ライフサイエンスコーパス: intratracheally

1 (i.p.), or mucosally (i.e., intranasally or intratracheally).

2 for 4 days followed by 1.2 x 108 Pseudomonas intratracheally.

3 posed to 1 x 10 cells/mouse of C. neoformans intratracheally.

4 ession in the lung (>42 days) when delivered intratracheally.

5 tion when administered systemically, but not intratracheally.

6 ory settings, 4 mL/kg of beractant was given intratracheally.

7 eak that occurs after administration of IL-1 intratracheally.

8 il chemoattractant levels as rats given IL-1 intratracheally.

9 (HNE) when the inhibitors were administered intratracheally.

10 scular leak that develops in rats given IL-1 intratracheally.

11 e in vivo when administered either orally or intratracheally.

12 attractant (CINC) levels, in rats given IL-1 intratracheally.

13 crease in peak airway pressure when measured intratracheally.

14 tein increases compared with rats given IL-1 intratracheally.

15 e and absent in hamsters who received quartz intratracheally.

16 nge only in monkeys given booster injections intratracheally.

17 then exposed these mice to PM(2.5) or saline intratracheally.

18 ount of normal saline (pH 5.3) was instilled intratracheally.

19 Control mice received saline solution intratracheally (0.05 mL, pulmonary control) or intraper

20 received Escherichia coli lipopolysaccharide intratracheally (2 mg/kg in 0.05 mL of saline/mouse, pul

21 were sensitized to cockroach Ag, challenged intratracheally 21 days later, and compared with STAT4-c

22 The MAbs were administered intratracheally 24 h before the calves were challenged w

23 ed either Fas-, caspase-8-, or control-siRNA intratracheally 4 hours after hemorrhage.

24 nt with keratinocyte growth factor (injected intratracheally 48 hrs before the experiment) on alpha-n

25 volved effect, we administered KGF (5 mg/kg, intratracheally) 48 h prior to ANTU (50 mg/kg, intraperi

26 Moreover, GM-CSF applied intratracheally activated CD103+ DCs, inducing increased

27 ls were recruited to the lung in response to intratracheally administered A. fumigatus conidia.

28 mice were then pretreated with 10(9) PFU of intratracheally administered adenoviral vector containin

29 Intratracheally administered Cy-5-labeled Fas-siRNA loca

30 e lung injury in rats, we have compared four intratracheally administered cytokines for their protect

31 onse of the lung and systemic circulation to intratracheally administered Escherichia coli lipopolysa

32 ered recombinant (r) interleukin (IL)-10 was intratracheally administered for 3 doses initiated 5 h f

33 s (hUC-MSCs) primed with Liproxstatin-1 were intratracheally administered four days prior to sampling

34 the increase in white blood cells induced by intratracheally administered HNE (100 micrograms/hamster

35 We intratracheally administered Klebsiella pneumoniae to wi

36 independent approaches, we demonstrate that intratracheally administered LNA gapmer ASOs robustly in

37 Intratracheally administered NONOates result in selectiv

38 Exogenous, intratracheally administered PAI-1 prevented the inhibit

39 Intratracheally administered PEG-PLGA based optimized fo

40 e (WT) and transgenic mice were injured with intratracheally administered saline or bleomycin, and th

41 Intratracheally administered sildenafil particles elicit

42 Intratracheally administered TLR2 agonist caused increas

43 impact of sRAGE, the recombinant protein was intratracheally administered to mice, which demonstrated

44 L-33 knockout, ST2 knockout mice were either intratracheally administrated with 500 ng of rIL-33 per

45 g with wild-type C57BL/6 mice were immunized intratracheally against P. carinii, depleted of T cells

46 LPS-induced acute lung injury by delivering intratracheally an adenovirus construct that expressed M

47 nactivated white birch pollen extract (BPEx) intratracheally and injected with the antioxidants, N-ac

48 neration adenoviral (Ad) vector administered intratracheally and intravenously.

