ライフサイエンスコーパス: intracellular signal

1 ass II (MHC II) also transmits or may modify intracellular signals.

2 plasma membrane to control a defined set of intracellular signals.

3 gands and couple to G proteins that transmit intracellular signals.

4 the precise transmission and integration of intracellular signals.

5 ation, stable ligand binding, and subsequent intracellular signaling.

6 causing conformational changes that trigger intracellular signaling.

7 ossibility that morphogenesis itself affects intracellular signaling.

8 as microdomains for protein interactions and intracellular signaling.

9 plored whether CC2D1A controls male-specific intracellular signaling.

10 ction as the catalytic subunits that mediate intracellular signaling.

11 (+) T cells and the subsequent triggering of intracellular signaling.

12 al ABC transporters and their regulation via intracellular signaling.

13 n, the common structural change that enables intracellular signaling.

14 fate commitment, depends almost entirely on intracellular signaling.

15 ich scavenges human chemokines and modulates intracellular signaling.

16 receptors (GPCRs) are intimately involved in intracellular signaling.

17 ard to G protein and beta-arrestin-dependent intracellular signaling.

18 ase, thereby serving as crucial mediators of intracellular signaling.

19 2)) levels; and RAGE, RAGE ligands, and RAGE intracellular signaling.

20 riving polarization of membrane proteins and intracellular signaling.

21 e increasingly emerging as critical hubs for intracellular signaling.

22 itted across the T-cell membrane to initiate intracellular signaling.

23 lar myocytes were studied for morphology and intracellular signaling.

24 dent cell adhesion properties from canonical intracellular signaling.

25 king FMRP show aberrant mRNA translation and intracellular signalling.

26 We found that adropin(34-76) enhances major intracellular signaling activities in the liver that are

27 ctivities associated with receptor dependent intracellular signaling activity.

28 ria are vital for cellular energy supply and intracellular signaling after stress.

29 be fully understood by genetic mutations or intracellular signaling alone.

30 ate how this MAPK-phosphatase might regulate intracellular signaling and cardiac growth dynamics in v

31 In the absence of lysis, MAC may induce intracellular signaling and cell activation, responses i

32 gest a direct Hh-mediated regulation of both intracellular signaling and cell adhesion through Ihog.

33 expressed the IL-5 receptor, which triggered intracellular signaling and changed gene expression.

34 act as hotspots for optimal coordination of intracellular signaling and clathrin-mediated endocytosi

35 herin adhesion complexes communicate through intracellular signaling and contribute to the integrity

36 ction with TLRs, TIR serves to both initiate intracellular signaling and facilitate recruitment of si

37 r energy status and nutrient availability to intracellular signaling and metabolic pathways.

38 tor linking extracellular physical cues with intracellular signaling and potentially facilitate the d

39 7-expressing LNCaP cell clone showed altered intracellular signaling and reduced spheroid formation p

40 ools have revealed fundamental principles of intracellular signaling and suggest paths forward for th

41 we explain lipolysis in terms of GH-induced intracellular signalling and its effect on obesity, insu

42 OR pathway integrates both extracellular and intracellular signals and serves as a central regulator

43 on and clustering is a prerequisite for TNFR intracellular signaling, and as m4-1BBL can only recruit

44 ace of cells to mediate motility, transport, intracellular signaling, and environmental sensing.

45 n factors that are activated by receptor and intracellular signaling, and microRNAs which are small n

46 Purkinje cell dendritic development, altered intracellular signaling, and motor coordination deficits

47 ls that regulate Ag recognition, kinetics of intracellular signaling, and the selectivity and efficie

48 otein of cadherin-based cell-cell junctions, intracellular signaling, and tissue homeostasis and repa

49 hanges tapping into cell membrane signaling, intracellular signaling, and transcriptional regulations

50 Dectin-1, a receptor that elicits TREM2-like intracellular signals, and cyclocreatine, a creatine ana

51 as metabolite exchange (Ca(2+) and lipids), intracellular signaling, apoptosis, and autophagy.

