ライフサイエンスコーパス: intracellular membrane

1 protein associating with or integrating into intracellular membrane.

2 discrimination between surface-connected and intracellular membranes.

3 ycles to shuttle reducing equivalents across intracellular membranes.

4 f disease-associated changes to GM1-enriched intracellular membranes.

5 genomic RNA on the surface of virus-induced intracellular membranes.

6 ial in controlling the shape and dynamics of intracellular membranes.

7 t generates reactive oxygen species (ROS) at intracellular membranes.

8 the major determinants of its recruitment to intracellular membranes.

9 o increased alpha-synuclein sequestration on intracellular membranes.

10 stance to infection by pathogens that damage intracellular membranes.

11 tive regulator of ARP2/3 function present on intracellular membranes.

12 vation of caspase-8 on the cytosolic side of intracellular membranes.

13 ication complexes on the cytoplasmic face of intracellular membranes.

14 ontrolling the morphology and trafficking of intracellular membranes.

15 ents occurring within or near the plasma and intracellular membranes.

16 iably associated with extensively rearranged intracellular membranes.

17 essed mu1 induces apoptosis and localizes to intracellular membranes.

18 ably replicate their RNA genomes on modified intracellular membranes.

19 tafazzin, which was associated with multiple intracellular membranes.

20 xpressed protein was targeted extensively to intracellular membranes.

21 lls are compartmentalized into organelles by intracellular membranes.

22 and KChIP3x all autonomously target eGFP to intracellular membranes.

23 acuoles and perinuclear spaces, and depleted intracellular membranes.

24 1/2 < 1 min) between the plasma membrane and intracellular membranes.

25 ially active G protein betagamma subunits to intracellular membranes.

26 A and is restricted to a subset of host cell intracellular membranes.

27 to the capacity of micro1 to associate with intracellular membranes.

28 cytosol but also in the plasma membrane and intracellular membranes.

29 stable association of AP-1 with appropriate intracellular membranes.

30 t a wide range of substrates across cell and intracellular membranes.

31 nhibit mutant SOD1 misfolding and binding to intracellular membranes.

32 vesicle exocytosis, but it is also found on intracellular membranes.

33 to assemble its RNA replication complexes on intracellular membranes.

34 he cell surface and rapidly redistributed to intracellular membranes.

35 ndicating association of these proteins with intracellular membranes.

36 the cost of growth rate and accumulation of intracellular membranes.

37 to the molecular composition and function of intracellular membranes.

38 ostasis leads to a dramatic rearrangement of intracellular membranes.

39 ted within both plasma membrane leaflets and intracellular membranes.

40 depends on the extensive remodeling of host intracellular membranes.

41 aquaporins from the plasma membrane (PM) to intracellular membranes.

42 otein found both in the cytosol and bound to intracellular membranes.

43 ion of vesicle trafficking and remodeling of intracellular membranes.

44 mble viral RNA replication complexes on host intracellular membranes, a process whose molecular detai

45 icity is compatible with simple necrosis and intracellular membrane accumulation.

46 her budding of DNA-containing HBV virions at intracellular membranes also involves MVB functions, we

47 ive liposome fusion and lysis, the fusion of intracellular membranes also requires Rab GTPases, Rab e

48 ndent genes, as gene fusions, or targeted to intracellular membranes, also demonstrate the potential

49 ses control vesicle formation from different intracellular membranes and are regulated by Arf guanine

50 irmed protein recovery from plasma membrane, intracellular membranes and cell cytosol without associa

51 striking differences in the organization of intracellular membranes and in the assembly of mature vi

52 man endothelial cells, GPER was expressed on intracellular membranes and mediated eNOS activation and

53 have shown that Bcl-2 is present on several intracellular membranes and mitochondria may not be the

54 ule ends exert pulling and pushing forces on intracellular membranes and organelles.

55 tiporters are located in the cytoplasmic and intracellular membranes and play crucial roles in regula

56 nction as dynamin-like proteins that bind to intracellular membranes and promote remodeling and traff

57 y extended SNARE sequences at the surface of intracellular membranes and prompting our development of

58 infection induces the massive remodeling of intracellular membranes and the development of specializ

59 he non-vesicular transfer of sterols between intracellular membranes and the plasma membrane.

