ライフサイエンスコーパス: intracellularly

1 e etiological agent of TB, both in vitro and intracellularly.

2 s systems, with most receptors being trapped intracellularly.

3 VHHs that elicit a phenotype when expressed intracellularly.

4 rganelles that manufacture organic compounds intracellularly.

5 dicating the demonstrated interaction occurs intracellularly.

6 here it is phosphorylated by TK1 and trapped intracellularly.

7 ptomycin, whether applied extracellularly or intracellularly.

8 synaptic transmission (EPSC(A)) when applied intracellularly.

9 ting that the observed chemistry would occur intracellularly.

10 proteins, although a low amount was detected intracellularly.

11 across the plasma membrane, and releasing it intracellularly.

12 chemical level, nor have they been localized intracellularly.

13 e parasitism that allows bacteria to persist intracellularly.

14 kinetics and amount of HIV epitopes produced intracellularly.

15 responses were assessed in supernatants and intracellularly.

16 , escaped into the cytoplasm, and replicated intracellularly.

17 penetrate the embryo and later are deposited intracellularly.

18 a single type of GluN2 subunit) are retained intracellularly.

19 S proteins co-localize with latent TGF-beta1 intracellularly.

20 report here that C3 activation also occurred intracellularly.

21 may be expressed both at the sarcolemma and intracellularly.

22 B system primarily sustain energy generation intracellularly.

23 lated KV1.2 channel, by trapping the channel intracellularly.

24 to the cell surface and instead accumulates intracellularly.

25 d degradation of a protein of interest (POI) intracellularly.

26 enzymatic activity and delivering radiation intracellularly.

27 ytosed by alveolar macrophages and replicate intracellularly.

28 entified as ciliogenesis regulators that act intracellularly.

29 IRF3 and TBK1 when challenged with poly(I:C) intracellularly.

30 ediates the unfolded protein response acting intracellularly.

31 t protein folding or enzyme activity, or act intracellularly.

32 olgi trafficking where the cargo is released intracellularly.

33 preserve transport activity but are retained intracellularly.

34 d some macrophage populations expressed C3aR intracellularly.

35 using inactive GDF11 precursor to accumulate intracellularly.

36 rgeting the NGF-TrkA pathway both extra- and intracellularly.

37 stending toxins (CDTs) compose a subclass of intracellularly acting genotoxins produced by many Gram-

38 Anthrax toxin is an intracellularly acting toxin in which sufficient informa

39 Anthrax toxin is an intracellularly acting toxin where sufficient detail is

40 Intracellularly activated PCCAs ranged from 500nm to 6mu

41 2(Q390X) subunits accumulated and aggregated intracellularly, activated caspase 3 and caused widespre

42 We previously demonstrated that IL1R2 intracellularly activates the expression of several proi

43 The intracellularly active bacterial toxin TcdB is a major C

44 al differences between serum circulating and intracellularly active complement and will describe and

45 Specifically, the discovery of an intracellularly active complement system-the complosome-

46 cific markers but were not able to replicate intracellularly after infecting macrophages.

47 ctive for Gram-negative bacteria, which acts intracellularly after membrane translocation.

48 ion of caspase-1 extracellularly, as well as intracellularly after phagocytosis by surrounding macrop

49 s an inner-membrane motor complex that moves intracellularly along a right-handed helical path; when

50 nisms that enable this pathogen to replicate intracellularly also function when mammalian macrophages

51 Processing by endogenous furin occurs mostly intracellularly, although also extracellular processing

52 the MR1-ligand interaction and are degraded intracellularly, although some MR1 molecules acquire new

53 rs (GPCRs), including betaARs, are activated intracellularly, although the biological significance is

54 N249Q mutation) caused R345W F3 to aggregate intracellularly and adopt an altered secreted conformati

55 n the prefusion conformation interact with H intracellularly and at the cell surface, while destabili

56 The probe signal localized intracellularly and at the cell wall-membrane interface,

57 lete model for Wnt signalosome assembly both intracellularly and at the membrane.

