143 e show that phosphate deprivation shifts the intracellular localization of BES1/BZR2 to yield a lower

144 ndent shuttling of Cby modulates the dynamic intracellular localization of beta-catenin.

145 The mutation of both SIMs changed the intracellular localization of BGLF4 from nuclear to cyto

146 Here, we show that EZH2 controls the intracellular localization of BRCA1 protein.

147 The intracellular localization of cathepsin L activity and t

148 t Bmpr2(+/-) PECs have increased numbers and intracellular localization of caveolae and caveolar stru

149 late endosomal compartment and changing the intracellular localization of CD1d.

150 Therefore, the intracellular localization of CD38 needs to be carefully

151 This, together with the extensive intracellular localization of CD40 and the strong correl

152 Together, these findings establish the intracellular localization of CgrA in A. fumigatus and d

153 To determine the intracellular localization of CgrA, the protein was tagg

154 In exploring the intracellular localization of chicken p7(ARF), we found

155 -translational modifications, and asymmetric intracellular localization of compound.

156 athways control the activity, structure, and intracellular localization of copper,zinc superoxide dis

157 We observed conspicuous differences in the intracellular localization of Cx43 protein in PRA versus

158 rovides mechanistic and functional data that intracellular localization of deltaR in neurons is a key

159 Confocal microscopic analysis showed that intracellular localization of dmCTs differed from that o

160 ghlights the importance of understanding the intracellular localization of drugs and proposes a ratio

161 zation revealed a striking difference in the intracellular localization of DVGs and full-length viral

162 cted cells that can be differentiated by the intracellular localization of DVGs.

163 luorescence microscopy demonstrated that the intracellular localization of each of the X-RAR alpha pr

164 sequences for symbiosome targeting and that intracellular localization of ectopically expressed MtEN

165 The intracellular localization of FGD6-Arg329 is distinct fr

166 lasm, suggesting that NPM may also determine intracellular localization of FOXM1.

167 downstream protein kinase Akt to change the intracellular localization of Foxo3a preferentially to t

168 The intracellular localization of fucosylated glycoconjugate

169 a novel insight into FMRP involvement in the intracellular localization of FUS and pathology of FUS-r

170 sence of PI(4,5)P(2) and prevent promiscuous intracellular localization of Gag.

171 By examining the intracellular localization of green fluorescent protein

172 h C. trachomatis inclusions, we examined the intracellular localization of guanine nucleotide-binding

173 e (PS)-modified oligonucleotides (ON) on the intracellular localization of hAgo2 and the efficiency o

174 In this work, we hypothesized that the intracellular localization of iNOS is significant for ef

175 , and reduced protein levels and altered the intracellular localization of Jag1 and the intracellular

176 futile ATP consumption and to ensure proper intracellular localization of kinesin-1 and its cargoes.

177 leic acid-binding protein substrates of Lon, intracellular localization of Lon, and cell morphology.

178 take studied using Western blot analysis and intracellular localization of Lp(a) by confocal microsco

179 take studied using Western blot analysis and intracellular localization of Lp(a) by confocal microsco

180 d by electron microscopy demonstrating clear intracellular localization of lymphocytes in vitro and b

181 Stimulation by interferon-gamma increased intracellular localization of lymphocytes within HSECs.

182 To explain this phenomenon we examined intracellular localization of MB and its fluorescence li

183 The expression of 5-HT(2A)R also augmented intracellular localization of mGluR2 in mouse frontal co

184 We characterized the intracellular localization of miR-206 at higher spatial

185 es for in situ hybridization analysis of the intracellular localization of miR-206 during differentia

186 f mTORC1, but, like amino acids, promote the intracellular localization of mTOR to a compartment that

187 Because aberrant intracellular localization of MUC1 in tumor cells correl

188 1 cells or lens epithelial cells altered the intracellular localization of muskelin, recruiting it to

189 Intracellular localization of mutant CARP proteins is no

190 mutants of E12 or E47 also led to an altered intracellular localization of MyoD and Id1.

191 We also show that the intracellular localization of myosin VI is substantially

192 determine the post-internalization fate and intracellular localization of nanoparticles.