49 We injected elastase intratracheally and the RAGE antagonist FPS-ZM1 in mice,

50 In contrast, rats given IL-1 intratracheally and TNFbp intravenously had the same ele

51 ficient (BLT1(-/-)) BMDCs or wild-type BMDCs intratracheally and were then challenged with OVA for 3

52 e were challenged with Klebsiella pneumoniae intratracheally, and organs were harvested at 8, 24, and

53 a good pharmacokinetic property, when given intratracheally, and the blood cells from such pharmacok

54 When mutants were inoculated intratracheally, any receptor, except for GerX, was suff

55 duced by Escherichia coli lipopolysaccharide intratracheally (ARDSp) or intraperitoneally (ARDSexp).

56 nized orally and intranasally at 0 weeks and intratracheally at 12 weeks with an adenovirus type 5 ho

57 containing 8.5 mg/kg cHyp or tHyp instilled intratracheally at 7 and 14 d after bleo.

58 Recombinant IL-6 instilled intratracheally at commencement of injury led to substan

59 Pregnant rats were inoculated intratracheally at midterm using recombinant RSV express

60 T+P was administered intratracheally at the time of sensitization in three do

61 (n = 6) or O(2) combined with rhSOD (5 mg/kg intratracheally) at birth (n = 4), rhSOD at 4 h of age (

62 Exogenous SP-D administered intratracheally attenuated BLM-induced lung fibrosis in

63 H4R agonist 4-methylhistamine when delivered intratracheally before Ag challenge mitigated airway hyp

64 osis when low doses of HKL were administered intratracheally but did not support the proliferation of

65 model of lung injury, anti-C5a administered intratracheally (but not intravenously) reduced in a dos

66 The Syk inhibitor NVP-QAB-205 was nebulized intratracheally by using a treatment-based protocol 15 m

67 R4-, MyD88-deficient and WT BALB/c mice were intratracheally challenged with PM2.5 +/- ovalbumin (OVA

68 (100% mortality) to pulmonary infection when intratracheally challenged, at day 3 after CLP, with via

69 entrations were increased in rats given IL-1 intratracheally compared with sham-treated control rats.

70 trol mice (Healthy) received saline solution intratracheally (Cp) or intraperitoneally (Cexp).

71 aging techniques for real-time monitoring of intratracheally delivered cells.

72 the effect of FGF-10 on LR-MSCs, FGF-10 was intratracheally delivered into the lungs of rats.

73 In addition, we explored the effect of intratracheally delivered liposomally encapsulated CG/NE

74 We report on the transport and deposition of intratracheally delivered stem cells as well as strategi

75 h the murine IFN-gamma (mIFN-gamma) gene and intratracheally delivered the macrophages to express mIF

76 Mice were administered bleomycin intratracheally followed by intravenous injection of rec

77 ptor 1 knockout (IL-1R(-/-)) mice challenged intratracheally, fungal recovery on day 7 after infectio

78 We found that rats given IL-1 intratracheally had increased lung lavage fluid tumor ne

79 ncreases risk of mycobacterial infection, we intratracheally (I.T.) administered silica, a control du

80 ation of LT-HDM plus recombinant IL-33, were intratracheally (i.t.) administered to induce allergic a

81 tes neuropeptide stores, and then challenged intratracheally (i.t.) with hen egg lysozyme (HEL).

82 Mice were inoculated with live E. coli intratracheally (i.t.) with or without adenosine or a no

83 T), TLR2(-/-), TLR4(-/-), or MyD88(-/-) mice intratracheally (i.t.) with recombinant cHSP60 (50 micro

84 rst intranasally (i.n.) plus orally and then intratracheally (i.t.), followed by envelope protein boo

85 Mice were challenged intratracheally (i.t.), intravenously (i.v.), or intrape

86 nged with 10(2) CFU of Klebsiella pneumoniae intratracheally (i.t.), resulting in the time-dependent

87 esothelioma) and LKR (lung cancer) tumors or intratracheally in a Kras orthotopic lung tumor model.

88 l accumulation, after administration of IL-1 intratracheally in rats.

89 more widespread in the respiratory tract for intratracheally infected guinea pigs.