52 Conversely, cytoskeletal reorganization and intracellular signaling are sensitive to the pillar dime

53 We show that intracellular signals are observed in motile and stabili

54 anoikis resistance pathway, focusing on the intracellular signals associated with integrins that mod

55 2, ErbB3/HER3, and ErbB4/HER4, which trigger intracellular signals at the origin of essential cellula

56 vents such as polarization, endocytosis, and intracellular signaling, but challenging to quantify usi

57 ted that efficient HIV entry also depends on intracellular signaling, but this remains controversial.

58 phosphorylation events that characterize the intracellular signaling by activated TLRs.

59 LPS-induced NF-kappaB reporter activity and intracellular signaling by NF-kappaB and MAPK pathways w

60 ned Y705 STAT3 phosphorylation, outlining an intracellular signaling cascade activated by antiviral a

61 ma membrane of macrophages that activate the intracellular signaling cascade in response to pathogeni

62 myr-Akt mouse model for GBM are enriched for intracellular signaling cascade proteins (GO: 0007242) a

63 We discovered that the intracellular signaling cascade requires activation of t

64 We further examined the intracellular signaling cascade triggered by Sema4D and

65 acellular domain of RAGE initiates a complex intracellular signaling cascade, resulting in the produc

66 , and CSF3), silencing of major inflammatory intracellular signaling cascades (STAT1, STAT3, STAT5, p

67 hemical signals via adhesion, and integrates intracellular signaling cascades associated with cytoske

68 Toll-like receptors (TLRs) coupled to intracellular signaling cascades function as central ele

69 ce suggests PRR can also act in a variety of intracellular signaling cascades independently of RAS in

70 y to assess the role of KORs and KOR-coupled intracellular signaling cascades on reinstatement of nic

71 However, the intracellular signaling cascades that mediate the osteob

72 these results show that OXT recruits several intracellular signaling cascades to induce protein synth

73 1R hypersensitivity, a shift from PKA to ERK intracellular signaling cascades upon D1R activation, an

74 mbrane receptors P2Y1 and P2Y12, stimulating intracellular signaling cascades, leading to integrin al

75 nstream of cell-surface receptors to control intracellular signaling cascades.

76 degradation, and act as scaffolds to enhance intracellular signaling cascades.

77 ns transducing the encapsulation effect into intracellular signalling cascades promoting differentiat

78 Inflammasomes are intracellular signaling complexes that are assembled in

79 g an unexpected specificity of selected GPCR intracellular signalling components.

80 isualize the intricate relationships between intracellular signaling, cytoskeletal organization and d

81 Initially, starvation-induced intracellular signals direct changes in gene expression.

82 ta signaling domain (CAR) and one lacking an intracellular signaling domain (DeltaCAR).

83 cellular ligand binding domain but lacks the intracellular signaling domain.

84 nonstimulating control CAR construct lacking intracellular signaling domains termed CAR-Stop.

85 This allows SPRY2 to inhibit intracellular signaling downstream of other receptor tyr

86 static tumors is, in part, driven by altered intracellular signaling downstream of receptor tyrosine

87 in either age group, possibly due to intact intracellular signalling downstream of deoxygenation as

88 ify the receptor tyrosine kinase Axl and its intracellular signaling effectors as important for MLC1

89 We have now characterized the responses and intracellular signals elicited by mechanical activation

90 ormation is due to direct inhibition of Dsg, intracellular signaling events causing desmosome destabi

91 model system that allows for observation of intracellular signaling events during collagen matrix as

92 membrane depolarization into precisely timed intracellular signaling events in the mammalian brain.

93 sed by receptors at the surface that trigger intracellular signaling events modulating the cytoskelet

94 n CD11b with such lectins results in altered intracellular signaling events that inhibit TEpM and dif

95 e pathogens and initiate a series of complex intracellular signaling events that result in various im

96 oss talk between extracellular ATP and JA in intracellular signaling events.

97 ufficient to couple extracellular stimuli to intracellular signaling events.

98 Here we sought to investigate the intracellular signaling from cannabinoid 2 receptor (CB2

99 regulates microglial function by transducing intracellular signals from aminophospholipids on apoptot

100 assembly has been suggested to be induced by intracellular signals from CD36, similar to integrin ins

101 cal functions as, epidermal differentiation, intracellular signal function, transcriptional factors c

102 s including cell motility, intercellular and intracellular signaling, gene expression, and membrane i

103 anismal functions such as neuronal activity, intracellular signaling, gene expression, cell prolifera

104 e, but it is poised to rapidly assemble into intracellular signal-generating complexes as well.

