ライフサイエンスコーパス: intramolecular cyclization

1 d unexpected benzoisobacteriochlorins via an intramolecular cyclization.

2 d aryl halides, followed by copper-catalyzed intramolecular cyclization.

3 AICAR Tfase active site to one that promotes intramolecular cyclization.

4 nstability stemming from an amine to nitrile intramolecular cyclization.

5 approach to access multisubstituted BCPs via intramolecular cyclization.

6 rming event via hydrogen-bonding followed by intramolecular cyclization.

7 ne-boranes into phosphinites, followed by an intramolecular cyclization.

8 lyzed C(sp(2))-H bond activation followed by intramolecular cyclization.

9 reactions that can compete with the desired intramolecular cyclization.

10 cascade of C(sp(2))-H allylation followed by intramolecular cyclization.

11 tion, ortho-alkenylation and finally cascade intramolecular cyclization.

12 oss coupling with boronic acids, followed by intramolecular cyclization.

13 d formation followed by Lewis acid catalyzed intramolecular cyclization.

14 dimethoxyethoxy)-pyridines via acid promoted intramolecular cyclization.

15 iated by an aza-Michael reaction followed by intramolecular cyclization.

16 mation of the heteroaromatic ring through an intramolecular cyclization.

17 of cinnamic acid esters and subsequent inter/intramolecular cyclization.

18 esized from N-substituted diethanolamines by intramolecular cyclization.

19 m DMSM on the ketone enolate followed by the intramolecular cyclization.

20 ough sequential release of the C4'-amine and intramolecular cyclization.

21 D was accomplished via condensation and two intramolecular cyclizations.

22 hich includes base-mediated Michael addition/intramolecular cyclization/[1,5]-H shift/cleavage of CS(

23 hich includes base-mediated Michael addition/intramolecular cyclization/[1,5]-H shift/cleavage of CS(

24 Subsequent additions, followed by intramolecular cyclization, afforded an array of 1,2-dih

25 protocol involves sequential imine formation-intramolecular cyclization-air oxidation followed by 7-e

26 gly unfolding conditions was used to achieve intramolecular cyclization and a high yield of the cross

27 (or ortho-acyl) cinnamate ester followed by intramolecular cyclization and aromatization with exclus

28 Phosgene was used to initiate intramolecular cyclization and convert nonfluorescent mo

29 ed to examine mechanisms of Pd(II) catalyzed intramolecular cyclization and dehydration in acyclic an

30 yl hydroxyalkenal groups, can undergo a slow intramolecular cyclization and dehydration reaction to f

31 ionic intermediates through Michael addition/intramolecular cyclization and double [1,5] acyl shift r

32 This anion undergoes intramolecular cyclization and hydrolysis to generate ar

33 enyl acetate with acid chloride, followed by intramolecular cyclization and microwave-assisted cross-

34 The role of NHC in the intramolecular cyclization and preliminary mechanistic e

35 mediacy of benzylic carbocations followed by intramolecular cyclization and subsequent aromatization

36 al and highly efficient Pd(OAc)(2)-catalyzed intramolecular cyclization and vinylation of o-alkynylph

37 e process involving tandem Michael addition, intramolecular cyclization, and Cadogan-Sundberg reducti

38 sed via enamine formation, Michael addition, intramolecular cyclization, and intramolecular iminium i

39 e following 1,5-hydrogen atom translocation, intramolecular cyclization, and rearomatization steps le

40 is assumed to proceed via enamine formation, intramolecular cyclization, and rearrangement.

41 Notably, sequential Michael addition, intramolecular cyclization, and silica gel-promoted nucl

42 correct molecular design to avoid competing intramolecular cyclization, and the necessary reaction c

43 ctive bromination, a biaryl coupling, and an intramolecular cyclization are the key steps in the synt

44 iffer by a factor of 7.5 for the first order intramolecular cyclization (C) following electron transf

45 nsible for prodrug cleavage unless 3-exo-tet intramolecular cyclization can occur, suggesting that en

46 st/ligand free cascade Michael-type addition/intramolecular cyclization/carbohydrate-ring opening of

47 uction of the designer amides, triggering an intramolecular cyclization cascade and furnishing three

48 sequential C-H activation/ortho-alkenylation/intramolecular cyclization cascade is reported.

49 emiaminal ether via a reduction/condensation/intramolecular cyclization cascade with the C21-alcohol.

50 and dehydrogenative silylation-deoxygenative intramolecular cyclization cascade.

