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1 (Y/F)G sequence is extracellular rather than intramembranous.
2 xG motifs, I speculate that accumulations of intramembranous Abeta peptides might affect the function
3  of a new type of polytopic protease with an intramembranous active site.
4                        Bone wound created in intramembranous alveolar bone heals without the formatio
5 d the role of B cells in osteoblast-mediated intramembranous anabolic bone modeling.
6            Although the latter cleavages are intramembranous and although lipid alterations have been
7  stem cells (RZSCs) critically contribute to intramembranous and endochondral bone formation, respect
8 cient in PSCs display progressive defects in intramembranous and endochondral bone formation, the lat
9 g signaling pathway, differentiate into both intramembranous and endochondral bones.
10 ting callus, the artificial tissue undergoes intramembranous and endochondral ossification and forms
11                                         Both intramembranous and endochondral ossification of the cra
12 er described regulatory networks that govern intramembranous and endochondral ossification.
13 se of osteoblast differentiation during both intramembranous and endochondral ossification.
14 tion is controlled by distinct mechanisms in intramembranous and endochondral ossification.
15 eoblast differentiation and specification of intramembranous and endochondral ossification.
16 asts fail to differentiate leading to severe intramembranous and perichondral ossification defects.
17  In this model, two conserved and apparently intramembranous aspartic acids participate in catalysis.
18  the first identified substrates of a unique intramembranous aspartyl protease that has presenilin as
19  is itself gamma-secretase, an autoactivated intramembranous aspartyl protease.
20                                 It possesses intramembranous binding sites for haem and cytoplasmic b
21 uated phenotypic changes in the structure of intramembranous bone and dentin mineralization using 3 d
22                                        Thick intramembranous bone collars develop, but the formation
23 ify a key mechanistic pathway for regulating intramembranous bone development within the skull that i
24 nscriptional regulatory machinery to control intramembranous bone development.
25 creased expression of osteogenic markers and intramembranous bone formation and by decreased expressi
26 uman (rh) BMP-2 increases the rate of normal intramembranous bone formation and enhanced cementum for
27 ult indicating Tgfbr2 has a critical role in intramembranous bone formation as well as endochondral b
28  with ADAS or BMS cells produced significant intramembranous bone formation by 2 weeks and areas of c
29  development that is mainly due to defective intramembranous bone formation by osteoblasts.
30 hat mOSM, a product of macrophages, sustains intramembranous bone formation by signaling through Osmr
31 s an essential role in both endochondral and intramembranous bone formation during skeletal repair.
32 TH-related protein (PTHrP) receptor (PPR) in intramembranous bone formation in the craniofacial regio
33 w that Tbx22 is an important determinant for intramembranous bone formation in the posterior hard pal
34                                       During intramembranous bone formation in the shafts of long bon
35  mandibular ramus (chondrocyte-derived) with intramembranous bone formation of the mandibular body (n
36                                   Similarly, intramembranous bone formation on the calvaria was reduc
37  for coordination of chondrocyte maturation, intramembranous bone formation, and chondrogenic condyla
38 rtant roles of VEGF in both endochondral and intramembranous bone formation, as well as some insights
39  Here we show PSCs are not only required for intramembranous bone formation, but also for the growth
40                                 Thus, during intramembranous bone formation, EN1 acts both cell auton
41 xpressed very early during in vivo models of intramembranous bone formation, highly enriched in conde
42 t mice demonstrated delayed endochondral and intramembranous bone formation, whereas heterozygous Pkd
43  sufficient for early osteoblastogenesis and intramembranous bone formation, whereas Runx2-II is nece
44 in CNCC-derived osteoprogenitor cells during intramembranous bone formation.
45 ling regulates endochondral, periosteal, and intramembranous bone growth are not known.
46                  The knockout of 5LO favored intramembranous bone healing in aged female mice, with a
47  Taf4b is down-regulated in the CNCC-derived intramembranous bone in Tgfbr2(fl/fl);Wnt1-Cre mice.
48 a-catenin is necessary for fate selection of intramembranous bone progenitors in the skull.
49 ent of functional Runx2 for the formation of intramembranous bone tissues during embryogenesis.
50 formation, and large regions of disorganized intramembranous bone.
51 environment, FCSCs engrafted and regenerated intramembranous bone.
52  well-understood, the development of dermal (intramembranous) bone featured by many craniofacial skel
53 es, such as cartilage, ganglia, and cranial (intramembranous) bone.
