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1 1F, and Q242L) indicate that both the alpha1 intrasubunit and beta3-alpha1 intersubunit sites are cri
2 Shaker potassium (K+) channels normally lack intrasubunit and intersubunit disulfide bonds.
3 d surrounding alpha-helices reveal that both intrasubunit and intersubunit interactions mediate the i
4 ctural findings are discussed in relation to intrasubunit and intersubunit interactions that may conf
5 odeling, identify important sites of dynamic intrasubunit and intersubunit interactions that regulate
6 tent with such an evolutionary trade between intrasubunit and intersubunit interactions, we showed in
7                        We conclude that both intrasubunit and intersubunit reaction mechanisms are ne
8          Residues in the GLIC TMD that frame intrasubunit and intersubunit water-accessible cavities
9  tRNAs trapped in transit, bound in chimeric intrasubunit ap/P and pe/E hybrid states.
10 t contains an independent active site (i.e., intrasubunit arrangement) or whether the active site res
11                                        Novel intrasubunit binding sites were identified within the tr
12 3)H]S-mTFD-MPPB photolabeling of these nAChR intrasubunit binding sites.
13 date binding site to an intersubunit, not an intrasubunit, binding pocket is a novel conclusion that
14 topes into two binding regions at inter- and intrasubunit boundaries of the calcium-dependent trimer.
15 e and di-Fe(2+) forms of BFR showed that the intrasubunit catalytic center, known as the ferroxidase
16                   Key to this activity is an intrasubunit catalytic dinuclear iron center called the
17 n the virion assembly, probably involving an intrasubunit cation-pi interaction between the guanidini
18 ting state propofol does not bind in the TMD intrasubunit cavity as observed in the crystal structure
19 ent stabilize subunit flattening in Arp3, an intrasubunit change that converts Arp3 from a conformati
20  and P3 dictates intersubunit (trans) versus intrasubunit (cis) autophosphorylation, with the trans r
21 talytic domain in the sister subunit, but no intrasubunit collisions are detected.
22 irst transmembrane domain alter in inter- or intrasubunit communication.
23  suggest that the effects of dimerization on intrasubunit conformation reflect the need to adjust the
24 er831 decreases the activation energy for an intrasubunit conformational change that regulates the co
25 h I domains remain individually sensitive to intrasubunit conformational changes induced by allosteri
26  activation includes subunit rotation and/or intrasubunit conformational changes that move N170 to a
27 stants of ~40 and ~900 ms for the inter- and intrasubunit conformational changes, respectively.
28 tition the restraints between explicit inter/intrasubunit contacts and a class wherein both were reta
29                                        These intrasubunit contacts as well as those between MD helix
30 distal loop does not contact Hsp70 but makes intrasubunit contacts with nucleotide-binding domain 2 (
31 t it may not exhibit the pronounced negative intrasubunit cooperativity in the absence of Mg2+ that i
32 ine-valine-proline (PVP) motif, Cd(2+) forms intrasubunit coordination with a native glutamate E321,
33                                          The intrasubunit correlated motions were decreased in the mo
34  long-range couplings across the ring, while intrasubunit couplings connected the motif to the conser
35                      In addition there is an intrasubunit covalent linkage between two tryptophan sid
36 ly inhibits the formation of both inter- and intrasubunit cross-links.
37 ural Zn2+ is coordinated in a highly stable, intrasubunit Cys4:Zn2+ site.
38 normally participate in the formation of the intrasubunit disulfide bond (Cys-57 to Cys-146) or are b
39 er by metal binding and the formation of the intrasubunit disulfide bond are mediated by independent
40 activity and resulted in the formation of an intrasubunit disulfide bond between Cys315 and Cys318.
41                  These results indicate that intrasubunit disulfide bond formation leads to a global
42 eroxide radical, and the connectivity of the intrasubunit disulfide bond in P. leiognathi CuZnSOD are
43 ependent upon the oxidation of the conserved intrasubunit disulfide bond in SOD1.
44 5) compromised CCS-mediated oxidation of the intrasubunit disulfide bond in vivo.
45 ubunit loop 2 and its end is "latched" by an intrasubunit disulfide bond to the beta-subunit core.
