ライフサイエンスコーパス: intracellular receptor

1 nding of Ins(1,4,5)P3 to its Ca2+-mobilizing intracellular receptor.

2 ion of the minor receptor subunit, with some intracellular receptor.

3 grammed switch from cell surface receptor to intracellular receptor.

4 it is degraded to a product recognized by an intracellular receptor.

5 receptors and Usp4 failing to rescue another intracellular receptor.

6 s others, such as Eps8, were found only with intracellular receptors.

7 ceived at the plasma membrane rather than by intracellular receptors.

8 acting on membrane receptors or by acting on intracellular receptors.

9 ate transcriptional activation via different intracellular receptors.

10 ere believed to act only on cells containing intracellular receptors.

11 h are crucial in plant immunity initiated by intracellular receptors.

12 ating microbial ligands become accessible to intracellular receptors.

13 e purported ability of the blockers to reach intracellular receptors.

14 It binds to a multitude of intracellular receptors.

15 NLR family proteins act as intracellular receptors.

16 asma membrane and causes a redistribution of intracellular receptors.

17 g motifs in the cytosolic tails (C-tails) of intracellular receptors.

18 EGULATORY COMPONENTS OF ABA RECEPTORS (RCAR) intracellular receptors.

19 g of pathogen-associated "danger" signals by intracellular receptors.

20 to select ligand peptides and identify their intracellular receptors.

21 ffector-triggered immunity (ETI), induced by intracellular receptors.

22 alent or cross-linking fusion protein led to intracellular receptor accumulation.

23 The aryl hydrocarbon receptor (AhR) is an intracellular receptor activated by ligands important in

24 ived RNA and DNA can function as ligands for intracellular receptor activation and induce downstream

25 e may modulate serotonergic function through intracellular receptors, alpha (ER alpha) and/or beta (E

26 bout the molecular mechanism of recycling of intracellular receptors and lipid raft-associated protei

27 s, our findings suggest that either L2 or an intracellular receptor are cleaved by gamma secretase as

28 ll context in which it is expressed and that intracellular receptors are capable of translocation to

29 The activities of intracellular receptors are regulated by their cognate l

30 protein 4 (NSP4) is known to function as an intracellular receptor at the endoplasmic reticulum (ER)

31 proteins by plants is typically mediated by intracellular receptors belonging to the nucleotide-bind

32 led by limiting the access of DNA and RNA to intracellular receptors, but the mechanisms by which end

33 us, agonists elicit up-regulation (mainly of intracellular receptors) by interacting with cell surfac

34 s a member of the highly conserved family of intracellular receptors called immunophilins.

35 Binding of calcium to its intracellular receptor calmodulin (CaM) activates a fami

36 Binding of the peptidoglycan product to the intracellular receptor causes a proinflammatory response

37 II binding to MELADL by binding to different intracellular receptors, cholesterol to Scap and oxyster

38 ta-fold hydrolase, that is a component of an intracellular receptor complex involved in the detection

39 product ComS, is thought to be sensed by an intracellular receptor, ComR, after uptake by oligopepti

40 We sought to determine whether intracellular receptors constitute a static pool or repr

41 Intracellular receptor DAF-12 regulates dauer formation

42 CR cell surface receptor to that from the GR intracellular receptor, demonstrate the importance of th

43 The RIG-like helicase (RLH) family of intracellular receptors detect viral nucleic acid and si

44 n of Notch receptors leads to release of the intracellular receptor domain (Notch IC), which transloc

45 quitin-proteasome system by docking with its intracellular receptor domain.

46 begun to be unraveled, implicating specific intracellular receptor domains and protein kinases in th

47 This observation suggests that multiple intracellular receptor domains form a binding pocket for

48 ned by sequences other than those located in intracellular receptor domains.

49 family can be determined by different single intracellular receptor domains.

50 formational changes in the extracellular and intracellular receptor domains.

51 Extracellular and intracellular receptors engage distinct signaling proces

52 R functions as both an entry receptor and an intracellular receptor essential for transduction.

53 side chains and increased flexibility at the intracellular receptor face as features that coincide wi

54 ved assembly motif may exist between the two intracellular receptor families.

