ライフサイエンスコーパス: intrachain

1 ins (interchain) and within a polymer chain (intrachain).

2 growth pathways defined by diverse covalent intrachain and anisotropic vdW interchain interactions a

3 this behavior is sensitive to the details of intrachain and chain-solvent interactions, the collapse

4 ut there being an actual counterbalancing of intrachain and chain-solvent interactions.

5 The emissions are caused by intrachain and interchain aurophilic interactions betwee

6 e-residue contact predictor) to predict both intrachain and interchain contacts for homomultimers usi

7 tronic structure calculations show that both intrachain and interchain couplings of monomer units are

8 cluded absence of the cysteines required for intrachain and interchain disulfide bonds.

9 The different intrachain and interchain energy transfer time scales ex

10 omagnetic (AF) ordering at T(N) = 7 K due to intrachain and interchain exchange interactions.

11 Stable intrachain and interchain H-bonds are identified as a fu

12 tematic Mn variation greatly influences both intrachain and interchain interactions and ultimately th

13 on solvation environment and to evaluate the intrachain and interchain Li-ion hopping mechanisms.

14 contain the co-evolutionary signals of both intrachain and interchain residue pairs in contact, we a

15 charge separation pathways originating from intrachain and interchain species.

16 S and IMS(n) can be used to characterize the intrachain anomerism in tri- and tetrasaccharides in a b

17 references, we succeeded in determining the intrachain anomerism of a a1,2-mannotriose and a mix-lin

18 ity measurements demonstrate the presence of intrachain antiferromagnetic (2) and ferromagnetic (3-5)

19 The intrachain antiferromagnetic coupling in 2 is by far str

20 in-1 ( S = 1) chain of organic radicals with intrachain antiferromagnetic coupling of J'/ k = -14 K,

21 one-dimensional S = 1 Heisenberg chains with intrachain antiferromagnetic coupling.

22 0.59) scaling can simultaneously accommodate intrachain attractions and detectable long-range contact

23 om repulsive excluded-volume interactions to intrachain attractions as the vitrimer density decreases

24 a random coil or, in the presence of strong intrachain attractions, a so-called 'molten globule'.

25 s in ICBS interfaces are similar to those in intrachain beta-sheet interfaces.

26 s with interchain vibronic dispersion reveal intrachain biexciton correlations and vice versa.

27 Normal VWF has a Cys1149-Cys1169 intrachain bond.

28 , the newly synthesized Vp1 monomers acquire intrachain bonds as they fold and begin to interact.

29 are reoxidized to reform covalent inter- and intrachain bonds.

30 ium groups of conserved arginines in the two intrachain cAMP-binding sites of regulatory (R) subunit

31 se, its electronic states have a predominant intrachain character.

32 e excited states, including the formation of intrachain charge transfer excitons.

33 polymers, and demonstrate the importance of intrachain charge transport in plastic electronics.

34 ns are aligned along the fiber to facilitate intrachain charge transport.

35 removal by self-cyclization, rather than by intrachain cleavage by endogenous thiols.

36 al (with a 2H crystal structure) has a short intrachain Co-Co distance of about 2.07 angstrom.

37 significant "internal friction" arising from intrachain collisions.

38 We argue that quantifying intrachain competition is likely to be mechanistically i

39 ling transfer from chiral monomers to chiral intrachain conformation.

40 ined using these data plus an additional 509 intrachain constraints per chain.

41 followed by discrimination of interchain and intrachain contacts according to the tertiary structure

42 e 50-58 loop, in beta-turns, and in specific intrachain contacts between amino- and carboxyl domains.

43 e that using predicted tertiary structure or intrachain contacts of monomers in the unbound state as

44 anges to the pattern of local and long-range intrachain contacts.

45 A competition from intrachain coupling has also been demonstrated by compar

46 oteins has frequently been limited to use as intrachain covalent staples that reinforce existing stru

47 myosin containing RLC-C165, the yield of one intrachain cross-linked band decreased significantly whe

48 these distance constraints, as well as three intrachain cross-links, were used to further refine an i

49 hain tadpole polymers (SCTPs), containing an intrachain crosslinked globule and a pH-sensitive linear

50 This suggests that the intrachain Cys359/Cys384 disulfide bond within C9 is not

51 overy from serum, revealed that the unpaired intrachain cysteine residues (Cys22-Cys96) reformed thei

52 ts five occupied glycosylation sites and six intrachain cystine bridges with Cys-158 of the very flex

53 were decomposed into interchain motions and intrachain deformations.