90 In contrast, lungs from intratracheally infected mindin-deficient mice contained

91 Rats were intratracheally infected with 109 colony-forming units o

92 When pigs were intratracheally infected with A. pleuropneumoniae, pigs

93 Mice were intratracheally infected with either a wild-type P. aeru

94 rgeted (IL-12p40-/-) and wild-type mice were intratracheally infected with respiratory syncytial viru

95 ent (CCSP(-/-)) and wild-type (WT) mice were intratracheally infected with RSV and the lung inflammat

96 00-PPM (supplemented) alpha-Toc for 4 wk and intratracheally infected with S. pneumoniae.

97 In rat pups, we intratracheally injected either bleomycin to induce ALI

98 The migration of intratracheally injected eosinophils into paratracheal l

99 ic mice, fluorescently labeled ex vivo, were intratracheally injected into ovalbumin-sensitized and o

100 L/6J wild-type (WT) and Mfge8(-/-) mice were intratracheally injected with LPS (5 mg/kg).

101 defective in acute lethality (24 to 48 h) to intratracheally inoculated A/J mice.

102 All three viruses replicated in lungs of intratracheally inoculated pigs, yet nasal shedding was

103 he lack of PPARgamma, PPARgamma KO mice were intratracheally inoculated with a PPARgamma lentivirus c

104 Albino C57 female mice were intratracheally inoculated with either live or dead Kleb

105 Mice were intratracheally inoculated with Klebsiella pneumoniae an

106 d of their TCR beta- and/or delta-chain were intratracheally inoculated with Klebsiella pneumoniae.

107 RAP-deficient and wild-type littermates were intratracheally inoculated with Kp or Pa.

108 Ten 8-week-old pigs were intratracheally inoculated with M. hyopneumoniae Matched

109 1,250 6-week-old pigs housed in 46 pens were intratracheally inoculated with M. hyopneumoniae Thereaf

110 thout selective CD4(+)-T-cell depletion were intratracheally inoculated with Pneumocystis organisms.

111 To do so, Escherichia coli was intratracheally instilled into C57BL/6 mice in the prese

112 The mIFN-gamma-producing macrophages were intratracheally instilled into mechanically ventilated s

113 Here, we describe an intratracheally instilled lentiviral system able to deli

114 cterial DNA in lower airway inflammation, we intratracheally instilled prokaryotic and eukaryotic DNA

115 (SH), and SH heart failure (SHHF) rats were intratracheally instilled with 0.0, 0.25, or 1.0 mg LA (

116 rmula: see text] (wild-type, tgWT) mice were intratracheally instilled with either vehicle or DEP for

117 nflux by 93% and protein leak by 55% in mice intratracheally instilled with FMLP.

118 After challenge, mice were intratracheally instilled with saline vehicle or 3 mg/kg

119 Control mice were intratracheally instilled with sterile phosphate-buffere

120 c alcohol abuse mouse model was developed by intratracheally instilling the subunit 1 (S1) of SARS-Co

121 fibrosing alveolitis, we instilled bleomycin intratracheally into gelatinase B-deficient mice and gel

122 of heat-killed Listeria (HKL) were injected intratracheally into Lewis rats.

123 These AMs were administered intratracheally into mechanically ventilated SCID mice.

124 Cryptococcus neoformans was inoculated intratracheally into mice lacking the IFN-gamma receptor

125 These labeled cells, instilled intratracheally into normal mice, migrated into draining

126 after 7 days of culture and were inoculated intratracheally into susceptible scid mice.

