ライフサイエンスコーパス: intractable

1 categories generated by AW-Fisher can become intractable.

2 Their dynamics might appear intractable.

3 ibrium for a general-sum game is known to be intractable.

4 n in vitro techniques are termed genetically intractable.

5 t arise in road networks are computationally intractable.

6 ct amino acid translation is computationally intractable.

7 ion is not explicitly available or is highly intractable.

8 ystem state dynamics that might otherwise be intractable.

9 ucture between genes, or are computationally intractable.

10 tigations of sialoglycans in brain have been intractable.

11 ted Bayesian networks become computationally intractable.

12 in experimental settings typically viewed as intractable.

13 NP-complete, and so probably computationally intractable.

14 neage-level differences when fine-mapping is intractable.

15 mics, for which the likelihood functions are intractable.

16 decision-making problems that are currently intractable.

17 like breast cancer (BLBC) remains clinically intractable.

18 ing conventional scientific approaches seems intractable.

19 cal in a chassis organism is computationally intractable.

20 rase family members previously thought of as intractable.

21 ct rare diseases that are largely clinically intractable.

22 ted in favor of a simple but computationally intractable acid-base mechanism.

23 ert from their native functional states into intractable amyloid aggregates.

24 oteins from their soluble native states into intractable amyloid deposits is associated with a wide r

25 However, exact Bayesian inference is intractable and approximate methods such as Markov chain

26 formation of bacteria and archaea considered intractable and difficult-to-transfect, while facilitati

27 ecially for genome engineering strategies of intractable and economically important microbial species

28 to address cell biology questions otherwise intractable and engineer cell functions for future synth

29 difficult to locate and are morphologically intractable and genetically divergent.

30 g the performance of PBT was computationally intractable and previous attempts succeeded only with sm

31 used, the reconstitution process is often an intractable and time-consuming trial-and-error procedure

32 While intractable as a whole, modern machine learning (ML) is

33 from such unconstrained reactions is not as intractable as often suggested, when viewed through a ch

34 mab provided a good clinical response for an intractable asthma.

35 harmonization of experimental methods may be intractable at the current pace of research.

36 mputational barriers that made such analyses intractable at this scale.

37 ype-to-phenotype relationships in previously intractable bacteria.

38 design problem is generally computationally intractable because of parametric uncertainties in the m

39 ools that have enabled elucidating otherwise intractable biological processes by leveraging the uniqu

40 In intractable bronchial asthma cases, it is necessary to c

41 ith a large number of degrees of freedom are intractable by classical computers, since their complexi

42 ffectively utilized against targets that are intractable by other approaches.

43 approach is well suited for samples that are intractable by X-ray crystallography.

44 nics, previously thought to be fundamentally intractable, can now be addressed with confidence.

45 nt therapy to alleviate this therapeutically intractable cancer.

46 rocolitis (NEC), which remains a leading and intractable cause of mortality in preterm infants.

47 An intractable challenge in glaucoma treatment has been to

48 ed to model and extend understanding of this intractable childhood disease.

49 ript is a promising approach to treatment of intractable childhood epilepsies.

50 egalencephaly (HME), are important causes of intractable childhood epilepsy.

51 ial, patients (aged 1-30 years) with severe, intractable, childhood-onset, treatment-resistant epilep

52 Recurrent and intractable chronic itch is a worldwide problem, but mec

53 Neuropathic pain is a major, intractable clinical problem and its pathophysiology is

54 be staged as necessary, avoiding the almost intractable complexity apparent in even the simplest cur

55 chronic itch, chronic itch remains an often intractable condition.

56 The outbreak has occurred in an area of intractable conflict among multiple armed groups at a ti

57 olence within the context of one of the most intractable conflicts in the world, the intervention led

58 rm the intestine-critical region (ICR) cause intractable congenital diarrhoea in infants(1,2).

59 The ability to infer intractable control models from sensor data opens new po

60 ients developed persistent chest discomfort, intractable cough, or other complications.

61 e potential to modify the natural history of intractable critical limb ischemia.

62 e scientific insights from large, previously intractable datasets.

63 Cancer cachexia remains a largely intractable, deadly condition for patients with no appro

64 ype 1 (LAD1) had severe periodontitis and an intractable, deep, nonhealing sacral wound.

65 been introduced in which a surrogate for the intractable density is learned, including normalizing fl

66 DR equation has been considered analytically intractable, depending on the initial and boundary condi

67 ce, opening a new strategy for treating this intractable developmental disorder.

