ライフサイエンスコーパス: intralesional

1 This study shows that the intralesional 1470 nm bare-fibre diode laser significant

2 The most common treatments were intralesional (19 014 [41.8%]), topical (18 604 [40.9%])

3 Whether intralesional abciximab administration and thrombus aspi

4 Intralesional abciximab and thrombus aspiration may have

5 days and 1 year of follow-up, treatment with intralesional abciximab compared with no abciximab was a

6 Treatment with intralesional abciximab, thrombus aspiration, or both th

7 opic examination of primary tissues revealed intralesional accumulations of viral nucleocapsids with

8 An in vivo study further showed that the intralesional administration of Ad/gTRAIL effectively su

9 the APM defects in SCCHN cells suggests that intralesional administration of IFN-gamma may have a ben

10 Intralesional administration of the PROTAC(E6) reduced t

11 d with corticosteroid treatment (topical and intralesional) alone or in combination with cryosurgery,

12 -fold and 3.8-fold delivery increases to the intralesional and perilesional spaces, respectively.

13 imen was 2 mg/kg daily oral propranolol, but intralesional and topical beta-blockers were also used.

14 Intralesional antigen therapy has been used in the treat

15 Most of the intralesional APCs expressed the CD86 maturation marker

16 MM biopsies exhibited intralesional as well as spatial heterogeneity, with coe

17 We also evaluated tissue sparing and intralesional axon density six weeks after injury.

18 of Crb1 are characterized by the presence of intralesional bacteria.

19 teen participants were randomized to receive intralesional botulinum toxin A (5 U per 1 cm2) or equiv

20 ), intralesional cavities (n = 28; 60%), and intralesional calcification (n = 29; 62%).

21 umor showed OESs (n = 43; 91%), representing intralesional calcification or cavitation, and each OES

22 the tumor and shadowing corresponding to the intralesional calcification.

23 eratin 19 (K19) structures to progression of intralesional carcinogenesis has not been explored.

24 n = 6; 13%), retinal traction (n = 11; 23%), intralesional cavities (n = 28; 60%), and intralesional

25 lesional vessels were apparent in 30 (100%), intralesional cavities in 6 (20%), intralesional granula

26 Intralesional CD8+ T cells showed blunted expression of

27 is significantly better at depicting certain intralesional characteristics compared to EDI-OCT.

28 of 254 patients (12.6%) first prescribed an intralesional corticosteroid and in 44 of 194 (22.7%) fi

29 Intralesional corticosteroid injection greatly reduced S

30 of medication (635 [64.1%]), most frequently intralesional corticosteroids (370 [37.3%]) and topical

31 ear in 71 of 200 patients (35.5%) prescribed intralesional corticosteroids and 7 of 29 patients (24.1

32 Although DLE usually responds to topical or intralesional corticosteroids and/or oral antimalarials,

33 iled, treatment with adalimumab, etanercept, intralesional corticosteroids, ustekinumab, methotrexate

34 is generally managed with topical, oral, or intralesional corticosteroids.

35 ) and thickness (<1 vs 1 mm, P < .0001), and intralesional cysts (0% vs 7%, P < .0001), feeder vessel

36 Intralesional cysts are visible in 65% of nevi.

37 al nevi with SS-OCT enables visualization of intralesional details such as vessels (present in 100% o

38 SS-OCT allowed for an appreciation of intralesional details: Of the 30 nevi imaged, intralesio

39 Intralesional dosing resulted in individual tumor regres

40 ng the spatial and temporal heterogeneity of intralesional drug PK, have major implications for antim

41 or progression was defined as any tumor with intralesional enhancement or a serial increase in tumor

42 Wall enhancement (but no intralesional enhancement) was found in two of six lesio

43 epresent molecular patterns of heterogeneous intralesional evolution during anti-programmed cell deat

44 eukocytes to express mIL-8RH, and associated intralesional expression of its ligands such as KC/GROal

45 T2 hyperintensity, Atoll sign, and intralesional fat were encountered more in HCAs, and cen

46 sion, we present the evidence for the use of intralesional fibrin glue and intralesional sclerosant,

47 en recent publications discussing the use of intralesional fibrin glue to aid dissection and intrales

48 sualizing intralesional vessels (P = .0002), intralesional granularity (P = .0005), and abnormal chor

49 0 (100%), intralesional cavities in 6 (20%), intralesional granularity in 14 (47%), abnormal chorioca

50 advanced lesions, characterized by extensive intralesional hemorrhage.

