ライフサイエンスコーパス: intravenous dose

1 currently recommended for adults (twice the intravenous dose).

2 rmacokinetics were determined after a single intravenous dose.

3 vided doses starting at five times the daily intravenous dose.

4 metric mean ratio of the subcutaneous to the intravenous dose.

5 ion in the tumor was less than 1% of 20mg/kg intravenous dose.

6 micromol/L and 13 400 micromol/L for a 50-g intravenous dose.

7 1 oral dose of HAV was equivalent to 10(4.5) intravenous doses.

8 oral voriconazole (VRC) doses are lower than intravenous doses.

9 duced TNF release and shock as compared with intravenous dosing.

10 ted with both T. congolense and T. vivax via intravenous dosing.

11 ieving an MED of 1.5 mg/kg, following weekly intravenous dosing.

12 d the safety and pharmacodynamics of single, intravenous doses (0.025, 0.05, and 0.1 mg/kg) of Hemati

13 After the single intravenous dose (1.52 +/- 0.47 mg/kg), gastric pH incre

14 r patients with IgG4-RSD were treated with 2 intravenous doses (1 gram each) of rituximab.

15 Except for the maximum intravenous dose (10 microg/kg), neither delivery method

16 vasopressin receptor antagonist, at a single intravenous dose (10, 20, or 40 mg) or placebo.

17 eliver beta-radiation to tumors via a single intravenous dose (3 or 6 MBq) in mice bearing SK-RC-52 R

18 been given a single oral (10 g) and a single intravenous dose (30 g) of exogenous L-arginine.

19 disease received six cycles every 3 weeks of intravenous, dose-adjusted etoposide, prednisone, vincri

20 esiologist infusing a single, subanesthetic, intravenous dose, and required hospitalization for at le

21 time in tumor tissue, is well-tolerated upon intravenous dosing, and is highly efficacious in the COL

22 lethal Staphylococcus aureus infection after intravenous dosing, and one compound showed protective e

23 l cord, skin and muscle of rats after single intravenous dose at 6 mg/kg.

24 loride vehicle in a divided subcutaneous and intravenous dose at PN commencement.

25 re measured after administration of oral and intravenous doses at a dose range of 0.015 to 1.25 g, an

26 Intravenous-dose clearance, volume of distribution at st

27 BP transgenic mice, for which a single 1 mug intravenous dose cleared established infection.

28 ock the LH surge in all animals, whereas all intravenous doses consistently blocked the LH surge.

29 After administration of a single intravenous dose, each drug was rapidly cleared from pla

30 Pharmacokinetics support intravenous dosing every 28 days.

31 ative urinary d6-alpha-CEHC derived from the intravenous dose excreted over 72 h during the 40% fat (

32 umulative urinary d6-a-CEHC derived from the intravenous dose excreted over 72 h during the 40% fat (

33 or 7 days (with or without an initial 400-mg intravenous dose) followed by placebo for 7 days (n = 12

34 The suggested intravenous dose for a phase II study will be 1.5 mg/m2/

35 prednisolone 0.5 to 1 mg/kg/day divided in 2 intravenous doses for 3 days.

36 brain and cerebrospinal fluid after repeated intravenous dosing for up to 4 months in Tg2576 transgen

37 , and 15 of every 21-day cycle (group 2); or intravenous dose-fractionated carboplatin (AUC2) and int

38 nous carboplatin (AUC5 or AUC6) on day 1 and intravenous dose-fractionated paclitaxel (80 mg/m(2) by

39 ous dose-fractionated carboplatin (AUC2) and intravenous dose-fractionated paclitaxel (80 mg/m(2) by

40 dose-escalation design, including different intravenous doses (from 5 mg/kg to 30 mg/kg) and interva

41 ationale for a 1000 mg twice or thrice daily intravenous dose in humans or saline as a control.

42 to-plasma ratio of approximately 3 following intravenous dosing in mice.

43 ical clearance data were generated following intravenous dosing in rats/NHPs and compared to the huma

44 ugs in use against HAT are toxic and require intravenous dosing, new drugs are needed.