51 ion of carbene equivalents to imines, and 3) intramolecular cyclization chemistry.

52 lation of 33a to the phenol 33b, followed by intramolecular cyclization, completed the fabrication of

53 l-designed aldol condensation/regioselective intramolecular cyclization/conjugate addition cascade re

54 tion and (ii) carbanion-mediated phosphonate intramolecular cyclization (denoted CPIC) was used.

55 rresponding isothiouronium salt undergoes an intramolecular cyclization during silica gel chromatogra

56 ecomes an active compound via a pH-triggered intramolecular cyclization-elimination reaction.

57 s in a series of acyl group transfers and an intramolecular cyclization event to form a 3-oxidopyryli

58 N-tethered epoxy-indoles that trigger facile intramolecular cyclization followed by an oxidative quen

59 -S-Ppant enzyme intermediate which undergoes intramolecular cyclization followed by condensation with

60 cts is presumably derived from tandem double intramolecular cyclization followed by the ring-opening

61 amidyl radicals, cascade processes involving intramolecular cyclization, followed by reaction with bo

62 3-ethoxy cyclobutanone rearranges itself by intramolecular cyclization for the in situ generation of

63 ydes to form an imine, which upon subsequent intramolecular cyclization forms the product under one-p

64 clic iminium intermediates that underwent an intramolecular cyclization from the appendant oxygen.

65 eatment with Cs2CO3 underwent regioselective intramolecular cyclization furnishing tetrasubstituted f

66 sequential removal of acetal protection and intramolecular cyclization/hydration (7% aqueous HCl, ac

67 cetoxyglutarimide, stereoselective reductive intramolecular cyclization, hydroxyl group-assisted in s

68 Intramolecular cyclization in a series of thiophene-base

69 Dienes containing one aryl alkene underwent intramolecular cyclization in good yields.

70 ctionalization of ortho C-H bond followed by intramolecular cyclization in moderate to high yields (u

71 cesses have been selected such as inter- and intramolecular cyclizations, including carba-, oxa-, thi

72 e into aliphatic aldehydes followed by their intramolecular cyclization into 1,3,5-trioxane ((1) H NM

73 generated hydroamination product led to the intramolecular cyclization into 1-imino-2-phenylpyrazino

74 The reaction proceeded through intramolecular cyclization involving C-N bond formation,

75 he enol double-bond protonation, followed by intramolecular cyclization involving the interaction of

76 mpounds via C-H activation/carbene insertion/intramolecular cyclization is explored.

77 e functionalized in order to undergo further intramolecular cyclization leading to a new class of mac

78 a late-stage oxidative lactonization, and an intramolecular cyclization leading to the indolenine rin

79 ,6-diyn-3-ones undergo triflic acid-mediated intramolecular cyclization, leading to benzo[b]fluorenon

80 nd subsequent tautomerization is followed by intramolecular cyclization, leading to the formation of

81 h application of a tandem conjugate addition-intramolecular cyclization method developed by Toru.

82 d or amide derivatives 9 and 20, followed by intramolecular cyclization (method C: BC + D + A --> ABC

83 nucleosides were formed via a base-catalyzed intramolecular cyclization (N3 --> C5' and O2 --> C5', r

84 This work describes the unprecedented intramolecular cyclization occurring in a set of alpha-a

85 periment-theory study of the photo-oxidative intramolecular cyclization of 2'-alkynylacetophenone oxi

86 azo precursors can be easily prepared by the intramolecular cyclization of 2-(5-iodo-1,2,3-triazolyl)

87 er the reported conditions, a gold-catalyzed intramolecular cyclization of 2-alkynylarylketones takes

88 o show that the amidohydrolase PyfA mediates intramolecular cyclization of 2-hydrazinylidenepentanedi

89 he synthesis of 1-4, in 73% and 32% yield by intramolecular cyclization of 31 and 40, respectively.

90 zymes involved in formation, attachment, and intramolecular cyclization of a glycerate-derived three-

91 transfer steps to accelerate 3 x 10(4)-fold intramolecular cyclization of a guanidino group and alde

92 Our synthetic strategy also features an intramolecular cyclization of a N-chloroamine to forge t

93 O bond cleavage of O-acetyl oxime, promoting intramolecular cyclization of a nitrogen-centered imine

94 The key step involves an intramolecular cyclization of a nitronate onto a conjuga

95 llustrate the usefulness of this protocol by intramolecular cyclization of a pyrrole substrate, an ad

96 An acid- and oxidant-promoted intramolecular cyclization of a tetrahydro-beta-carbolin

97 A competing reaction in an intramolecular cyclization of a tosylate led to a bicycl

98 The highly diastereoselective base-promoted intramolecular cyclization of a variety of enantiopure s

99 uickly (30-45 min) via in situ formation and intramolecular cyclization of alkyl 2-[(2-alkoxybuta-2,3

100 elenylisoxazoles via FeCl(3)/RSeSeR-mediated intramolecular cyclization of alkynone O-methyloximes.

