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1 ntion with increasing dose (0.01-3.00 mg/kg, intravenously).
2 kg loading dose, then 6 mg/kg every 3 weeks, intravenously).
3 en MSCs are injected endotracheally (but not intravenously).
4 ay 1, followed by 100mg for Days 2-10, given intravenously).
5 nously and all subsequent doses were 2000 mg intravenously.
6 phro- and hepatotoxicities when administered intravenously.
7 ng samples from 120 rhesus macaques infected intravenously.
8 ks, and nivolumab was administered at 240 mg intravenously.
9 rapeutic dose (~18.5 GBq) of HSA (131)I-MIBG intravenously.
10 or at least 60 min every 3 weeks), all given intravenously.
11 iodinated contrast media (ICM) administered intravenously.
12 rown chronically at 5% O2, were administered intravenously.
13 very 4 weeks after cycle 4, was administered intravenously.
14 mids with Foxm1 or Foxf1 cDNAs were injected intravenously.
15 man biospecimens when delivered topically or intravenously.
16 micals and metabolite administered orally or intravenously.
17 or cells expressing high PDGFB when injected intravenously.
18 tokines compared to CAR T cells administered intravenously.
19 n improve the delivery of IVIg, administered intravenously (0.4 g/kg), to the hippocampus and reach a
21 ly improved renal function when administered intravenously 24 and 48 hours after renal ischemia in ra
26 e of nano-SOD/CAT in saline was administered intravenously 6 h post-injury, and the spinal cords were
27 1.8 mg/kg and a placebo form of vincristine intravenously (A+CHP group) or vincristine 1.4 mg/m(2) a
28 his protocol, we describe how to produce and intravenously administer AAVs to adult mice to specifica
30 ed at 40 min and at 2, 4, 24, and 72 h after intravenously administered (38 +/- 9 MBq) (131)I-GMIB-an
32 f-life is an important consideration for any intravenously administered agent in preclinical developm
33 bjective, we determined the accessibility of intravenously administered biodegradable nanoparticles (
34 derlies the acute psychotomimetic effects of intravenously administered delta-9-tetrahydrocannabinol
35 antage of the preferential colocalization of intravenously administered erythrocytes with metastases
36 Moreover, this approach revealed that the intravenously administered GO accumulated predominantly
38 When regulatory T cells (2 x 106/mouse) were intravenously administered immediately after delayed tPA
44 demonstrated extravasation and retention of intravenously administered nanoparticles specifically at
45 s an opportunity for passive accumulation of intravenously administered nanoparticles through an enha
54 scular access site, 2358 received ALPS drugs intravenously and 661 patients by the intraosseous route
56 articles (NP-[CPP]) that can be administered intravenously and allow local drug delivery to the disea
58 ived a lethal dose of AFB(1) (0.5-1.0 mg/kg) intravenously and hemoperfusion with a CS or Control dev
60 east cancer were administered (11)C-vorozole intravenously and PET emission data collected between 40
61 oxorubicin 50 mg/m(2) on day 1 of each cycle intravenously and prednisone 100 mg once daily on days 1
62 me of three iv. pulses of methylprednisolone intravenously and the continuation of treatment with im.
64 mg loading dose, then 420 mg every 3 weeks, intravenously) and trastuzumab (8 mg/kg loading dose, th
65 east cancer were administered (11)C-vorozole intravenously, and PET emission data were collected betw
66 travenously, doxorubicin 50 mg/m(2) on day 1 intravenously, and prednisone 100 mg once daily on days
68 mg once weekly, 300/450 mg every 2 weeks, or intravenously at 20 mg/kg once every 4 weeks up to day 5
69 inacumab subcutaneously at 75/150/250 mg, or intravenously at 5/10/20 mg/kg, monitored up to day 126.