105 The fidelity of intracellular signaling hinges on the organization of dy

106 rmembrane contact sites constitute important intracellular signalling hotspots to mediate a plethora

107 o four broad categories-DNA damage response, intracellular signaling, immune engagement, and genetic

108 Our findings show that CC2D1A regulates cAMP intracellular signaling in a male-specific manner in the

109 A is not a pure BCR mimic but rather rewires intracellular signaling in EBV-infected B cells that opt

110 e modulation of spatiotemporal regulation of intracellular signaling in intact cells and multicellula

111 lation of MsrB1 did not preclude LPS-induced intracellular signaling in macrophages, but resulted in

112 ulated protein kinases are key components of intracellular signaling in plants that mediate rapid str

113 etic strategy highlights the impact of Nlgn1 intracellular signaling in synaptic differentiation and

114 ity and female-specific resilience impacting intracellular signaling in the brain.

115 e acidic lysosomal compartment that mediates intracellular signalling in several cell types.

116 In response to intracellular signals in Gram--negative bacteria, transl

117 f electrical activity and the propagation of intracellular signals in neuronal networks.

118 -10)) act as molecular checkpoints mediating intracellular signaling induced by 19 mammalian, secrete

119 ytic degradation of extracellular matrix and intracellular signaling initiated upon its binding to uP

120 ors (CRTCs) are a newly discovered family of intracellular signaling integrators that serve as the co

121 Therefore, we set out to determine the intracellular signalling involved in carotid body-mediat

122 via targeting the tumor microenvironment and intracellular signals is provided.

123 d CyclinD1, as well as the activation of the intracellular signaling kinases Akt and GSK3beta was per

124 Mac-1-dependent cell spreading and initiated intracellular signaling manifested in phosphorylation of

125 oxyester-linked ubiquitylation is used as an intracellular signaling mechanism.

126 t evolutionarily-conserved intercellular and intracellular signaling mechanisms critical for learning

127 The intracellular signaling mechanisms involved in different

128 nal discharge properties, and elucidated the intracellular signaling mechanisms involved.

129 A presynaptic mechanism mediated by distinct intracellular signaling mechanisms may account for this

130 Understanding the intracellular signaling mechanisms that govern growth co

131 Little is known about intracellular signaling mechanisms that persistently exc

132 eceptors on the platelet surface and through intracellular signaling mechanisms that remain systemati

133 to reduce the computational complexity of an intracellular signaling mechanistic model.

134 t that membrane depolarization triggered IKC intracellular signals mediated by small GTPases of the R

135 Our results identify a novel intracellular signaling module that synergistically regu

136 The intracellular signaling molecule cyclic di-GMP (c-di-GMP

137 olecule-associated protein (SAP), a critical intracellular signaling molecule for T-B lymphocyte inte

138 This report implicates calcineurin as an intracellular signaling molecule responsible for immune

139 nosine monophosphate (c-di-GMP) is a dynamic intracellular signaling molecule that plays a central ro

140 in a deficiency of ARHGEF1, a hematopoietic intracellular signaling molecule that transmits signals

141 as a result of variegated surface receptor, intracellular signaling molecule, and transcription fact

142 Moreover, we identified a novel intracellular signaling molecule, cAMP-response element

143 ts, ERK was the most significantly activated intracellular signaling molecule.

144 at the P2X7 receptor may also activate other intracellular signaling molecules or other ion channels.

145 1 and -2 (Barr1 and Barr2, respectively) are intracellular signaling molecules that regulate many imp

146 ween an epigenetic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1

147 ng as adaptors for various transmembrane and intracellular signaling molecules.

148 through membrane-bound receptors and related intracellular signaling molecules.

149 n multiple stimuli, including the binding of intracellular signaling molecules.