193 he gene that encodes the channel NaV1.6, and intracellular localization of NaV1.6 to regions near F-a

194 Intracellular localization of OLFM2 was studied by confo

195 ultured progenitor cells to BMP4 changed the intracellular localization of OLIG1 and OLIG2 from a pre

196 no alterations in protein expression and/or intracellular localization of other TJ-related proteins

197 ys but also provides the first evidence that intracellular localization of p38 kinase and complex int

198 tionary phase, we show that SprE changes the intracellular localization of PAP I.

199 Intracellular localization of Pdlim2 was investigated by

200 Our model reproduces observed patterns of intracellular localization of PERIOD and TIMELESS during

201 this study support a model in which dynamic intracellular localization of peripheral membrane protei

202 tting and lipid kinase assays to examine the intracellular localization of PIP5K in resting and activ

203 inase anchoring proteins (AKAPs) mediate the intracellular localization of PKA and control the specif

204 ranule movement, here we studied dynamics of intracellular localization of PKC delta in living CD8(+)

205 lytic granule exocytosis by revealing novel intracellular localization of PKC delta, providing the f

206 ant function for this cellular GTPase in the intracellular localization of pp150 during virus assembl

207 the latter finding suggested that authentic intracellular localization of pp28, not only the express

208 vacuoles, impaired autophagic flux, altered intracellular localization of prosaposin, and an aggrega

209 ful for many reporter-based assays including intracellular localization of proteins, studying cellula

210 Although much is known about how the intracellular localization of PTEN regulates signaling i

211 Similar to other small GTPases, intracellular localization of RhoH is dependent upon the

212 NF-kappaB activity and intracellular localization of RIP1 was monitored by repo

213 Finally, intracellular localization of Ro52 dramatically changed

214 The intracellular localization of S1P phosphohydrolase-1 nec

215 Intracellular localization of Saccharomyces cerevisiae G

216 The intracellular localization of ScUGPase-1 indicated parti

217 nalysis of immunoisolated COPII vesicles and intracellular localization of Sec24 isoforms indicate th

218 However, recent descriptions of the intracellular localization of SH3TC2 are conflicting.

219 The intracellular localization of SLC26A7 suggests the possi

220 Given the intracellular localization of SLIP-GC to sites of replic

221 The intracellular localization of sphingosine kinase has bee

222 gulate the enzymatic activity as well as the intracellular localization of SR, potentially coupling t

223 mote normal hepatic expression, function and intracellular localization of SR-BI.

224 ative groups distinguished by activation and intracellular localization of SRC-family kinases, especi

225 Here, we investigate the intracellular localization of sRNAs transcribed from pla

226 Recently, we made the novel observation of intracellular localization of Staphylococcus aureus with

227 Inhibition of BIG2 also disturbed the intracellular localization of such molecules as E-cadher

228 Over 80% of the cells showed intracellular localization of the amyloid light chains.

229 dies in cell cultures revealed predominantly intracellular localization of the CB1 receptor and it wa

230 To understand the processing and intracellular localization of the CCHFV glycoproteins as

231 en combined are sufficient for directing the intracellular localization of the constituent protein.

232 widely recognized that determination of the intracellular localization of the encoded proteins may a

233 We characterized the intracellular localization of the four proteins.

234 tobleaching demonstrated delayed kinetics of intracellular localization of the gM/gN protein to the v

235 We investigated the intracellular localization of the multifunctional nonstr

236 rized the molecular components that regulate intracellular localization of the ORF 3b protein.

237 6K2 from nuclei to mitochondria, whereas the intracellular localization of the other isoforms of the

238 result in reduced PADI3 expression, abnormal intracellular localization of the protein, and decreased

239 ubsets, has not been possible because of the intracellular localization of the protein.

240 D or Id1 with E12 or E47 resulted in altered intracellular localization of the proteins largely depen

241 pproaches, a consideration of the inter- and intracellular localization of the proteins, along with t

242 yl-terminal tail (P1148L) does not alter the intracellular localization of the receptor, but it induc

243 omponents of a ribonucleoprotein complex, or intracellular localization of the RNA substrate.

244 nelle-specific DNA repair, we determined the intracellular localization of the Saccharomyces cerevisi

245 Here we investigated the expression and intracellular localization of the TRPM8 channel in relat

246 UL8 also influences the intracellular localization of the UL5/UL52 subunits, but

247 ult in degradation, aberrant folding, and/or intracellular localization of the viral polymerase.