46 beled hBCATm showed that during labeling, an intrasubunit disulfide bond was formed in a significant
47                             Reduction of the intrasubunit disulfide bond within each SOD1 subunit by
48 lfide mechanism, Tpx contains a redox-active intrasubunit disulfide bond yet is homodimeric in soluti
49 mature form, lacking metal and a stabilizing intrasubunit disulfide bond, apoSOD1(2SH), is dynamic an
50 impaired metal ion binding, reduction of the intrasubunit disulfide bond, or oxidative modification.
51  of SOD1, a protein incapable of forming the intrasubunit disulfide bond, sediments as a monomer in t
52                                           An intrasubunit disulfide bond, seen in the crystal structu
53 tion of alpha-bungarotoxin-binding sites and intrasubunit disulfide bonding, apparently within the al
54  indicates that native as well as non-native intrasubunit disulfide bonds form in monomeric intermedi
55                                              Intrasubunit disulfide bonds formed between these Cys pa
56              Mutants of gp45 with inter- and intrasubunit disulfide bonds were created to alter the s
57    Mutation of two cysteines not involved in intrasubunit disulfide bonds, C49 and C146, had modest e
58                                    Among six intrasubunit disulfide bonds, Cys 48-Cys 139 and Cys' 48
59 hydrogenase (MADH) requires formation of six intrasubunit disulfide bonds, incorporation of two oxyge
60        The structure also reveals inter- and intrasubunit disulfide bonds, mostly in the extended N-t
61 on response, likely by formation of multiple intrasubunit disulfide bonds.
62 CL (gammaCys-7/gammaCys-16) that likely form intrasubunit disulfide bonds.
63 :Zn2+ site by H2O2 leads to the formation of intrasubunit disulfide bonds.
64 XC motif at the C terminus, and two pairs of intrasubunit disulfide bridges may play an important rol
65  domain (C289A), predicted to be involved in intrasubunit disulfide bridging, resulted in disulfide-l
66                                       For an intrasubunit disulfide mutant, the distance between thes
67 monstrate that Cys(429) and Cys(476) form an intrasubunit disulfide while the intersubunit disulfides
68 tersubunit disulfide formation by forming an intrasubunit disulfide with Cys578 and therefore mutated
69 globulin polypeptides largely accumulated as intrasubunit disulfide-linked polypeptides with apparent
70                      For the mutants without intrasubunit disulfides, the efficiency of fluorescence-
71  a combination of an ion pair cluster and an intrasubunit disulphide bond.
72 curs with positive cooperativity and induces intrasubunit domain reorientations to expose the catalyt
73 ely 20 A from the ligand binding site at the intrasubunit domain-domain interface.
74 robe the conformational heterogeneity at the intrasubunit domain-domain interface.
75 wn whether ligand binding is intersubunit or intrasubunit, either for agonists or for allosteric modu
76               Modeling studies imply that an intrasubunit electron transfer accounts for the reductio
77 ional as a homodimer and that it utilizes an intrasubunit electron transfer pathway through the singl
78 on-glucosylated glycogenin produced by dimer intrasubunit glucosylation was 16% of that produced by t
79 red fifth methylation site, E502, lies at an intrasubunit helix interface closest to the HAMP domain
80  intersubunit connection and the other is an intrasubunit hinge located between domains I and II.
81                              One point is an intrasubunit hinge point that sharply divides the struct
82 a lever-like swinging motion pivoting on the intrasubunit hinge, and the entire TM2 bundle undergoes
83 ke" sequential formation of intersubunit and intrasubunit hydrogen bonds between backbone atoms of se
84  that suggests that Ala-40 contributes to an intrasubunit hydrophobic core, the principal effect of t
85                The substrate-binding site is intrasubunit in P22 and HK620 tailspikes, but intersubun
86 increased the rate of modification of T254C (intrasubunit), indicating that propofol binding induces
87 ers in which 1) cis-allostery is mediated by intrasubunit interactions and 2) trans-allostery require
88 hese results highlight the distinct roles of intrasubunit interactions and intersubunit communication
89 tatics and open duration changes result from intrasubunit interactions and structural flexibility.
