ライフサイエンスコーパス: intraspinal

1 oven, that this residual 5-HT is produced by intraspinal 5-HT neurons.

2 lts demonstrate that GLT1 overexpression via intraspinal AAV-Gfa2-GLT1 delivery exacerbates neuronal

3 e if it has been exposed to the afferent and intraspinal activation patterns that are associated with

4 Furthermore, intraspinal administration of a miR-124 inhibitor signif

5 Intraspinal administration of an interleukin-converting

6 acy of the remaining synapses and neurons of intraspinal and peripheral afferent (dorsal root ganglio

7 that sensory neurons receive intraganglion, intraspinal, and supraspinal inputs, the latter of which

8 ould be restored by acute systemic E2, or by intraspinal application of the membrane-impermeable E2 (

9 that ephrins affect nerve-muscle matching by intraspinal as well as intramuscular mechanisms.

10 which they were allocated to receive either intraspinal autologous cells derived from olfactory muco

11 dal to the lesion and their integration into intraspinal axonal circuits.

12 Three to four months after intraspinal (C4) injection of AAV driving Cre-dependent

13 57Bl/6) and ChAT-Cre mice received bilateral intraspinal (C4) injections of an adeno-associated virus

14 Thus, intraspinal cholinergic systems mediate balanced, multim

15 otor and visceral inputs and are part of the intraspinal circuit that regulates sexual and voiding fu

16 These studies demonstrate the multisegmental intraspinal circuitry responsible for ejaculatory-like r

17 ections, prompting us to examine whether the intraspinal circuitry that coordinates motor activity li

18 tion in mice, further suggesting that spared intraspinal circuits serve as the neural substrates for

19 SCI caused pathology, in part by activating intraspinal complement and cells bearing Fc receptors.

20 cues instruct pSN identities and patterns of intraspinal connectivity.

21 The intraspinal cues that orchestrate T-cell migration and a

22 Intraspinal delivery of AAV8-Gfa2-GLT1 resulted in trans

23 We used intraspinal delivery of adeno-associated virus type 8 (A

24 f the current study was to determine whether intraspinal delivery of Ch'ase ABC, following T10 hemise

25 Finally, an intraspinal delivery of recombinant APRIL before disease

26 ssing ESYT1 were investigated; one for local intraspinal delivery, and the other for systemic adminis

27 antly, the devices maintain functionality in intraspinal electrophysiology recordings over eight mont

28 r, Shimada histopathology, primary site, and intraspinal extension were significant univariate progno

29 MRI was also superior for the detection of intraspinal extension, involvement of multiple body comp

30 evelop swelling ("nodes") along their entire intraspinal extent and elaborate interstitial collateral

31 Moreover, intraspinal extravasation of fibrinogen and immunoglobul

32 Peripheral and intraspinal feedback is required to shape and update the

33 and that part of them deliver peripheral and intraspinal feedback to the cerebellum.

34 s been investigated by using cord dorsum and intraspinal field potential recording.

35 xCT deletion modulates intraspinal glial activation by shifting towards an anti

36 ressing astrocytes in ventral horn and total intraspinal GLT1 protein expression were reduced soon af

37 >/=6 weeks postinjury, as well as increased intraspinal GLT1 protein expression.

38 We observed robust and long-term intraspinal IGF-1 expression and partial rescue of lumba

39 Intraspinal IL-23 reconstitution restored EAE in CCR4(-/

40 tes could also be created in rats by direct, intraspinal immune activation of astrocytes and microgli

41 Strains with marked intraspinal inflammation also developed the most intense

42 the future to reduce the adverse effects of intraspinal inflammation and augment activity-dependent

43 otor and sensory loss that is exacerbated by intraspinal inflammation and persists months to years af

44 Only in C57BL/6 mice was the magnitude of intraspinal inflammation predictive of secondary neurode

45 We delivered Bcl-2 by intraspinal injection of a DNA plasmid encoding this gen

46 We found that intraspinal injection of chondroitinase-ABC, known to di

47 We treated WT mice with a single intraspinal injection of either full-length or processed

48 s induced more than 1 year previously by the intraspinal injection of ethidium bromide (EB).