68 Norovirus enteritis can cause intractable diarrhea in solid organ transplant (SOT) rec

69 ovides recommendations to prevent and manage intractable disagreements about the use of such treatmen

70 could provide therapeutic benefit against an intractable disease for which there are no effective tre

71 This intractable disease is associated with increased abundan

72 Malignant mesothelioma (MM), is an intractable disease with limited therapeutic options and

73 viding a potential druggable target for this intractable disease.

74 ial fraction of patients diagnosed with this intractable disease.

75 for patients suffering from EB, a currently intractable disease.

76 nd therapeutic strategies for this otherwise intractable disease.

77 ell-type specific intervention in this often intractable disease.

78 sing treatment strategy for PXE, a currently intractable disease.

79 ted opportunities for cell therapies against intractable diseases and injuries.

80 Intractable diseases such as cancer are associated with

81 s potential for cell-based therapies against intractable diseases such as those that affect the centr

82 d in many cases, reshaped the course of once-intractable diseases.

83 e and provided new treatments for previously intractable diseases.

84 novel class of drugs to combat the hitherto intractable disorder of chronic asthma.

85 promising route to treating these otherwise intractable disorders than seeking to adjust levels of o

86 nd treatment development for these currently intractable disorders.

87 gets for drug development in these currently intractable disorders.

88 ies can target the underlying cause of these intractable disorders.

89 pment of durable therapy for these currently intractable disorders.

90 ated susceptibility to seizures, even in the intractable Dravet syndrome epilepsy model.

91 ebrafish findings, we treated five medically intractable Dravet syndrome patients with a clinically-a

92 ylase (ACC), an attractive but traditionally intractable drug target.

93 ration of other enzymes previously viewed as intractable drug targets.

94 rmore, manual annotation of the data remains intractable due to the large number of samples in the ar

95 heterogeneous catalysts, a problem typically intractable due to the multiplicity of coordination envi

96 a representative set of complex mixtures is intractable due to the vast number of possibilities.

97 and c.343A>G, p.N115D) in six patients with intractable early onset epileptic encephalopathy.

98 ized arterial calcification of infancy is an intractable ectopic mineralization disorder caused by mu

99 The remaining patients had intractable epilepsies of different causes and type.

100 The subjects further developed intractable epilepsy (7/7) and nystagmus (6/6) with incr

101 l migration, severe intellectual disability, intractable epilepsy and early death.

102 We recorded from patients with chronically intractable epilepsy as they performed a task that requi

103 phic (ECoG) data from 15 human patients with intractable epilepsy during a word completion task and e

104 tic resonance imaging (MRI) in children with intractable epilepsy has not been quantified in relation

105 In a sample of children with intractable epilepsy who underwent prospective resting-s

106 l EEG data from rare patients with medically intractable epilepsy, and found evidence for respiratory

107 order associated with mental retardation and intractable epilepsy, and Miller-Dieker syndrome (MDS) i

108 on (VNS) is a common treatment for medically intractable epilepsy, but response rates are highly vari

109 racterized by abnormal brain development and intractable epilepsy, caused similar defects in Golgi lo

110 Among patients with intractable epilepsy, the most commonly performed surgic

111 tolerated treatment option for infants with intractable epilepsy.

112 l temporal lobe resection in 25 patients for intractable epilepsy.

113 ment (FMCDs) that are highly associated with intractable epilepsy.

114 et (KD) is an effective treatment option for intractable epilepsy.

115 3% accurate on a dataset of 16 patients with intractable epilepsy.

116 y is a valuable option for pharmacologically intractable epilepsy.

117 most common cause of death in patients with intractable epilepsy.

118 haly, movement disorders, and/or early-onset intractable epilepsy.

119 injury (TBI) is one of the leading causes of intractable epilepsy.

120 utcome in patients with localization-related intractable epilepsy.

121 s are devastating disorders characterized by intractable epileptic seizures and developmental delay.

122 They can be computationally intractable even for mining a dataset containing just a

123 tive distribution functions are analytically intractable, existing methods usually do not work well w

124 dies (LBs), leading to neurodegeneration and intractable fatal epilepsy.

125 sfunction is a prevalent and therapeutically intractable feature of heart failure (HF).

126 Impaired myocardial relaxation is an intractable feature of several heart failure (HF) causes

127 robed directly and revealing computationally intractable features that rely on the long-range interac

128 anguage dominance in patients with medically intractable focal epilepsies against the results of an i

129 for deep brain stimulation in patients with intractable focal epilepsies.