150 regulate physiology, and there are a host of intracellular signalling molecules that tune different a

151 ized, the connection of the enzymes with the intracellular signaling network and thus their regulatio

152 l model for the activation of the CD8 T cell intracellular signaling network by mono- or dual-costimu

153 An intracellular signaling network largely initiated by thr

154 AKAPbeta as a nodal regulator in the myocyte intracellular signaling network.

155 n of approximately 50 pseudokinases, control intracellular signaling networks by catalyzing the phosp

156 The intracellular signaling networks regulated by the p75 ne

157 A high-dimensional analysis of intracellular signaling networks revealed immune system-

158 or human cancer cells is largely mediated by intracellular signaling networks that regulate viral rep

159 reonine protein kinase and a key node in the intracellular signaling networks that transduce and ampl

160 The activation of complex intracellular signaling networks underlies these respons

161 GF receptor and previously indistinguishable intracellular signaling networks, only TGF-alpha stimula

162 Despite its central position in oncogenic intracellular signaling networks, the role of mTORC1 in

163 erstood, including their potentially diverse intracellular signaling networks, their roles in the tum

164 g extracellular growth factor stimulation to intracellular signaling networks.

165 environment by relaying external inputs via intracellular signaling networks.

166 Additive/competitive assays indicate that intracellular signaling-networks for multiple ligands ut

167 ecular understanding of signaling as well as intracellular signaling nodes in Arabidopsis.

168 er integrity and mechanisms of heme-mediated intracellular signaling of human lung microvascular endo

169 YK2 is a mediator of type 3 immunity through intracellular signaling of IL-23.

170 t defense mediated through activation of the intracellular signaling of jasmonate (JA), a well-charac

171 ermore, we found that the fumarase-dependent intracellular signaling of the B. subtilis DDR is achiev

172 Indeed, functions for MCSs in intracellular signalling (particularly calcium signallin

173 mmon architecture and structurally conserved intracellular signaling partners.

174 The ERK/MAPK intracellular signaling pathway is hypothesized to be a

175 ging secretory needs, cells employ a dynamic intracellular signaling pathway known as the unfolded pr

176 lthough dependent on CD44, is mediated by an intracellular signaling pathway rather than as a competi

177 The effects of these proteins converge on an intracellular signaling pathway that depends on a protei

178 eptor potential canonical 6 (TRPC6)-mediated intracellular signaling pathway that regulates the stabi

179 ntegrated stress response (ISR), a universal intracellular signaling pathway that responds to a varie

180 However, the intracellular signaling pathway that senses dietary fat

181 However, the intracellular signaling pathway triggering Src activatio

182 ally, we show that RET drives a multifaceted intracellular signaling pathway, including key signaling

183 king are mediated via activation of the PI3K intracellular signaling pathway, providing an insight on

184 permits the design of rational cytokine and intracellular signaling pathway-targeted therapeutics, r

185 ing systems biology approaches to analyze an intracellular signaling pathway.

186 otein, given an absence of any effect on the intracellular signalling pathway predominantly associate

187 NFR ligands, CD70 has been shown to initiate intracellular signaling pathways (CD70 reverse signaling

188 Inhibitors for components of intracellular signaling pathways activated by CD44, incl

189 pecific biological effects through different intracellular signaling pathways and has a complex prote

190 isoforms use similar receptors but different intracellular signaling pathways and have different effe

191 ceptors, which classically activate distinct intracellular signaling pathways and responses.

192 pes depending on their environment and which intracellular signaling pathways are activated.

193 Cytokine-mediated intracellular signaling pathways are fundamental for the

194 Interleukin (IL) 11 activates multiple intracellular signaling pathways by forming a complex wi

195 Tight junctions (TJ) act as hubs for intracellular signaling pathways controlling epithelial

196 Conversely, activation of intracellular signaling pathways coupled to mGluRI in D1

197 receptors on myelin, and the integration of intracellular signaling pathways emanating downstream fr

198 activation requires stimulation of specific intracellular signaling pathways in which protein-tyrosi

199 stablished, and the molecular mechanisms and intracellular signaling pathways involved are not known.

200 However, the intracellular signaling pathways involved are unknown.

201 from sphingomyelin as a second messenger in intracellular signaling pathways involved in cell prolif

202 Although many of the intracellular signaling pathways involved in the proinfl

203 guanylate cyclase (NO-GC, sGC) and triggers intracellular signaling pathways involving cGMP.