55 and are mediated via binding of RAPA to its intracellular receptor FK506-binding protein 12 (FKBP12)

56 The complex of rapamycin with its intracellular receptor, FKBP12, interacts with RAFT1/FRA

57 Calmodulin (CaM) is the major intracellular receptor for Ca2+ and is responsible for t

58 Calmodulin is the main intracellular receptor for calcium.

59 Because the R subunit of PKA is the only intracellular receptor for cAMP, the abnormal isozyme ki

60 NPC1 is also the intracellular receptor for Ebola virus (EBOV).

61 ght be through a direct interaction with the intracellular receptor for estrogen, estrogen receptor a

62 The intracellular receptor for inositol 1,4,5-trisphosphate

63 ivate the transcription factor PPARgamma, an intracellular receptor for LPA, in CV1 cells transfected

64 r-activated receptor gamma (PPARgamma) as an intracellular receptor for LPA.

65 we show that full-length PGRP-LE acted as an intracellular receptor for monomeric peptidoglycan, wher

66 anine-rich C-kinase substrate (MARCKS) is an intracellular receptor for polysialic acid.

67 We find that CD163 acts as an intracellular receptor for simian hemorrhagic fever viru

68 ties of Pto, which appears to function as an intracellular receptor for the AvrPto signal molecule.

69 rase FKBP12 was originally identified as the intracellular receptor for the immunosuppressive drugs F

70 RACK1 is an intracellular receptor for the serine/ threonine protein

71 kappaB and functions downstream of RIG-I, an intracellular receptor for viral RNA.

72 Fatty acid-binding proteins (FABPs) act as intracellular receptors for a variety of hydrophobic com

73 of the lysosomal proteins NPC1 and LAMP1 as intracellular receptors for Ebola virus and Lassa virus,

74 Cytoplasmic lipid-binding proteins are the intracellular receptors for hydrophobic ligands, deliver

75 e conditions led to the description of novel intracellular receptors for infectious and noninfectious

76 oteins 12 and 12.6 (FKBP12 and FKBP12.6) are intracellular receptors for the immunosuppressant drug F

77 Immunophilins are intracellular receptors for the immunosuppressants cyclo

78 in is a member of the "non-protein kinase C" intracellular receptors for the second messenger diacylg

79 amma-secretase leads to release of a soluble intracellular receptor fragment with functional activity

80 We selectively targeted the intracellular receptor-G protein interface by using cell

81 /Dvl proteins to interpret distinct types of intracellular, receptor-generated stimuli and transmit t

82 their many biological effects by binding an intracellular receptor (GR) that, in turn, translocates

83 In the intracellular receptor half, the bulkier L310(6.37) side

84 extensively studied(1), but that mediated by intracellular receptors has rarely been investigated in

85 g uptake, distribution, and interaction with intracellular receptors - highlighting how these steps i

86 al CC chemokine receptor 1 pool (surface and intracellular receptors), however, showed no significant

87 ignaling pathway, and PPARgamma is the first intracellular receptor identified for LPA.

88 roles of cell surface mGlu(5) as well as the intracellular receptor in a well-known mGlu(5) synaptic

89 nals through TLR13; however, the most likely intracellular receptor in human subjects is TLR8.

90 ding and Western blot analyses indicate that intracellular receptor in normal rat kidney cells is fun

91 mportant signaling molecule with ZBP1 as its intracellular receptor in the development of an inflamma

92 structural glycoprotein NSP4 functions as an intracellular receptor in the ER membrane, and it has be

93 d by the interaction of N-propeptide with an intracellular receptor in the secretory pathway, because

94 mmune pathways activated by cell-surface and intracellular receptors in plants mutually potentiate to

95 ing immunogold labeling was used to quantify intracellular receptors in segments of apical and basal

96 To find intracellular receptors involved in the JH response, we

97 Hsp90 and p23, interact with members of the intracellular receptor (IR) family.

98 rved in the zinc-binding region (ZBR) of the intracellular receptor (IR) superfamily; when it was mut

99 For example, hormone-bound intracellular receptors (IRs) nucleate formation of tran

100 e findings indicate that the distribution of intracellular receptors is related to that of synaptic r

101 the hypersensitive response that depends on intracellular receptors is strongly enhanced by the acti

102 ly characterized as an endoplasmic reticulum intracellular receptor, is a multifunctional viral enter

103 regulatory level through interaction with an intracellular receptor (JH receptor [JHR]), a ligand-act

104 nses to microbial pathogens are regulated by intracellular receptors known as nucleotide-binding leuc

105 ted quisqualate or glutamate from activating intracellular receptors leading to Ca2+ responses.