130 Data in 23 patients with medically intractable focal epilepsy were retrospectively analyzed

131 ngle neurons in 27 patients (13 female) with intractable focal epilepsy, that were tracked throughout

132 nguage laterality in patients with medically intractable focal epilepsy.

133 nrelated males who presented in infancy with intractable focal seizures and severe developmental dela

134 for arbitrary circulant quantum circuits is intractable for a classical computer, assuming conjectur

135 ress large and complex optimization problems intractable for classical computers.

136 ns, allowing them to solve problems that are intractable for existing algorithms.

137 Tripedalia cystophora, a species previously intractable for gene transfer, although no clear evidenc

138 often renders direct ab initio calculations intractable for large or complex systems.

139 in memory to start their workflows, which is intractable for mammalian genomes.

140 mental data rapidly becoming computationally intractable for models possessing more than ~50 paramete

141 lzheimer's and Parkinson's, are particularly intractable for structure-targeted therapeutic design.

142 Dravet Syndrome is an intractable form of childhood epilepsy associated with d

143 pective optimization of crystallographically intractable fragment hits into more potent binders.

144 GPCRs, which could be used to treat numerous intractable fungal diseases(4).

145 pioneer TF Sox2 to facilitate its binding to intractable genomic loci in embryonic stem cells.

146 ey feature of other pioneer TFs operating at intractable genomic loci.

147 oma drainage device can successfully control intractable glaucoma even after a very long period of ti

148 atin derivative (6OTD), limits the growth of intractable glioblastoma (grade IV glioma) and glioma st

149 Four patients had dose-limiting toxicities (intractable grade 2 nausea [n=1] and grade 3 rash [n=1]

150 ication for SOT was organ failure related to intractable graft-vs-host disease in 16 children (36.3%)

151 dex, 28 kg/m(2) [range, 20-35 kg/m(2)]) with intractable groin pain were included.

152 ovel treatment modalities for this currently intractable group of disorders.

153 e revealed many new species in taxonomically intractable groups, but unbiased studies of previously w

154 reedom until 2010 when she was evaluated for intractable headaches, and electroencephalography reveal

155 le alternative strategy for the treatment of intractable heroin addiction, particularly in individual

156 We represent three cases of intractable high-volume diarrhea associated with combine

157 53 mutations are observed frequently in most intractable human cancers and establish dependency for t

158 dous promise for the treatment of previously intractable human diseases but to exert their effects on

159 tion and deposition are associated with many intractable human diseases.

160 Three patients had bradycardia and intractable hypotension requiring inotropes.

161 nhibitors as a generalized strategy to treat intractable hypoxic cancer cells found widely in most so

162 solve the one-to-many mapping issue that is intractable in a deterministic model.

163 eformities (69%); and epilepsy (66%) that is intractable in a subset.

164 aches to parameter estimation quickly become intractable in complex branching processes.

165 owever, existing methods are computationally intractable in large cohorts and may not optimize power.

166 with severe neurodevelopmental delay and an intractable infantile-onset seizure disorder.

167 sting future therapeutic strategies for this intractable infection.

168 linical utility in resolving these otherwise intractable infections.

169 these drugs is their inability to target the intractable infectious stage of the parasite.

170 Patients with chronic intractable insomnia undergoing PCSL (n=20) were evaluat

171 Patient-Controlled Sleep (PCSL) for chronic intractable insomnia where the traditional analgesics in

172 otential treatment for patients with chronic intractable insomnia.

173 the new method for the treatment of chronic intractable insomnia.

174 Findings suggest that in cases of intractable intergroup conflict, top-down control mechan

175 and de-escalating conflict before it become intractable is a preferred approach.

176 assembly facilitates analysis of previously intractable large-scale structural variation, allowing,

177 density that they implicitly define is often intractable, leading to challenging inverse problems for

178 ands out in its high speed but is limited to intractable light curable thermosets.

179 ayesian inference for models associated with intractable likelihood functions.

180 observation of one network, often leading to intractable likelihoods regardless of the modeling parad

181 ted the search for alternative therapies for intractable liver diseases.

182 esign, control, and planning over the large, intractable locomotor-terrain parameter space to generat

183 e: Chronic critical limb ischemia, marked by intractable lower extremity ischemic rest pain and tissu

184 imetallic systems and enables the previously intractable mechanistic investigation of restructuring d

185 Neuropathic pain is an intractable medical condition with few or no options for

186 rgery can be a last resort for patients with intractable, medically refractory epilepsy.

