ライフサイエンスコーパス: intrastriatal

1 tomical and behavioral protection against an intrastriatal 6-hydroxydopamine (6-OHDA) lesion in the c

2 compared the effects of a partial unilateral intrastriatal 6-hydroxydopamine (6-OHDA) lesion model of

3 y UOx manipulations were assessed in a mouse intrastriatal 6-hydroxydopamine (6-OHDA) model of hemipa

4 In the current studies, unilateral, intrastriatal 6-hydroxydopamine (6-OHDA) was used to inv

5 protective effects of the GDNF product in an intrastriatal 6-hydroxydopamine lesion model.

6 We made localized intrastriatal 6-hydroxydopamine lesions in rats and reco

7 loss of dopaminergic markers in response to intrastriatal 6-OHDA administration compared with wild-t

8 RO5166017 aggravated degeneration induced by intrastriatal 6-OHDA in WT mice.

9 These findings indicate that intrastriatal 6-OHDA lesion differentially affects dopam

10 hydroxylase-immunoreactive (TH-IR) axons in intrastriatal 6-OHDA lesioned rats, focusing on two calc

11 by the systemic (1 mg/kg, i.p.) or bilateral intrastriatal (7 microg/0.5 microl under halothane anaes

12 Fischer 344 rats bearing intrastriatal 9L tumors engineered to secrete SF/HGF (9L

13 Intrastriatal AAO, but not saline vehicle, caused a rapi

14 Daily intrastriatal administration for 1 week of > or = 50 ng

15 Intrastriatal administration of AAV5-miHTT resulted in d

16 We show that intrastriatal administration of AAV5-miHTT results in po

17 Intrastriatal administration of compounds structurally r

18 Previous work indicates that intrastriatal administration of MK-801 does not complete

19 cell death were significantly reduced by the intrastriatal administration of NF kappa B SN50, a cell-

20 ated responses, we determined the effects of intrastriatal administration of NMDA antagonists on imme

21 Unilateral intrastriatal administration of NMDA to rats resulted in

22 ndings from in vivo animal studies involving intrastriatal administration of pre-formed fibrils in mi

23 Intrastriatal administration of QA between 7 days and 21

24 Intrastriatal administration of the D1 antagonist inhibi

25 natomical and behavioral consequences of the intrastriatal administration of the NMDA agonist quinoli

26 nd associated behavioral deficits induced by intrastriatal administration of the NMDA receptor agonis

27 vides these beneficial effects, systemic and intrastriatal administration of the selective M1 and M4

28 erein, we used primary cell cultures and the intrastriatal alphaSyn preformed fibril (alphaSyn-PFF) m

29 In contrast, intrastriatal amphetamine administration to amphetamine-

30 ine-induced change in the effect of an acute intrastriatal amphetamine infusion on nigrostriatal term

31 mbrane properties, soma-dendritic shape, and intrastriatal and extrastriatal synaptic interactions of

32 Foxp2 deletion de-represses Mef2c, and both intrastriatal and global decrease of Mef2c rescue vocali

33 We compared the effectiveness of intrastriatal and intracerebroventricular administration

34 f the blood-brain barrier, intraventricular, intrastriatal, and intranigral routes of administration

35 s in modulating glutamate neurotransmission, intrastriatal application of RO5166017 prevented the inc

36 n neurons have been identified: 1) one whose intrastriatal arborization arises as a collateral of a p

37 In present study, intrastriatal autologous-blood injection was used to mim

38 Intrastriatal blood injection in rodents and primary mic

39 More than 70% of TH-positive intrastriatal cell bodies were found in the caudate nucl

40 ther confirmed by the study in which neither intrastriatal CHA nor DPCPX significantly altered the MI

41 uced MI but also blocked its accentuation by intrastriatal CHA.

42 at brain slices, we find that stimulation of intrastriatal cholinergic fibers evokes polysynaptic GAB

43 -state potentials, and they are modulated by intrastriatal cholinergic interneurons, providing a mech

44 In vitro studies have revealed an intrastriatal circuit in which acetylcholine, released b

45 new conceptualization of the organization of intrastriatal circuitry and their cortical and thalamic

46 Perspective will examine the organization of intrastriatal circuitry, review recent findings in this

47 ling in MSNs is critical for the function of intrastriatal circuits.