101 ped an hexafluoroisopropanol (HFIP)-mediated intramolecular cyclization of allenamides, providing tet

102 indenones, benzofurans, and isochromenes via intramolecular cyclization of allene intermediates/precu

103 e of the synthesis is a putative biomimetic, intramolecular cyclization of alpha-functionalized imida

104 phine-catalyzed tandem umpolung addition and intramolecular cyclization of amidine pronucleophiles on

105 under mild reaction conditions, followed by intramolecular cyclization of an intermediate formed aft

106 nes has been demonstrated via site-selective intramolecular cyclization of aryl-fused 1,6-diyn-3-ones

107 and Cu-catalyzed direct one-pot alkynylation/intramolecular cyclization of azolium N-imides are repor

108 In this paper, we report an intramolecular cyclization of benzylic-substituted propa

109 d scaffolds were controllably constructed by intramolecular cyclization of beta-enamino diketone, fol

110 Chalcone isomerase (CHI) catalyzes the intramolecular cyclization of bicyclic chalcones into tr

111 esis, chalcone isomerase (CHI) catalyzes the intramolecular cyclization of chalcones into (S)-flavano

112 CHI accelerates the stereochemically defined intramolecular cyclization of chalcones into biologicall

113 onalized 2-(methylthio)-4H-chromen-4-ones by intramolecular cyclization of easily accessible 1-(2-ben

114 n, we disclose a method for its formation by intramolecular cyclization of ester-tethered enaminones,

115 lective allylation of a beta-keto ester; and intramolecular cyclization of furan onto an iminium ion.

116 -translational modifications that arise from intramolecular cyclization of glutamine or asparagine re

117 form during protein cleavage events via the intramolecular cyclization of glutamine within the prote

118 Subsequent base-promoted intramolecular cyclization of homocysteine into Dha form

119 ve been synthesized by indium(III)-catalyzed intramolecular cyclization of homopropargyl azides.

120 D/DBU)-mediated Michael addition followed by intramolecular cyclization of isomeric 2/3-(azidomethyl)

121 ma-carbolines via PIFA/BF(3).OEt(2)-mediated intramolecular cyclization of isomeric azidomethyl(indol

122 nistically, we observed that iodine-mediated intramolecular cyclization of ketene dithioacetal procee

123 A metal-free intramolecular cyclization of N-acyl amides for the synt

124 The intramolecular cyclization of N-benzylfumaramide [2]rota

125 Gold-catalyzed and NaH-supported intramolecular cyclization of N-propargyl indole derivat

126 n efficient and mild one-pot, gold-catalyzed intramolecular cyclization of N-propargylic beta-enamino

127 Intramolecular cyclization of nitrogen tethered alkenols

128 f]quinoxaline-7,12-dione, which is formed by intramolecular cyclization of one alkylamino side chain

129 din-3-yl)carbamic acid benzyl ester] and the intramolecular cyclization of protected diol 19 [(3'R)-[

130 membered heterocycle, which circumvented the intramolecular cyclization of pyrazole-based inhibitors

131 Sodium cyanide promoted the facile, intramolecular cyclization of several dialdimines in N,N

132 [Au]-catalyzed and substrate-dependent intramolecular cyclization of sulfonyl ene-amides with a

133 a 9-bromodipyrromethane-1-carbinol and (ii) intramolecular cyclization of the 1-bromo-19-acylbilane

134 e and that Au also rapidly promoted a second intramolecular cyclization of the aminoallene intermedia

135 hydrocannabinol analogs is an acid-catalyzed intramolecular cyclization of the cannabidiol precursor.

