ライフサイエンスコーパス: intramolecular interaction

1 n regulates connecdenn 1 function through an intramolecular interaction.

2 suppressed by its C-terminal portion via an intramolecular interaction.

3 ndicates poorer complementarity for the weak intramolecular interaction.

4 1 and inactivated ("closed") Axin through an intramolecular interaction.

5 or autoinhibition of its function through an intramolecular interaction.

6 ating destabilization of the distal-proximal intramolecular interaction.

7 Most formins are regulated by an intramolecular interaction.

8 vary the effective concentration within this intramolecular interaction.

9 form of ESCRT-III subunit autoinhibition via intramolecular interaction.

10 e proline-rich region, are critical for this intramolecular interaction.

11 ) and show that phosphorylation regulates an intramolecular interaction.

12 ains that regulate actin assembly through an intramolecular interaction.

13 g of disease-causing mutations near sites of intramolecular interaction.

14 lso conducted, supporting the involvement of intramolecular interactions.

15 er shielded by the ligand or involved in new intramolecular interactions.

16 he misfolded UBL is apparently masked by the intramolecular interactions.

17 elieving its autoinhibited state effected by intramolecular interactions.

18 er quantify the nature of various inter- and intramolecular interactions.

19 ules formed by subdomain-specific inter- and intramolecular interactions.

20 ll signaling and is under strict control via intramolecular interactions.

21 ion of the effective molarities (EM) for the intramolecular interactions.

22 properties such as atomic charges or inter-/intramolecular interactions.

23 region in the C terminus must be intact for intramolecular interactions.

24 rough the modulation of competing inter- and intramolecular interactions.

25 residues 802-990) participates in inhibitory intramolecular interactions.

26 cal for binding, and binding is modulated by intramolecular interactions.

27 replacing amino acid residue was involved in intramolecular interactions.

28 390, suggesting that these residues may form intramolecular interactions.

29 e catalysis and do not become immobilized by intramolecular interactions.

30 oinhibition of the catalytic HECT domains by intramolecular interactions.

31 irst formin studied that is not regulated by intramolecular interactions.

32 rallel to the betaB strand, eliminating many intramolecular interactions.

33 ce of receptor triggering through inhibitory intramolecular interactions.

34 The conservation of intramolecular interactions across animal species and th

35 ain and phosphorylation of S289 disrupts the intramolecular interaction, allowing the N terminus to b

36 ues in the hydrophobic peptide disrupted the intramolecular interaction and increased p53 binding, pr

37 gomerization of mPar3 is able to relieve the intramolecular interaction and thereby promote microtubu

38 uring activation of NMD and suggest that cis intramolecular interaction and trans self-association ma

39 Here we define the required intramolecular interactions and biochemical properties o

40 been suggested that due to the influence of intramolecular interactions and chain connectivity, the

41 on of Jak3 at the SH2 domain decreased these intramolecular interactions and facilitated binding of t

42 However, Sca2 displays intramolecular interactions and functional cooperativity

43 These mutations disrupt ID-mediated intramolecular interactions and ID-dependent inhibition

44 n of Von Willebrand factor is accelerated by intramolecular interactions and increases GPIbalpha diss

45 y offers insight into the patterns of strong intramolecular interactions and other local determinants

46 nhibitory domain (ID), which participates in intramolecular interactions and prevents cofactor bindin

47 idic domain binds to the RING domain through intramolecular interactions and stimulates the catalytic

48 t the mutations affect regulatory inter- and intramolecular interactions and support the conclusion t

49 ay be auto-inhibited in the resting state by intramolecular interactions and that during signaling, N

50 3 kinase dimers identify specific inter- and intramolecular interactions and were in good agreement w

51 ecruitment of Ste20p to the plasma membrane, intramolecular interactions, and interaction with the GE

52 By incorporating the stereochemistry, intramolecular interactions, and solvent effects into th

53 ssembly of membrane proteins for elucidating intramolecular interactions, and they offer the possibil

54 Intramolecular interactions are by far the most common m

55 This review discusses how these intramolecular interactions are influenced by the specif

56 backbones (fewer than five rotatable bonds), intramolecular interactions are not observed, and foldin

57 protonated peptide [YAPAA+H](+), where only intramolecular interactions are possible.