58 resulting monophosphate compound is trapped intracellularly and available for locality specific inhi

59 rotein C is predominantly performed by furin intracellularly and by all three proprotein convertases

60 Galectins can function intracellularly and can also be secreted to bind to cell

61 Elevated CD44 staining was detected intracellularly and CD44 colocalized with alpha-tubulin

62 multimeric adiponectin similarly accumulated intracellularly and colocalized with CD63-positive endos

63 Glycan degradation mainly occurs intracellularly and depends on the import of oligosaccha

64 It exists as a free molecule, intracellularly and extracellularly, and conjugated to t

65 lter the fatty acid synthesis and metabolism intracellularly and extracellularly, but also in the mac

66 pitate elemental Se and Te as nanoparticles, intracellularly and extracellularly, when grown with sel

67 Zn(2+)) exerts its biological functions both intracellularly and extracellularly.

68 d had a polydisperse size distribution, both intracellularly and in suspensions.

69 the ubiquitous sources of DNA damage present intracellularly and in the external environment.

70 GPR30 was localized both intracellularly and in the plasma membrane and subject t

71 deliver the OMV-associated virulence factors intracellularly and induce caspase-9-mediated apoptosis

72 found that this protein variant is retained intracellularly and induces endoplasmic reticulum stress

73 suggest that P2X receptors are also present intracellularly and involved in vesicle fusion with the

74 ort that human GPRC6A(ICL3_KGKY) is retained intracellularly and lacks function.

75 l complement system and initially functioned intracellularly and on the membrane of single-celled org

76 Additionally, UFPs can penetrate intracellularly and potentially cause DNA damage.

77 proteins can act as ligands to activate DR5 intracellularly and promote apoptosis.

78 riments confirmed that xylose is transported intracellularly and reduced to the dead-end metabolite x

79 wed that murine spleen NK cells express TLR9 intracellularly and respond to CpG oligodeoxynucleotide

80 to form dimers, was still able to replicate intracellularly and retained virulence in mice.

81 that both cell types survived and replicated intracellularly and that both ultimately established a s

82 eased from the ER, the viral vesicles mature intracellularly and then move intercellularly.

83 lar signals have to be precisely interpreted intracellularly and translated into diverse cellular beh

84 Hh pathway activation occurred intracellularly and triggered Rac1 synthesis.

85 d upon redox triggering by glutathione (GSH) intracellularly and was actually observed upon redox tri

86 es that 1) do not require perforin, 2) occur intracellularly, and 3) for which cell death is not the

87 ial fraction of Clr-a molecules are retained intracellularly, and analyses of Clr-a/Clr-f hybrids att

88 CrVI is rapidly converted to CrIII intracellularly, and can induce apoptosis through differ

89 alize with the exosome markers CD63 and ALIX intracellularly, and GSDMD and NEDD4 are required for re

90 IgM was produced, since it was detected intracellularly, and impaired secretion was not due to a

91 bacteria to escape from endosomes, replicate intracellularly, and induce apoptosis.

92 egrin-mediated process, releases its payload intracellularly, and is a highly potent inhibitor of bra

93 recording Purkinje neuron membrane potential intracellularly, and motor neuron spikes extracellularly

94 to the extracellular space but is localized intracellularly, and only the short C terminus is extrac

95 e assay for the ability to invade, replicate intracellularly, and spread to adjacent epithelial cells

96 CA IV contributes robust catalytic activity intracellularly, and that this activity participates in

97 transmission, the causative agent replicates intracellularly, and the disease is fundamentally a vasc

98 e-channel currents using extracellularly and intracellularly applied methanethiosulfonate (MTS) reage

99 tracellularly applied MTS probes, but not to intracellularly applied reagents.

100 ce; therefore, we transiently expressed them intracellularly as "intrabodies" to test their effects o

101 tire Factor VIII (FVIII)-amino-acid sequence intracellularly as 2 non-secreted polypeptides and have

102 ione S-transferase P1 (GSTP1) protein exists intracellularly as a dimer in reversible equilibrium wit

103 Iron oxide nanoparticles are synthesized intracellularly as a GFP-tagged ferritin heavy and light

104 efficiently infect host cells and replicate intracellularly as amastigotes.

105 coupled receptor (GPCR) that is found mainly intracellularly as most GPCRs.

106 neumocytes, where it is assembled and stored intracellularly as multilayered organelles known as lame

107 drimers to a multitude of smaller thiols was intracellularly assessed as a means to disrupt the balan

108 drenergic receptor (alpha2C-AR) is localized intracellularly at physiologic temperature.