45 one experiment, 2 monkeys received a single intravenous dose of (225)Ac-HuM195 at 28 kBq/kg.

46 ts (6 PC, 2 BC, and 2 UBC) received a single intravenous dose of (68)Ga-NOTA-AE105 (154 +/- 59 MBq; r

47 ts (6 PC, 2 BC, and 2 UBC) received a single intravenous dose of (68)Ga-NOTA-AE105 (154 +/- 59 MBq; r

48 icipants were randomized 4:4:1 to a one-time intravenous dose of (R)-propafenone, (S)-propafenone, or

49 Each patient received tacrolimus (4-hr intravenous dose of 0.04 mg/kg between postoperative day

50 at an oral dose of 0.8 mg/kg in rats and an intravenous dose of 0.06 mg/kg in baboons.

51 After randomization, an intravenous dose of 0.125 mg/kg lenercept or placebo was

52 Four groups received a single intravenous dose of 1, 5, 20, or 40 mg/kg of VRC07-523LS

53 ion in the allergic guinea pig by 50%, at an intravenous dose of 10 mg/kg.

54 A single preoperative intravenous dose of 1000 mg of cefazolin (cefazolin grou

55 Patients were treated with O(6)-BG at an intravenous dose of 120 mg/m(2) followed 1 hour later by

56 tructure infections received either a single intravenous dose of 1200 mg of oritavancin or a regimen

57 The drug is administered as a single intravenous dose of 1200 mg over 3 hours in adult patien

58 We have found that a single intravenous dose of 150 microCi (200 microg) 90Y-CHX-A"-

59 as not detected in plasma 5 min following an intravenous dose of 2 mg/kg.

60 plasminogen activator (tPA) using a standard intravenous dose of 3.3mg/kg (20% bolus, 80% infused), w

61 lant protein c2 was administered as a single intravenous dose of 30 mug/kg body weight at onset of he

62 umab, n = 169 placebo), and 333 received >=1 intravenous dose of 300 mg vedolizumab (n = 168) or plac

63 Phase 1c patients (n = 27) received one intravenous dose of 300 or 1800 mg MTPS9579A or placebo.

64 a 31% T/C at its solubility-limited maximum intravenous dose of 33 micromol/kg in MDA-MB-435 breast

65 atic malignancies were administered a single intravenous dose of 5 mCi 111In-diethylenetriaminepentaa

66 al resection were each administered a single intravenous dose of 5 mg of isothiocyanatobenzyl diethyl

67 Results suggest an intravenous dose of 5 mg/kg/dose every 12 hours may be a

68 Cetuximab was given as an intravenous dose of 500 mg/m(2) every 2 weeks with regim

69 The dexamethasone group received a 2-mL intravenous dose of 8 mg of dexamethasone 60 minutes bef

70 ants, 203 were randomly assigned to a single intravenous dose of 800 mg iron-carboxymaltose and 202 t

71 We infused a single intravenous dose of a codon-optimized adeno-associated v

72 9(+) lymphoma xenograft model using a single intravenous dose of AAV expressing a secreted version of

73 Single intravenous dose of AB103 (0.5 or 0.25 mg/kg) within 6 h

74 Factor XI inhibition with a single intravenous dose of abelacimab after total knee arthropl

75 Here we demonstrate that a single intravenous dose of acellular hAF provides functional ca

76 Patients received a single intravenous dose of afami-cel (transduced dose range 1.0

77 nteractive web response system to receive an intravenous dose of ALD403 1000 mg or placebo.

78 No safety concerns were noted with an intravenous dose of ALD403 1000 mg.

79 ntidepressant effects resulted from a single intravenous dose of an N-methyl-D-aspartate antagonist.

80 ntidepressant effects resulted from a single intravenous dose of an N-methyl-D-aspartate antagonist;

81 Nurses then administered an intravenous dose of an opioid from a sliding scale presc

82 The evidence favors an intravenous dose of around 1 mg of elemental iron per da

83 A or Ad5PA and then challenged with a lethal intravenous dose of Bacillus anthracis lethal toxin.

84 ed by measuring changes in blood T2 after an intravenous dose of BMS 180550 were used to determine cl

85 Patients received four intravenous dose of bortezomib (1.3 mg/m(2)) over 2 week

86 gram, to receive either a single, continuous intravenous dose of brexanolone or placebo for 60 h.