136 The following electrophile-mediated intramolecular cyclization of the cis-alkene (5) was fou

137 ted reduction with subsequent acid-catalyzed intramolecular cyclization of the Diels-Alder adducts wa

138 Intramolecular cyclization of the heteroenyne-allene, 2-

139 ion involves generation of the 1,3-dipole by intramolecular cyclization of the keto carbenoid onto th

140 system); (4) low-temperature (<15 degrees C) intramolecular cyclization of the latter into potassium

141 of the oxazole is believed to result from an intramolecular cyclization of the O-tert-butyl ester on

142 wnstream of rifE, is thought to catalyse the intramolecular cyclization of the PKS product, thereby f

143 Following intramolecular cyclization of the resin-bound guanidines

144 Spontaneous intramolecular cyclization of the resulting aldehyde wit

145 oose a molecule of benzotriazole followed by intramolecular cyclization of the resulting intermediate

146 Intramolecular cyclization of the tertiary allylic amine

147 ur-component reaction (U-4CR) followed by an intramolecular cyclization of the Ugi products at room t

148 Intramolecular cyclization of these thioamides via nucle

149 An acid-catalyzed intramolecular cyclization of three such indolines gave

150 on lithium bis(trimethylsilyl)amide-mediated intramolecular cyclization of trisubstitued cyclopentane

151 A diastereoselective mercury(II)-promoted intramolecular cyclization of unsaturated aldehyde via a

152 f 3-azidopiperidines has been achieved by an intramolecular cyclization of unsaturated amines that al

153 soquinolin-8(6H)-ones 22a-e were prepared by intramolecular cyclizations of 1-(2-arylethyl)-5-benzotr

154 derivatives of 3,4-disusbstituted pyridines, intramolecular cyclizations of alkylidene dihydropyridin

155 with B(C6 F5 )3 enabled the first catalytic intramolecular cyclizations of carboxylic acid substrate

156 In addition, intramolecular cyclizations of esters enable C-C bond fo

157 Acid-catalyzed intramolecular cyclizations of the cyclic hydroxy nitril

158 eling experiments with (13)C suggest a fully intramolecular cyclization pattern due to the lack of la

159 ermizine C have been accomplished through an intramolecular cyclization process of a N-Boc-protected

160 atalyzed alpha-arylation step followed by an intramolecular cyclization process.

161 ng of this tetracyclic ring system including intramolecular cyclizations promoted by Lewis acids or b

162 nvolving a Michael-type addition followed by intramolecular cyclization, provides an effective entry

163 esters to o-quinone methides, followed by an intramolecular cyclization, providing 3,4-dihydrocoumari

164 enyl copper intermediate on the imine and an intramolecular cyclization, rather than through the prev

165 ylene-cLNA nucleoside was accomplished by an intramolecular cyclization reaction between a radical at

166 yclic ether structural motifs and a modified intramolecular cyclization reaction between alkyl iodide

167 nosugars through a tandem beta-fragmentation-intramolecular cyclization reaction is described.

168 An intramolecular cyclization reaction leading to the loss

169 4-azoniaspiro[3.4]octane, formed via a slow intramolecular cyclization reaction of chloropyrrolidine

170 ides are prepared through a stereocontrolled intramolecular cyclization reaction that has been evalua

171 e substrates is described, which involves an intramolecular cyclization reaction through a nucleophil

172 meta-quaterphenylene acetylene undergoes an intramolecular cyclization reaction to form benz[e]inden

173 intermediate was prepared and studied in the intramolecular cyclization reaction under acidic conditi

174 do not significantly alter the pK(a) of the intramolecular cyclization reaction.

175 enesulfonamide by employing a Pd(0)-mediated intramolecular cyclization reaction.

176 ma,pi-gold coordinated diyne for the further intramolecular cyclization reaction.

177 nch, and second, a tandem beta-fragmentation-intramolecular cyclization reaction.

178 The intramolecular cyclization reactions of aziridines with

179 lfonyl oxaziridines participate in efficient intramolecular cyclization reactions to afford a variety

180 the problem of dimerization observed in the intramolecular cyclization reactions.

181 ransition states/intermediates in asymmetric intramolecular cyclization reactions.

182 An unprecedented Cs(2)CO(3)-mediated intramolecular cyclization/rearrangement cascade that tr

183 nes with tetrahydroquinoline, followed by an intramolecular cyclization (ring-opening cyclization, RO

184 mechanistic study to understand the crucial intramolecular cyclization step largely favors an iminiu

185 The intramolecular cyclization step was completed in a short

186 first to the amide formation followed by an intramolecular cyclization step, as revealed by computat

187 ng reactant via consecutive C-alkylation and intramolecular cyclization steps.

188 romophore that is formed in the periplasm by intramolecular cyclization steps.