109 and DAP12 but that the complex was retained intracellularly at the endoplasmic reticulum instead of

110 ytes and macrophages that not only functions intracellularly but is also secreted.

111 We show that CAT processes Cm intracellularly but not extracellularly.

112 These protein-derived peptides can be found intracellularly, but also in the plant secretome.

113 omerase A (PPIA), as a foldase is beneficial intracellularly, but extracellularly has detrimental fun

114 structural protein, predominantly expressed intracellularly, but whose localization on the cell surf

115 ion reaction, whereas the second is produced intracellularly by a pathway enzyme that converts exogen

116 helial cells forms AJs, which are stabilized intracellularly by binding of p120-catenin and cortical

117 Stress-internalized EGFR is retained intracellularly by continued p38 activity in a mechanism

118 These organisms succeed intracellularly by effecting remarkable changes in a bro

119 nisms: extracellularly by neutralization and intracellularly by engaging TRIM21, which mediates a rap

120 was processed into a shorter form of ANGPTL3 intracellularly by furin only, and extracellularly mainl

121 prodomain from the proBDNF precursor either intracellularly by furin-like proteases or extracellular

122 strate that this truncated form is generated intracellularly by limited proteolysis mediated by propr

123 a adjusts its metabolism in order to survive intracellularly by modulating central carbon metabolism.

124 elial cells that 3OC12 is rapidly hydrolyzed intracellularly by PON2 to 3OC12 acid, which becomes tra

125 ve oligomeric forms and are rapidly degraded intracellularly by the endoplasmic reticulum-associated

126 nificant membrane permeability to be applied intracellularly by whole-cell dialysis.

127 ancer agents were synthesized simultaneously intracellularly, by two totally different mechanisms (in

128 en alkaline earth metals was not inherent to intracellularly calcifying cyanobacteria but was likely

129 Here we develop a technique for intracellularly calibrated superresolution microscopy th

130 s stable, aggregation-prone, and sequestered intracellularly, causing cytotoxicity.

131 ane of myofibers both in mice and human, and intracellularly colocalized with endosomes positive for

132 e ((11)C-BMP), a prodrug radiotracer that is intracellularly conjugated with glutathione to form the

133 box-amide-1-beta-D-ribofuranoside (AICAR) is intracellularly converted to the AMP analog ZMP, which a

134 Intracellularly, dCIRL quenches cAMP levels upon mechani

135 Overexpression of AID intracellularly decreased surface expression of gp96 cli

136 an E3/19K molecule that was largely retained intracellularly despite having a mutated ER retrieval mo

137 In the first mechanism, Dab2 intracellularly downregulates the integrin alpha(IIb)bet

138 extracellularly applied PSA or PSA-NCAM and intracellularly expressed MARCKS-GFP are in close contac

139 Interactome analysis of intracellularly expressed monobodies revealed that they

140 rsion as demonstrated by the ability for the intracellularly expressed nanobodies to selectively bind

141 When coexpressed with a recombinase, these intracellularly expressed ssDNAs target specific genomic

142 Both molecules were intracellularly expressed, confined to the late endosoma

143 CC18 C. acnes ATCC6919 isolate could survive intracellularly for at least 96 hours.

144 To redress this we here record intracellularly from a higher order visual neuron in the

145 Adenosine may be formed intracellularly from adenine nucleotides or extracellula

146 We recorded intracellularly from CC neurons in the locust Schistocer

147 -one, whether added exogenously or generated intracellularly from cholesterol, inhibits the growth of

148 By recording intracellularly from dissociated neurons and intact gang

149 We recorded intracellularly from eight types of CX neuron while stim

150 To answer these questions, we recorded intracellularly from hippocampal CA1 of awake, behaving

151 sentation of DQ2-restricted epitopes derived intracellularly from inactivated HSV type 2, influenza h

152 We have recorded intracellularly from lagged cells in the cat LGN and fou

153 We recorded intracellularly from motoneurons in a reduced preparatio

154 Here, by recording intracellularly from Purkinje neurons in unanesthetized

155 tion between coiled-coil domains that extend intracellularly from the S4s.