58 These intramolecular interactions are presumably important for

59 ed size, shape, mass, charge density, but no intramolecular interactions, are ideal model systems to

60 ensity of unfolded chains to form non-random intramolecular interactions as monomers and to self-asse

61 a weaker coupling to the bath (and stronger intramolecular interactions) as the ring size is increas

62 del explicitly takes into account inter- and intramolecular interactions, as well as the finite size

63 , as well as donor:acceptor (D:A) inter- and intramolecular interactions at an atomic-level resolutio

64 erminal tail plays a key role in stabilizing intramolecular interactions at rest.

65 upports the model in which the unique set of intramolecular interactions at the trinucleotide core of

66 pe inhibitor (i.e. the first structure of an intramolecular interaction between a Kunitz and another

67 er DivK, which is modulated by an allosteric intramolecular interaction between adjacent domains.

68 by which this phosphorylation regulates the intramolecular interaction between CAR's DBD and ligand-

69 he folded domain and eIF1A-CTT; and (iii) an intramolecular interaction between eIF5B-D3 and -D4.

70 osphomimetic mutation of Ser-561 promotes an intramolecular interaction between GK and the nearby Src

71 onformational compaction likely involving an intramolecular interaction between its C-tail and the C2

72 This is because Itch is autoinhibited by an intramolecular interaction between its HECT (homologous

73 ncommon among NRs in that ligand triggers an intramolecular interaction between its N- and C-terminal

74 Akt appears to be autoinhibited by an intramolecular interaction between its N-terminal plecks

75 Dlg is autoinhibited by an intramolecular interaction between its SH3 and GK domain

76 Intramolecular interaction between myosin heads, blockin

77 ch receiver phosphorylation destabilizes the intramolecular interaction between SL and receiver domai

78 It has been shown that an intramolecular interaction between the acetylation mark

79 est that activity is switched off through an intramolecular interaction between the actin-binding reg

80 strated diminished activity in promoting the intramolecular interaction between the AR carboxyl (C) a

81 Autoinhibition involves the intramolecular interaction between the autoinhibitory do

82 the other, the origin of which stems from an intramolecular interaction between the carbonyl oxygen o

83 We show that STING is autoinhibited by an intramolecular interaction between the CBD and the C-ter

84 tepwise redox events, indicating significant intramolecular interaction between the cobalt ions acros

85 Intramolecular interaction between the extracellular and

86 We demonstrate that the intramolecular interaction between the FERM and SH2 doma

87 Recent studies identified the dynamic intramolecular interaction between the Gbeta(5) and DEP

88 ding activity of vinculin is inhibited by an intramolecular interaction between the head (D1-D4) and

89 th heads is suppressed due to an asymmetric, intramolecular interaction between the heads.

90 l basis for the autoinhibition of RIAM by an intramolecular interaction between the IN region (aa 27-

91 domain that overlaps with the known site of intramolecular interaction between the J domain and the

92 d biophysical approaches, we describe how an intramolecular interaction between the KLC2(TPR) domain

93 y phosphorylates ICAP-1alpha and disrupts an intramolecular interaction between the N- and the C-term

94 s that LEOPARD syndrome mutations weaken the intramolecular interaction between the N-SH2 and phospha

95 on is of interest in view of data indicating intramolecular interaction between the N-terminal extens

96 globular and extended conformations, and an intramolecular interaction between the N-terminal F3 FER

97 Integrin binding is regulated by an intramolecular interaction between the N-terminal head a

98 ching frequency (nu(NO)) is sensitive to the intramolecular interaction between the pendant ligand an

99 vealed that the R1060C mutation disrupts the intramolecular interaction between the POLD1 CysB motif

100 ese simulations pointed to a key role for an intramolecular interaction between the pseudopilin N-ter

101 howed that MDM2 E3 activity is stimulated by intramolecular interaction between the RING and acidic d

102 The PFR assay also revealed a second intramolecular interaction between the RING domain and c

103 We also show that there is an intramolecular interaction between the SH3 and GK domain

104 In solution, we uncovered a yet unknown intramolecular interaction between the Spir-2 FYVE-type

105 Allosteric regulation of an intramolecular interaction between the Src homology 3 (S

106 uclear localization of COP1 by disrupting an intramolecular interaction between the WD40 domain and a