49 had been experimentally demyelinated by the intraspinal injection of ethidium bromide.

50 Demyelinating lesions induced by intraspinal injection of gliotoxin have been studied for

51 We conclude that the intraspinal injection of LPS results in inflammation and

52 ype-9 (scAAV-9) in spinal cord tissues after intraspinal injection of mouse embryos (E16).

53 Intraspinal injection of NG2 acutely depressed axonal co

54 ated against neuronal injury produced by the intraspinal injection of NMDA and alpha-amino-3-hydroxy-

55 In gain-of-function studies, intraspinal injection of PAP protein has potent antinoci

56 Previous studies have shown that intraspinal injection of quisqualic acid (QUIS) produces

57 We describe a technique for intraspinal injection targeting the lumbar ventral horn

58 rVRG axons toward PhMN targets by performing intraspinal injections of adeno-associated virus serotyp

59 Acute intraspinal injections of anti-NG2 monoclonal antibodies

60 emic injury, in male Sprague-Dawley rats via intraspinal injections of chondroitinase ABC.

61 ection, were quantitated following strategic intraspinal injections of dual retrograde tracers (Fluor

62 cord were demyelinated by x-irradiation and intraspinal injections of ethidium bromide.

63 In this study, we demonstrate that acute intraspinal injections of NG2-Ab prevented an acute bloc

64 ted in 14 male Long-Evans rats that received intraspinal injections of QUIS.

65 y-inhibiting signals in the spinal cord (via intraspinal injections of the enzyme chondroitinase ABC)

66 Macrophages were activated via intraspinal injections of zymosan, a potent inflammatory

67 55 transgenic mice but is evident also after intraspinal inoculation into Cynomolgus monkeys.

68 movements generated via epidural (ES) and/or intraspinal (IS) stimulation.

69 otomy, difficulty in axonal elongation after intraspinal lesion and the lack of target specificity du

70 for the management of complicated as well as intraspinal lesions and peripheral nerve trunk injuries

71 set of injured and uninjured axons following intraspinal lysolecithin-induced demyelination.

72 arrival and maximal appearance of activated intraspinal macrophages.

73 zebrafish spinal cord, which is embedded by intraspinal mechanosensory neurons expressing Piezo2 cha

74 Deficient CX3CR1 signaling in intraspinal microglia and monocyte-derived macrophages (

75 ontusion of the spinal cord, we synchronized intraspinal microstimulation below the injury with the a

76 excitatory) were evoked after contralateral intraspinal microstimulation in the gray matter (cISMS;

77 tidromic volley evoked in the sural nerve by intraspinal microstimulation in the L4/5 spinal segment

78 the bladder and urethral pressures evoked by intraspinal microstimulation of the sacral segments (S1-

79 sulfate proteoglycans, greatly enhanced the intraspinal migration of caErbB2-expressing SCs, enablin

80 ify the first guidance receptor required for intraspinal migration of pioneering motor axons and impl

81 appears that noncontingent shock induces an intraspinal modification that inhibits the capacity to l

82 nction is required cell non-autonomously for intraspinal motor axon guidance and peripheral branch fo

83 wn about the molecular mechanisms underlying intraspinal motor axon guidance.

84 n via Plexin A3 is a major driving force for intraspinal motor growth cone guidance.

85 omplete neurologic recovery in children with intraspinal NB inversely correlated with the severity of

86 rospective review of children diagnosed with intraspinal NB registered on POG NB Biology Protocol 904

87 May 1990 and January 1998, 83 children with intraspinal NB were entered onto the study.

88 central pattern generator (CPG), which is an intraspinal network of neurons capable of generating a r

89 ons within descending brainstem pathways and intraspinal networks are poorly investigated, despite th

90 ALS subjects receiving 5 unilateral cervical intraspinal neural stem cell injections.

91 The underlying mechanism may be related to intraspinal neuronal processing of noxious convergent in

92 T2-immunoreactive terminals originating from intraspinal neurons were less frequent, or were practica

93 icular glutamate transporters 1 and 2 and by intraspinal neurons.