54 ties to understand the effect charge carrier intrachain delocalization has on electronic transport.

55 onation of two indole side chains to form an intrachain delta(1),delta(1)'-ditryptophan derivative.

56 ing conformational transitions is set by the intrachain diffusion coefficient, D.

57 and denaturant concentration on the rate of intrachain diffusion in an unfolded protein.

58 ide] = 5.4 M) that is limited by the rate of intrachain diffusion to bring the Zn-porphyrin and Ru co

59 t (5 micros) is near the predicted value for intrachain diffusion.

60 llapse may in turn be limited by the rate of intrachain diffusion.

61 invariant cysteine that is required for the intrachain disulfide bond and, on the other chromosome,

62 red mutant of III3 that was stabilized by an intrachain disulfide bond did not interact with anastell

63 The effect was preceded by reduction of the intrachain disulfide bond encompassing the platelet-bind

64 ing one participating Cys to Ser, precluding intrachain disulfide bond formation, retained full activ

65 tion, acetylation, proteolytic cleavage, and intrachain disulfide bond formation.

66 5 and Cys-50, which are predicted to form an intrachain disulfide bond in Tva, drastically reduced th

67 This suggests that formation of an intrachain disulfide bond is required for SPC-mediated c

68 dimentation equilibrium and CD and formed an intrachain disulfide bond predicted from the structure o

69 (IgG1) contains 12 domains, and each has an intrachain disulfide bond that connects the two layers o

70 Cys326, reasoning that Cys321 would form an intrachain disulfide bond with Cys326 as in prekallikrei

71 that the propeptide should form a transient intrachain disulfide bond with the D3 domain before mult

72 41-kDa monomeric intermediate containing an intrachain disulfide bond(s).

73 nalyses revealed that C95 and C105 formed an intrachain disulfide bond, whereas C95 by itself produce

74 the cysteine is thought to be involved in an intrachain disulfide bond.

75 tide chains linked by two interchain and one intrachain disulfide bond.

76 three pairs of cysteine residues involved in intrachain disulfide bonding, a cysteine near the carbox

77 unique three-looped trefoil motif formed by intrachain disulfide bonds among six conserved cysteine

78 core but diverge otherwise due to different intrachain disulfide bonds and extension of the J chain

79 magglutinin major subunit that contains four intrachain disulfide bonds and is connected to the virio

80 These intrachain disulfide bonds are shielded from solvents un

81 ages (below 0.6%), whereas those involved in intrachain disulfide bonds exhibited higher percentages

82 op structure of the trefoil motif, formed by intrachain disulfide bonds in a 1-5, 2-4, 3-6 configurat

83 inically approved mucolytic drug) can reduce intrachain disulfide bonds in large polymeric proteins.

84 n with reducing agents to break the numerous intrachain disulfide bonds in Muclin's scavenger recepto

85 hese data therefore suggest that tubulin has intrachain disulfide bonds in the alpha- and beta-subuni

86 y interchain disulfide bonds but has 239-242 intrachain disulfide bonds instead.

87 The four cysteines may thus form two intrachain disulfide bonds integral to the secondary str

88 In contrast, intrachain disulfide bonds of the two proteins are compl

89 ADC subunits in both the partially reduced (intrachain disulfide bonds remain intact) and fully redu

90 he two inter heavy chain disulfide bonds and intrachain disulfide bonds was not changed significantly

91 ry, and amino acid sequencing, the remaining intrachain disulfide bonds were characterized: Cys(1961)

92 ture, as assessed by the formation of native intrachain disulfide bonds, only approximately 50% of na

93 in disulfide bond, while for peptides having intrachain disulfide bonds, the reaction products typica

94 Each half-molecule has 6 intrachain disulfide bonds, which form loops in the carb

95 ce duplication and 10 cysteines forming five intrachain disulfide bonds.

96 ithin lysosomes, and reduction of inter- and intrachain disulfide bonds.

97 5: four conserved cysteines allowing for two intrachain disulfide bonds.

98 The chains are linked by 29 inter- and intrachain disulfide bonds.

99 ck interheavy chain disulfide bonds and form intrachain disulfide bonds.

100 ed recognition element tethered by insulin's intrachain disulfide bridge.