70 3, 6, and 11 after HCT; tacrolimus was given intravenously at a dose of 0.05 mg/kg twice daily (or or
72 practices (GMP) conditions, and administered intravenously at either 0.5-1 million Tregs/kg or 3-4.5
74 Participants received vedolizumab (300 mg intravenously) at weeks 0, 2, and 6, and then every 8 we
76 ncreased significantly when drugs were given intravenously but not intraosseously, and favored improv
77 platin AUC5 and paclitaxel 175 mg/m(2) given intravenously), by use of a biased coin minimisation pro
80 ubcutaneously daily or decitabine 20 mg/m(2) intravenously daily for 3 consecutive days on a 28-day c
82 assigned to first-line cladribine 0.15 mg/kg intravenously days 1-5 with 8 weekly doses of rituximab
83 al studies have shown that LAmB administered intravenously distributes to tissues frequently infected
84 ceived cyclophosphamide 750 mg/m(2) on day 1 intravenously, doxorubicin 50 mg/m(2) on day 1 intraveno
85 py (two cycles of cisplatin 50 mg/m(2) given intravenously during radiotherapy, followed by four cycl
86 (2), in combination with cytarabine received intravenously every 12 h at either 100 mg/m(2) for 20 do
87 ratio) to receive omadacycline (100 mg given intravenously every 12 hours for two doses, then 100 mg
88 III, or IV) to receive omadacycline (100 mg intravenously every 12 hours for two doses, then 100 mg
90 imab (doses of 2, 6, or 20 mg), administered intravenously every 2 weeks for 12 weeks during hemodial
92 gent chemotherapy received avelumab 10 mg/kg intravenously every 2 weeks until human chorionic gonado
93 papillomavirus status, to nivolumab (3 mg/kg intravenously every 2 weeks) or nivolumab (same dose) pl
94 web response system to atezolizumab (840 mg intravenously every 2 weeks) plus cobimetinib (60 mg ora
97 ry 12 hours for two doses, then 100 mg given intravenously every 24 hours) or linezolid (600 mg given
98 ly every 12 hours for two doses, then 100 mg intravenously every 24 hours), or moxifloxacin (400 mg i
101 taxane were treated with T-DM1 at 3.6 mg/kg intravenously every 3 weeks and dose-escalating neratini
102 g/kg intravenously plus pembrolizumab 200 mg intravenously every 3 weeks and six received the recomme
103 0 mg/m(2) and carboplatin area under curve 5 intravenously every 3 weeks for four cycles, followed by
104 receive VRC01 (40 mg/kg) or placebo (saline) intravenously every 3 weeks for up to 24 weeks during an
105 signed (1:1) to receive 200 mg pembrolizumab intravenously every 3 weeks for up to 35 cycles plus 5 m
107 orally twice daily plus pembrolizumab 200 mg intravenously every 3 weeks or placebo plus pembrolizuma
108 Patients received 200 mg of pembrolizumab intravenously every 3 weeks until definitive progression
109 t with or without bevacizumab 15 mg/kg given intravenously every 3 weeks until disease progression.
110 nse system) to receive atezolizumab (1200 mg intravenously every 3 weeks) plus chemotherapy (carbopla
111 ay cycle), atezolizumab monotherapy (1200 mg intravenously every 3 weeks), or regorafenib (160 mg ora
113 se system to receive cabazitaxel (25 mg/m(2) intravenously every 3 weeks, 10 mg daily prednisone, and
114 25 mg per square meter of body-surface area intravenously every 3 weeks, plus prednisone daily and g
121 0 mg) plus tremelimumab (75 mg) administered intravenously every 4 weeks for up to four doses, follow
122 urvalumab monotherapy (1500 mg) administered intravenously every 4 weeks; durvalumab (1500 mg) plus t
125 ry 3 weeks] plus nab-paclitaxel [100 mg/m(2) intravenously every week]) or chemotherapy alone for fou
126 r four doses, followed by nivolumab (3 mg/kg intravenously) every 2 weeks; or sunitinib (50 mg orally
127 g/kg intravenously) plus ipilimumab (1 mg/kg intravenously) every 3 weeks for four doses, followed by
128 mab (240 mg intravenously) and BV (1.8 mg/kg intravenously) every 3 weeks until disease progression o
130 us placebo and 6 (85.7%) versus 1 (50.0%) on intravenously evinacumab versus placebo reported treatme
132 received 148-444 MBq (4-12mCi) of (18)F-MFBG intravenously followed by serial whole-body imaging at 0