156 es a Cre recombinase interaction reporter to intracellularly fuse the coding sequences of two interac

157 ange inside cells, and the probe responds to intracellularly generated (1) O2 with an increase in flu

158 As markers for antioxidative activity, the intracellularly generated ROS levels, oxidative DNA dama

159 10 mug/ml, whereas, similar activity against intracellularly growing M. tb was observed at 5 mug/ml o

160 Intracellularly, heterotrimeric molecules associate to f

161 y control of foods and beverages, biosensing intracellularly, identification of bacteria and fungi, a

162 uch as using CRISPR/cas9, offer the prospect intracellularly immunized T cells in HIV+ patients.

163 pathway, such as when poly(I:C) is delivered intracellularly in a complex with liposomes or via nucle

164 e light or dark in HEp2 cells and accumulate intracellularly in a time-dependent manner, mainly in th

165 eolar macrophages in the lung and replicates intracellularly in a vacuolar compartment with endoplasm

166 FR-targeted PCCAs were observed intracellularly in both cell lines, but uptake was signi

167 are present in infected cells or accumulate intracellularly in certain tumor cells.

168 ne A production was enhanced both extra- and intracellularly in Deltagpy2 mutants.

169 steine (SPARC) is up-regulated and expressed intracellularly in developing muscle, during regeneratio

170 LR10 was found to be predominantly expressed intracellularly in epithelia, and activation required vi

171 sensitively in a partial aqueous medium and intracellularly in HeLa cells.

172 er strips, in protein medium (like BSA), and intracellularly in HeLa cells.

173 neri is capable of infecting and replicating intracellularly in human enteroids derived from differen

174 anized mouse mGPRC6A(ICL3_KGKY) are retained intracellularly in ligand naive cells, yet exhibit beta-

175 xpression, mammalian P2X4 was also localized intracellularly in lysosomes.

176 Leishmania replicates intracellularly in macrophages, a process that is essent

177 The bacteria replicate intracellularly in macrophages, and the restriction of b

178 here that IL-1alpha and -beta were degraded intracellularly in murine bone marrow-derived DC and tha

179 animals that causes disease by proliferating intracellularly in muscle and the central nervous system

180 ifestyle for the chlamydia, which were found intracellularly in Onychodromopsis-like ciliates.

181 at the sarcolemma but also could accumulate intracellularly in some patients with inclusion body myo

182 organelles, which compartmentalize molecules intracellularly in the absence of a lipid membrane.

183 Ubc13 accumulates intracellularly in the absence of STAT3.

184 cases analyzed in detail (n = 39) Hi resided intracellularly in the core tonsillar tissue.

185 ul conditions and reduced ability to survive intracellularly in the host plant.

186 aled that the MERS-CoV M protein is retained intracellularly in the trans-Golgi network (TGN), and we

187 helial cells and to its inability to survive intracellularly in these cells as well as in MH-S murine

188 Yeast-derived VLPs (yVLPs) assemble intracellularly in vivo during recombinant protein produ

189 hetized cats and spiny stellates were filled intracellularly in vivo with horseradish peroxidase.

190 ne also has little or no effect when applied intracellularly in whole-cell recording, but blocks effe

191 ch allow for coordinated protein homeostasis intracellularly, in between cells and even across organs

192 but the deferrated siderophores accumulated intracellularly, indicating a blockade of siderophore re

193 As with HPV pseudoviruses (PsV) generated intracellularly, infection by cell-free particles assemb

194 disease-causing myocilin variants aggregate intracellularly instead of being secreted to the trabecu

195 AaVA-1 intracellularly interacts with a dominant negative binde

196 W) expressed in Escherichia coli can arrange intracellularly into highly stable macro-structures thro

197 MeV envelope glycoproteins preassemble intracellularly into tightly associated hetero-oligomers

198 a yeast strain capable of consuming lactose intracellularly is engineered to produce tagatose from l

199 other required signaling molecules and acts intracellularly is unknown.

200 ch a truncated SLRP protein core is retained intracellularly, its accumulation triggering endoplasmic

201 Intracellularly labeled DAO expression by basophils meri

202 Intracellularly labeled DAO(+) and surface expression of

203 CD63, CD203c (P = 0.0086, P = 0.04205), and intracellularly labeled diamine oxidase (P = 0.0003, P =

204 ered by difficulties in detecting CO release intracellularly, limited understanding of the biological

205 genous lipidation activity, the substrate is intracellularly lipidated.