204 , we quantified the effect of the flicker on intracellular signaling pathways known to regulate cytok

205 l studies on MOR gene have not addressed how intracellular signaling pathways mediate extracellular m

206 -activated protein kinase 1 (MSK1)-ranges of intracellular signaling pathways similar to those activa

207 the gene targets of which were enriched for intracellular signaling pathways that are important to c

208 ression of MOR gene requires the activity of intracellular signaling pathways that have been implicat

209 identified an RvD2/DRV2 axis that activates intracellular signaling pathways that increase phagocyto

210 the success of CAR T therapy in clinics, the intracellular signaling pathways that lead to CAR T cell

211 small molecules and dramatically stimulating intracellular signaling pathways to determine cell fate.

212 tage-activated calcium (Cav) channels couple intracellular signaling pathways to membrane potential b

213 ggers two broad, TRAF6- and TRAF5-dependent, intracellular signaling pathways to produce representati

214 ive oxygen species, autophagy activation and intracellular signaling pathways were analyzed in Mincle

215 exploring the role and impact of modulating intracellular signaling pathways with more direct myocar

216 ion of cell membrane fluidity, regulation of intracellular signaling pathways, and production of bioa

217 Eukaryotic cells evolved a set of intracellular signaling pathways, collectively termed th

218 erabilities in receptor tyrosine kinases and intracellular signaling pathways, epigenetics, metabolis

219 strocytes regulate behavior through multiple intracellular signaling pathways, including G-protein co

220 Autophagy is intricately linked with many intracellular signaling pathways, particularly nutrient-

221 increasing the capacity of IL-13 to activate intracellular signaling pathways, such as signal transdu

222 The scaffold protein IQGAP1 regulates intracellular signaling pathways, such as the mitogen-ac

223 n the surface of immune cells and activating intracellular signaling pathways, thereby resulting in i

224 ow and fast neurotransmitter systems through intracellular signaling pathways-and may unify a number

225 rases (PKMTs), is a key player in regulating intracellular signaling pathways.

226 and exhibits pleiotropic effect on multiple intracellular signaling pathways.

227 nrichment in genes that regulate kinases and intracellular signaling pathways.

228 SR, which was associated with alterations in intracellular signaling pathways.

229 FRs reside and how they control such diverse intracellular signaling pathways.

230 mes play critical roles in a wide variety of intracellular signaling pathways.

231 ansmitted through the glycocalyx to initiate intracellular signaling pathways.

232 by the host innate immune system and related intracellular signaling pathways.

233 e and polarity to coordinate the activity of intracellular signaling pathways.

234 ial firing as critical components regulating intracellular signalling pathways and gene expression in

235 nsed by lung cells and can activate specific intracellular signalling pathways, and thus have physiol

236 aptor molecules that also activate different intracellular signalling pathways.

237 r understanding of how mitochondria serve as intracellular signaling platforms with a particular emph

238 g been established as a major contributor to intracellular signaling, primarily by virtue of its role

239 In response, the ER evokes a set of intracellular signaling processes, collectively known as

240 act to regulate membrane properties and many intracellular signaling processes.

241 nd the mechanisms of receptor activation and intracellular signal propagation by individual ligand/re

242 The intracellular signaling protein regulator of presynaptic

243 zinc finger (PLZF), as well as expression of intracellular signaling proteins FcepsilonRgamma, spleen

244 actor-beta (TGF-beta) network of ligands and intracellular signaling proteins is a subject of intense

245 A positive intracellular signal relay of sufficient gain from parti

246 e extracellular TCR-pMHC interaction into an intracellular signal remains unknown.

247 olved in resolution and tissue repair, whose intracellular signaling remains of interest.

248 nding events trigger receptor activation and intracellular signaling remains unclear.

249 sduce mechanical forces from blood flow into intracellular signals required for vascular homeostasis.