133 Afterward, (18)F-BMS-986192 was administered intravenously, followed by a 60-min dynamic PET scan.
134 roups 1-2) or metformin (100 mg/kg; group 3) intravenously, followed by a single radiotherapy dose of
135 t received therapy with glucocorticosteroids intravenously, followed by intramuscular injections with
136 patients received broad-spectrum antibiotics intravenously for 10 days and orally for the remainder,
137 Patients received decitabine 20 mg/m(2) intravenously for 10 days with oral venetoclax 400 mg da
138 Wistar rats were given omeprazole orally or intravenously for 30 days, and caerulein as a positive c
139 orally twice daily and pembrolizumab 200 mg intravenously for 30 min on day 8 and every 3 weeks for
141 re assigned to receive 20 mg/m(2) decitabine intravenously for 5 or 10 consecutive days as induction
145 docetaxel and cabazitaxel, are administered intravenously for the treatment of castration-resistant
147 d to receive monthly tremelimumab (10 mg/kg, intravenously) for six doses, followed by infusions ever
148 with high-dose methylprednisolone (1 g/day, intravenously, for 3-5 days), participants were assigned
149 tudy to evaluate DSTP3086S (0.3 to 2.8 mg/kg intravenously) given once every 3 weeks followed by coho
150 that of extracellular fluid and, when given intravenously, have fewer adverse effects on acid-base b
151 ) relationships that underlie the ability of intravenously (i.v.) administered STING-NPs to induce ST
153 Mice were challenged intratracheally (i.t.), intravenously (i.v.), or intraperitoneally (i.p.) with E
155 ne of the (89)Zr-labeled antibodies injected intravenously in a peripheral vessel in the left arm.
156 inophil numbers, received 750 mg mepolizumab intravenously in a placebo-controlled double-blind trial
157 either high-dose iron sucrose, administered intravenously in a proactive fashion (400 mg monthly, un
158 40%), or low-dose iron sucrose, administered intravenously in a reactive fashion (0 to 400 mg monthly
160 ld, patient's metastatic tumor extract given intravenously in dogs, produced significantly increased
164 as (HIP rats) and amylin knockout (AKO) rats intravenously infused with aggregated amylin were used f
165 stabilize GANT58, providing a fully aqueous, intravenously injectable formulation based on the polyme
166 o address these limitations, we developed an intravenously-injectable formulation with R848 using the
168 or alpha (TNFalpha), we found that uptake of intravenously injected antibody to vascular cell adhesio
170 (using gut, liver and kidney chips) and for intravenously injected cisplatin (using coupled bone mar
171 g E.G-7 tumor-bearing immune-deficient mice, intravenously injected Cy5.5-CTLs were clearly observed
176 burst release of the protein annexin A5 from intravenously injected hollow mesoporous nanoparticles m
177 abeled gold nanoclusters, (64)Cu-AuNCs, were intravenously injected into the mice and imaged by posit
179 MALDI-MSI experiments on spleen tissues from intravenously injected mice indicate that NPSCs loaded w
180 focused ultrasound (FUS), in the presence of intravenously injected microbubbles, to safely and trans
182 rmore, following biodistribution analysis of intravenously injected nanoparticles in nude mice bearin
183 sed delivery system is reported that enables intravenously injected nerve growth factor (NGF) to ente
185 tion time allow for capturing the flow of an intravenously injected tracer through the heart of a mou
187 sed from previous studies in which mice were intravenously injected with 0.064-42 kBq of (211)At and
190 ght healthy, malaria-naive participants were intravenously inoculated with blood-stage P. vivax and s
191 l trial involved 2 healthy subjects who were intravenously inoculated with cryopreserved P. malariae-
192 sing small hairpin RNAs; cells were injected intravenously into immune-competent and NOD/SCID mice, a
193 Furthermore, 5% IONP-loaded PFH-NDs injected intravenously into melanoma-bearing mice at a dose of 12
195 lations can be pooled together, administered intravenously into mice as a single pool, and their deli
196 with Alexa750 or (64)Cu-NODAGA and injected intravenously into separate cohorts of nude mice bearing
197 -poly(lactic-co-glycolic) acid, were infused intravenously into wild-type C57BL/6 mice following 2 di
200 be administered once daily either orally or intravenously, is active against pathogens that commonly