87 We demonstrate applications of a single, intravenous dose of CAP-Mac to deliver functional GCaMP

88 atients were recruited and received a single intravenous dose of cefazolin (15 mg/kg) and tobramycin

89 f oral doxycycline, with or without a single intravenous dose of ceftriaxone, or 20 days of oral doxy

90 ion subjects were randomized 3:1 to a single intravenous dose of ciraparantag (Study 1: 30, 60, or 12

91 In the present study a single intravenous dose of clomipramine (200 mg) was compared w

92 ted lipid-lowering therapy received a single intravenous dose of CTX310 (0.1, 0.3, 0.6, 0.7, or 0.8 m

93 A single systemic intravenous dose of D-2MPPA on postnatal day 1 (PND1) de

94 Two days later, a single intravenous dose of diclofenac (2 mg/kg) (treated animal

95 Ten pigs (35-45 kg) received an intravenous dose of disrupted mitochondrial products and

96 e sequentially allocated to receive a single intravenous dose of either 0.1, 1, 5, or 10 mg/kg of MRA

97 atment in a randomized fashion with a single intravenous dose of either CDP571 (5 mg/kg) or an equiva

98 > 20, ability to swallow, and </= one single intravenous dose of empiric antibiotic therapy before st

99 both adult and juvenile Fabry mice, a single intravenous dose of EXG110 achieved supraphysiological p

100 5 concomitant with or 4 hours after a single intravenous dose of hemoglobin abolished hemoglobin-indu

101 , 8, 20, and 40 mg/kg) and received a single intravenous dose of HGS004 or placebo.

102 en-label, two-part study evaluating a single intravenous dose of HIV-1 bNAbs, PGT121, PGDM1400 and VR

103 A single intravenous dose of IceMG (2mg/kg) induced a significant

104 naive Wistar rats immediately after a single intravenous dose of indinavir.

105 in rats administered a nontoxic 0.5 mumol/kg intravenous dose of inorganic mercury with or without 2.

106 e five arms in a 1:1:1:1:1 fashion: a single intravenous dose of ketamine 0.1 mg/kg (n = 18), a singl

107 Rapid anti-OCD effects from a single intravenous dose of ketamine can persist for at least 1

108 A single intravenous dose of lipid-siRNA conjugate was delivered

109 trecogin alfa (activated) infusion before an intravenous dose of lipopolysaccharide.

110 A low intravenous dose of M8-B did not affect T(b) at either a

111 was reduced for at least 7 days by a single intravenous dose of mAb 2021.

112 treated rejection (P=0.035) and lower median intravenous dose of methyl-prednisolone (P=0.017) than N

113 andomised trial to assess treatment with one intravenous dose of MSCs compared with placebo.

114 s, which regressed completely after a single intravenous dose of MV-NIS, and in MM1 myeloma xenograft

115 2 copies of SMN2 previously treated with an intravenous dose of onasemnogene abeparvovec in START.

116 e of >=5 were randomized to receive a single intravenous dose of placebo (n = 7 patients) or OP-101 a

117 Patients were randomized to receive a single intravenous dose of placebo or an infusion of ibutilide

118 Patients received a single intravenous dose of placebo, 10 000 U/kg of pegorgotein,

119 There were 182 patients receiving standard intravenous dose of PPI, 63 (34.6%) women and 119 (65.4%

120 In contrast, a high intravenous dose of probenecid (250 mg/kg) only slightly

121 ith magnetic resonance imaging (MRI) that an intravenous dose of protamine labeled with gadolinium ac

122 he kidney and that a single 50- to 200-ng/kg intravenous dose of purified Stx-1 results in thrombocyt