54                                  The loss of intramembranous bones and the enlargement of endochondra
55 that elmo2 originated upon the appearance of intramembranous bones and the jaw in ancestral vertebrat
56 xpansion of the jaw, craniofacial, and other intramembranous bones caused by malformed blood vessels
57  all of the mesodermal skeletal elements and intramembranous bones were essentially conserved.
58 ntaining vascular integrity, specifically in intramembranous bones.
59               Interestingly, formation of an intramembranous bony collar around the diaphysis was not
60                                  Currents of intramembranous charge movement were recorded, together
61       Activation of Notch signaling requires intramembranous cleavage by gamma-secretase to release t
62                                          The intramembranous cleavage of Alzheimer beta-amyloid precu
63 amma-Secretase, which is responsible for the intramembranous cleavage of Alzheimer beta-amyloid precu
64 t of gamma-secretase, is responsible for the intramembranous cleavage of amyloid precursor protein an
65  that the DIG fraction is probably where the intramembranous cleavage of APP occurs.
66 amma-secretase protein complex that mediates intramembranous cleavage of betaAPP and Notch proteins.
67 nent of gamma-secretase, responsible for the intramembranous cleavage of substrates that include the
68 l enzymatic step generating beta-amyloid via intramembranous cleavage of the amyloid precursor protei
69 mplex, a protein assembly that catalyzes the intramembranous cleavage of the amyloid precursor protei
70 iberates the amyloid beta (Abeta) peptide by intramembranous cleavage of the B-carboxy terminal fragm
71                                   An unusual intramembranous cleavage of the beta-amyloid precursor p
72 ver, presenilins also mediate the apparently intramembranous cleavage of the Notch receptor, an event
73                             This facilitates intramembranous cleavage of the remaining Notch receptor
74 extracellular domain is followed by a second intramembranous cleavage of the residual CD44 fragment,
75 ti-component enzyme complex that performs an intramembranous cleavage, releasing amyloid-beta (Abeta)
76 kely to underlie the regulatory mechanism of intramembranous cleavage.
77  and is therefore unlikely to proceed via an intramembranous cleavage.
78 onsible for this highly unusual, purportedly intramembranous, cleavage has been definitively identifi
79 derived activator of caspase (Smac) from the intramembranous compartment of the mitochondria to the c
80 he linker between M1 and M2 has little or no intramembranous component.
81 st and a series of distinct sites within the intramembranous confluence of helices and extracellular
82 ch BAX death agonist activity may require an intramembranous conformation of this molecule that is no
83 nally, steady-state expression levels of the intramembranous COOH-terminal fragment of cleaved PC1 re
84 ogether, we believe these data indicate that intramembranous cysteines are constrained, possibly via
85 acterized by dense osmiophilic mesangial and intramembranous deposits along the glomerular basement m
86 n of C3 convertase and highly electron-dense intramembranous deposits.
87 drug influx, possibly through an increase in intramembranous dipole potential.
88 probe, proof that surface-cleaved TNF has an intramembranous disposition.
89 ghly expressed in neurons, is cleaved in its intramembranous domain by gamma secretase to generate am
90                         At extracellular and intramembranous domains, CD44 undergoes sequential metal
91                  Widespread endochondral and intramembranous ectopic bone formation is mediated by ex
92 tate the final step in Abeta production, the intramembranous gamma-secretase cleavage of amyloid prec
93                                              Intramembranous gamma-secretase cleavage of APP plays a
94 omplexes are known to be responsible for the intramembranous gamma-secretase cleavage of the beta-amy
95 eries of sequential proteases, including the intramembranous gamma-secretase complex, which also proc
96   Presenilin (PS) plays an essential role in intramembranous gamma-secretase processing of amyloid pr
97                                              Intramembranous "gamma-secretase" processing of beta-amy
98 resenilin 1 (PS1) plays an essential role in intramembranous "gamma-secretase" processing of several
99 d2 are subject to presenilin (PS)-dependent, intramembranous "gamma-secretase" processing, resulting
100 PH-1), and PS enhancer 2 (PEN-2) mediate the intramembranous, gamma-secretase cleavage of beta-amyloi
101 hat presenilins (PS) play a critical role in intramembranous, gamma-secretase proteolysis of selected
102 ected to the second loop (residue 204) or to intramembranous helix two (residue 94).