48 Intrastriatal co-infusion of hrIL-1beta (10 ng) with S-A

49 al properties and dopaminergic modulation of intrastriatal connections formed by striatopallidal neur

50 These results are in support of intrastriatal connections of D2R(+)-MSNs (iMSNs) with dM

51 characterized, and little is known about the intrastriatal connectivity of interneurons and the distr

52 With a rat model of intrastriatal DA injection, we studied the molecular eve

53 Methods: Rhesus macaques received MRI-guided intrastriatal delivery of a mixture of AAV2 and AAV2.ret

54 Intrastriatal delivery of anti-N-terminal htt scFv-C4 us

55 We show that intrastriatal delivery of Cas13d-CAG(EX) via an adeno-as

56 ty, tolerability, and efficacy of bilateral, intrastriatal delivery of ProSavin, a lentiviral vector-

57 Adult rats received chronic intrastriatal dialytic exposure to quinolinic acid (QUIN

58 rol over a cocaine-seeking habit by using an intrastriatal disconnection procedure that combined a se

59 gical correlates of the response to a single intrastriatal dispersed cell graft of fetal rat ventral

60 In a separate experiment, intrastriatal DNQX was shown to block kainic acid (KA)-i

61 The intrastriatal dopamine depletion severely affected the l

62 Intrastriatal dopaminergic neurons increase substantiall

63 t extrastriatal dopaminergic projections and intrastriatal dopaminergic neurons.

64 These data indicate that intrastriatal DORs modulate a calcium-dependent, ampheta

65 luR-dependent component of IPSCs elicited by intrastriatal electrical stimulation is almost exclusive

66 We show that intrastriatal expression of 97Q-GFP causes the rapid for

67 nesias have been a surprising side-effect of intrastriatal foetal ventral mesencephalic transplantati

68 ce calls for a reformulation for the role of intrastriatal GABAergic circuits.

69 Furthermore, we help to show how altered intrastriatal GABAergic signaling may produce aberrant n

70 Nonselectively reducing intrastriatal gamma-aminobutyric acid (GABA) receptor-A

71 Intrastriatal GFAP-hNGF-secreting implants also induced

72 Furthermore, intrastriatal glutamate antagonist infusions increased t

73 C57Bl/6J mice received an intrastriatal graft of MHP36 neural stem cells 3 days af

74 mplete recovery of motor functions following intrastriatal grafting of fetal ventral mesencephalon.

75 ic neurons and their striatal projections by intrastriatal grafting.

76 We hypothesized that intrastriatal grafts are more vulnerable to alpha-syn pr

77 Intrastriatal grafts of embryonic mesencephalic tissue c

78 Two patients received intrastriatal grafts of human fetal ventral mesencephali

79 Finally, intrastriatal implants of engineered adenosine-releasing

80 We gave cynomolgus monkeys intrastriatal implants of polymer-encapsulated baby hams

81 Rats underwent intrastriatal infusion and were observed and then sacrif

82 Intrastriatal infusion of 1.6 or 8.1 mM oxotremorine did

83 adiol pellet were subjected to an unilateral intrastriatal infusion of 6-hydroxydopamine (6-OHDA).

84 Adult, male rats (n=10) underwent unilateral intrastriatal infusion of 6-OHDA (12.5mug).

85 gene expression is also downregulated by an intrastriatal infusion of a cholinergic muscarinic antag

86 Intrastriatal infusion of a neuronal NO synthase inhibit

87 Intrastriatal infusion of a NO scavenger also decreased

88 to amphetamine, we studied the effect of an intrastriatal infusion of amphetamine on nigrostriatal a

89 We investigated the effect of intrastriatal infusion of blood on hematoma volume, neur

90 inhibitor PD098059 or after a continuous 7 d intrastriatal infusion of ERK1/2 antisense oligodeoxynuc

91 nthine (DMPX) (A2a antagonist) 30 min before intrastriatal infusion of malonate (mitochondrial comple

92 reatment in mice which received a unilateral intrastriatal infusion of malonate, a metabolic inhibito

93 um or substantia nigra of rats 30 min before intrastriatal infusion of malonate.