123 One month after a single intravenous dose of rApoAI-PBGDms, the protein was still

124 After a single intravenous dose of rifampin (1 mg/kg), a 1.7-fold incre

125 ry immune thrombocytopenia received a single intravenous dose of rozrolimupab ranging from 75 to 300

126 nosed with BCBM and rGBM to receive a single intravenous dose of SG at 10 mg/kg given one day before

127 and at risk of disease progression, a single intravenous dose of sotrovimab, compared with placebo, s

128 Most of an intravenous dose of species C adenovirus serotype 5 (Ad5

129 -blind, placebo-controlled trial of a single intravenous dose of synthetic human secretin in 60 child

130 00 mg) was administered followed by the same intravenous dose of tacrolimus, and subsequent samples w

131 mouse model of IP, we administered a single intravenous dose of the adeno-associated virus (AAV) vec

132 We assessed the effects of a single 20 mg intravenous dose of the arginine vasopressin receptor 1A

133 Within 90 minutes after receiving a single intravenous dose of the drug, all six volunteers had a s

134 ients with treatment-resistant MDD, a single intravenous dose of the low-trapping NMDA channel blocke

135 A single intravenous dose of thrombopoietin (0.3 to 2.4 microgram

136 lysis on transporter-deficient mice after an intravenous dose of topotecan (4 mg/kg).

137 rboxymaltose (n = 558) initially given at an intravenous dose of up to 2000 mg that was followed by 5

138 ndomly assigned patients to receive a single intravenous dose of ustekinumab (either 130 mg or approx

139 Oral and intravenous doses of (33)P and serial blood and urine sa

140 ic modeling of serum data following oral and intravenous doses of (33)Phosphate ((33)P).

141 After intravenous doses of 1 or 10 mg/kg body weight were admi

142 (10-25 mg weekly) were randomized to receive intravenous doses of 10 mg/kg MDX-1100 (n = 35) or place

143 Intravenous doses of 200, 600, and 1500 mg/kg were admin

144 After intravenous doses of 250 units/g body weight were admini

145 After intravenous doses of 250 units/g of native GALNS, and 25

146 ic monoclonal antibody against TNF-alpha, in intravenous doses of 3 or 10 mg per kilogram of body wei

147 cokinetic/pharmacodynamic modeling predicted intravenous doses of 3800 mg every 4 weeks would be nece

148 adult patients with HPP received 3 ascending intravenous doses of 5, 10, and 20 mg/kg BPS804, a fully

149 The patient received 40 intravenous doses of a single phage (KpJH46O2) targeting

150 5x10(11) vg per kilogram, one of the lowest intravenous doses of AAV used for any indication.

151 crease in WI rates by giving 2 postoperative intravenous doses of Abx, suggesting postoperative Abx a

152 Dosing included five weekly intravenous doses of ALXN1830 (10 mg/kg) and follow-up t

153 abeled mAb B72.3 in combination with various intravenous doses of AP.

154 Specifically, rats were given intravenous doses of CsA 2.5 mg/kg and SRL 1 mg/kg, alon

155 The effects of four increasing intravenous doses of diazepam on saccadic eye movement v

156 The hemodynamic effects of cumulative intravenous doses of FE 204038, terlipressin, or vehicle

157 tent of tissue deposition following multiple intravenous doses of gadolinium-based contrast agent (GB

158 y comparing GCV levels after single oral and intravenous doses of GCV.

159 the effects of acute administration of small intravenous doses of heroin on rates of glucose utilizat

160 9 bpm) and decreased heart rate responses to intravenous doses of isoproterenol.

161 Patients received 6 monthly intravenous doses of lirentelimab (0.3, 1, and up to 3 m

162 uential placebo injections and one after two intravenous doses of methylphenidate.

163 A total of 346 intravenous doses of mRNA-3927 were administered over a

164 okers received saline followed by escalating intravenous doses of nicotine (0.5 and 1.0 mg/70 kg) giv

165 We administered intravenous doses of nivolumab and ipilimumab in patient

166 peratively to receive either 2 postoperative intravenous doses of placebo or antibiotics (Abx).

