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1 lts suggest that TET1 deficiency impairs the intrinsic ability of hESCs to differentiate to neuroecto
2 trol over neuronal circuit function by their intrinsic ability to generate rhythmic bursts of action
4 urface properties, as a result, enhances the intrinsic activity and availability of surface iridium s
6 primary cilia not only orchestrate beta-cell-intrinsic activity but also mediate cross talk both with
7 efficient C-C formation is restricted by the intrinsic activity of these catalysts often being compar
8 onic nature of the C-3 substituents affected intrinsic activity to afford partial agonists with a ran
9 amine neurons are controlled by afferent and intrinsic activity to generate sensory cue and predictio
10 ituents investigated effects on NOP binding, intrinsic activity, and selectivity and showed that whil
11 gies demonstrated effectiveness in improving intrinsic activity, increasing active site density, and
12 ic nervous system, and demonstrate that cell-intrinsic adrenergic signaling is required for optimal a
13 re in later life reflects both influences of intrinsic aging and those of lifestyle, environment and
14 extracellular domain of PC-1 functions as an intrinsic agonist that is necessary and sufficient for c
18 governing clonal evolution in MPNs, the cell-intrinsic and -extrinsic mechanisms driving leukemic tra
20 The loss of splenic ESAM(+) cDC2s was cell-intrinsic and could be rescued by conditional overexpres
22 ivation states (plastic phenotypes driven by intrinsic and extrinsic cues) can be identified, associa
24 e nanomedicine requires scrutiny of tumours' intrinsic and extrinsic factors that may impact host ant
25 l and scRNAseq analyses identified germ-cell intrinsic and extrinsic genes responsive to Sertoli-cell
28 in B-cell lymphomagenesis, and characterize intrinsic and extrinsic vulnerabilities of cancer cells
29 several signalling pathways (referred to as intrinsic and extrinsic) triggered by multiple factors,
30 type potassium channel inhibition, triggered intrinsic and synaptic homeostatic plasticity at differe
40 xhibit outstanding photophysical properties: intrinsic blinking even in air, excellent fluorescence r
41 d hypothesis suggests these patterns are not intrinsic but result from passive responses to seasonal
42 tments revealed that the prodrug exhibits an intrinsic capability to prevent the progression of tumor
43 has been hypothesized that MTs also possess intrinsic capacitive and inductive properties, leading t
44 tion, but it is unknown whether Pol I has an intrinsic capacity to transcribe through nucleosomes.
45 our results reveal that RUNX1(+) PLCs is an intrinsic castration-resistant and self-sustained lineag
48 emained unclear, at least in part due to the intrinsic challenges of connecting repressors to gene up
50 cies and shrinkage of the Li-layer size, the intrinsic charge storage mechanism (two-phase vs solid-s
53 In addition, many noncanonical genes have intrinsic circadian rhythms, especially within the liver
54 that these thirst-controlling sCVOs possess intrinsic circadian timekeeping properties and raise the
55 bility assay revealed high stability and low intrinsic clearance of 17d (T(1/2) > 145 min and CL(int(
56 me P450 (CYP) enzymes is responsible for the intrinsic clearance of the majority of therapeutic drugs
57 1650-1665) now shows a requirement for the intrinsic clock in the regenerative capacity of insulin-
59 Together, these findings demonstrate a cell-intrinsic coinhibitory function of FcgammaRIIB in regula
61 he present data-driven analysis suggest that intrinsic communication of frontal regions engaged in ex
62 s and treatment targets whereas dysregulated intrinsic communication of the striato-amygdala system e
63 -dependent colonization is responsive to the intrinsic conditions within the host upper respiratory t
65 e metastability is explained in terms of the intrinsic conformations of the three trapezoidal substru
66 ifests as aberrant effective connectivity in intrinsic connections involving inhibitory interneurons.