187 therapeutically important but experimentally intractable membrane proteins.

188 on and surgical specimens from patients with intractable Meniere's disease.

189 ic tools for the manipulation of genetically intractable microorganisms.

190 inated arenes, substrates that would produce intractable mixtures when typical ligands are used.

191 An intractable model of immune recognition with close to a

192 rge numbers, searching databases, simulating intractable models from quantum physics, and optimizing

193 vances in Bayesian statistical inference for intractable models, we fitted a nonlinear control model

194 y be therapeutic for patients with otherwise intractable mood, anxiety and pain syndromes.

195 78 patients with intractable mTLE and unilateral hippocampal sclerosis un

196 res (limited recovery from ON, bilateral ON, intractable nausea, progressive course of disability), l

197 nging from mild speech and language delay to intractable neurodevelopmental disorders, including but

198 est a novel means of tackling the frequently intractable neurological consequences of this devastatin

199 Chronic, intractable neuropathic pain is a common and debilitatin

200 used cancer drug which induces a serious and intractable neuropathy.

201 g its quantum state, a task which demands an intractable number of measurements even for modestly-siz

202 To cope with the intractable number of possible networks, we developed a

203 ventral gamma capsulotomy for patients with intractable OCD.

204 cally a target for the surgical treatment of intractable OCD.

205 for treating infections caused by this most intractable of drug resistant pathogens.

206 blastoma multiforme (GBM) is one of the most intractable of human cancers, principally because of the

207 citrant cancer driven by a pharmacologically intractable oncoprotein, KRAS(1-4).

208 to solve complex policy problems considered intractable only a few years ago.

209 Intractable or recurrent chronic itch greatly reduces th

210 t an innovative pharmacological strategy for intractable organ fibrosis.

211 ns of a poorly characterized and genetically intractable organism such as Ot.

212 oteins in both model species and genetically intractable organisms.

213 ycolysis has been considered therapeutically intractable owing to its essential housekeeping role.

214 cal cortical dysplasia, are common causes of intractable paediatric epilepsy.

215 Patients with chronic, intractable pain of the back and legs (Visual Analog Sca

216 ovide unprecedented insights into a hitherto intractable panoply of complex models across many scient

217 sy syndrome in adult patients with medically intractable partial epilepsy.

218 le combination of choices is computationally intractable, particularly for longer multistep decisions

219 ugs for novel therapeutic effects with often intractable pathological scenarios.

220 and efficacy of autologous cell therapy for intractable peripheral arterial disease/critical limb is

221 The dynamics of intractable polysulfide migration at different length sc

222 log-barrier function to compute analytically intractable, positively constrained Beta parameters.

223 ferentiated tumor cell lines and genetically-intractable primary cells.

224 tinence (FI) is a severe, underreported, and intractable problem in many patients for which limited p

225 n the developing mammalian brain has been an intractable problem, in part because it has not been pos

226 given target is therefore a computationally intractable problem.

227 se is known to be a complexity-theoretically intractable problem.

228 f complex mixtures is an important but often intractable problem.

229 on is generally a very difficult, not to say intractable, problem.

230 amic ocean management can address previously intractable problems at scales associated with coactive

231 ing and analytical equations created several intractable problems for estimating key parameters.

232 alone but suffers from a number of seemingly intractable problems.

233 and Duplimab, that were effective in AD with intractable prurigo nodularis, are expected to become in

234 We present three cases of AD children with intractable prurigo nodularis.

235 d a preliminary genetic architecture of this intractable psychiatric disorder and yielded new hypothe

236 and allow experimentalists to ask otherwise intractable questions about chromosome structure, functi

237 Non-infectious uveitis (NIU) is an intractable, recurrent, and painful disease that is a co

238 Patients with intractable refractory arrhythmic storm and cardiogenic

239 We are able to characterize SVs in many intractable regions of the genome, including segmental d

240 ying nucleosome organization at a previously intractable resolution and offers up new avenues for mod

241 spid valve (TV) is increasing and results in intractable right heart failure.

242 xcessive alcohol consumption also remains an intractable risk factor, as does aflatoxin contamination

243 ral lobe epilepsy is a common and frequently intractable seizure disorder.

