ライフサイエンスコーパス: intrachromosomal

1 e frequent over gene footprints and most are intrachromosomal.

2 that pairing correlates with the strength of intrachromosomal 3D interactions, such as active (A) com

3 Until recently, such stable intrachromosomal aberrations have been very hard to dete

4 t the detection and quantification of stable intrachromosomal aberrations in lymphocytes of healthy f

5 The control groups contained very few such intrachromosomal aberrations.

6 lu-quasipalindromes lead to the formation of intrachromosomal amplicons with large inverted repeats (

7 Intrachromosomal amplification of a region of chromosome

8 th acute lymphoblastic leukemia (ALL) and an intrachromosomal amplification of chromosome 21 (iAMP21)

9 Intrachromosomal amplification of chromosome 21 (iAMP21)

10 Intrachromosomal amplification of chromosome 21 (iAMP21)

11 sor acute lymphoblastic leukemia, defined by intrachromosomal amplification of chromosome 21 (iAMP21)

12 ssociated with an increased risk of relapse (intrachromosomal amplification of chromosome 21 [iAMP21]

13 Intrachromosomal amplification of chromosome 21 defines

14 ted with a poor outcome and characterized by intrachromosomal amplification of chromosome 21 includin

15 recede chromosomal gains in B-ALL cases with intrachromosomal amplification of chromosome 21.

16 analysis of metaphase chromosomes showed an intrachromosomal amplification of the rrm1 locus.

17 Intrachromosomal amplifications that formed initially un

18 t stalled replication forks lead to elevated intrachromosomal and ectopic recombination promoting sit

19 Both spontaneous intrachromosomal and heteroallelic gene conversion event

20 elp define how CTCF mediates both long-range intrachromosomal and interchromosomal interactions, and

21 tic increases in CAN1 duplication mutations, intrachromosomal and interchromosomal recombination, and

22 11 validated clustered breakpoints involving intrachromosomal and interchromosomal translocations bet

23 A specific 3-dimensional intrachromosomal architecture of core stem cell factor g

24 RNAs (lncRNAs) embedded in the 3-dimensional intrachromosomal architecture of stem cell core factor g

25 ous reciprocal exchanges, most of which were intrachromosomal as determined by fluorescence in situ h

26 These data suggest two related phenomena: an intrachromosomal association that holds the halves of a

27 First, intrachromosomal associations increase at longer distanc

28 CYREN allows cNHEJ to occur at telomeres and intrachromosomal breaks during the S and G2 phases, and

29 ven autophagy pathway that is not induced by intrachromosomal breaks.

30 cetartiodactyls was characterized by mostly intrachromosomal changes, whereas the lineage leading to

31 udies of genome organization have focused on intrachromosomal (cis) contacts because they harbor key

32 The intrachromosomal contact map of the X chromosome in TS e

33 of integration sites and in their inter- and intrachromosomal contact regions.

34 roughout life, establishing ultra-long-range intrachromosomal contacts and specific interchromosomal

35 Such intrachromosomal contacts appear to be a general mechani

36 Fewer short-range intrachromosomal contacts are detected for the inactive

37 We also connect disparate data on intrachromosomal contacts involving DUX4 and emphasize t

38 inactive X has two superdomains of frequent intrachromosomal contacts separated by a boundary region

39 anscription factories, multiscale loops, and intrachromosomal contacts that mimic those found in vivo

40 Insulators mediate inter- and intrachromosomal contacts to regulate enhancer-promoter

41 ize as they arise spontaneously by inter- or intrachromosomal crossover events within misaligned dupl

42 ult from translocation with the IGH locus or intrachromosomal deletion and is associated with poor ou

43 lass switch recombination (CSR) occurs by an intrachromosomal deletion requiring generation of double

44 lass switch recombination (CSR) occurs by an intrachromosomal deletion whereby the IgM constant regio

45 insertional chromosomal rearrangement or by intrachromosomal deletion.

46 downstream C(H) regions and functions via an intrachromosomal deletional event between the donor Smic

47 lass switch recombination (CSR) occurs by an intrachromosomal deletional process between switch (S) r

48 ombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch regio

49 It occurs by a unique type of intrachromosomal deletional recombination within special

50 CSR generally occurs by an intrachromosomal deletional recombination within switch

51 me, involving mainly translocations but also intrachromosomal deletions and inversions.

52 in ATR(+/-)p53(+/-) mice was associated with intrachromosomal deletions and loss of wild-type p53.