101 ith an associated kappa light chain with two intrachain disulfide bridges in each of the heavy and li

102 and constant domains in addition to the two intrachain disulfide bridges shared with mouse and human

103 nd that CD4 retro-translocates with oxidized intrachain disulfide bridges, and only upon proteasomal

104 The other Cys residues exclusively form intrachain disulfide bridges.

105 immunoglobulin-like domains containing three intrachain disulfide bridges.

106 Important PTM information, including intrachain disulfide connectivity and N-glycosylation si

107 s of scrambling were identified, such as the intrachain disulfide for CxxC in the heavy chain, and th

108 where 46% of the antibody was trapped in the intrachain disulfide form.

109 f a novel subvariant of IgG2-B containing an intrachain disulfide linkage in the lower hinge region i

110 premature disulfide linkage in the ER, where intrachain disulfide linkages are formed.

111 ning six conserved cysteines that form three intrachain disulfide linkages known as the tumor necrosi

112 es likely are either reduced or form a tight intrachain disulfide loop rather than contribute to a me

113 cysteine masked within the native Ag via an intrachain disulfide, the latter of which is reduced dur

114 ney cells, the propeptide and D'D3 formed an intrachain disulfide-linked species in the endoplasmic r

115 ffective in the reduction of intramolecular (intrachain) disulfide bonds.

116 In addition to mapping the 4 inter- and 12 intrachain disulfides (total 16), the identification of

117 of the B chain of ricin, the elimination of intrachain disulfides in CdtC and CdtA by genetic replac

118 A diminished role for intrachain disulfides in stabilizing CdtA and CdtC may h

119 gests it may be involved in the reduction of intrachain disulfides prior to retrotranslocation.

120 hese challenges by demonstrating that strong intrachain donor-acceptor interactions are a key design

121 ell-mixed sequences, and in these sequences, intrachain electrostatic repulsions and attractions are

122 polymer leads to a quenching of short-delay intrachain emission and an increase in the long-delay ph

123 troluminescence shows high-quality deep-blue intrachain emission with a CIE (0.16, 0.12) and a very n

124 We find that rapid intrachain energy migration toward complex sites with th

125 d polymers such as MEH-PPV where much slower intrachain energy transfer was reported.

126 FM exchange behavior over 1.8-300 K with an intrachain exchange constant of Jchain/k = +22 K.

127 magnet Na(2)Cu(3)Ge(4)O(12) (having periodic intrachain exchange interactions J(1)-J(1)-J(2)) and its

128 lymers show a substantial enhancement in the intrachain exciton migration rate, which is attributed t

129 ng between the chains but rather to dominant intrachain excitonic coupling that greatly reduces the m

130 radical ions results in RDD with significant intrachain fragmentation of acyl moieties.

131 ions does not give rise to product ions from intrachain fragmentation of the fatty acyl moieties.

132 s an addition to all relaxation times due to intrachain friction sources.

133 nd a flexible hydrocarbon backbone, exhibits intrachain H-bonding-reinforced folding and hierarchical

134 nt amine groups, which, at pH ~5, adopted an intrachain H-bonding-stabilized pleated structure.

135 ils is a network of hydrogen (H) bonds: both intrachain H-bonds between neighboring monomers of a sin

136 ing that equilibration of the interchain and intrachain hinge disulfide pairing was not always attain

137 We study the occurrence and effect of intrachain homocoupling defects in alternating push-pull

138 The loss of the longer chains involves intrachain hydride transfer from the C(alpha)-H bond to

139 Thus, increased intrachain hydrogen bonding guides secondary structure a

140 intermediate state, characterized by relaxed intrachain hydrogen bonds and a hexagonal packing arrang

141 at differences in hydrogen bond strength for intrachain hydrogen bonds and amide...water hydrogen bon

142 Since it is extended, flexible, lacks intrachain hydrogen bonds and is fully hydrated in aqueo

143 ctively preventing formation of the regular, intrachain hydrogen bonds that stabilize peptide alpha-h

144 igomers become more rigid and likely to form intrachain hydrogen bonds, like those found in crystals.

145 The solenoid is reinforced by intrachain hydrogen bonds, side-chain salt bridges, and

146 ckbone chirality and their inability to form intrachain hydrogen bonds.