60 e enzyme in order to modify the structure of intracellular membranes and use them for the constructio

61 he spatial contribution of the cytoskeleton, intracellular membranes, and ATP-dependent active forces

62 PDE3A1, which is localized to intracellular membranes, and PDE3A2, which is cytosolic,

63 iruses, including herpesviruses, envelope at intracellular membranes, and the effect of tetherin on s

64 ion of hepatitis C virus (HCV) RNA occurs on intracellular membranes, and the replication complex (RC

65 Intracellular membranes are critical for replication of

66 During dengue virus infection of host cells, intracellular membranes are rearranged into distinct sub

67 -1-P may function to recruit cPLA(2)alpha to intracellular membranes as well as allosterically activa

68 In group 1 cells intracellular membranes associated with t-tubular struct

69 The NF2 tumor suppressor gene encodes an intracellular membrane-associated protein, called merlin

70 to purified D3 and D5 phosphoinositides, the intracellular membrane association of pleckstrin-2 and c

71 fect on protein A synthesis, degradation, or intracellular membrane association.

72 cturally and mechanistically analogous to an intracellular membrane-attached contractile phage tail.

73 as predominantly cytosolic and showed little intracellular membrane binding despite having a higher H

74 inding is more readily reversed than that of intracellular membrane binding.

75 3 charge neutralizing point mutations at the intracellular membrane border and characterized them ele

76 most of the visible biota coming to rely on intracellular membrane-bound organelles.

77 uring infection chlamydial pathogens form an intracellular membrane-bound replicative niche termed th

78 ially colocalized with PLD1-hemagglutinin on intracellular membrane-bound vesicles and with PLD2-hema

79 nd that the APP TM helix is disrupted at the intracellular membrane boundary near the epsilon-cleavag

80 ectly associated with the plasma membrane or intracellular membranes but instead colocalizes with int

81 In cells, BAX targets several intracellular membranes but notably does not target the

82 ulation of misfolded SOD1 and its binding to intracellular membranes, but the role of endogenous MIF

83 Hundreds of proteins are anchored in intracellular membranes by a single transmembrane domain

84 -gammaB families can influence the shape of intracellular membranes by mediating intraluminal intera

85 rred protection against subsequent damage to intracellular membranes caused by photooxidative chemist

86 charged O2 (-) is unable to diffuse through intracellular membranes, cells express distinct SOD isof

87 Ryanodine receptors (RyRs) are intracellular membrane channels playing key roles in man

88 They biomineralize magnetosomes, intracellular membrane-coated magnetic nanoparticles, th

89 es; (iii) Planctomycetes, which possesses an intracellular membrane compartment, is placed at the bas

90 n-1/Vps34/UVRAG protein complex is formed in intracellular membrane compartments as it is found witho

91 lut4, but not of IRAP, to insulin-responsive intracellular membrane compartments in 3T3-L1 adipocytes

92 onium chloride is routinely used to alkalize intracellular membrane compartments under the assumption

93 ence cross-correlation spectroscopy data for intracellular membrane compartments, we show that the co

94 rt that PI is broadly distributed throughout intracellular membrane compartments.

95 ARF GEFs to be recruited from the cytosol to intracellular membrane compartments.

96 ng different transport pathways that connect intracellular membrane compartments.

97 eins have higher raft affinity than those of intracellular membranes, consistent with raft-mediated p

98 eptides such as adiponectin and recycling of intracellular membranes containing GLUT4 glucose transpo

99 Poliovirus infection remodels intracellular membranes, creating a large number of memb

100 imeras map the molecular organization of AIS intracellular membrane, cytosolic, and microtubule compa

101 egument-associated capsids to bud through an intracellular membrane derived from the cell's secretory

102 cells transduced with 3AB protein displayed intracellular membrane disruption; specifically, the for

103 ompanied by the formation of phase-separated intracellular membrane domains.

104 tin-like conjugation systems that reorganize intracellular membranes during canonical autophagy are n

105 Phosphoinositides play crucial roles in intracellular membrane dynamics and cell signaling, with

106 uration, including vesicular trafficking and intracellular membrane dynamics.