206 , we report that novel signaling through the intracellularly localized D2R long isoform (D2LR) elicit

207 duced [12(S)-HETE-induced] activation of the intracellularly located cation channel transient recepto

208 Sigma(1) receptors (sigma(1)Rs) are intracellularly mobile chaperone proteins implicated in

209 tion of these cells was decreased through an intracellularly modulated manner.

210 ellular M. tb bacterial growth only, or both intracellularly on infected macrophages as well as extra

211 We establish that Mn(2+) accumulates intracellularly on injection into the living Aplysia and

212 whether the downstream actions of GrB occur intracellularly or extracellularly, producing apoptotic

213 on was not affected by the presence of VEGFA intracellularly or extracellularly.

214 not due to a failure to invade, to replicate intracellularly, or to polymerize actin via IcsA for mov

215 In contrast, miR-494 accumulated intracellularly (P < 0.05).

216 Intracellularly, pDox nanoparticles are transported to t

217 vealed that while giant obscurin-B localizes intracellularly, possessing dual kinase activity, a smal

218 PrfA-regulated genes are activated intracellularly (PrfA 'ON') but shut down outside the ho

219 , morbillivirus glycoproteins first assemble intracellularly prior to receptor binding, raising the q

220 , while destabilized F mutants interact only intracellularly, prior to F maturation.

221 fluid is insignificant and that glutamate is intracellularly produced.

222 In pseudocurrent-clamp mode, the array intracellularly recorded action potentials and postsynap

223 attachment and 1 year later motoneurons were intracellularly recorded and filled with neurobiotin to

224 his question, we analyzed the sensitivity of intracellularly recorded central-complex neurons to the

225 Comparison with intracellularly recorded EPSCs revealed that most proper

226 tions from more than 1,700 neurons that were intracellularly recorded for 19 min.

227 cal processes significantly over-represented intracellularly relate to biosynthetic processes.

228 nd releasing a functional nucleic acid cargo intracellularly remains a formidable challenge.

229 The intracellularly replicating lung pathogen Legionella pne

230 umulation of endoglycosidase H-sensitive IgM intracellularly, resembling the trafficking block in ane

231 Internalization assays indicated that intracellularly retained radioactivity for (18)F-RL-I-5F

232 This mutant protein was intracellularly retained, incompletely glycosylated, and

233 S20 thus have an additional proteolytic role intracellularly, revealing an unexpected regulatory dime

234 In contrast, when Ca(2+) was supplied intracellularly, robust CDI occurred for both GluN2A and

235 Intracellularly, S1P is dephosphorylated by the actions

236 Cleavage liberates intracellularly sequestered GLUT4 glucose transporters f

237 lecule important in transducing signals from intracellularly signaling Toll-like receptor 3 (TLR3) an

238 Intracellularly, SN reduced Ca(2+)/calmodulin (CaM)-depe

239 a invade colonic epithelial cells, replicate intracellularly, spread to adjacent cells, and provoke a

240 in concentrations 1000-fold lower than found intracellularly, suggesting the dominance of specific in

241 In parallel, APP accumulated intracellularly, suggestive of a putative dysfunction of

242 Small microbes triggered ROS intracellularly, suppressing IL-1beta expression to limi

243 ycolata family of actinobacteria, a group of intracellularly surviving bacterial pathogens that inclu

244 of McC imported from the cultured medium and intracellularly synthesized antibiotic.

245 ugs, can be used to mediate the secretion of intracellularly synthesized model isoprenoid biofuel com

246 constriction sites outline the potential of intracellularly targeted fluorescent tension probes to a

247 ogated by the GDP analog GDP-beta-S (applied intracellularly), the phospholipase C inhibitor U-73122,

248 l nanoparticles showed two release processes intracellularly: the dissolution of the dye aggregates i

249 3 suggest that urea is hydrolyzed to ammonia intracellularly, then a portion is lost to the dissolved

250 ome replication to be specifically localised intracellularly, thereby helping the virus to avoid host

251 These events occur when VacA is not detected intracellularly, therefore do not require the direct int

252 Intracellularly, thiols were found unevenly distributed

253 TRPM8 retains Rap1 intracellularly through direct protein-protein interacti

254 ur extracellularly via external receptors or intracellularly through GAP junctions.