53 wo alternative ways: (i) the creation of two intrachromosomal deletions or (ii) the formation of a pa

54 es varying from <100 kb to 66 Mb, indicating intrachromosomal deletions or inversions.

55 ty including the generation of chimeric L1s, intrachromosomal deletions, intrachromosomal duplication

56 ases with LOH limited to less than 9 Mb were intrachromosomal deletions.

57 formed approximately as often as the pair of intrachromosomal deletions.

58 or gene-targeting (plasmid-to-chromosome) or intrachromosomal (direct repeat) homologous recombinatio

59 onfirmed by microscopy by measurement of the intrachromosomal distances between two sites on one chro

60 ex chromosomes yet differ in copy number and intrachromosomal distribution.

61 lated mitochondrial cytochrome c release and intrachromosomal DNA fragmentation, which lead to apopto

62 in achieves this by setting up longer-range, intrachromosomal DNA interactions, which compact and ind

63 (CSR) is a late B cell process that involves intrachromosomal DNA rearrangement.

64 Isotype switching occurs by intrachromosomal DNA recombination between switch (S) re

65 effector functions to antibodies through an intrachromosomal DNA recombination process at the heavy-

66 We explore the role of 53BP1 in intrachromosomal DNA repair using I-SceI to introduce pa

67 Intrachromosomal domains are formed by chromatin anchori

68 We observed that intrachromosomal DSB repair is accomplished with nearly

69 53BP1 facilitates joining of intrachromosomal DSBs but only at distances correspondin

70 st that CSR exploits a general propensity of intrachromosomal DSBs separated by several hundred kilob

71 Among intrachromosomal duplicates, however, there is no correl

72 However, a minimum of three independent intrachromosomal duplication events have resulted in >37

73 t the positional candidate locus D15S122, an intrachromosomal duplication of proximal 15q was detecte

74 However, intrachromosomal duplications also have been reported.

75 e locus for the formation of the majority of intrachromosomal duplications blocks on human chromosome

76 mic sequence stretches and by long segmental intrachromosomal duplications in which highly homologous

77 We find that most of the intrachromosomal duplications seem to share a common anc

78 that show a 12-fold excess of recent (>98%) intrachromosomal duplications when compared with duplica

79 gene family evolved by transchromosomal and intrachromosomal duplications within the human genome.

80 region also contains seven out of the eight intrachromosomal duplications within the sequence, inclu

81 of chimeric L1s, intrachromosomal deletions, intrachromosomal duplications, and intra-L1 rearrangemen

82 de further evidence of gene formation within intrachromosomal duplications, but indicate that recent

83 gest human chromosomes and contains numerous intrachromosomal duplications, yet it has one of the low

84 show evidence of extensive, species-specific intrachromosomal duplications.

85 redominantly as tandem and tightly clustered intrachromosomal duplications.

86 romosomal duplications occurred prior to the intrachromosomal duplications.

87 Analysis of intrachromosomal end joining in individual DSBR survivor

88 n DNA and is involved in the formation of an intrachromosomal enhancer/promoter loop.

89 and R2 eliminations appear to occur by large intrachromosomal events (i.e., loop-out events) that inv

90 We describe 36 novel PDL SRs, including 17 intrachromosomal events (inversions, duplications, delet

91 ngements occur via both interchromosomal and intrachromosomal exchange events between the proximal an

92 equent resolution of one or two DSB(s) in an intrachromosomal fluorescent reporter following the expr

93 Two of the recurrent transcripts involved an intrachromosomal fusion between RCC1 and HENMT1 located

94 Spectral karyotype analysis showed frequent intrachromosomal fusions and fragmentations 26 hours aft

95 erentially mapped to certain chromosomes and intrachromosomal gene clusters.

96 ctive and nonproductive pathways, whereas in intrachromosomal gene conversion and mating-type switchi

97 ery generation, a process accomplished by an intrachromosomal gene conversion between an expressor lo

98 A specific intrachromosomal gene conversion event between two compl

99 The induction of intrachromosomal gene conversion in Arabidopsis by HO re

100 We could establish intrachromosomal gene conversion in the male germline as

101 a high degree of similarity, suggesting that intrachromosomal gene conversion is frequent, perhaps pr

102 d for interhomologue gene conversion but not intrachromosomal gene conversion.

103 ses indicated high wheat-specific inter- and intrachromosomal gene duplication activities that are po

104 separate sets of cooperating loci exist for intrachromosomal genomic instability in human colorectal

105 han is possible through natural selection of intrachromosomal genomic loci.