106 ng receptor selectivity, biased agonism, and intracellular receptor localization.

107 To what extent pathogens manipulate intracellular receptor-mediated immunity, and how plants

108 ne-tolerant (MET) is well established as the intracellular receptor mediating the genomic actions of

109 alternative treatment approaches targeted to intracellular receptors might be of benefit in controlli

110 n is proteolytically primed and bound to its intracellular receptor, Niemann-Pick C1.

111 sults show a role for the microbiota and the intracellular receptor Nod2 in promoting the mucosal adj

112 rom memory T cells through activation of the intracellular receptor NOD2.

113 binding oligomerization domain (NOD) 2 is an intracellular receptor of bacterial peptidoglycan produc

114 Because protein kinase C (PKC) is the intracellular receptor of phorbol ester tumor promoters

115 as been shown to activate various extra- and intracellular receptors of airway epithelial cells, whic

116 in directly activated by cAMP (Epac) are two intracellular receptors of cAMP.

117 Immunophilins are intracellular receptors of the immunosuppressants cyclos

118 The T6.34(279)K mutant displayed a higher intracellular receptor pool than the wild type.

119 endocytic exchange of surface receptors with intracellular receptor pools, and the lateral diffusion

120 ion, which quenches the pHluorin signal from intracellular receptor pools.

121 ent with rapid exchange of extracellular and intracellular receptor pools.

122 The large intracellular receptor population, and potential for fun

123 cies, these voltage changes are dominated by intracellular receptor potentials (RPs).

124 cellular receptor potentials but reduced OHC intracellular receptor potentials and impaired low-frequ

125 OHC intracellular receptor potentials are electrically low-p

126 Importantly, the agonists also stabilized intracellular receptor precursors, possibly via their ph

127 kinases and NADPH oxidases, and we find that intracellular receptors primarily potentiate the activat

128 regulates reproductive function through two intracellular receptors, progesterone receptor-A (PR-A)

129 The aryl hydrocarbon receptor (AhR) is an intracellular receptor protein that regulates gene trans

130 glucocorticoids are mediated by a ubiquitous intracellular receptor protein, the glucocorticoid recep

131 The modular nature of intracellular receptor proteins has allowed the recent d

132 he actions of these hormones are mediated by intracellular receptor proteins that act as ligand-activ

133 In metazoans, intracellular receptors recognize these molecules.

134 well as that IFN-inducible protein 16 is the intracellular receptor recognizing transfected DNA.

135 ivation of Janus kinases (Jaks) bound at the intracellular receptor region.

136 The functional significance of these intracellular receptors remains unclear, including wheth

137 mined by recruitment of specific proteins to intracellular receptor signaling complexes.

138 R) plays a central role in the regulation of intracellular receptor signaling pathways by acting as a

139 ays a central role in the regulation of many intracellular receptor signalling pathways and can media

140 illisecond FRET recordings between labels at intracellular receptor sites were used to record conform

141 stimulates cGMP synthesis by activating its intracellular receptor, soluble guanylyl cyclase (sGC).

142 transported into the cell, can also activate intracellular receptors such as mGluR5.

143 ein interaction studies and the discovery of intracellular receptors, such as affinity-capture comple

144 Taking the intracellular receptor superfamily as a whole revealed a

145 nic factor 1 (SF-1), an orphan member of the intracellular receptor superfamily, plays an essential r

146 pronounced structural reorganization of the intracellular receptor surface.