94 ivity in a manner that was blocked following intrastriatal infusion of ODQ (50 mum).

95 ed gene expression in the barrel cortex, and intrastriatal infusion of SCH-23390 attenuated this effe

96 Intrastriatal infusion of the competitive NMDA receptor

97 Intrastriatal infusion of the neurokinin-1 receptor agon

98 Like the competitive antagonists, intrastriatal infusion of the non-competitive NMDA antag

99 Unilateral intrastriatal infusion of the selective D1 receptor anta

100 MDA receptor agonist quinolinic acid (QA) by intrastriatal infusion, and the role of NF-kappaB in the

101 sis, freely behaving rats received bilateral intrastriatal infusions of ascorbate oxidase (AAO) to in

102 MPTP was administered to mice which received intrastriatal infusions of saline or malonate.

103 Bilateral intrastriatal infusions of the full D1 agonist SKF 82958

104 vity in awake rats during quiet resting that intrastriatal inhibition maintains a low-correlation str

105 ions/min over 1 h) were randomly assigned to intrastriatal injection (ipsilateral to the lesion) of b

106 ncrease in zif/268 mRNA measured at 6 h post-intrastriatal injection in the pCPA/QA group as compared

107 Intrastriatal injection of 3-nitrotyrosine, which is a b

108 iglets, cerebral hyperemia was induced after intrastriatal injection of 5 mumol of N-methyl-D-asparti

109 sphorylation of Trk-type proteins 2 hr after intrastriatal injection of 50 ng of NGF.

110 l, lateral and caudal striatum 4 weeks after intrastriatal injection of 6-hydroxydopamine (6-OHDA), a

111 Intrastriatal injection of 6-hydroxydopamine results in

112 unilateral nigrostriatal lesion produced by intrastriatal injection of 6-hydroxydopamine was indisti

113 Twenty-four hours following an intrastriatal injection of [125I]GDNF, label was observe

114 Intrastriatal injection of a D1 receptor antagonist amel

115 Intrastriatal injection of a Tat-fusion and CaMKIIalpha-

116 The intrastriatal injection of a tyrosine kinase inhibitor,

117 Intrastriatal injection of AAV-hCDNF reduced motor impai

118 via viral vectors following the stereotaxic intrastriatal injection of alpha-syn PFF cause a reducti

119 Here we report that intrastriatal injection of alpha-syn preformed fibrils (

120 Intrastriatal injection of alpha-synuclein preformed fib

121 does not seem to directly increase CNTF, as intrastriatal injection of an ischemic solution or expos

122 Intrastriatal injection of an mGluR agonist increases mo

123 sion of pioglitazone into gliomas induced by intrastriatal injection of C6 cells reduced tumor volume

124 nsplant for those animals pretreated with an intrastriatal injection of citrate buffer and subsequent

125 this study, we produced ICH in mice with an intrastriatal injection of collagenase to investigate wh

126 Here we tested this assumption using intrastriatal injection of collagenase, a well-establish

127 bsequently, transplanted animals received an intrastriatal injection of either GDNF (10 microg) or ci

128 Intrastriatal injection of either malonate or quinolinat

129 uced in Lewis rats (n = 24) via stereotactic intrastriatal injection of heat-killed bacillus Calmette

130 ogenous CCL2 exerted neuroprotection against intrastriatal injection of HIV-1 Tat.

131 ment with tACPD did not alter the effects of intrastriatal injection of KA.

132 were examined in adult rat striatum after an intrastriatal injection of low doses of quinolinic acid,

133 ter the acute systemic treatment of 3-NP and intrastriatal injection of malonate.

134 Furthermore, intrastriatal injection of neutralizing antibodies augme

135 p) and, after 20 min, by a single unilateral intrastriatal injection of NMDA (15 nmol, n = 12).