107 ranes of their own, disrupt or perforate the intracellular, membrane-enclosed compartment into which

108 While intracellular membrane expression of Abeta1-42 in APP48

109 activated only when H2O2 was present at the intracellular membrane face.

110 nnels are located in the plasma membrane and intracellular membranes, facilitating Ca(2+) entry into

111 her enteroviruses, initiates a remodeling of intracellular membrane for genomic replication, the regu

112 ansfected cells demonstrated localization to intracellular membranes for E-Syt1 and to plasma membran

113 CIRV is more restricted in utilizing various intracellular membranes for replication.

114 These viruses subvert intracellular membranes for virus replication and coopt

115 describes a procedure to prepare a raft-like intracellular membrane fraction enriched for the trans-G

116 eticulum stress but was not found within the intracellular membrane fractions and may represent a new

117 , consistent with indiscriminate sampling of intracellular membranes from the cytosol rather than tra

118 SNARE proteins play a critical role in intracellular membrane fusion by forming tight complexes

119 y adapted to investigation of other types of intracellular membrane fusion by using appropriate alter

120 Our results suggest that the intracellular membrane fusion complex is designed to fus

121 complexes play essential roles in catalyzing intracellular membrane fusion events although the assemb

122 N-ethylmaleimide-sensitive factor (NSF), an intracellular membrane fusion factor.

123 s collectively suggest that the mechanism of intracellular membrane fusion induced by peripherin-2 an

124 Intracellular membrane fusion is mediated by the concert

125 ein receptors (SNAREs) form part of the core intracellular membrane fusion machinery, but it is uncle

126 e two universally required components of the intracellular membrane fusion machinery, SNARE and SM (S

127 Intracellular membrane fusion mediates diverse processes

128 tive factor (NSF) is known to be crucial for intracellular membrane fusion processes, but its role in

129 on machinery and mediate virtually all known intracellular membrane fusion reactions on which exocyto

130 syts might contribute to the specificity of intracellular membrane fusion reactions.

131 ns into SNARE complexes is required for many intracellular membrane fusion reactions.

132 Intracellular membrane fusion requires R-SNAREs and Q-SN

133 Intracellular membrane fusion requires Rab-family GTPase

134 Intracellular membrane fusion requires SNARE proteins in

135 Sec1/Munc18 (SM) proteins activate intracellular membrane fusion through binding to cognate

136 nd target (t)-SNAREs play essential roles in intracellular membrane fusion through the formation of c

137 achment protein receptors) are essential for intracellular membrane fusion, but the general mechanism

138 (SM) proteins are required for every step of intracellular membrane fusion, but their molecular mecha

139 SNAREs constitute the core machinery of intracellular membrane fusion, but vesicular SNAREs loca

140 ARE proteins and tethering complexes mediate intracellular membrane fusion, fission requires the pres

141 , likely underlying a universal mechanism of intracellular membrane fusion.

142 ein receptors (SNAREs) play central roles in intracellular membrane fusion.

143 lies, and SM SNARE-binding proteins catalyze intracellular membrane fusion.

144 physically link two apposed membranes before intracellular membrane fusion.

145 nesis of small seamless tubes occurs through intracellular membrane growth and directed vesicle fusio

146 Accumulation of misfolded proteins on intracellular membranes has been implicated in neurodege

147 of the endoplasmic reticulum (ER) and other intracellular membranes have important functions in cell

148 part explaining the association of AP-3 with intracellular membranes having less acidic phosphoinosit

149 tion efflux that would follow a titration of intracellular membrane-impermeant anions by the intracel

150 the negative electrostatic surface charge of intracellular membranes in a way that renders the cell l

151 s the close contact between cell surface and intracellular membranes in muscle cells ensuring efficie

152 HID-1 is essential for its association with intracellular membranes in nematodes and PC12 cells.

153 C. elegans neuronal HID-1 resides on intracellular membranes in neuronal cell somas; however,

154 becomes accessible on the cytosolic side of intracellular membranes in order to interact with cytoso

155 ack a chaperone that precludes mSOD1 binding intracellular membranes in other cells.