106 oncerted evolution of the tandem U2 genes is intrachromosomal homogenization; interchromosomal geneti

107 d by an 8-bp XhoI linker insertion; rates of intrachromosomal homologous recombination between the ma

108 nterchromosomal mating-type switching and on intrachromosomal homologous recombination but not on int

109 on from one allele to the other is caused by intrachromosomal homologous recombination mediated by se

110 Intrachromosomal homologous recombination, manifest as r

111 creased rates of chromosomal aberrations and intrachromosomal homologous recombinational events in th

112 ed a ?selectable marker system to screen for intrachromosomal illegitimate recombination events in or

113 short direct repeats, a unique signature of intrachromosomal illegitimate recombination.

114 age, 10 cM apart to quantitate the extent of intrachromosomal instability in 59 human sporadic colore

115 ficient GH1 expression requires a long-range intrachromosomal interaction between remote enhancer seq

116 Thus, BN analysis of large intrachromosomal interaction datasets is a useful tool f

117 TNF gene regulation thus reveals a mode of intrachromosomal interaction that combines a looped gene

118 wn of IRAIN lncRNA with shRNA abolishes this intrachromosomal interaction.

119 n BN modeling indicates that the strength of intrachromosomal interactions (hic_strength) is directly

120 interactions and the unsurprisingly frequent intrachromosomal interactions along the diagonal of a ch

121 Existing computational methods focus on intrachromosomal interactions and ignore interchromosoma

122 nation (CSR) is regulated through long-range intrachromosomal interactions between germline transcrip

123 ortantly, poly(ADP-ribosyl)ation facilitates intrachromosomal interactions between insulator sites me

124 ked Rad50 gene, but it did reduce long-range intrachromosomal interactions between the locus control

125 en by long-range protein-mediated inter- and intrachromosomal interactions have been reported to infl

126 Intrachromosomal interactions in the T(H)2 cytokine locu

127 We propose that short-range intrachromosomal interactions may form the basis of coor

128 We demonstrate that numerous intrachromosomal interactions occur along both parental

129 interaction but otherwise a predominance of intrachromosomal interactions over interchromosomal inte

130 Long-range intrachromosomal interactions play an important role in

131 otic prophase is predominated by short-range intrachromosomal interactions that represent a condensed

132 r biological functions, and are enriched for intrachromosomal interactions with synchronized promoter

133 ng TH2-cell-related cytokines and diminished intrachromosomal interactions within that locus.

134 recently, it has become clear that not only intrachromosomal interactions, but also interchromosomal

135 directs Dlx5/6 ultraconserved enhancer(UCE)-intrachromosomal interactions, regulating genes across a

136 In addition to these intrachromosomal interactions, we now describe interchro

137 TNF gene, which undergo activation-dependent intrachromosomal interactions.

138 g to analyze publicly available datasets for intrachromosomal interactions.

139 fect gene expression by mediating inter- and intrachromosomal interactions.

140 We further demonstrated intrachromosomal inversion and excision, mobilizing up t

141 gene controlling androgen synthesis, and an intrachromosomal inversion involving the pro-testicular

142 angements (translocations or insertions) and intrachromosomal inversions that contain long (1-4000 kb

143 ps, nested insertion of rice linkage groups, intrachromosomal inversions, and a nonreciprocal translo

144 With the use of an intrachromosomal inverted repeat as a recombination repo

145 With the use of an intrachromosomal inverted-repeat as a recombination repo

146 d to be similar in structure to conventional intrachromosomal joints.

147 Selection for the intranuclear and intrachromosomal location of the provirus and host trans

148 tial proximity of potentially recombinogenic intrachromosomal loci.Oncogene advance online publicatio

149 g repair of a single site-specific DSB at an intrachromosomal locus.

150 This inter- or intrachromosomal long-range regulation does not require

151 H19 imprinting domain and forms a long-range intrachromosomal loop to interact with the three cluster

152 tion capture (3C) analysis indicated that an intrachromosomal loop was formed by CTCF self-dimerisati

153 , we demonstrate that upon T cell activation intrachromosomal looping occurs in the TNF locus.

154 CSR occurs via an intrachromosomal looping out and deletion mechanism that

155 Osilr9 participated in the formation of the intrachromosomal looping required for the maintenance of

156 nscriptional start site of the CA12 gene via intrachromosomal looping upon hormone treatment.

157 r; either distributed intragenic binding and intrachromosomal looping, or dense binding at promoters.