250 ver, this approach does not directly prevent intracellular signalling, such as through tonic or susta

251 en the orthosteric drug binding site and the intracellular signaling surface, revealing strong intera

252 The calcium-based intracellular signalling system is used ubiquitously to

253 s sensed by the innate immune system and how intracellular signalling systems are consequently activa

254 othesis that opioid tolerance is mediated by intracellular signaling that can be selectively targeted

255 Its activation resulted in intracellular signals that altered organization of the c

256 equires the integration of extracellular and intracellular signals that converge on a competition bet

257 a costimulatory molecule on T cells, induces intracellular signals that mediate cellular activation,

258 TREM2 is a myeloid receptor that transmits intracellular signals that sustain microglial responses

259 T-cell receptor (TCR) and LFA-1 can generate intracellular signals, the immune cell adaptor protein l

260 etween thymocytes and APCs, while monitoring intracellular signaling, this study reveals that distinc

261 ltikinase (HsIPMK) critically contributes to intracellular signaling through its inositol-1,4,5-trisp

262 s, showing that BcR immunoglobulins initiate intracellular signalling through homotypic interactions

263 y mediators that propagate extracellular and intracellular signals through to changes in gene express

264 Attachment triggers intracellular signaling to change gene expression from t

265 q acts as a functional hNSC ligand, inducing intracellular signaling to control cell behavior.

266 itates a strict spatiotemporal regulation of intracellular signaling to ensure the cues are detected

267 ogical synapse affects synapse formation and intracellular signaling to impact the downstream T cell

268 ltering G(alphai) protein-mediated MAPK/MMP9 intracellular signaling to increase nAR-negative BCa cel

269 nize and parse microbial elicitors and drive intracellular signaling to limit or facilitate microbial

270 ic splenocytes require MerTK transmission of intracellular signaling to suppress the production of in

271 Cells integrate environmental stimuli into intracellular signals to motility machineries to direct

272 t subcellular organization, and consequently intracellular signaling, to control information flow nee

273 r Ca(2+) ( Cai2+ ) and beta-catenin as major intracellular signal transducers.

274 1 expression was not due to stochasticity of intracellular signal transduction but rather to preexist

275 partners, the extracellular factors and the intracellular signal transduction pathways engaged in th

276 nk energy balance and cellular stress to the intracellular signal transduction pathways that drive th

277 NPM-ALK co-opts several intracellular signal transduction pathways, foremost bei

278 rst during defence response) and GO:0035556 (intracellular signal transduction) were significantly ov

279 dhesion, all with important implications for intracellular signal transduction, cell migration, and d

280 se C, a key enzyme playing critical roles in intracellular signal transduction, is essential for epid

281 to detachment of myocytes and alteration of intracellular signal transduction.

282 proteins constitutes a central mechanism of intracellular signal transduction.

283 protein complexes, such as those observed in intracellular signal transduction.

284 inciple in GTPase signaling and explains why intracellular signal transmission is a multi-step proces

285 s voltage-coupled calcium influx to transmit intracellular signals, typically studied in neurons and

286 The abnormal intracellular signaling underlying TSC has been the focu

287 BoSS, an open source software which combines intracellular signalling using Boolean modelling (MaBoSS

288 histocompatibility complex (MHC), and induce intracellular signaling via a TCR-like signal after bind

289 othesized that the Cys23Ser alters 5-HT(2C)R intracellular signaling via changes in subcellular local

290 c extracellular matrix and are the origin of intracellular signaling via FAK and paxillin.

291 tions of TIMP-1 are mediated by induction of intracellular signaling via its cell surface receptor CD

292 activated protein C), independently modulate intracellular signaling via partially distinct receptors

293 This reduction required intracellular signaling via second messengers-cytosolic

294 ls EGFR protein levels, thereby impinging on intracellular signaling, viability, and response to targ

295 RvD2-DRV2-initiated intracellular signals were investigated using mass cytom

296 time-dependent changes in intercellular and intracellular signaling, which can be interrogated by ma

297 (EC) triggers proliferative and prosurvival intracellular signaling, which is implicated in the proc

298 e ROP1 Rho GTPase signaling and coordinating intracellular signaling with cell wall mechanics.

299 alysis for pattern recognition receptors and intracellular signals, with lactate dehydrogenase assay

300 Altered intracellular signaling within the immune system may int