156 pid for the translocation of cPLA(2)alpha to intracellular membranes in response to inflammatory agon

157 n light chain 3 (LC3), which are enriched at intracellular membranes in response to proteotoxic stres

158 luR5), is expressed on both cell surface and intracellular membranes in striatal neurons.

159 assembly of the viral replicase complexes on intracellular membranes in the host cells.

160 MtFPN2 is located in intracellular membranes in the nodule vasculature and in

161 and its association with lipid droplets and intracellular membranes in transfected cells were abroga

162 cross contamination with other PM domains or intracellular membranes, in marked contrast to DRM that

163 The proteins localize to intracellular membranes including vacuoles that contain

164 dance of mGluR5 both on the cell surface and intracellular membranes, including the endoplasmic retic

165 Ras have revealed signaling on a variety of intracellular membranes, including the Golgi apparatus.

166 CV NS3/4A serine protease is associated with intracellular membranes, including the MAM, through memb

167 on of K-Ras from the PM and association with intracellular membranes, including the outer membrane of

168 (PAM) around the fungal arbuscule creates an intracellular membrane interface between the symbionts.

169 functions of C3 in all four locations (i.e. intracellular, membrane, interstitium and circulation) a

170 The assembly of RNA replication complexes on intracellular membranes is an essential step in the life

171 nionic porphyrins (for example, haem) across intracellular membranes is crucial to many biological pr

172 The fusion of intracellular membranes is driven by the formation of a

173 studies suggest that copper movement across intracellular membranes is mechanistically similar to th

174 imary phosphate group, acts only through the intracellular membrane leaflet and depends on the presen

175 th anionic lipids that are restricted to the intracellular membrane leaflet.

176 changer slc24a5 (nckx5) that localizes to an intracellular membrane, likely the melanosome or its pre

177 ligands, sortilin is primarily localized to intracellular membranes, limiting the formation of a cel

178 Replication, intracellular membrane localization, and packaging chara

179 r the mRNA untranslated regions or protein A intracellular membrane localization.

180 . recently propose in Cell that expansion of intracellular membrane microdomains induced by saturated

181 owth, RNA synthesis, protein expression, and intracellular membrane modifications.

182 suggests a model in which the SM content of intracellular membranes modulates the secretion of nasce

183 Although Bcl-xL is active primarily at intracellular membranes, most studies have focused on so

184 rain mGluR5 is localized on cell surface and intracellular membranes, neither the presence nor physio

185 rans-Golgi network and are a key part of the intracellular membrane network.

186 Positive-strand RNA viruses reshape the intracellular membranes of cells to form a compartment w

187 ons in which DAG is evenly distributed among intracellular membranes of HEK293 cells.

188 which hijack this cellular enzyme to remodel intracellular membranes of infected cells to set up the

189 To determine whether mGluR5 signals from intracellular membranes of other cell types, such as exc

190 was functionally competent and localized to intracellular membranes of yeast, suggesting that Ca(2+)

191 mical probes with targeted affinity for DNA, intracellular membranes or the plasma membrane.

192 proteomic analysis provided a global view of intracellular membrane organization.

193 oinositides play important roles in numerous intracellular membrane pathways.

194 d redistribution of endogenous ergosterol to intracellular membranes, phenotypes that are Kes1p depen

195 lation, beta-NAD and ATP were compared using intracellular membrane potential and force measurements.

196 with vascular hyperpolarization, as shown by intracellular membrane potential measurements.

197 hybrid model, demonstrate that it generates intracellular membrane potential profiles that closely m

198 Here we combined intracellular membrane potential recordings in cat V1 wi

199 During dilation, the intracellular membrane potential was desynchronized, sen

200 anoelectrodes, and can simultaneously record intracellular membrane potentials from hundreds of conne

201 tors mediate docking, the initial contact of intracellular membranes preceding bilayer fusion.