202 ent antidepressant effects when administered intravenously (IV) at subanesthetic doses (0.5 mg/kg ove
203 andomized 1:1 to receive lefamulin at 150 mg intravenously (IV) every 12 hours or moxifloxacin at 400
204 ith either decitabine (20 mg/m(2), days 1-5, intravenously [IV]) or azacitidine (75 mg/m(2), days 1-7
205 inct clinical signs in C3H/HeN mice infected intravenously, leading to selection of this mouse strain
206 12-month trastuzumab delivered every 3 weeks intravenously (loading dose of 8 mg/kg followed by maint
208 ls administered intracerebroventricularly or intravenously mediate antigen-specific protection from t
209 ived two doses of either bimagrumab 30 mg/kg intravenously (n = 33) or placebo (n = 34) (Weeks 0 and
211 en up to six 28-day cycles were administered intravenously of fludarabine (25 mg/m(2), days 1-3), cyc
212 ived either 10 mg/kg prednisolone (P), or LP intravenously on day 0, 3, and 6, or no additional treat
213 receive four 3-week cycles of CE (75 mg/m(2) intravenously on day 1 and 100 mg/m(2) on days 1 through
214 ived atezolizumab 840 mg or matching placebo intravenously on day 1 and day 15 of every 28-day cycle
215 iltration rate <50 mL/min only) administered intravenously on day 1 and gemcitabine (1000 mg/m(2)) ad
218 lly (CHP), plus either rituximab 375 mg/m(2) intravenously on day 1 of each cycle (R-CHP) or obinutuz
220 .4 mg/m(2) [to a maximum of 2 mg total dose] intravenously on day 1 of the cycle, and prednisolone 10
224 cers who received sacituzumab govitecan-hziy intravenously on days 1 and 8 of each 21-day cycle until
225 1000 mg/m(2) body surface area, administered intravenously on days 1 and 8 of each cycle), plus eithe
226 and gemcitabine (1000 mg/m(2)) administered intravenously on days 1 and 8; chemotherapy was initiate
227 receive VI (vincristine, 1.5 mg/m(2) per day intravenously on days 1 and 8; irinotecan, 20 mg/m(2) pe
228 1.3 mg/m(2) of bortezomib subcutaneously or intravenously on days 1, 4, 8, and 11 of cycles 1-8, and
229 ), bortezomib (1.3 mg/m(2) subcutaneously or intravenously on days 1, 4, 8, and 11), and dexamethason
230 xate, and bortezomib (bortezomib 1.3 mg/m(2) intravenously on days 1, 4, and 7 after HCT); or tacroli
231 mide-dexamethasone group received isatuximab intravenously on days 1, 8, 15, and 22 in the first 28-d
232 ression with or without elotuzumab (10 mg/kg intravenously on days 1, 8, and 15 for cycles 1-2, on da
233 f each cycle (R-CHP) or obinutuzumab 1000 mg intravenously on days 1, 8, and 15 of cycle 1 and on day
234 -arm study of enfortumab vedotin 1.25 mg/kg (intravenously on days 1, 8, and 15 of every 28-day cycle
235 -paclitaxel 100 mg/m(2) of body surface area intravenously on days 1, 8, and 15 until progression or
236 bumin bound paclitaxel, 100 mg/m2, was given intravenously on days 1, 8, and 15, and repeated every 2
237 cycles of doxorubicin 37.5 mg/m(2) per dose intravenously on days 1-2 every 3 weeks with sequence ad
238 esna) and doxorubicin (37.5 mg/m(2) per dose intravenously on days 1-2) with 45 Gy preoperative radio
239 d six cycles of ifosfamide 3 g/m(2) per dose intravenously on days 1-3 and five cycles of doxorubicin
240 nts received ifosfamide (2.5 g/m(2) per dose intravenously on days 1-3 with mesna) and doxorubicin (3
241 days 1 and 8; irinotecan, 20 mg/m(2) per day intravenously on days 1-5 and 8-12 of a 21-day cycle) in
244 latin 25 mg/m(2) and gemcitabine 600 mg/m(2) intravenously on days 3 and 10; treatment for patients i
245 nder the concentration curve 6 mg/mL per min intravenously) on day 1 and paclitaxel (80 mg/m(2) intra
246 n (70 mg/m(2) body surface area administered intravenously) on day 1 of each cycle with either atezol
247 enously) on day 1 and paclitaxel (80 mg/m(2) intravenously) on days 1, 8, and 15 of 21-day cycles com
248 tisotumab vedotin between 0.3 and 2.2 mg/kg intravenously once every 3 weeks in a traditional 3 + 3
249 ezolizumab 1200 mg plus bevacizumab 15 mg/kg intravenously once every 3 weeks or sunitinib 50 mg oral
250 1 to switch maintenance pembrolizumab 200 mg intravenously once every 3 weeks versus placebo for up t
251 e; therefore, 2.0 mg/kg of tisotumab vedotin intravenously once every 3 weeks was established as the
253 the SAD and of 83.1% at day 2 with 20 mg/kg intravenously once every 4 weeks (P=0.0003) in the MAD.