167 ynamic contrast enhanced MRI that sequential intravenous doses of protamine in 12 tumor-bearing rats

168 dose (MTD) and safety of single and multiple intravenous doses of PV701 as a single agent in patients

169 kinetics, and antitumor activity of multiple intravenous doses of rhApo2L/TRAIL in patients with adva

170 of trial entry, were recruited to receive 2 intravenous doses of rituximab (1,000 mg), administered

171 atic solid tumors received escalating weekly intravenous doses of RO7122290 as a single agent (n = 65

172 dpoint of the trial assessed the impact of 6 intravenous doses of RSLV-132 on the mean change from ba

173 hetic baroreflex sensitivity was assessed by intravenous doses of sodium nitroprusside and phenylephr

174 reshold device, abdominal binding, and large intravenous doses of sodium nitroprusside.

175 tumours and with a human immune system, high intravenous doses of such a 'switchable T cell nanoengag

176 Administration of multiple intravenous doses of the hMCAD mRNA-LNP complex (LNP-MCA

177 Single intravenous doses of this oligonucleotide were given to

178 Participants received initial intravenous doses of trastuzumab deruxtecan from 0.8 to

179 to be nonemetic in a canine emesis model at intravenous doses of up to 3 mg/kg.

180 s, with a plasma elimination half-life after intravenous dosing of 4.5 h, oral bioavailability of 77%

181 We evaluated nonhuman primates following intravenous dosing of AAV8 and AAVrh10 vectors for over

182 cecal ligation and puncture (CLP) procedure, intravenous dosing of AVR-25 (10 mg/kg, 6-12 h post-CLP)

183 Repeated intravenous dosing of PRN100 was well tolerated and reac

184 In subsequent experiments, standard systemic intravenous dosing of stabilized siRNA 72 hours after in

185 Carboplatin was administered as a single intravenous dose once every 21 days at a target area und

186 Patients received one 1000 microg intravenous dose or 1000 microg daily for 7 days inhaled

187 -5, which was administered as either a 75-mg intravenous dose or a 100-mg subcutaneous dose, or place

188 Dawley rats received either a single 5 mg/kg intravenous dose or a single 10 mg/kg oral dose of moxif

189 mg) administered postoperatively in a single intravenous dose or to receive 40 mg of enoxaparin admin

190 Part A evaluated escalating single intravenous doses or subcutaneous infusion of PGT121.414

191 mly assigned at a 2:1 ratio to receive seven intravenous doses over 10 weeks of AMG 714 (8 mg/kg) or

192 lprednisolone (1 mg/kg) plus four additional intravenous doses over 24 h, and Group B received intrav

193 elbine [oral or intravenous] or gemcitabine [intravenous]; dosing per local label) at 3-weekly or 4-w

194 xplored treatment protocols such as repeated intravenous dosing, personalized patient selection based

195 ate that PEG-rmMGDF administered as a single intravenous dose potently stimulates platelet production

196 Four PV701 intravenous dosing regimens were evaluated: (1) single d

197 The pharmacokinetic study of DMA at oral and intravenous doses showed its C(max) = 1 hour, bioavailab

198 olae-immunotargeted fluorophores even at low intravenous doses showed rapid and robust pumping across

199 0%) after the 2 largest oral doses and the 1 intravenous dose, suggesting 100% bioavailability of the

200 trations were higher after administration of intravenous doses than after administration of oral dose

201 o be treated 18 hours before craniotomy with intravenous doses that ranged between 40 and 100 mg/m2 g

202 -daily oral doses and 200-300 mg twice-daily intravenous doses, the predicted probabilities of achiev

203 metabolites after administration of a bolus intravenous dose to rats.

204 , and an effective half-life of 46 min after intravenous dosing to rats.

205 r levels of NTP predictive of efficacy after intravenous dosing to rats.

206 At the highest intravenous dose used (24 mg/kg), in 5/6 sheep we observ

207 Temsirolimus was administered in a 250-mg intravenous dose weekly.

208 us rituximab and 40 (45%) patients given the intravenous dose, with differences between administratio

209 es reveal that rat lungs extract most of the intravenous dose within minutes to achieve precision lun