147 Further, we uncover an apparent intrachain interaction between E(14) in transmembrane he

148 at the interplay between chain solvation and intrachain interactions (self-solvation) leads to confor

149 The simulations indicate that intrachain interactions and dihedral angle rotation corr

150 n be understood only by considering specific intrachain interactions and intermediate (and hierarchic

151 e marginally more favorable than nonspecific intrachain interactions are beneficial to protein functi

152 Only intrachain interactions are considered, including one ad

153 ctions were observed, as well as stabilizing intrachain interactions between residues of opposite cha

154 into compact conformations due to extensive intrachain interactions between Ub subunits, this topolo

155 favorable chain-solvent interactions causes intrachain interactions to be repulsive, on average.

156 epeats are highly dynamic random coils, lack intrachain interactions, and exhibit significant entropi

157 Stiff polymers with strong intrachain interactions, in contrast, are expected to co

158 n the Fe oxidation state and additional weak intrachain interactions, is hypothesized to prevent long

159 istical mechanical calculations of inter and intrachain interactions.

160 own to 2.7 K, despite the presence of strong intrachain interactions.

161 the folding free energy surface arising from intrachain interactions.

162 es as well as an estimate of the strength of intrachain interactions.

163 red proteins (IDPs) devoid of any persistent intrachain interactions?

164 ns or binding of MDM2 changed the pattern of intrachain kinetics.

165 3D TEM)] that chirality at the monomeric and intrachain level ultimately manifests in the symmetry of

166 A procedure for the efficient preparation of intrachain-linked polypeptides is presented, and it is d

167 Measuring the rate at which this 62 residue intrachain loop forms under both folding and unfolding c

168 ng beta integrin subunits and lies within an intrachain loop implicated in subunit association.

169 Cysteines, postulated to form an intrachain loop, are present in the IgSF domain and are

170 The intrachain loops are conserved in fibrinogens of differe

171 , the formation of short (<10 peptide bonds) intrachain loops around the heme group.

172 d mutagenesis, the cysteines, which form the intrachain loops, to serine or alanine.

173 el mechanism for chitin binding, mediated by intrachain LysM dimerization, leading to a chitin-bindin

174 om the appropriate balance of interchain and intrachain metal ion coordination by Gla residues in sim

175 The conformational diffusion coefficient for intrachain motions in biopolymers, D, sets the timescale

176 ide exhibits 123 sequential and medium range intrachain NOE cross peaks per chain, characteristic of

177 le and by, second, calculating intraplane or intrachain nucleus-independent chemical shifts that quan

178 three essential pairs-one interchain and two intrachain-of disulfide bonds.

179 molecular tunnel junctions to determine when intrachain or interchain CT dominates and under which co

180 charge state) generated from peptides having intrachain peptides were subjected to collision-induced

181 SDS-PAGE showed that, for RLC-C18, the intrachain photo-cross-linking in myosin was inhibited b

182 These structures allow the study of possible intrachain photoinduced charge separation, in contrast t

183 thesized pi-conjugated polymers that contain intrachain platinum (Pt) atoms separated by one (Pt-1) o

184 ugated polymers with strong SOC that contain intrachain platinum atoms, to weak SOC polymers, to C60

185 ss peaks, which therefore identify reference intrachain proximities.

186 and folded states is expected to arise from intrachain reorganization in the protein.

187 ct result of interchain Cu-ion migration and intrachain reorganization.

188 pplied DNCON2 (a deep learning-based protein intrachain residue-residue contact predictor) to predict

189 ds that achieved great success in predicting intrachain residue-residue contacts have been applied to

190 om multiple sequence alignments of monomers, intrachain residue-residue contacts of monomers extracte

191 r arginine, which is probably involved in an intrachain salt bridge, has no effect on the assembly.

192 ectron donor, it assists the formation of an intrachain singlet exciton that has a strong charge-tran

193 By removing 6-O-sulfates from specific HS intrachain sites on the cell surface, Sulf1 has been sho

194 c Heisenberg S = 1/2 linear chain model with intrachain spin coupling J = -52.3 cm(-1).

195 ng down to 0.5 K, despite the strong Fe-F-Fe intrachain spin exchange J with J/k(B)=-16.2(1) K.

196 activation barrier that separates the local intrachain state and the excimer-like state in the forme

197 ility of this material to adopt higher order intrachain structures.

198 ling a high level of variation in inter- and intrachain symmetry that provides a structural explanati

199 s at the nanoscale, in combination with fast intrachain transport.

200 is that dsDNA forms ordered monolayers where intrachain tunneling dominates, resulting in high CT rat