256 ib (RB-CHOP group; experimental; 1.3 mg/m(2) intravenously or 1.6 mg/m(2) subcutaneously) on days 1 a
258 o receive pembrolizumab 200 mg every 3 weeks intravenously or investigator's choice of standard doses
259 ne antibiotic agent that can be administered intravenously or orally, reaches high concentrations in
260 ponse system to receive 100 mg/kg opicinumab intravenously or placebo once every 4 weeks (six doses)
261 ously until protocol amendment 1 then either intravenously or subcutaneously on days 1, 4, 8, and 11
262 the curve of 4.5 mg/mL per min administered intravenously) or cisplatin (70 mg/m(2) body surface are
264 otics, or synbiotics; were delivered orally, intravenously, or per rectum; were on biomarkers of syst
265 herapies, and antibodies, which may be dosed intravenously, orally, topically, or by other routes of
266 d photodynamic therapy (4 mg/kg padeliporfin intravenously over 10 min and optical fibres inserted in
267 ne), or oxaliplatin 130 mg/m(2) administered intravenously over 2 h and oral capecitabine 1000 mg/m(2
268 -folinic acid (175 mg flat dose administered intravenously over 2 h) or d,l-folinic acid (350 mg flat
269 -folinic acid (350 mg flat dose administered intravenously over 2 h), and fluorouracil bolus 400 mg/m
270 isted of oxaliplatin 85 mg/m(2) administered intravenously over 2 h, l-folinic acid (175 mg flat dose
271 e status of 0-1) received cemiplimab 3 mg/kg intravenously over 30 min every 2 weeks for up to 96 wee
272 nd instead received melphalan at 200 mg/m(2) intravenously over 30 min on 1 day, followed by ASCT (co
274 fluorouracil bolus 400 mg/m(2) administered intravenously over 5 min, followed by a 46 h infusion of
275 e or 3.3 mg/kg per dose for children <10 kg) intravenously over 6 h on day 1; fluorouracil (600 mg/m(
276 s in part A and were given nivolumab 3 mg/kg intravenously over 60 min on days 1 and 15 of a 28-day c
277 um reduction of 76.9% at day 3 with 10 mg/kg intravenously (P<0.0001) in the SAD and of 83.1% at day
278 reated: three received margetuximab 10 mg/kg intravenously plus pembrolizumab 200 mg intravenously ev
279 igned (1:1) to open-label nivolumab (3 mg/kg intravenously) plus ipilimumab (1 mg/kg intravenously) e
283 ign to receive either azacitidine 75 mg/m(2) intravenously/subcutaneously daily or decitabine 20 mg/m
286 oid injection to model orthotopic tumors, or intravenously to model hematogenous metastasis, and pros
287 /kg trastuzumab deruxtecan were administered intravenously to patients once every 3 weeks until withd
288 inister deuterated oxytocin intranasally and intravenously to rhesus macaques and measure, with mass
289 days (interquartile range, 14 to 25) in the intravenously treated group and 17 days (interquartile r
290 tcome occurred in 24 patients (12.1%) in the intravenously treated group and in 18 (9.0%) in the oral
291 Bortezomib (1.3 mg/m(2)) was administered intravenously until protocol amendment 1 then either int
292 NSC-derived EV treatment administered either intravenously via retro-orbital vein injection or via in
295 r, skin, and lymphoid cancers) were injected intravenously with 9.25 MBq of (86)Y-NM600 and imaged lo
300 ed bendamustine on days 1 and 2 (100 mg/m(2) intravenously) with 40 mg of weekly dexamethasone in 28-