103 onegative funnel connects this region to the intramembranous high-affinity ion-binding site and may p
104 e is a macromolecular complex that catalyzes intramembranous hydrolysis of more than 100 membrane-bou
105      We revealed that TMD4 and TMD5 face the intramembranous hydrophilic milieu together with TMD1, T
106  on a specific orientation of desaturase and intramembranous interactions between desaturase and the
107 ATPase regulation of SLN via protein-protein intramembranous interactions between the highly conserve
108 ure GYG sequence (143-145) rather than being intramembranous is extracellular.
109 9(+) population that lead to endochondral or intramembranous-like bone formation.
110 ferences in bone genesis by endochondral and intramembranous mechanisms.
111 t function during anabolic bone modeling via intramembranous mechanisms.
112 om Corti's organ possesses voltage-dependent intramembranous molecular motors evolved from the SLC26
113 mplification relies on an expansive array of intramembranous molecular motors, identified as prestin,
114 n allosteric activation of BAK, inducing its intramembranous oligomerization into a proposed pore for
115 and Notch, might also be cleaved at a third, intramembranous or cytoplasmic site, resulting in the re
116 mote orthotopic bone regeneration via either intramembranous or endochondral ossification, both withi
117 n perichondrial tissues, including excessive intramembranous ossification all along the perichondrial
118           Interestingly, there was excessive intramembranous ossification along the perichondrium, ac
119           Interestingly, there was excessive intramembranous ossification along the perichondrium, ac
120 g cells exhibited a lack of endochondral and intramembranous ossification and a lack of mature osteob
121 e in mice in guarding the distinctiveness of intramembranous ossification and how loss of Gnas trigge
122 ossification of nonadipogenic cells, whereas intramembranous ossification and preosteoblast prolifera
123 ) mice exhibited a delay in endochondral and intramembranous ossification as well as in chondrocyte d
124 ex of IFT20 and GMAP210 is essential for the intramembranous ossification during skull development.
125 e-differentiation of the digit tip occurs by intramembranous ossification forming a trabecular bone n
126 he mechanism of craniosynostosis, we studied intramembranous ossification in Axin2-null mice.
127 indings help us understand the mechanisms of intramembranous ossification in general, which occurs no
128                                    Likewise, intramembranous ossification in the skull is more develo
129 sses the formation of cartilage and promotes intramembranous ossification in the skull.
130      Premature closure of cranial sutures in intramembranous ossification is a feature of syndromes d
131 vere defects in skeletal development, though intramembranous ossification occurs to some extent.
132 tilage and FGFR2 and FGFR3 have roles during intramembranous ossification of mandibular bones.
133 ibits parietal ossification, suggesting that intramembranous ossification of this mesodermal bone req
134 , and craniofacial bones derived from either intramembranous ossification or mesenchymal cells of the
135 on during normal growth and bone healing via intramembranous ossification proceeded normally in the a
136 esenchyme in the mandibular primordium where intramembranous ossification takes place.
137 ranial connective tissue framework undergoes intramembranous ossification to form skull bones (calvar
138 e majority of the mandible is formed through intramembranous ossification whereas the proximal region
139 l vault and craniofacial complex develop via intramembranous ossification, and are separated by fibro
140 formations that affect both endochondral and intramembranous ossification, and is the basis for sever
141 erated endochondral ossification but delayed intramembranous ossification, as well as skeletal deform
142  of cranial sutures, caused by deficiency in intramembranous ossification, occurs at early postnatal
143 mmalian skull, which forms predominantly via intramembranous ossification, requires precise pre- and
144 e and body of the mandible, which develop by intramembranous ossification, was less affected by age a
145           Skeletal tissues develop either by intramembranous ossification, where bone is formed withi
146                                              Intramembranous ossification, which consists of direct c
147                        During the process of intramembranous ossification, which leads to the formati
148 osteogenesis in areas where repair occurs by intramembranous ossification.
149  macrocephaly, which affect endochondral and intramembranous ossification.
150 teoblasts from mesenchymal cells in areas of intramembranous ossification.
151  of ciliary and golgin proteins required for intramembranous ossification.
152 ferential roles of TRPM7 in endochondral and intramembranous ossification.
153 es of the mammalian skull vault form through intramembranous ossification.
154 ng ectopic cartilage formation and excessive intramembranous ossification.
155 plastic clavicles that result from defective intramembranous ossification.
156 chondral ossification, whereas rhBMP-2 drove intramembranous osteogenesis; cmRNA provides an innovati
157 ee-dimensional agent-based model of in vitro intramembranous osteogenic condensation.