202 Gag-YFP bound nonspecifically to the PM and intracellular membranes, presumably via the myristoyl mo

203 ction that prevents MA from associating with intracellular membranes prior to arrival at the PI(4,5)P

204 seases, including type 1 diabetes (T1D), are intracellular membrane proteins, whose initial encounter

205 asmic tail of the ligand Jagged1, one in the intracellular membrane proximal region and the other nea

206 Ibbeta, and GPIX subunits, revealed that the intracellular membrane-proximal calmodulin-binding regio

207 inus of both alpha(IIb) and beta(3) TMs, the intracellular membrane-proximal regions, and the whole c

208 ytokine-receptor interactions are modulating intracellular membrane-proximal signaling events.

209 CCOX was confirmed as being the first intracellular membrane receptor for sPLA(2) by alternati

210 arker for caveolae, in both cell-surface and intracellular membrane regions.

211 have emerged: defects in (i) sarcolemmal and intracellular membrane remodelling and excitation-contra

212 n of cells with poliovirus induces a massive intracellular membrane reorganization to form vesicle-li

213 Intracellular membrane reorganization to support viral R

214 sembly of viral RNA replication complexes on intracellular membranes represents a critical step in th

215 yze ATP to pump protons across the plasma or intracellular membrane, secreting acids to the lumen or

216 iferative phase followed by expansion of the intracellular membrane secretory network to support Ig p

217 interaction with TRAF6 for the assembly of "intracellular membrane signalosomes."

218 ic residues with the lipid headgroups at the intracellular membrane-solution interface reduce the mem

219 These findings indicate that functions at intracellular membranes, specifically those of the endop

220 In most of the group 2 cells, a faint intracellular membrane staining was observed.

221 y mobilizing Glut4 glucose transporters from intracellular membrane storage sites to the plasma membr

222 s infection results in the disintegration of intracellular membrane structures and formation of speci

223 crophages, HIV-1 Gag localizes to convoluted intracellular membrane structures termed virus-containin

224 Dengue virus induces several distinct intracellular membrane structures within the endoplasmic

225 ation, likely through signal transduction on intracellular membrane structures.

226 ution of c-Src, causing it to partition into intracellular membrane subdomains, where it likely becom

227 their genomes in association with rearranged intracellular membranes such as single- or double-membra

228 occurrence of preBCR signal propagation from intracellular membranes such as the endoplasmic reticulu

229 However, for some intracellular membranes such as the endoplasmic reticulu

230 presence of PDZ domain proteins attached to intracellular membranes suggests that PDZ-type interacti

231 er leading to an open activation gate at the intracellular membrane surface and the intracellular C-t

232 within the transmembrane (TM)5-6 loop on the intracellular membrane surface.

233 its form a 350-kilodalton gating ring at the intracellular membrane surface.

234 tric charge density on the extracellular and intracellular membrane surfaces.

235 expression in a prokaryotic host lacking any intracellular membrane system drives the formation of cy

236 in form and function is displayed among the intracellular membrane systems of different eukaryotes.

237 in-lipid interaction between this enzyme and intracellular membranes that inhibits catalytic activity

238 Positive-sense RNA viruses hijack intracellular membranes that provide niches for viral RN

239 anes exposed to the extracellular space from intracellular membranes; the second interrogated the ori

240 d signal through the MAVS adaptor protein on intracellular membranes, thus directing downstream activ

241 eases in Golgi diacylglycerol, allowing this intracellular membrane to serve as a platform for signal

242 f large cytoplasmic DNA viruses, rely on the intracellular membranes to develop their envelope, and p

243 endomembranes to maintain G protein pools in intracellular membranes to establish direct communicatio

244 V), an arbovirus of global concern, remodels intracellular membranes to form replication sites.

245 Positive-sense RNA viruses remodel intracellular membranes to generate specialized membrane

246 Many RNA viruses remodel intracellular membranes to generate specialized sites fo

247 they need to translocate from the cytosol to intracellular membranes to participate in glycerolipid s

248 slocation of GLUT4 glucose transporters from intracellular membranes to the cell surface.

249 distributing GLUT4 glucose transporters from intracellular membranes to the cell surface.