67 much less attention has been devoted to its intrinsic connectivity and whether its local excitatory
68 ata-driven intrinsic network-level analysis (intrinsic connectivity contrast, ICC) to resting-state f
70 delled lymphatic vessel displayed increasing intrinsic contractile frequency, force generation and ve
72 rmacological variants of DIDS suggested that intrinsic cysteine, and not lysine, reactivity was impor
77 gh sorting has previously been attributed to intrinsic differences between the epithelial lineages, w
78 on thermodynamics, primarily attributable to intrinsic differences in surface reactivity of different
81 lly disordered proteins (IDPs) or regions of intrinsic disorder in otherwise folded proteins (IDRs) p
82 me shows that protein folding initiated with intrinsic disorder, supported through a short, primitive
85 namic correlation," quantifies similarity in intrinsic dynamics of populations, independently of whet
86 We identify two robust spatial gradients of intrinsic dynamics, one spanning a ventromedial-dorsolat
89 gy revealed an IL-4 signaling-dependent cell-intrinsic effect on SI MMC9 accumulation and food allerg
91 iased opioids have been shown to exhibit low intrinsic efficacy for G protein signaling when ceiling
93 rtions, and pursuit of appropriately reduced intrinsic efficacy should guide development of safer opi
95 s, yet little attention has been paid to the intrinsic electrocrystallization characteristics of Li m
96 nd influence structural compatibility has on intrinsic electronic properties, and indicate that the t
98 y LSD1-mediated enhancer silencing as a cell-intrinsic epigenetic feedback mechanism by which the dur
99 gh-activity L4 pyramidal neurons had greater intrinsic excitability and recurrent excitatory synaptic
101 hagy regulates neuronal activity: control of intrinsic excitability via the regulation of potassium c
105 y and indoor/outdoor trapping location) than intrinsic factors (namely, the (sibling) species of the
109 ists of multiple areas that each process the intrinsic features of a few particular categories (e.g.
111 -, and 3-h cohorts, respectively, and a mean intrinsic fluorescence of 0.035 vs. 0.023 mm(-1) (P < 0.
112 n the focal adhesion complex but did exhibit intrinsic focal adhesion assembly as well as contractile
114 function in the dorsal striatum and aberrant intrinsic functional connectivity (iFC) between distinct
115 res of loneliness in grey matter morphology, intrinsic functional coupling, and fiber tract microstru
116 hip between the hierarchical organization of intrinsic functional networks and the causal modulation
117 e development of 3D printable materials with intrinsic functionalities, through the so-called 4D prin
118 low doses these SCFAs directly impact B cell intrinsic functions to moderately enhance class-switch D
119 rica, we approximate broad-scale patterns in intrinsic fungal-mediated wood decomposition rates.
120 We further identify several cancer cell-intrinsic gene expression signatures associated with ICB
123 scribe a diversity of approaches to quantify intrinsic growth rates of plant populations, including e
128 sembly CNF, natural cellulose materials with intrinsic hierarchical structure (wood and BNC), and com
129 for transcriptional suppression of the tumor-intrinsic HLA class I (HLA-I) antigen processing and pre
130 loss in vitro abolished synaptic scaling and intrinsic homeostatic plasticity, deficits that could be
131 hosphatase (GTPase) Rab32 coordinates a cell-intrinsic host defense mechanism that restricts the repl
132 c CD4 T cells, and ultimately requires tumor-intrinsic IFN-gamma signaling, via a mechanism that is d
133 er, ZIKV-triggered AHR activation suppresses intrinsic immunity driven by the promyelocytic leukemia
134 imately, a better understanding of how donor intrinsic immunity influences allograft acceptance and s
135 parasite development, the mechanisms of cell-intrinsic immunity to T. gondii in the brain and muscle,
139 ne-rich Akt substrate of 40 kDa (PRAS40), an intrinsic inhibitory component of mTORC1, and prevented
140 of neurons and glial cells that ensures the intrinsic innervation of the gastrointestinal tract.
142 the shortening speed) macroscopic, while the intrinsic instability of in-series force generators is l
143 of their signaling centers, highlighting the intrinsic instability of the upper molar developmental s
144 Conclusion: Our findings demonstrate the intrinsic integration of a fluorophore in the pharmacoph
147 ranscriptional and epigenetic regulator with intrinsic kinase and histone acetyltransferase (HAT) act
148 iliary subunits and other factors modify the intrinsic kinetic mechanism to result in new molecular a
149 as drawbacks, including its hitherto unknown intrinsic lack of stability vis-a-vis practical conditio
151 n the delta(13) C and WUE(plant) suggests an intrinsic link of delta(13) C with WUE(i) in this C(4) p
153 ntal in revealing the spatial specificity of intrinsic M1 connections, which appear to be woven into
154 ious models of quark nuggets have assumed no intrinsic magnetic field; however, Tatsumi found that qu
155 he same time, recently discovered long-range intrinsic magnetic orders in the two-dimensional van der
158 onse, indicating that MHV68 may, in a B cell-intrinsic manner, usurp IRF-1 to promote the germinal ce
161 te organic and mineral (ceramic) phases, the intrinsic mechanical properties of the mineral phases ar
162 n the lesional epidermis is mediated by a KC intrinsic mechanism, as suggested from murine data and c
164 this Review, we focus predominantly on cell intrinsic mechanisms and their contribution to cell pola
167 ings indicate that in addition to tumor cell-intrinsic mechanisms that cause constitutive PI3K/AKT/MT
170 le ion-selective polymer membranes with both intrinsic microporosity and ion-conductive functionality
171 deficiency and have shown activation of the intrinsic (mitochondrial mediated) apoptosis pathway in
175 s and clinical laboratories, suggesting that intrinsic molecular features are potential root causes.