158 ole exome sequencing of 40 and 81 APAs found intramembranous p.Val380Asp or p.Gly379Asp variants in t
159                Rhoptry exocytosis depends on intramembranous particles in the shape of a rosette embe
160 acture replicas showed strand-like arrays of intramembranous particles in treated cells resembling ru
161 les: A membrane with a high density of small intramembranous particles surrounds a uniform, coarsely
162                                In axons, few intramembranous particles were present outside of these
163                                              Intramembranous photolabeling shows that (i) protonation
164 to the top of TM5, including portions of the intramembranous pocket as well as the second extracellul
165 attributable to distinct residues lining the intramembranous pocket in the two receptor subtypes.
166            The distinct conformation of this intramembranous pocket within Y140A CCK1R provides an op
167 racellular loops, E1 and E2, separated by an intramembranous pore-forming segment, H5.
168 panning segments, M1 and M2, connected by an intramembranous pore-forming segment, H5.
169 CTP mechanism due to (i) the presence of two intramembranous positive charges that are essential for
170 e results support the proposal that aberrant intramembranous processing and defective signaling via t
171 in, and presenilin enhancer 2, catalyzes the intramembranous processing of a wide variety of type I m
172 amma-secretase, which is responsible for the intramembranous processing of APP, has never been more e
173  the presenilins (PS) as the executioners of intramembranous processing of APP.
174 milar molecular apparatus is responsible for intramembranous processing of Notch and it's ligands.
175 secretase complexes, in turn, compromise the intramembranous processing of Notch.
176              Our results show that efficient intramembranous processing of Notch1 is indispensable fo
177 sociated with a single point mutation at the intramembranous processing site of Notch1, Val1,744-->Gl
178 lular domain after gamma-secretase-dependent intramembranous processing.
179 e of their intracellular domain (ICD) by the intramembranous protease gamma-secretase.
180                gamma-Secretase is an unusual intramembranous protease that has been reported to cleav
181                        gamma-Secretase is an intramembranous protein complex composed of Aph1, Pen2,
182 e first consider hydrophobic matching of the intramembranous proteolipid boundary to explain the conf
183 NTR signalling by the induction of regulated intramembranous proteolysis (RIP) and the release of bot
184 ophic factor administration by 1) initiating intramembranous proteolysis (RIP) of p75(NTR), leading t
185 a-amyloid precursor protein is an apparently intramembranous proteolysis by the elusive gamma-secreta
186 protein (APP) and the Notch receptor undergo intramembranous proteolysis by the Presenilin-dependent
187                                              Intramembranous proteolysis of amyloid precursor protein
188 ndent signaling pathway, suggesting that the intramembranous proteolysis of APP may play a signaling
189 ctly involved in the pathogenically critical intramembranous proteolysis of APP.
190  a highly regulated manner and catalyzes the intramembranous proteolysis of many type I membrane prot
191                                          The intramembranous proteolysis of Notch and the amyloid pre
192  Presenilins are required for the putatively intramembranous proteolysis of Notch to release its intr
193 e complex plays a critical role in mediating intramembranous proteolysis of several type I membrane p
194 nteracts with APP in a way that enhances the intramembranous proteolysis of the latter by a gamma-sec
195 se data demonstrate gamma-secretase-mediated intramembranous proteolysis of TREM2 and functionally li
196 strin (NCT), APH-1, and PEN-2, catalyzes the intramembranous proteolysis of truncated beta-amyloid pr
197 are aspartyl proteases that catalyze a novel intramembranous proteolysis.
198               Presenilins mediate an unusual intramembranous proteolytic activity known as gamma-secr
199  mutations within type III NRG1 that disrupt intramembranous proteolytic processing and abolish intra
200 cytosolic, ATP hydrolytic domain (V1) and an intramembranous proton channel, V0.
201 n is structurally specific, dependent on the intramembranous region of the RAMP and TM6 and TM7 of th
202 eting with and compromising the functions of intramembranous segments of membrane-bound proteins that
203 es: one transient Met148-Cys382 site and one intramembranous site formed by trigonal coordination to
204 herence due to exposure of previously buried intramembranous sites of band 3.
205  triazolobenzodiazepinones docked within the intramembranous small molecule allosteric ligand pocket,
206 m); (b) the release of cytochrome c from the intramembranous space to the cytosol; and (c) the releas
207  Freeze fracture reveals that tight junction intramembranous strands are absent in CNS myelin and bet
208 parvum, results in the formation of a unique intramembranous yet extracytoplasmic niche on the apical

 
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