127 constitutively active form of Akt introduced intratracheally into the lungs of mice by adenovirus gen

128 n fluorescent protein-siRNA was administered intratracheally into transgenic mice overexpressing gree

129 7.2 x 105 or 1.9 x 107 cfu/mL) was instilled intratracheally into untreated C57Bl/6 mice, C57Bl/6 mic

130 carinii directly, organisms were inoculated intratracheally into wild-type mice and into three group

131 cubated with OVA Ag in vitro, were instilled intratracheally into wild-type recipient mice that adopt

132 , PCF alone, or RW alone and then challenged intratracheally, intranasally, and supraocularly with RW

133 ntrol, BALB/c (wild-type), mice were treated intratracheally, intraperitoneally, or intravenously, wi

134 45 virus, administered intranasally (in) and intratracheally (it) in the presence of high levels of P

135 model in mice with lipopolysaccharide (LPS) intratracheally (IT), 1 mg kg(-1), or intravenously (IV)

136 A potent and selective Rip2 siRNA given intratracheally knocked down Rip2 expression in OVA-chal

137 Following intratracheally LPS treatment, CD44(-/-) mice demonstrat

138 se ragweed-immunized mice were given ragweed intratracheally on day 11.

139 BALB/c mice were exposed intratracheally once to DEP or 9 times over 3-weeks to e

140 e (5 mL/kg each) was administered as a bolus intratracheally or by aerosolization for 6 hrs.

141 ese studies, apoptotic thymocytes were given intratracheally or i.p. to normal mice, and then AMphi o

142 g injury, animals treated with anti-PcrV IgG intratracheally or i.v. had significant decreases in lun

143 ere given Escherichia coli or saline, either intratracheally or intravenously.

144 stromal cell-derived extracellular vesicles intratracheally preceding ventilation.

145 In the present studies, HMG-1 given intratracheally produced acute inflammatory injury to th

146 y Escherichia coli lipopolysaccharide either intratracheally (pulmonary acute lung injury) or intrape

147 erichia coli lipopolysaccharide administered intratracheally (pulmonary acute respiratory distress sy

148 ngeneic WT but not TLR9-/- mice administered intratracheally reconstituted antibacterial immunity in

149 nged with 10(2) CFU of Klebsiella pneumoniae intratracheally, resulting in the time-dependent express

150 For asthma induction, mice were intratracheally sensitized with OVA or cat dander extrac

151 can green monkeys immunized intranasally and intratracheally, the mean peak titer of the P chimera wa

152 vector in PBS, or PBS alone was administered intratracheally to ACI (RT1(a)) rats.

153 P. aeruginosa was administered intratracheally to determine the mortality rate at incre

154 e protein (MPV/S-2P), delivered intranasally/intratracheally to male rhesus macaques.

155 t attenuating inflammation when administered intratracheally to mice challenged with LPS.

156 e proinflammatory, bombesin was administered intratracheally to mice.

157 after administration of interleukin-1 (IL-1) intratracheally to rats and tested this premise by using

158 ry distress syndrome, and administering IL-1 intratracheally to rats causes an acute, neutrophil-depe

159 IL-13 was delivered intratracheally to wild-type, signal transducer and acti

160 Alveolar-like macrophages were intratracheally transplanted to the injured animals and

161 I restimulation by lymphoid cells from three intratracheally treated mice showed an attenuation in th

162 ells isolated by bronchoalveolar lavage from intratracheally treated TRAF1-/- mice produced more TNF-

163 Rats were inoculated intratracheally with 1 of 6 S. aureus isolates from the

164 knockout (TLR9-/-) BALB/c mice were infected intratracheally with 10(4) C. neoformans 52D.

165 ations in IFN-gamma and IL-4 were inoculated intratracheally with 10(5) CAR bacillus organisms, and s

166 male BALB/c and C57BL/6 mice were inoculated intratracheally with 10(5) CAR bacillus organisms.

167 e of monoclonal antibodies, and rechallenged intratracheally with 10(7) viable P. carinii organisms.

168 erent routes such as i.m., intradermally, or intratracheally with a DNA vaccine to rabies virus devel

169 NHPs were challenged intranasally and intratracheally with a high dose (3 x 10(6) plaque formi

170 ched nonvaccinated controls intranasally and intratracheally with a high dose of heterologous SARS-Co

171 nockout (MIP-1alpha(-/-)) mice were infected intratracheally with a highly virulent strain of C. neof

172 duration of disease in naive rats challenged intratracheally with a lethal dose of the virulent type

173 C3H/HeN mice were inoculated intratracheally with a mouse-adapted clinical Ureaplasma

174 a study, in which we inoculated C57Bl/6 mice intratracheally with BLM or saline, and tested the anima