248 on, alternative splicing, RNA stability, and intracellular localization of the viral transcripts.

249 0ts mutation confers opposite effects on the intracellular localization of these GTPases.

250 Intracellular localization of these receptors is thought

251 Here we demonstrate that the intracellular localization of TLR3 is achieved by a 23-a

252 In contrast, the intracellular localization of TLR7 is achieved by its tr

253 These data demonstrated that intracellular localization of TLR9 was not required for

254 al that the association with UNC93B1 and the intracellular localization of TLRs are not unique featur

255 ch may be owing to abnormal stability and/or intracellular localization of TTC37 target proteins.

256 We found that the intracellular localization of TTP in hepatocytes is dyna

257 We studied intracellular localization of variants of ATP7B that had

258 latasvir-induced clustering of HCV proteins, intracellular localization of viral RNAs, and inhibition

259 In contrast, the intracellular localizations of geranylgeranylated Rho GT

260 after treatment with saponin, indicating the intracellular localizations of loops 1 (50-73), 2 (150-1

261 The intracellular localizations of several OsHPs and OsRRs w

262 ascribed to SPARC, but the influence of its intracellular localization on each of these activities i

263 However, the intracellular localization or functional domains of Par-

264 of hnRNP K-targeted RNAs but not for hnRNP K intracellular localization or RNA binding.

265 bserved differences in trafficking patterns, intracellular localization, or binding partners.

266 ification with SUMO alters protein function, intracellular localization, or protein-protein interacti

267 Because of its intracellular localization, p53 is inaccessible to class

268 The aberrant intracellular localization patterns of lipid binding-def

269 ng cells fluorescently, revealing intriguing intracellular localization patterns of mRNA.

270 This discovery highlights the role that intracellular localization plays in specialized metaboli

271 Therefore, we propose that its intracellular localization prevents Epac1 from activatin

272 edge, cytoskeletal organization, phospho-ERK intracellular localization, proliferation, human skin wo

273 The trafficking events leading to this intracellular localization remain controversial.

274 Intracellular localization showed that neither HCR/T nor

275 proteins from group 2 coronaviruses lack an intracellular localization signal.

276 LD proteins, each of which was confirmed by intracellular localization studies with fluorescent prot

277 Here, we describe our intracellular localization studies, supported by biochem

278 copper-transporting ATPase ATP7B has a dual intracellular localization: the trans-Golgi network (TGN

279 their using distinct regulatory elements for intracellular localization, TLR3 was found to co-localiz

280 This allowed the dynamics of its intracellular localization to be tracked at super resolu

281 he results demonstrate that PAG1 directs SFK intracellular localization to control activity and to me

282 If Pet requires intracellular localization to execute its toxic effects,

283 Although their intracellular localization to mitochondria and the endop

284 either participates in the response of Gln3 intracellular localization to nitrogen limitation before

285 hat directs TLR9 intracellularly and confers intracellular localization to the normally cell surface-

286 ripts were linked to the cytoskeleton and to intracellular localization, trafficking and transport.

287 rs, FcRLA is uniquely interesting due to its intracellular localization, unusual structural features,

288 res of bitopic proteins; (v) TM topology and intracellular localization, (vi) physical interactions b

289 els of GRP and integrin receptors, and their intracellular localization was evaluated via confocal fl

290 Its intracellular localization was found to be consistent wi

291 Similar intracellular localization was observed when TRPM1 was h

292 Intracellular localization was segment specific; in the

293 henotypic markers, and nuclear factor-kappaB intracellular localization were assessed using fluoresce

294 lements responsible for UL16 trafficking and intracellular localization were investigated by preparin

295 d their acceptor substrate specificities and intracellular localizations were determined.

296 lutamate (Y892E) is sufficient to drive this intracellular localization, while other point mutants (Y

297 ous studies of CLN3P tissue distribution and intracellular localization will require extensive reanal

298 FGD2 has a complex intracellular localization, with concentrations found in

299 horylation has been thought to determine its intracellular localization, with phosphorylated and deph

300 erence between the two proteins was in their intracellular localization, with UL12 localizing to the