136 chanisms were probably also not involved, as intrastriatal injection of proinflammatory cytokines (IF

137 ntrol stem cells followed 9 days later by an intrastriatal injection of quinolinic acid (QA).

138 Selective neuronal loss caused by intrastriatal injection of quinolinic acid resulted in a

139 triatal output neurons from death induced by intrastriatal injection of quinolinic acid, an N-methyl-

140 xamined neuronal degeneration resulting from intrastriatal injection of quinolinic acid, an NMDA rece

141 We found that unilateral intrastriatal injection of rAAV resulting in the express

142 Intrastriatal injection of rAAV4betagal resulted again i

143 FEDV allowed for the detection of RONS after intrastriatal injection of sodium nitroprusside, in the

144 Consistent with our in vitro findings, intrastriatal injection of specific antisense against mi

145 Male rats were given an intrastriatal injection of Tat (25 micro g) or vehicle 2

146 The acute intrastriatal injection of the CaMKII inhibitor KN93 (1.

147 eloping dystonic movements after systemic or intrastriatal injection of the cholinergic agonist oxotr

148 signaling in dMSNs by cocaine is rescued by intrastriatal injection of the GABA antagonist, bicucull

149 athway was selectively inhibited by a single intrastriatal injection of the MAPK/ERK kinase inhibitor

150 optosis can be induced during development by intrastriatal injection of the neurotoxin 6-hydroxydopam

151 In pHSVpkcDelta-infected animals, intrastriatal injection of the PKC inhibitor NPC-15437 (

152 Here, using MRI, we demonstrate that a focal intrastriatal injection of TNF-alpha causes a significan

153 ssue water diffusion was apparent 24 h after intrastriatal injection of TNF-alpha injection, which ma

154 unilateral inhibition of striatal PTP by an intrastriatal injection of vanadate induced contralatera

155 At the time of the intrastriatal injection, 5-HT levels were depleted great

156 toxin 6-hydroxydopamine (6-OHDA) (unilateral intrastriatal injection, 64 nmol) were compared with fre

157 cts of the aminoglycoside neomycin following intrastriatal injection.

158 rAAV2betagal and rAAV5betagal intrastriatal injections led to beta-gal-positive parenc

159 d-type control mice (WT) received unilateral intrastriatal injections of 3-NP (200 nmol/microl) or QA

160 r GDNF or BDNF, or both vectors, followed by intrastriatal injections of 6-hydroxydopamine (6-OHDA).

161 lar superoxide dismutase received unilateral intrastriatal injections of 6-hydroxydopamine.

162 t microdialysis experiments after unilateral intrastriatal injections of a recombinant adeno-associat

163 Intrastriatal injections of AAV1-GFP-IC10 significantly

164 Intrastriatal injections of DA in amounts from 1 to 2 mi

165 Several studies have demonstrated that intrastriatal injections of fibrillar alpha-synuclein in

166 Rats received unilateral intrastriatal injections of HSV-1 vectors that express e

167 Intrastriatal injections of malonate resulted in a signi

168 d adult neurons at different times following intrastriatal injections of non-NMDA and NMDA GluR agoni

169 2 and naive controls were tested with single intrastriatal injections of rAAV2 encoding human glial c

170 field by determining the capacity of direct intrastriatal injections of RY 008, a partial inverse ag

171 icrog/0.5 microl/side), as also were control intrastriatal injections of saline (0.5 microl/side).

172 Intrastriatal injections of the mamba snake toxin MT-7,

173 l dopamine neuron loss induced by unilateral intrastriatal injections of the toxin 6-hydroxydopamine.

174 Survival of rats with large intrastriatal inocula of C6trkA cells was significantly

175 at in wild-type nontransgenic mice, a single intrastriatal inoculation of synthetic alpha-Syn fibrils

176 In both mice and monkeys, intranigral or intrastriatal inoculations of PD-derived LB extracts res

177 out a framework for an updated model of the intrastriatal lateral inhibition, where we explore its c

178 /-) mice were more sensitive to NMDA-induced intrastriatal lesions than were wild-type animals.