250 promotes the translocation of V-ATPase from intracellular membranes to the plasma membrane via a pat

251 icles, is well characterized for its role in intracellular membrane traffic and endocytosis from the

252 smitter release with those of other types of intracellular membrane traffic and, in turn, support a r

253 simian immunodeficiency virus (SIV) subvert intracellular membrane traffic as part of their replicat

254 Rab guanosine triphosphatases regulate intracellular membrane traffic by binding specific effec

255 Clathrin plays important roles in intracellular membrane traffic including endocytosis of

256 CHC22 clathrin plays a key role in intracellular membrane traffic of the insulin-responsive

257 Arfs control distinct steps in intracellular membrane traffic, and one of the Arf-activ

258 machinery have homologues in other types of intracellular membrane traffic, likely underlying a univ

259 function to dissect the role of clathrin in intracellular membrane traffic.

260 ransport is a general mechanism that governs intracellular membrane trafficking along the endocytic a

261 gy is a conserved cellular process involving intracellular membrane trafficking and degradation.

262 ularly the endoplasmic reticulum, as well as intracellular membrane trafficking and distribution as p

263 otein functioning in membrane tubulation for intracellular membrane trafficking and specific organell

264 ity, cell proliferation and differentiation, intracellular membrane trafficking and transport vesicle

265 ylinositol 3-kinase Vps34 complexes regulate intracellular membrane trafficking in endocytic sorting,

266 Intracellular membrane trafficking of glutamate receptor

267 transferase, plays a significant role in the intracellular membrane trafficking of Wnt3 and subsequen

268 a cellular degradation process involving an intracellular membrane trafficking pathway that recycles

269 Circumstantial evidence suggests that intracellular membrane trafficking pathways diversified

270 4 is involved in the control of multiple key intracellular membrane trafficking pathways including en

271 s required for membrane fusion in eukaryotic intracellular membrane trafficking pathways.

272 roteins play an essential role in regulating intracellular membrane trafficking processes.

273 Intracellular membrane trafficking requires correct and

274 y multiple genes involved in endocytosis and intracellular membrane trafficking that strongly regulat

275 It plays an essential role in most intracellular membrane trafficking through its binding t

276 provide evidence that cholesterol regulates intracellular membrane trafficking via modulation of the

277 measures, provides a novel tool for studying intracellular membrane trafficking, and presents a new p

278 Neurons require highly specialized intracellular membrane trafficking, especially at synaps

279 esses such as receptor-mediated endocytosis, intracellular membrane trafficking, pro-hormone processi

280 play a fundamental role in multiple steps of intracellular membrane trafficking.

281 specific type(s) and/or specific step(s) in intracellular membrane trafficking.

282 mes to evaluate the impact of cholesterol on intracellular membrane trafficking.

283 cytosis, and instead plays multiple roles in intracellular membrane trafficking.

284 ptors) are two key protein components of the intracellular membrane-trafficking machinery.

285 Autophagy, a unique intracellular membrane-trafficking pathway, is initiated

286 mutations in the NPC1 gene, which encodes an intracellular membrane transporter of non-esterified cho

287 with the notion that mGluR5 can signal from intracellular membranes, uncaging glutamate on a CA1 den

288 ctivated Akt are instead largely confined to intracellular membranes upon receptor tyrosine kinase ac

289 Historically, the intracellular membranes used for particle budding were t

290 trand RNA viruses replicate their genomes on intracellular membranes, usually in conjunction with vir

291 ion, active Rab proteins need to localize to intracellular membranes via posttranslationally attached

292 der awake and idling conditions, spontaneous intracellular membrane voltage is characterized by large

293 roscopy reveals the accumulation of aberrant intracellular membranes when LpxB is overexpressed.

294 amate receptor, mGlu5, are also localized on intracellular membranes where they can mediate both over

295 tor 5 (mGluR5), are also highly expressed on intracellular membranes where they serve unknown functio

296 L to move from the cytosol to the plasma and intracellular membranes, where it directly disrupts memb

297 PV16 L2 are exposed on the cytosolic side of intracellular membranes, whereas an epitope within resid

298 , image PLD activity in disease, and remodel intracellular membranes with new functionality.

299 tween the FAC1 globular catalytic domain and intracellular membranes, with N-terminal transmembrane a

300 In D. discoideum, the receptor was found on intracellular membranes, with prominent localization to