158 or SMC1 to orchestrate pluripotency-specific intrachromosomal looping.

159 Our findings reveal trans-regulation of intrachromosomal loops by interchromosomal interactions

160 The intrachromosomal loops detected in genomic studies conta

161 Here we show that each opsin gene forms intrachromosomal loops in the appropriate photoreceptor

162 , indicating that it arises predominantly by intrachromosomal misalignment during meiosis.

163 s of Alt-NHEJ that results in more extensive intrachromosomal mutations at a single double-strand bre

164 with Y chromosomes that evidently formed by intrachromosomal NAHR between inverted repeat pairs comp

165 ght the recombinogenic nature of the MSY, as intrachromosomal NAHR occurs for nearly all Y-chromosome

166 We utilized an intrachromosomal NHEJ substrate in which DSBs are genera

167 n Y chromosome (MSY) and provide targets for intrachromosomal non-allelic homologous recombination (N

168 suggested that the inversions were caused by intrachromosomal nonhomologous recombination.

169 nteractions are apparently lost in favour of intrachromosomal ones upon gene activation.

170 hyroid carcinoma (PTC) typically have either intrachromosomal or extrachromosomal rearrangements that

171 Haplotype analysis indicated an intrachromosomal origin for the duplication.

172 significance, LD was found among 8 of the 34 intrachromosomal pairs of loci.

173 e demonstrate that Platr10 helps orchestrate intrachromosomal promoter-enhancer looping and recruits

174 Here, an intrachromosomal rearrangement between the distal upstre

175 One intrachromosomal rearrangement was detected in this link

176 , the human sequence has undergone extensive intrachromosomal rearrangement, whereas the mouse sequen

177 Comparative genome analyses support intrachromosomal rearrangements across the phylum, dispr

178 Thus, intrachromosomal rearrangements and inversions appear to

179 Both inter- and intrachromosomal rearrangements are facilitated by the p

180 angement scenario, and provide evidence that intrachromosomal rearrangements are more frequent than i

181 nts are more often interchromosomal, whereas intrachromosomal rearrangements are more prominent in ra

182 enome allowed an assessment of the number of intrachromosomal rearrangements between it and the chick

183 o) genome it has become possible to describe intrachromosomal rearrangements between these three impo

184 there was a greater than expected degree of intrachromosomal rearrangements compared to the chicken,

185 Only one interchromosomal and two intrachromosomal rearrangements differentiated both S. o

186 nd DeltaN599) were identified as products of intrachromosomal rearrangements fusing the 3' coding por

187 This shows that intrachromosomal rearrangements have been fixed more fre

188 These results suggest that intrachromosomal rearrangements may be a common mechanis

189 We studied intrachromosomal rearrangements of the syntenic block 3/

190 Intrachromosomal rearrangements or deletions are produce

191 frequent occurrence of inversions and other intrachromosomal rearrangements since the divergence of

192 eran autosomes; in contrast, higher rates of intrachromosomal rearrangements support a special role o

193 A number of intrachromosomal rearrangements were detected by mapping

194 firmed, but a larger than expected number of intrachromosomal rearrangements were reported; (2) to hy

195 Intrachromosomal rearrangements, as shown here, make up

196 oci on 12 chromosomes, and only DAs mediated intrachromosomal rearrangements, based on our reconstruc

197 a finch and chicken, but they differ in many intrachromosomal rearrangements, lineage-specific gene f

198 In contrast to several intrachromosomal rearrangements, only two evolutionary t

199 he chromosome pairs 5-8 can be attributed to intrachromosomal rearrangements, which led to transition

200 th genomes have been extensively reshaped by intrachromosomal rearrangements.

201 le the felid lineage has primarily undergone intrachromosomal rearrangements.

202 lthy plutonium workers contain large (>6 Mb) intrachromosomal rearrangements.

203 n reveals high genome synteny and five large intrachromosomal rearrangements.

204 abundance and splicing, and both inter- and intrachromosomal rearrangements.

205 usion oncogenes that arose primarily through intrachromosomal rearrangements.

206 ome, revealing a surprisingly high number of intrachromosomal rearrangements.

207 ne families or palindromes that might enable intrachromosomal recombination and repair.