107 Here we report an intramolecular interaction between the yeast Fab1 kinase

108 two new types of molecular interactions: an intramolecular interaction between these two domains and

109 t in the CD4-unbound prefusion state mediate intramolecular interaction between V2 and the conserved

110 Crystal structures revealed pi-pi intramolecular interactions between a donor and an accep

111 we have determined the relative strengths of intramolecular interactions between a series of monosacc

112 uitination-promoting effect of ASXM requires intramolecular interactions between catalytic and non-ca

113 ast in part, to stronger highly cooperative, intramolecular interactions between consecutive exocycli

114 , in addition to variable domain "matching," intramolecular interactions between constant domains pro

115 Our analysis reveals that intramolecular interactions between DBMs and eight-resid

116 Here we have measured the strength of intramolecular interactions between H-bond donor and acc

117 Transient intramolecular interactions between its charged N and C

118 homotrimer in an autoinhibited state due to intramolecular interactions between its pyrin domain (PY

119 The effects of intramolecular interactions between modular domains with

120 hase during concentration of Gag3 into foci, intramolecular interactions between negatively charged S

121 F1 is held in an autoinhibited state through intramolecular interactions between PDZ2 and the CT doma

122 e length of the INO protein, suggesting that intramolecular interactions between regions of INO may c

123 greater burial of residue 105 and heightened intramolecular interactions between residue 105 and resi

124 esult of a subtle balance of many inter- and intramolecular interactions between the Abeta42 and memb

125 kens actin binding by stabilizing inhibitory intramolecular interactions between the actin-binding do

126 an autoinhibited state, which is mediated by intramolecular interactions between the amino-terminal G

127 tudy, we provide evidence demonstrating that intramolecular interactions between the DH domain (resid

128 at the R290H mutation alters the strength of intramolecular interactions between the diffuse B-cell l

129 es transmembrane signaling instead of direct intramolecular interactions between the input and the ou

130 -inhibited state stabilized by electrostatic intramolecular interactions between the intrinsically di

131 tion of Sis1 in vitro activity suggests that intramolecular interactions between the J-domain and gly

132 that RAF inhibitors induce the disruption of intramolecular interactions between the kinase domain an

133 The PDZ2CT structure shows weak intramolecular interactions between the largely disorder

134 This process interferes with the intramolecular interactions between the N- and C-termina

135 maintaining the proper protein structure via intramolecular interactions between the protease and bet

136 results in a completely different network of intramolecular interactions between the SCCH and adenyla

137 These results suggest that intramolecular interactions between the SH3 and guanylat

138 eatment with mild denaturants that disrupted intramolecular interactions between the two modules.

139 eric viruses provided evidence for extensive intramolecular interactions between the two RNA-binding

140 embly and disassembly of numerous inter- and intramolecular interactions between transcription factor

141 Lastly, we characterized intramolecular interactions between ZAR1 subdomains that

142 leaching that ICP27 undergoes a head-to-tail intramolecular interaction but not head-to-tail or tail-

143 o determine the effective molarities for the intramolecular interactions by comparison with the corre

144 Furthermore, investigations regarding intramolecular interactions, by means of steady-state an

145 Second, mutations that disrupt Upf1 intramolecular interaction cause loss of Upf1 function.

146 es, and helps define the dynamic networks of intramolecular interactions central to enzyme catalysis.

147 The strong intermolecular and intramolecular interactions, combined with CT, allow for

148 Whereas intramolecular interactions confer secondary and tertiar

149 on due to H-bonding with log EM, because the intramolecular interactions contribute fully to the stab

150 These results reveal that multiple intramolecular interactions coordinately regulate arrest

151 This intramolecular interaction could, at least partially, ex

152 The way in which the network of intramolecular interactions determines the cooperative f

153 Here we investigate the LBD as a candidate intramolecular interaction domain.

154 Controlling the network of intramolecular interactions encoded by Nalpha-chiral sid

155 ance-dependent threshold was observed in the intramolecular interaction energies.