147 nanobodies bind to epitopes displayed on the intracellular receptor surface; therefore, we transientl

148 Detecting pathogenic DNA by intracellular receptors termed "sensors" is critical tow

149 active complexes with members of a family of intracellular receptors termed the FK506 binding protein

150 tocyte nuclear factor 4 (HNF-4) is an orphan intracellular receptor that appears to be a key factor i

151 avirus nonstructural glycoprotein NSP4 is an intracellular receptor that mediates the acquisition of

152 omerization domain-containing 2 (NOD2) is an intracellular receptor that plays an essential role in i

153 r for the Toxoplasma protein profilin, is an intracellular receptor that resides in the endoplasmic r

154 e mitochondrial KATP channel is an important intracellular receptor that should be taken into account

155 ntercellular pathogen-derived molecules, and intracellular receptors that activate immunity upon dete

156 Steroid hormones bind and activate intracellular receptors that are ligand-regulated transc

157 eproduction through stimulation of classical intracellular receptors that bind DNA and regulate gene

158 d to the identification of extracellular and intracellular receptors that convert recognition of extr

159 We hypothesized that VAPs serve as intracellular receptors that couple lipid homeostasis th

160 cAMP-dependent protein kinase (PKA) are two intracellular receptors that mediate the effects of the

161 Hippocampal GC actions are mediated by intracellular receptors that modulate the transcription

162 Nod proteins are intracellular receptors that play key roles in innate im

163 (NOD)-like receptors (NLRs) are a family of intracellular receptors that recognize conserved pattern

164 The inflammasome contains intracellular receptors that recognize various pathogen-

165 erentiation-associated gene 5 (MDA5) are key intracellular receptors that recognize virus infection t

166 receptors (NLRs) are a specialized group of intracellular receptors that represent a key component o

167 R) genes from diverse Solanum species encode intracellular receptors that trigger effective defense r

168 species involved a pH-dependent switch to an intracellular receptor, the lysosome-resident protein LA

169 n antagonist to progesterone's action at its intracellular receptor, these results support the involv

170 ow CpG ODN are captured and delivered to the intracellular receptor TLR9, however, has been elusive.

171 phosphate (Ins[1,4,5]P3), which binds to its intracellular receptor to mobilize intracellular calcium

172 icroscopy or cause obvious redistribution of intracellular receptor to the surface, suggesting that t

173 Inositol 1,4,5-trisphosphate (InsP3) acts on intracellular receptors to cause liberation of Ca2+ ions

174 Plants deploy intracellular receptors to counteract pathogen effectors

175 Estradiol acts through both membrane and intracellular receptors to influence neuronal activity a

176 y an oligopeptide permease and interact with intracellular receptors to modulate gene expression.

177 ssically, progesterone acts through specific intracellular receptors to regulate gene expression.

178 xin was revealed to be due to recruitment of intracellular receptors to the cell surface upon agonist

179 synthesis inhibitors caused translocation of intracellular receptors to the cell surface, as shown by

180 In particular, the intracellular receptors toll-like receptors (TLR)3, TLR7

181 CXCR2 plays an essential role in both proper intracellular receptor trafficking and efficient cellula

182 receptor by more than 85%, without affecting intracellular receptor trafficking back to the cell surf

183 response to stress and functions to mediate intracellular receptor trafficking in this cell type.

184 es have been implicated in the regulation of intracellular receptor trafficking, and are known to bin

185 ted in the physiological function of RhoB in intracellular receptor trafficking, and these findings w

186 the central nervous system are mediated via intracellular receptor/transcription factors that intera

187 the central nervous system are mediated via intracellular receptor/transcription factors that intera

188 This suggests that ligand-specific intracellular receptor transport is required for chemoki

189 xtracellular (growth factor and insulin) and intracellular (receptor tyrosine kinases, Ras and Src) o

190 t impair hormone-dependent activation of the intracellular receptor tyrosine kinase (contained within

191 llular N-terminal ligand binding domains and intracellular receptor tyrosine kinase activity but reta

192 At the same time, the level of intracellular receptor was maintained at a constant leve

193 is assembly in the zinc binding domains from intracellular receptors, we systematically analyzed the

194 d no evidence for the existence of a pool of intracellular receptors, which could represent a recepto

195 mmals, drosophila use both extracellular and intracellular receptors, which have conserved signaling

196 The intracellular receptors with nucleotide-binding leucine-

197 its derivative, everolimus, act on specific intracellular receptors within lymphocytes, whereas othe

198 Here, by activating intracellular receptors without inducing surface-recepto