208 Ab class switching occurs by an intrachromosomal recombination and requires generation o

209 chromosome pairing reduces the frequency of intrachromosomal recombination and thus decreases, but d

210 ar to those in higher eukaryotes, and MMR on intrachromosomal recombination between highly diverged (

211 hat expression of HO in Arabidopsis enhances intrachromosomal recombination between inverted repeats

212 omal circular DNA molecule that results from intrachromosomal recombination between long terminal rep

213 Intrachromosomal recombination between repeated elements

214 system to show that the molecules excised by intrachromosomal recombination between tandem FLP recomb

215 Previous studies have shown that the rate of intrachromosomal recombination between tandem repeats is

216 Homologous intrachromosomal recombination between the repeated regi

217 ly unique IgH locus in every B cell clone by intrachromosomal recombination between two switch (S) re

218 showed antimutagenic effects in deletion and intrachromosomal recombination events against ethyl meth

219 We investigated the inducibility of such intrachromosomal recombination events at different stage

220 distant control elements and to orchestrate intrachromosomal recombination events by pairing appropr

221 In contrast, intrachromosomal recombination events in the progeny dec

222 me and the plasmid was generally higher than intrachromosomal recombination except for two loci, araA

223 Interplasmidic and intrachromosomal recombination in Deinococcus radioduran

224 We designed DNA substrates to study intrachromosomal recombination in mammalian chromosomes.

225 icity assays that score for DNA deletions by intrachromosomal recombination in vivo and in vitro.

226 Thus, the observed high intrachromosomal recombination is due to meiotic recombi

227 hree-generation families showed that meiotic intrachromosomal recombination mediated the deletion.

228 n repair and are also defective in a mitotic intrachromosomal recombination pathway.

229 The frequency of intrachromosomal recombination reaches a value of 3.1%,

230 determine whether UV damage-induced mitotic intrachromosomal recombination relies on damage-induced

231 lts in a significantly elevated frequency of intrachromosomal recombination resulting in deletion eve

232 -specific double-strand breaks (DSBs) within intrachromosomal recombination substrates in Schizosacch

233 Furthermore, spontaneous intrachromosomal recombination that gives rise to deleti

234 substrates and tk(+) segregants produced via intrachromosomal recombination were recovered.

235 substrate that can report triplex-stimulated intrachromosomal recombination were transfected with a s

236 The production of rDNA circles depends upon intrachromosomal recombination within the rDNA tandem ar

237 plore the effects of chromosomal topology on intrachromosomal recombination, distinct loop geometries

238 a rad50S mutation does not diminish meiotic intrachromosomal recombination, similar to the mutant ph

239 When separated from the active centromere by intrachromosomal recombination, the inactive centromere

240 elevated frequencies of spontaneous mitotic intrachromosomal recombination, which is a phenotype sha

241 of the parental chromosomes and were due to intrachromosomal recombination.

242 active-capable of influencing the course of intrachromosomal recombination.

243 rates is relaxed for both gene targeting and intrachromosomal recombination.

244 eptibility, telomere length maintenance, and intrachromosomal recombination.

245 c systems and the generation of deletions by intrachromosomal recombination.

246 ng displaced synapsis and crossing over, and intrachromosomal recombination.

247 suggest that RAD59 functions specifically in intrachromosomal recombination.

248 he processing of double-strand breaks during intrachromosomal recombination.

249 e greater impact from natural selection than intrachromosomal regions.

250 uggest that homologous recombination between intrachromosomal repeats can be specifically initiated b

251 e-breakage-fusion cycles that generate large intrachromosomal repeats; these are ultimately trimmed b

252 re there is no meiotic recombination map and intrachromosomal repetitive sequences are abundant.

253 African genomes harbor significantly more intrachromosomal SDs and are more likely to have recentl

254 We find that intrachromosomal SDs are among the most variable, with r

255 verified variant sites localized to areas of intrachromosomal segmental duplication within the human

256 hat the rapid expansion and fixation of some intrachromosomal segmental duplications during great-ape

257 Our analysis suggests that both inter- and intrachromosomal segmental duplications have impacted on

258 iated with the presence of highly homologous intrachromosomal segmental duplications.

259 crossover count, crossover interference, and intrachromosomal shuffling.

260 We suggest the increase in intrachromosomal SSA reflects an opportunistic default r

261 terchromosomal translocations and long-range intrachromosomal SVs (>1 Mb) at less-than-optimal resolu

262 hroughout the genome and are associated with intrachromosomal telomere repeats.

263 An intrachromosomal telomere-telomere fusion resulting in a

264 This includes intrachromosomal translocations involving GLIS2 and ETO2

265 ged as a result of inversions and inter- and intrachromosomal translocations.

266 heavy chain (IGH) locus consisting of either intrachromosomal (VDJ) rearrangements or interchromosoma