156 e one hand, incorporation of F would improve intramolecular interaction, enhance the push-pull effect

157 for primer annealing are initially locked in intramolecular interactions; hence, annealing requires t

158 d gap materials exhibit favorable inter- and intramolecular interactions, high thermal stabilities, l

159 face between eIF5B and eIF1A; (ii) a dynamic intramolecular interaction in eIF1A between the folded d

160 The intramolecular interaction in Isl1 may provide protectio

161 odel system to assess the role of the SH3-GK intramolecular interaction in MAGUK function.

162 fragment release (PFR) assay, we detected an intramolecular interaction in MDMX that mechanistically

163 ments suggested the presence of an important intramolecular interaction in the active conformation.

164 forces form the basis of intermolecular and intramolecular interactions in chemical and biochemical

165 These results establish the importance of intramolecular interactions in MDMX regulation, and vali

166 n, and validate a new assay for the study of intramolecular interactions in multidomain proteins with

167 no precedent in TCBD chemistry, results from intramolecular interactions in the excited state between

168 These results show that intramolecular interactions in the folded states of prot

169 aped distortion originating from conflicting intramolecular interactions in the latter case (8-10).

170 coil (NC) segment and its ability to undergo intramolecular interactions in the monomer state versus

171 f Phi values indicated that residues forming intramolecular interactions in the peripheral helices co

172 diffuse interactions and formation of native intramolecular interactions in the third NCBD helix duri

173 in TM 6, suggesting that disruption of this intramolecular interaction induces a receptor conformati

174 vides a quantitative glimpse of how specific intramolecular interactions influence protein folding ra

175 NTD mutation, W435L, in a motif involved in intramolecular interaction influenced promoter-selective

176 RNA binding disrupts an assembly inhibitory, intramolecular interaction involving SP and CTD.

177 simplify RNA folding landscapes by weakening intramolecular interactions involving guanosine and expl

178 8C6 is largely controlled by the strength of intramolecular interactions involving lysine residues.

179 es maintain an inactive conformation through intramolecular interactions involving SH3 and SH2 domain

180 used to determine if the NCap contributes to intramolecular interactions involving the Abl SH3 domain

181 in the ground and transition states, namely, intramolecular interactions involving the aromatic rings

182 R) results in destabilization of the domain, intramolecular interactions involving the domain, and th

183 the peptide on or near the droplet surface, intramolecular interactions involving the hydrophilic N-

184 This intramolecular interaction is disrupted by mutation of T

185 The acidic domain-RING domain intramolecular interaction is modulated by ATM-mediated

186 embryonic neuroblasts demonstrates that the intramolecular interaction is not required for Dlg local

187 Disruption of this intramolecular interaction is proposed to enhance the ac

188 Our results also demonstrate that, once this intramolecular interaction is released, the integrin-bou

189 ude that allosteric regulation of the SH3-GK intramolecular interaction is required for regulation of

190 quence binding site of the SH3.2 domain, the intramolecular interaction is self-inhibitory.

191 donors of the central urea moiety through an intramolecular interaction led to improved potency in wh

192 activity of the ANK repeat domain through an intramolecular interaction, likely with a groove on the

193 220), forming a fuzzy complex via inter- and intramolecular interactions, mainly through hydrophobici

194 A delicate balance of different types of intramolecular interactions makes the folded states of p

195 sumes a pathological conformation through an intramolecular interaction mediated by Arg-61 in the ami

196 nt domain, LATCH, or coiled coil can perturb intramolecular interactions mediated by multiple REs, su

197 iac troponin I (hcTnI), predicted a possible intramolecular interaction near the basic inhibitory pep

198 analyses demonstrate that these competitive intramolecular interactions negatively regulate Npm hist

199 he ETV1/4/5 subfamily involving a network of intramolecular interactions not present in other ETS fac

200 in the millimolar range, and thus, the weak intramolecular interactions observed here could conceiva

201 The enzyme is negatively regulated by intramolecular interactions occurring between the kinase

202 polarity solvents, there appear to be strong intramolecular interactions occurring, particularly when

203 We conclude that the intramolecular interaction of phosphorylated DBD with th

204 odelling revealed that two mutations disrupt intramolecular interaction of PTEN and open its conforma

205 he bound transition state by the effectively intramolecular interaction of the cationic side chain of

206 phosphorylation effects are likely due to an intramolecular interaction of the phosphorylated N-termi

207 mation mechanism: Under basal conditions, an intramolecular interaction of the pleckstrin homology (P

208 Also, the intramolecular interaction of the Snf2 bromodomain with

209 nt a monomer in the cell can be regulated by intramolecular interaction of the tail with the head.