175 immune complexes were treated either i.v. or intratracheally with blocking Ab to murine IL-12, there

176 6 mice and Hartley guinea pigs were infected intratracheally with C. burnetii Nine Mile phase I (NMI)

177 RA(+/+) mice and SRA(-/-) mice were infected intratracheally with C. neoformans.

178 ite rabbits were inoculated intranasally and intratracheally with C. pneumoniae, strain AR-39, and pr

179 Two groups of C. jacchus were inoculated intratracheally with cell culture supernatant containing

180 Mice infected intratracheally with Cryptococcus neoformans (Cne) requi

181 rted eosinophilic pneumonia in mice infected intratracheally with Cryptococcus neoformans.

182 Next, rats were instilled intratracheally with either saline (sal) or 1.2 U bleo,

183 onally, passive anti-PC IgM Abs administered intratracheally with HDMs decreased allergen uptake by e

184 ry immune response, Lewis rats were injected intratracheally with heat-killed Listeria (HKL), labeled

185 r proasthmatic effects, mice were inoculated intratracheally with IL-4 or IL-13, and pulmonary gene i

186 pe, Cfb(-/-), and C3(-/-) mice were infected intratracheally with Klebsiella pneumoniae (KP) and asse

187 sodium arsenite for 5 wk and then challenged intratracheally with Klebsiella pneumoniae, Streptococcu

188 ella pneumophila infections, were inoculated intratracheally with L. pneumophila (10(6) bacteria per

189 pneumophila lung infections, were inoculated intratracheally with L. pneumophila AA100, AA488, or AA5

190 lung infection, were subsequently inoculated intratracheally with L. pneumophila-infected H. vermifor

191 A/J mice inoculated intratracheally with L. pneumophila-infected H. vermifor

192 l diet or a liquid control diet and infected intratracheally with low-dose M. tuberculosis H37Rv.

193 Rats treated intratracheally with LPS generate lipid-derived free rad

194 p. OVA sensitization (day 0) were challenged intratracheally with OVA on days 8, 15, 18, and 21.

195 When pretreated mice were challenged intratracheally with OVA, their bronchoalveolar lavage f

196 Finally, IFN-gamma-/- mice challenged intratracheally with P. carinii resolved their infection

197 CR(+) T-cell-deficient) mice were inoculated intratracheally with P. carinii.

198 ined immunodeficiency (scid) were inoculated intratracheally with P. carinii.

199 were depleted of CD4+ T cells and inoculated intratracheally with Pneumocystis.

200 Mice were challenged intratracheally with Pseudomonas aeruginosa, and on the

201 tein promoter (CCSP-IL-4 mice) were infected intratracheally with Pseudomonas aeruginosa.

202 Mice were infected intratracheally with S. aureus, bronchoalveolar lavage a

203 .3(-/-)) mice were sensitized and challenged intratracheally with Schistosoma mansoni soluble egg ant

204 Subjects were inoculated intratracheally with Streptococcus pneumoniae and contro

205 V-seronegative monkeys to monkeys inoculated intratracheally with SVV, in which viral DNA and RNA per

206 Mice immunized intranasally or intratracheally with the F1 antigen of Yersinia pestis a

207 X [n = 25]) were inoculated intranasally and intratracheally with the ISU-1 strain of PRCV (1 x 10(7)

208 Aged mice injected intratracheally with TNF-alpha exhibited a more pronounc

209 ent BALB/c mice and GKO mice were inoculated intratracheally with virulent L. pneumophila (10(6) bact

210 Rabbits infected intratracheally with wild-type (wt) GBS developed focal

211 ate-buffered saline (PBS)/PBS and challenged intratracheally with wild-type measles virus (MeV) 8-9 m

212 lfonic acid-sensitized cells and challenged (intratracheally) with the hapten developed pulmonary int

213 Syrian hamsters were treated, intratracheally, with clodronate-encapsulated liposomes

214 obilized onto polystyrene beads and injected intratracheally yielded comparable results to those obse