51 between tumor lesions, whereas subcentimeter intralesional heterogeneity could be identified only by

52 guishing cross-sectional imaging results and intralesional heterogeneity resulting in biopsy sampling

53 , with multiple clusters per VOI, indicating intralesional heterogeneity.

54 etters; P = 0.016) and a higher frequency of intralesional HTC (69.2%) compared with eyes with comple

55 ratio [OR], 0.96; P = 0.054) and presence of intralesional HTC (OR, 0.06; P = 0.010) at baseline were

56 Intralesional (IL) injection of PV-10 has shown to induc

57 We evaluated 2 local treatments, intralesional (IL) Sb and cryotherapy, for single lesion

58 Therefore, we hypothesized that intralesional (IL) sodium thiosulfate may be an effectiv

59 sions, and revealing the determinants of the intralesional immune reaction during cancer development.

60 enital wart treatments, such as cryotherapy, intralesional immunotherapy, and prescription topical tr

61 Seventy patients were treated with weekly intralesional infiltrations of Glucantime((R)) (meglumin

62 Twelve patients received a single intralesional injection containing 10 micrograms (four p

63 e-established randomisation list to a single intralesional injection of 120 million Cx601 cells or 24

64 Intralesional injection of 2 x 10(6) lyophilized H5BVIFN

65 Intralesional injection of 5 x 10(8) plaque-forming unit

66 glioma tumors established in nude mice with intralesional injection of Ad5CMV-alphaVEGF inhibited tu

67 n HLA-B7-negative patients were treated with intralesional injection of Allovectin-7.

68 The intralesional injection of hCG induces the regression of

69 ncluded topical superpotent corticosteroids; intralesional injection of triamcinolone acetonide at th

70 teroid, and 1087 patients (9.4%) received an intralesional injection.

71 l patients were randomly assigned to receive intralesional injections of 2000 IU of hCG or diluent al

72 pulation of depleted cells in both diseases, intralesional injections of autologous concentrated plat

73 In a phase 1-2 trial, 24 patients received intralesional injections of hCG three times a week for t

74 including cryotherapy, thermotherapy and/or intralesional injections with antimonials.

75 cated in the retinal periphery (n = 16) with intralesional lacunae (n = 14) and surrounding nonpigmen

76 macrophages and T cells, resulting in a high intralesional load of parasites and delayed healing of t

77 Primary outcome was development of intralesional MA (>=175 mum greatest linear dimension of

78 Uncontrolled studies suggest that intralesional MA (IL-MA) may be noninferior and safer th

79 ds increasing if the fellow eye had baseline intralesional MA (OR, 2.43; 95% CI, 1.09-5.44; P = 0.030

80 iations were observed between development of intralesional MA and any other morphologic or visual fun

81 at baseline in 248 of whom 42 (16.9%) showed intralesional MA at baseline and 32 (12.9%) developed in

82 or 594 of 610 participants; 57 (9.6%) showed intralesional MA at baseline.

83 The odds of incident intralesional MA by final visit were lower in study eyes

84 Secondary analyses of incident or progressed intralesional MA in study eyes supported these findings,

85 Incident intralesional MA occurred in 24.4% by the final visit an

86 t baseline and 32 (12.9%) developed incident intralesional MA.

87 Intralesional macular atrophy was present in 31.8% of th

88 The scan can detect intralesional morphologic variation which is especially

89 At present, intralesional multi-injection of triamcinolone acetonide

90 mod group: 44 patients) or vehicle cream and intralesional Mw vaccine (Mw group: 45 patients).

91 Efficacy and safety of intralesional Mw vaccine is comparable to that of imiqui

92 These results provide human validation that intralesional oHSV treatment enhances anticancer immune

93 -VEC) is a herpes simplex virus type 1-based intralesional oncolytic immunotherapy approved for the t

94 ectiveness of a 1470 nm diode laser using an intralesional optical fibre delivery device in the treat

95 eported series of leishmaniasis treated with intralesional or intramuscular meglumine antimoniate but

96 ransient subacute effect characterized by an intralesional or perilesional reaction.