210 We characterized the inter- and intramolecular interactions of its cytosolic subunits by

211 egion by aurora B kinase interfered with the intramolecular interactions of MyoGEF.

212 unknown but may involve interference in the intramolecular interactions of Prf or to binding of the

213 ng variants that either stabilize or disrupt intramolecular interactions of STIM C termini, we show t

214 ation of phosphorylated KID due to favorable intramolecular interactions of the phosphate group of Se

215 The intramolecular interactions of these molecular torsional

216 complete, understanding of the influence of intramolecular interactions on the properties of aromati

217 ic defects resulting from deficiency in Upf1 intramolecular interaction or RNA binding are suppressed

218 t calcium binding, disulfide bond formation, intramolecular interactions, or sites for potential liga

219 xpansivity and revealed how mutations impact intramolecular interaction patterns.

220 model pK(a) values, thus reflecting the weak intramolecular interactions present in the unfolded ense

221 This intramolecular interaction reduces hRpn13's affinity for

222 However, this activity was repressed by an intramolecular interaction relieved by Cdk5 phosphorylat

223 he enzymatic cascade, the Atg3(E123IR) makes intramolecular interactions restraining Atg3's catalytic

224 ruption of substrate binding or mildly alter intramolecular interactions result in type 2 AME.

225 by enzyme-substrate interactions and not by intramolecular interactions resulting from the conformat

226 apping, SSB engages in long-range reversible intramolecular interactions resulting in condensation of

227 roponin switches between alternative sets of intramolecular interactions, similar to previous interme

228 Thus, phosphorylation of the intramolecular interaction site in the PRD is one of the

229 ocesses revealed that phosphorylation of the intramolecular interaction site in the PRD is required f

230 that M phase-specific phosphorylation of the intramolecular interaction site within the proline-rich

231 binding surface overlaps with the inhibitory intramolecular interaction sites in Src.

232 t the single mutation of Cys154-->Gly alters intramolecular interactions so that individual transmemb

233 ited by the central acidic region through an intramolecular interaction that competes for the p53 bin

234 ermini of ICP27 could undergo a head-to-tail intramolecular interaction that exists in open and close

235 rdinates to generate a homology model of the intramolecular interaction that indicates poorer complem

236 ation of GEF activity is achieved through an intramolecular interaction that is controlled by a key r

237 rther domain analysis revealed an unexpected intramolecular interaction that might control Rspo2 sign

238 elf, including a requisite A region-P region intramolecular interaction that occurs within the cell p

239 y present in a closed conformation due to an intramolecular interaction that renders ALIX unable to p

240 the extreme amino terminus of GRK2 forms an intramolecular interaction that selectively enhances the

241 ect membrane protein structures by promoting intramolecular interactions that are different from thos

242 and the fourth membrane-spanning helix, has intramolecular interactions that contribute to maintaini

243 Our goal was to define the intramolecular interactions that contribute to quaternar

244 CcdA is driven by a combination of specific intramolecular interactions that favor the final folded

245 ligand binding must function to disrupt the intramolecular interactions that keep hNotch intact and

246 These hydrophobic subdomains mediate intramolecular interactions that keep the molecule in a

247 zation sensitivity results from weakening of intramolecular interactions that maintain Env integrity.

248 g conditions, Sos activity is constrained by intramolecular interactions that maintain the protein in

249 nhibitory domain (ID), which participates in intramolecular interactions that prevent cofactor bindin

250 However, the complex intermolecular and intramolecular interactions that regulate FAK activity a

251 Currently, the intramolecular interactions that regulate the active sta

252 eotide binding pocket of Akt kinases enables intramolecular interactions that restrict phosphatase ac

253 cleotides, and characterize broad classes of intramolecular interactions that stabilize RNA.