94 Intraspinal olfactory ensheathing cell transplantation i

95 We conclude that intraspinal olfactory mucosal cell transplantation impro

96 ough either supraspinal structures or direct intraspinal pathways.

97 d intradurally at the injury site to monitor intraspinal pressure (ISP), spinal cord perfusion pressu

98 ngs provide proof-of-principle that subdural intraspinal pressure at the injury site can be measured

99 Intraspinal pressure at the injury site was higher than

100 injury was significantly higher than average intraspinal pressure from 12 subjects without traumatic

101 Average intraspinal pressure from the 18 patients with traumatic

102 Intraspinal pressure monitoring started within 72 hours

103 administration had no significant effect on intraspinal pressure or spinal cord perfusion pressure.

104 nt and laminectomy did not effectively lower intraspinal pressure.

105 Furthermore, significant intraspinal processing is likely to occur between thorac

106 n SCI-Tg mice were associated with increased intraspinal production of proinflammatory cytokine mRNA;

107 pletion of neurogenesis for SDH neurons with intraspinal projections.

108 intain inter-segmental communication via the intraspinal propriospinal network.

109 A major barrier to intraspinal regeneration after dorsal root (DR) injury i

110 tor (BDNF), and neurotrophin-3 (NT-3) on the intraspinal regeneration of anterogradely labeled axotom

111 f either corticospinal projection neurons or intraspinal relay neurons alone led to anatomically rest

112 In particular, intraspinal, retroperitoneal lymph node, and bone marrow

113 luenced by the presence of radiation-induced intraspinal Schwann cells extend misdirected processes i

114 al gray matter occupied by radiation-induced intraspinal Schwann cells revealed a loss of immunoreact

115 onvergent spinal neurons might contribute to intraspinal sensory transmission for cross-organ afferen

116 umbar sympathetic preganglionic neurons, and intraspinal sprouting of nerve growth factor (NGF)-respo

117 Thus, selective intraspinal sprouting transpires in regions containing i

118 Intraspinal stereotaxic microinjection of MIF resulted i

119 Intraspinal stimuli (typically 1 s, 20 Hz, 100 microA, 1

120 nhibitory postsynaptic potentials (IPSPs) in intraspinal stretch receptor neurons (edge cells).

121 cholinergic actions on Renshaw cells, their intraspinal synaptic targets.

122 Here, we show that chronic intraspinal T-cell accumulation in B10.PL and Tg mice is

123 , greater rubrospinal neuron loss, increased intraspinal T-cell accumulation, and enhanced macrophage

124 PL mice and were associated with accelerated intraspinal T-cell influx and enhanced CNS macrophage ac

125 a a channel-mediated depolarization of their intraspinal terminals which can be recorded extracellula

126 Thus, intraspinal therapy may augment rehabilitative training

127 For instance, we previously showed that intraspinal toll-like receptor 4 macrophage activation i

128 These data indicate that an intraspinal transplant placed into the contused adult ra

129 e I and IIa clinical trials involving direct intraspinal transplantation in humans.

130 Here, we measured the effects of intraspinal transplantation of cells derived from olfact

131 We have previously reported that intraspinal transplantation of mouse NPCs into JHMV-infe

132 e first report of cervical and dual-targeted intraspinal transplantation of neural stem cells in ALS

133 e also tested the antipruritic properties of intraspinal transplantation of precursors of GABAergic i

134 Three months later, intraspinal transplants were analyzed using correlative

135 tration of endogenous BDNF/neurotrophin 4 by intraspinal TrkB-Fc fusion protein administration does n

136 ing a motor task, while measuring the evoked intraspinal unit response to single pulse cortical stimu

137 rast-enhanced ultrasound imaging to quantify intraspinal vascular disruption acutely after tSCI.

138 ministration at C4 elicits long-lasting pMF; intraspinal VEGFA-165 increased integrated phrenic nerve

139 Furthermore, little is known about intraspinal visceroreceptive transmission and processing

140 g stimulus compared with direct placement of intraspinal wire electrodes.

141 ide evidence of a functional organization of intraspinal WM tracts and confirm that they produce hemo