244 These patients exhibit a wide spectrum of intractable seizure types, severe developmental delay, m

245 nt with HME, severe intellectual disability, intractable seizures and hypochromic skin patches, we id

246 Because recurrent intractable seizures are a common feature of FCDs, epile

247 However, ~20-50% of cases have intractable seizures post-surgery due to the imprecise d

248 lays, intellectual disability, microcephaly, intractable seizures, and progressive brain atrophy.

249 itive deficits, a more severe phenotype with intractable seizures, and the potential for sudden unexp

250 dly progressive postnatal encephalopathy and intractable seizures, leading to severe disability and e

251 h spiking regions of patients suffering from intractable seizures.

252 characterized by microcephaly; early-onset, intractable seizures; and developmental delay (MCSZ).

253 e a broad range of previously challenging or intractable separations.

254 ference genome, adding 1.03 Mb of previously intractable sequence.

255 nities to design inhibitors for an otherwise intractable set of PPIs.

256 g the possibility DBS might be used to treat intractable SIB associated with ASDs.

257 sibility of deep brain stimulation (DBS) for intractable SIB seen in some patients with an ASD, we ut

258 increase their accuracy and enable hitherto intractable simulations.

259 ract allows nnAA incorporation at previously intractable sites of an IgG1 and at multiple sites in th

260 arisons between networks are computationally intractable, so new methodologies are sought.

261 cal itch and persistent spontaneous itch are intractable symptoms in chronic itch patients.

262 ral therapy, and neurosurgery for those with intractable symptoms.

263 e base editing, enable editing at previously intractable targets, and provide new base editors with i

264 at can be applied to study other genetically intractable taxa.

265 ployed as a minimally invasive treatment for intractable temporal lobe epilepsy (TLE).

266 veals disulfide-bound regions that have been intractable, thus far, for sequencing with top-down MS.

267 eukocyte samples taken from 16 patients with intractable TLE prior to SLAH to test the hypothesis tha

268 s with PTH-CH were at a higher risk of being intractable to acute (OR 12.34, 95% CI 2.51 to 64.73) an

269 putational biology and neuroscience is often intractable to compute analytically or numerically.

270 eurological diseases that thus far have been intractable to drug therapy.

271 ly, cnidarians have thus far been relatively intractable to electrophysiological and genetic techniqu

272 sequence and structure diversity and proved intractable to existing methods.

273 ally conserved nucleus has proved relatively intractable to full characterization, despite more than

274 Notoriously, the MHC region has been intractable to high-throughput analysis at complete sequ

275 ny new protein families that were previously intractable to homology based fold recognition methods.

276 is leads to a vast combinatorial complexity, intractable to mass spectrometry and requiring large amo

277 tive intestinal Firmicutes bacterium that is intractable to molecular genetic manipulation.

278 of sofosbuvir is largely a function of being intractable to nucleotide-mediated excision compared wit

279 ee human pri-miRNAs, focusing on the regions intractable to previous high-throughput analyses.

280 Often, it is computationally intractable to resolve the finest features in the soluti

281 inistic polynomial-time hard and thus become intractable to solve as the system scales to a large num

282 ins one of the features of this disease most intractable to therapeutic intervention.

283 variant, have marked autonomic features, be intractable to treatment and have associated chronic mig

284 of catalysts for the synthesis of previously intractable Trp analogues.

285 e) 19-56 years old with severe and medically intractable TS were treated with high-frequency DBS of t

286 Glioblastoma multiforme (GBM) is an intractable tumor despite therapeutic advances, principa

287 e delivery of drugs and oncolytic viruses to intractable tumours and are also being engineered with a

288 cently been a promising treatment option for intractable type 1 diabetes patients.

289 to test ecological hypotheses that have been intractable using traditional approaches.

290 ses and provides insight into experimentally intractable viruses.

291 poor quality templates) that were previously intractable, viz, a "glass-ceiling" for previous templat

292 n, had concurrent or prior optic neuritis or intractable vomiting episodes more frequently, had short

293 blem might be expected to be computationally intractable, we find that, surprisingly, this problem ca

294 These problems become intractable when the dimensionality of the data is large

295 lassical likelihood-ratio statistic is often intractable when used to test composite null hypotheses

296 omically important, but many are genetically intractable which limits our understanding of their mole

297 able-range interactions, which are generally intractable with classical methods.

298 he opportunity to answer questions that were intractable with traditional approaches.

299 he opportunity to answer questions that were intractable with traditional approaches.

300 pression via the TRPC3-NFkB axis, leading to intractable wound contracture.