254 cyclophilin domain and establishes a strong intramolecular interaction, thereby preventing the acces

255 ely stabilize individual EGF repeats through intramolecular interactions, thereby regulating Notch tr

256 By mediating inter- and intramolecular interactions, they regulate the functions

257 ted nuclear export, and TRIB1 displaces this intramolecular interaction to induce nuclear retention o

258 Here we show that Nxf1 uses an intramolecular interaction to inhibit its own RNA-bindin

259 cs tRNA, but it uses a very different set of intramolecular interactions to achieve this shape.

260 k (MBS) domain and the motor domain, mediate intramolecular interactions to confer globular protein c

261 we explored the role of kinase activity and intramolecular interactions to further understand ULK fu

262 RM) domains of U2AF2 mediates autoinhibitory intramolecular interactions to reduce nonproductive bind

263 d information on contributions of inter- and intramolecular interactions to the binding energy and po

264 participates in the activation mechanism via intramolecular interactions, unlike the canonical linker

265 We confirm the functional relevance of this intramolecular interaction using differential scanning c

266 F497 residue that makes multiple hydrophobic intramolecular interactions was mutated.

267 plication of SMFS to characterize inter- and intramolecular interactions, which change the properties

268 It is clear that planarizing intramolecular interactions, which exist between the per

269 ng the beneficial thiophene-benzothiadiazole intramolecular interactions, while further extending the

270 bition of DNA binding potentially through an intramolecular interaction with or close to the HD.

271 e of the first beta-propeller domain through intramolecular interaction with other domains of LRP5 wh

272 rged surface that is partially masked by its intramolecular interaction with R9.

273 ion of the X/Y linker mediates high affinity intramolecular interaction with the C-terminal SH2 domai

274 r loop, the U6 region in ZO-1, forms a novel intramolecular interaction with the core module.

275 M(COD)], in which the metal atoms exhibit an intramolecular interaction with the N-aryl groups of the

276 ex, probably mediated by its highly flexible intramolecular interaction with the NEP C terminus.

277 how beta-CD can improve adduct stability via intramolecular interaction with the O2(*-) adduct.

278 N-terminal domain, which also coordinates an intramolecular interaction with the remainder of the mol

279 reorganization of the benzyl group, to avoid intramolecular interaction with the silyl group, is resp

280 ed that the highly conserved Asn(7.45) makes intramolecular interactions with a highly conserved Cys(

281 e that phosphorylated serines participate in intramolecular interactions with and sequester arginine

282 PknK revealed that PknK is autoregulated via intramolecular interactions with its C-terminal region.

283 ein phosphatase 5 (PP5) is auto-inhibited by intramolecular interactions with its tetratricopeptide r

284 RE1, RE2, and RE3 participate in intramolecular interactions with other CARD11 domains an

285 cular graphics modeling to demonstrate their intramolecular interactions with the catalytic triad and

286 uctures disclosed that the C-tail engages in intramolecular interactions with the DNA binding groove

287 insically disordered, yet utilizes transient intramolecular interactions with the DNA-recognition hel

288 ven-helix bundle head domain (Vh1) displaces intramolecular interactions with the vinculin tail domai

289 e to interact, suggesting the presence of an intramolecular interaction within C-RING1B.

290 We find that the inhibitory intramolecular interaction within DIAPH1 is disrupted by

291 osphorylation destabilizes an autoregulatory intramolecular interaction within eIF2alpha; and (ii) th

292 Here we report an interesting intramolecular interaction within Nck that occurs betwee

293 lation of Ser-33 relieving an autoinhibitory intramolecular interaction within PfCRT, leading to a st

294 Thus, intramolecular interactions within alphaE-catenin inhibi

295 at the NCap makes in stabilizing the various intramolecular interactions within c-Abl are less clear.

296 The intramolecular interactions within eIF1A and eIF5B inter

297 t specific cleavages are required to disrupt intramolecular interactions within HTT and to cause toxi

298 This study provides important insights into intramolecular interactions within the 7SK snRNP.

299 s can modulate myosin activity by disrupting intramolecular interactions within the proposed sequeste

300 ER/K alpha-helix reduces the on rate of the intramolecular interaction without significantly affecti