90 he extracellular domain by short linkers and intrasubunit interactions between residues in the putati
91        Interestingly, cTnI-R145G blunted the intrasubunit interactions between the cTnI N-terminal ex
92 osphomimic mutations led to the formation of intrasubunit interactions between the N-terminus and the
93                     The 986-990 region holds intrasubunit interactions between the TRP domain and the
94    Here we investigate both intersubunit and intrasubunit interactions between TM helices of P2X rece
95 TPase activity, identifying intersubunit and intrasubunit interactions by protein-protein crosslinkin
96   These findings indicate that inter- and/or intrasubunit interactions in the TRP domain are essentia
97 eutral pH structure through intersubunit and intrasubunit interactions that presumably inhibit the co
98                                    Extensive intrasubunit interactions were observed in the closed st
99 ily to intersubunit interactions rather than intrasubunit interactions.
100 well as a network of transitional inter- and intrasubunit interactions.
101 tions affect critical residues and inter- or intrasubunit interactions.
102 les formed by the N and C domains and in the intrasubunit interface between N and C domains form cond
103 a fourth cross-linking pair that spanned the intrasubunit interface between transmembrane helix 1 (TM
104 ctures reveal inhibitor binding sites in the intrasubunit interface that are validated by functional
105 ic phenoxyalkoxy side chains extend into the intrasubunit interfaces between helices S5 and S6.
106 ding and effector sites involving inter- and intrasubunit interfaces.
107  complete its autoglucosylation by the dimer intrasubunit mechanism.
108     The data imply some degree of inter- and intrasubunit negative cooperative interaction between si
109 erodimers able to glucosylate exclusively by intrasubunit or intersubunit reaction mechanisms.
110 hown to generate an approximately 1 angstrom intrasubunit piston-type movement of one transmembrane h
111  vestibule of the receptor, in a preexisting intrasubunit pocket opposite the agonist binding site an
112                Water fluxes through separate intrasubunit pores were unaltered by the furan compounds
113 l disulfide centers occurred as an inter- or intrasubunit process in dimeric AhpF.
114 ctron transfer between domains of AhpF is an intrasubunit process.
115 results identify for the first time a single intrasubunit propofol binding site in the nAChR transmem
116 GLIC via a membrane-embedded tunnel using an intrasubunit protein lumen as the conduit, an observatio
117 designed for examining both intersubunit and intrasubunit protein-protein interactions.
118 analysis of these mutant enzymes reveals the intrasubunit rearrangements that occur upon substrate bi
119 onovalent Fabs, while those that bind at the intrasubunit region require divalency.
120          Recent structural studies implicate intrasubunit rotation of the 30S head in translocation.
121 S-H groups increases, implying that specific intrasubunit S-H.X hydrogen bonds must be weakened to ef
122                 Here, we identify a critical intrasubunit salt bridge between conserved charged resid
123 s modification of Cys93(F9)beta disrupts the intrasubunit salt bridge between His146(HC3)beta and Asp
124 ther loop conformation favors an alternative intrasubunit salt bridge, similar to that found in the E
125 pH they form a complex network of inter- and intrasubunit salt bridges and hydrogen bonds near the bu
126 GAPDHs is also correlated with the number of intrasubunit salt links and total hydrogen bonds.
127 P and allow the identification of a possible intrasubunit signal transduction pathway that controls t
128 ithin the nAChR transmembrane domain: (i) an intrasubunit site in the delta subunit helix bundle, pho
129 intravenous anesthetic etomidate binds at an intrasubunit site in the transmembrane domain and stabil
130                                           An intrasubunit site is adjacent to the GABA-recognition si
131 but that state-dependent binding to a single intrasubunit site mediates DHA inhibition of ELIC.
132 d by molecular dynamics simulations revealed intrasubunit sites for most halothane binding and inters
133 regnanolone and epi-allopregnanolone bind to intrasubunit sites in the beta(3) subunit, promoting rec
134                    In the outer leaflet, two intrasubunit sites were evident in both closed and open
135                 Rather, S-mTFD-MPPB binds to intrasubunit sites within the alpha and delta subunits,
136  have provided evidence for intersubunit and intrasubunit steroid-binding sites in the GABA(A)R trans
137                               We find strong intrasubunit TM1-TM2 interactions, as well as TM1-TM1' a
138 gh the binding-gating coupling preferred the intrasubunit to intersubunit configuration within the C
139  reducing the Mn-to-Mn distance from 25.9 A (intrasubunit) to 21.5 A (intersubunit).
140 ta[c]quinoline-8-sulfonamide) interact at an intrasubunit transmembrane site.
141 ly packed conformation with water-accessible intrasubunit vestibules penetrating from the extracellul

 
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