179 values confirmed this finding and evidenced intrastriatal localization of seasonal effects to the ca

180 se in iron deposition in microglia following intrastriatal LPS injection compared to wild-type mice,

181 The combined treatment of intrastriatal malonate with systemic METH resulted in gr

182 These findings pinpoint where and suggest an intrastriatal mechanism for how ACh dynamics shape regio

183 Intrastriatal microinfusion of adenosine A1 receptor ago

184 the NPY (Y1R and Y2R) receptors infused via intrastriatal microinjection followed by a bolus of METH

185 Intrastriatal modulation of the moderate EtOH dose was s

186 We show that intrastriatal nitric oxide (NO) signaling elevates the e

187 tment for 21 days without the gene transfer, intrastriatal NPC-15437 had no effect on the response sh

188 vate the spiny projection neurons (SPNs) and intrastriatal parvalbumin-expressing neurons.

189 expressing human wild type (WT) alpha-syn by intrastriatal-PFF injection.

190 of the limitations of this approach is that intrastriatal placement of implants fails to consistentl

191 To distinguish intrastriatal processing from loop dynamics, cortex-stri

192 adversely affect neuronal survival following intrastriatal QA exposure and lend support to the hypoth

193 ne neurons, with some animals also receiving intrastriatal quinolinic acid (QA) injections to ablate

194 Six months after intrastriatal rAAV transduction, TH staining was present

195 Intrastriatal release of dopamine and inhibition of inte

196 Previously, we have shown that intrastriatal Ro15-4513 not only significantly attenuate

197 Intrastriatal RY 008 (50, 500 ng) and SR 95531 (50 ng) a

198 Rats received unilateral or bilateral intrastriatal saline injections to disrupt the blood-bra

199 Compared to control rats injected with intrastriatal saline, rats depleted of dopamine displaye

200 Intrastriatal scopolamine at a concentration of 62 mM, b

201 s or whether impulsivity and cocaine-induced intrastriatal shifts are additive processes is unknown.

202 tly attenuated locomotor activity induced by intrastriatal SKF 82958 (12.0 nmol).

203 Excitotoxic lesions were produced by intrastriatal stereotactic NMDA microinjections (10-20 n

204 was depressed during repetitive 2 Hz firing, intrastriatal stimulation reliably evoked large polysyna

205 During periods of induced regular firing, intrastriatal stimuli were used to evoke pharmacological

206 ajority of neostriatal neurons and intrinsic intrastriatal synapses are GABAergic, the latter arising

207 At the electron microscopic level, the intrastriatal terminals of both corticostriatal neuron t

208 t only intratelencephalically (IT-type), the intrastriatal terminals of which are 0.41 microm in mean

209 ateral projection to striatum (PT-type), the intrastriatal terminals of which are 0.82 microm in mean

210 label PT-type neurons and their ipsilateral intrastriatal terminals retrogradely, BDA3k was injected

211 to the contralateral striatum, whereas their intrastriatal terminals were labeled anterogradely by bi

212 e cortex, and in the size and shape of their intrastriatal terminals, suggest that they may differ in

213 perikaryal size, and the morphology of their intrastriatal terminals.

214 Intrastriatal TGFalpha infusion induced significant prol

215 erentiate into dopaminergic neurons, survive intrastriatal transplantation and induce functional reco

216 Intrastriatal transplantation of dopaminergic neurones a

217 Intrastriatal transplantation of dopaminergic neurons ca

218 Intrastriatal transplantation of Gpc4 hypomorphic cells

219 d-brain barrier (BBB) permeability following intrastriatal transplantation of mouse bone marrow strom

220 middle cerebral artery occlusion (MCAo) and intrastriatal transplantation of mouse bone marrow strom

221 Furthermore, ARE preactivation by means of intrastriatal transplantation of Nrf2-overexpressing ast

222 Rats received intrastriatal transplants of GFAP-hNGF stem cells or con

223 Intrastriatal transplants of human foetal mesencephalic

224 ch block dopamine (DA) D2 receptors, showing intrastriatal variation in their effectiveness in modula

225 ne-induced rotational behavior 3 weeks after intrastriatal vector injection.