255 plasmalemmal uPAS complex and directly acts intracellularly to alter uPAS endocytotic trafficking.

256 apable of infecting S2 cells and replicating intracellularly to high levels, an unusual feature of th

257 microscale, we delivered electrical stimuli intracellularly to individual cells while simultaneously

258 d that can function both extracellularly and intracellularly to mediate a variety of cellular process

259 ivery molecule should be localized extra- or intracellularly to produce desired biological effects.

260 r its major metabolite norketamine could act intracellularly to produce some behavioral effects.

261 e that matures extracellularly but functions intracellularly to regulate virulence.

262 The prototypical agonist nicotine acts intracellularly to upregulate many nAChR subtypes, a phe

263 des self-assemble pericellularly, as well as intracellularly, to result in cell death.

264 Most tested TrOCs are quickly taken up and intracellularly transformed.

265 epithelium-lined lumens, and how chloride is intracellularly transported to phagosomes remain largely

266 The intracellularly trapped misprocessed protein associates

267 UCD38B intracellularly triggers endocytosis, causing 40-50% of

268 e body but also a potent cellular toxin when intracellularly unbound.

269 ages, with MINCLE and MCL proteins localized intracellularly under resting conditions.

270 ococcus neoformans can survive and replicate intracellularly unless the macrophages become classicall

271 h are revealed by blocking action potentials intracellularly using QX314 during swimming and struggli

272 SSA in A1, we recorded neural activity in A1 intracellularly using sharp electrodes.

273 2, either in the medium of Neuro-2A cells or intracellularly via adenoviral 7B2 overexpression, block

274 The BMP signal is transduced intracellularly via C-terminal phosphorylation of the BM

275 mportantly, the increased ability to persist intracellularly was confirmed for S. aureus isolates wit

276 atterns of activation to drive these neurons intracellularly, we further demonstrated that activating

277 hat perturbs the ability of EGFR to dimerize intracellularly, we showed that a modest drug-induced in

278 ne, a zwitterionic compound that accumulates intracellularly when E. coli is exposed to high concentr

279 plasma membrane, whereas CaV1.1 is retained intracellularly when Stac3 is absent.

280 he presynaptic membrane and then translocate intracellularly, where the light-chain endopeptidase cle

281 ed out of the cell, but instead are retained intracellularly, whereas another large group of proteins

282 ntial for M. tuberculosis (Mtb) to replicate intracellularly while protecting it from antibiotic trea

283 d fermentation enzymes were highly expressed intracellularly, while tricarboxylic acid (TCA) cycle ox

284 Procollagen was retained intracellularly with concomitant dilation of ER cisterna

285 CCR5 also interacts intracellularly with G proteins, as part of its signal t

286 inactive, unable to dimerize, and complexed intracellularly with the endoplasmic reticulum chaperone

287 landin D2 (PGD2) synthase (L-PGDS) interacts intracellularly with the GPCR DP1 in an agonist-independ

288 Most mature ADAM17 is localised intracellularly, with only a small amount at the cell su

289 The S4 segment of the VS is drawn intracellularly, with three gating charges passing throu

290 lence is related to its capacity to multiply intracellularly within a membrane-bound compartment, the

291 cultative bacterial pathogen that replicates intracellularly within a variety of cell types and is th

292 rosymbionts, called bacteroids, are confined intracellularly within highly specialized symbiotic host

293 lioside GM2 and other glycolipids accumulate intracellularly within lysosomes.

294 for intercellular communication, are formed intracellularly within multivesicular bodies (MVBs) and

295 This sequential accumulation occurred mostly intracellularly within polyphosphate and carbonate granu

296 m an arbuscular mycorrhizal (AM) association intracellularly within the roots of more than 80% of lan

297 chemical route by which magnetite is formed intracellularly within the so-called magnetosomes has re

298 loaded with MV ex vivo, and MV was amplified intracellularly, without toxicity.

299 In myocytes, prion aggregates accumulate intracellularly, yet little is known about clearance pat

300 tly, even single nanoparticles could cluster intracellularly, yet their clustering state and subseque