189 esters by a formylation followed by in situ intramolecular cyclization strategy under optimized Vils

190 he triene framework by a palladium-catalyzed intramolecular cyclization-Suzuki-Miyaura coupling casca

191 lease two molar equivalents of H(2) S via an intramolecular cyclization that significantly augments t

192 In the case of intramolecular cyclization, the detailed reaction channe

193 The NCR formation triggers an intramolecular cyclization to a highly reactive pyrrolid

194 by P450 154A1 was shown to be an unexpected intramolecular cyclization to a Paterno-Buchi-like produ

195 ner, Phe- and Trp-derivatives 1a, 1d undergo intramolecular cyclization to afford 12 and 13, again wi

196 r(I) thiophene-2-carboxylate (CuTC)-mediated intramolecular cyclization to afford 18 in good overall

197 l eATRA addition products undergo subsequent intramolecular cyclization to afford five-membered lacto

198 acylates the oxidized indole for subsequent intramolecular cyclization to create the 6-5-5 imidazoli

199 he slow release and for the directed fate of intramolecular cyclization to create the DKP scaffold fo

200 roquinoline frameworks and the base-mediated intramolecular cyclization to establish the spiral quate

201 ormation involves domino imine formation and intramolecular cyclization to form 2-arylcyclopropyl-2,3

202 obenzonitrile undergoes a tandem nitroso-ene/intramolecular cyclization to form benzo[c]isoxazol-3(1H

203 action, a Tollens reaction, an acid-assisted intramolecular cyclization to form the C(7)-C(17) quater

204 th oxocarbenium ion formation and subsequent intramolecular cyclization to fully depolymerize the pol

205 tituted phenacyl bromide, finally leading to intramolecular cyclization to give a mixture of diastere

206 erwent subsequent Pd(II)-catalyzed oxidative intramolecular cyclization to give the corresponding pyr

207 forming step involves a Lewis acid-catalyzed intramolecular cyclization to install the tetrahydropyra

208 were used as efficient nucleophiles for this intramolecular cyclization to obtain the products in goo

209 ion reaction using BF(3).OEt(2), followed by intramolecular cyclization to produce 3-(dihydrofuran-3(

210 on generated a hydroquinone, which underwent intramolecular cyclization to release free spermine and

211 mediate to a chiral sulfinimine (4), and (d) intramolecular cyclization to the desired products.

212 ansfer (PET) with a photosensitizer, undergo intramolecular cyclization to yield substituted phenanth

213 But translating this from intramolecular cyclizations to an intermolecular process

214 pon oxidation of 6-8 can also undergo facile intramolecular cyclizations to bicyclic o-quinone imines

215 tically controlled product claulamine A, and intramolecular cyclizations to form bicyclic claulansine

216 The acyclic thioaminals formed undergo intramolecular cyclizations to provide nucleoside analog

217 g intermediates 3, 6a-6e, and 8 obtained via intramolecular cyclization under acidic conditions affor

218 the aminooxy functionality and a dehydrative intramolecular cyclization under mild conditions to form

219 tegy reported leverages desymmetrization via intramolecular cyclization used to assemble the key inte

220 The ring-opening products on intramolecular cyclization using AgNO(3)/DBU produced va

221 mediate 21 was prepared from a diol 20 by an intramolecular cyclization using CHI3-Ph3P-imidazole and

222 ddition of phthalide to the formyl group and intramolecular cyclization via substitution of triflate

223 The base-mediated intramolecular cyclization was found to be general for b

224 nes with methyl propiolate and CuCN-mediated intramolecular cyclization, was employed to obtain 11-R(

225 ate exchange of nitrogen regioselectivity in intramolecular cyclization were the decisive steps.

226 ductive and/or oxidative transformations and intramolecular cyclizations were performed on a pivotal

227 nantiomers were subjected to a base-promoted intramolecular cyclization, where their interlocked thre

228 This reactivity translates into an intramolecular cyclization, which can proceed in a facil

229 d ortho-quinone methides (o-QMs) followed by intramolecular cyclization, which delivers substituted c

230 d by p-toluenesulfonic acid (PTSA)-catalyzed intramolecular cyclization with aldehydes has been devel

231 Unlike intramolecular cyclization with alpha-iminocarboxylic ac

232 lides using an electron donor and subsequent intramolecular cyclization with arenes could be an impor

233 pane (HCl), further improvements in a unique intramolecular cyclization with N-O bond formation origi

234 hain based macrocycles, and its extension to intramolecular cyclizations with formation of common rin

235 ASA can undergo intramolecular cyclization, yielding an equilibrium with

236 e of O-O and C-C bond cleavages, followed by intramolecular cyclization, yielding functionalized tetr