97 Additionally, intralesional or systemic low-dose corticosteroids were

98 gic appraisals of inflammation, bone damage, intralesional osteoclasts (by semiquantitative histopath

99 articular bone while essentially eliminating intralesional osteoclasts.

100 ic), and 14 of 20 (70%, 95% CI 48-85.5%) for intralesional pentamidine.

101 vehicle (20 patients) vs a positive control (intralesional pentamidine; 20 patients) against L. brazi

102 The intralesional production of IL-7 in combination with the

103 Following exposure to oxazolone, the intralesional production of inflammatory cytokines was d

104 Median TTP and PFS for intralesional progression were longer with TEA than TACE

105 tter complete tumor response, longer time to intralesional progression, and longer PFS.

106 of allelic loss heterogeneity suggestive of intralesional progression, findings that were possible b

107 In contrast, intralesional regulatory T cells demonstrated intact sup

108 t GK1.5 combined with anti-IL-4 antibody and intralesional rIL-12 cured cutaneous lesions in 80% of m

109 n A (5 U per 1 cm2) or equivalent volumes of intralesional saline placebo.

110 ralesional fibrin glue to aid dissection and intralesional sclerosant to shrink the lesion.

111 for the use of intralesional fibrin glue and intralesional sclerosant, and describe using both in the

112 air follicles as well as in perilesional and intralesional skin of acne vulgaris lesions such as come

113 Intralesional sodium thiosulfate may be an effective and

114 Intralesional steatosis was exclusively seen in HNF-1alp

115 patients with AT or AU a lower frequency of intralesional steroid (359 [11.1%] vs 18 655 [44.1%], P

116 vious reports showing that subglottic serial intralesional steroid injections (SILSIs) improve clinic

117 The patient received an intralesional steroid, which improved the condition for

118 feration provided by lymphokines produced by intralesional T lymphocytes in psoriasis.

119 No markedly increased rate of intralesional T-cell apoptosis was identified, suggestin

120 e randomly assigned at a two-to-one ratio to intralesional T-VEC or subcutaneous GM-CSF.

121 Intralesional therapies, particularly collagenase clostr

122 rate the therapeutic potential of multimodal intralesional therapy for patients with unresectable and

123 Intralesional therapy is a promising approach for remode

124 Intralesional therapy is used to minimize the systemic e

125 gest that ISIM holds promise as a multimodal intralesional therapy to alter both lymphoid and myeloid

126 therapy, photodynamic therapy, radiotherapy, intralesional therapy, and topical therapy.

127 ival melanoma and nevi demonstrated the same intralesional tortuous patterns, whereas vasculature in

128 esponses, 11 has the potential to be used in intralesional treatment of accessible lymphoma tumors.

129 regression and protective immunity following intralesional treatment of murine A20 B-lymphomas.

130 ts were treated with clobetasol ointment and intralesional triamcinolone, alone or in combination wit

131 ad AK treatment with clobetasol ointment and intralesional triamcinolone; 2 patients also underwent o

132 r Sezary syndrome were enrolled and received intralesional TTI-621 (escalation, n=13; expansion, n=22

133 Intralesional TTI-621 was well tolerated and had activit

134 ts suggest it is not the only determinant of intralesional uptake heterogeneity.

135 virus expressing B7.1 (rV-B7.1) for monthly intralesional vaccination of accessible melanoma lesions

136 Kras(LA1) mice was associated with enhanced intralesional vascularity and neutrophilic inflammation,

137 r ultrasound examination of two cases showed intralesional vascularity of mild-to-moderate degree.

138 received either imiquimod, 5%, cream and an intralesional vehicle (imiquimod group: 44 patients) or

139 Findings on FLAIR* images included intralesional veins for lesions located throughout the b

140 s directly associated with the prominence of intralesional veins on susceptibility-based MRI.

141 CT was significantly superior at visualizing intralesional vessels (P = .0002), intralesional granula

142 ntralesional details: Of the 30 nevi imaged, intralesional vessels were apparent in 30 (100%), intral

143 Intralesional virotherapy with an HSV vector expressing