176 While it has long been suspected that an intrinsic molecular pilot, akin to a ship's pilot, guide
177 ikelihood, it was also associated with lower intrinsic motivation, lower visit happiness and higher v
180 omical features, including multiple pairs of intrinsic muscles, a robust tympanum and several accesso
183 xyl-terminal domain 2 (CITED2) as a critical intrinsic negative regulator of inflammation, which broa
184 2+) transients in ICC-SS, and stimulation of intrinsic nerves activated nitrergic responses in ICC-SS
186 nal disorder models with a fully data-driven intrinsic network-level analysis (intrinsic connectivity
188 results suggest a functional utilization of intrinsic neural oscillatory activities for an enhanced
193 sleep-stage/arousal transitions arises from intrinsic non-equilibrium critical dynamics, connecting
194 matches well with the 10-fold improvement of intrinsic OER activity, suggesting that the observed act
196 er cell polarity is established through cell-intrinsic or -extrinsic mechanisms and how polarity is c
199 In total, we identified 38 envelope membrane intrinsic or associated proteins exhibiting altered abun
201 reticulum (ER) stress, whether triggered by intrinsic or extrinsic factors, can be resolved by the u
203 ch as the TATA-box and microRNA targeting on intrinsic or extrinsic noises and reveal gene function-a
206 ansition metals is discussed, as well as the intrinsic oxygen redox process at high potentials, which
209 key regulator that integrates multiple cell-intrinsic pathways with external signals to direct paras
211 uce an information measure that reflects the intrinsic perspective of a receiver or sender of a singl
212 e (MetSyn) rats exhibited impairments in its intrinsic phasic contractile activity; however, the mole
213 ensitivity of this system for detecting cell-intrinsic phenotypes during short-term or long-term trac
214 f sugar-polyolefin FK A15 phases with unique intrinsic physical properties and chemical reactivities
220 at 24 hours, as were peak airway pressures, intrinsic positive end-expiratory pressure, and use of v
222 rdered regions (IDRs) in G3BP1 regulates its intrinsic propensity for LLPS, and this is fine-tuned by
224 he refinement of excitation, inhibition, and intrinsic properties is instructed by distinct cues.
225 nzymatic activity, a process that alters the intrinsic properties of CA1 interneurons 3 h following l
226 ational modeling to show that differences in intrinsic properties of different tubulins contribute to
229 l architecture of the neural network and the intrinsic properties of the motoneuron population drivin
232 isition of effector functions were due to an intrinsic property of fetal hematopoietic stem and precu
235 opic outcomes of evolution are shaped by the intrinsic randomness of the evolutionary process and by
236 tely control nanoparticle size, we find that intrinsic rates for propene combustion in the presence o
237 We fit a model to quantify costs (reduced intrinsic rates of increase) and benefits of resistance.
238 n provide valuable insights in understanding intrinsic reaction pathways, for affording structure-act
239 around the aromatic unit is dictated by the intrinsic reactivity profile of the method (electrophili
240 an also be extremely challenging for various intrinsic reasons (e.g. low target accessibility or natu
241 a digital health intervention targeting the intrinsic regulation of goal-directed alertness in patie
242 veals a critical role of lipin1 and DGATs as intrinsic regulators of glycerolipid metabolism in neuro
245 d intracranial activity and to mitigate ROS1-intrinsic resistance mechanisms have demonstrated clinic
246 of NK cell IFN-gamma production was not cell intrinsic, revealing a cell-extrinsic downregulation of
247 contexts correlates positively with a bird's intrinsic reward state and with opioid markers in the me
250 pical simple metal aluminum demonstrates how intrinsic satellite spectra can be extracted from measur
252 ition and behavior, which may partly reflect intrinsic sex differences in regional brain organization
255 rst mapped mouse visual cortical areas using intrinsic signal optical imaging and then injected fluor
257 we undertook simultaneous optical imaging of intrinsic signals in macaque V1, V2, and V4, supplemente
259 ssfully determine the pH-solubility profile, intrinsic solubility, common-ion effect, pK(a), pH(max),
260 ghly similar, largely state-invariant (i.e., intrinsic) spatial component across cognitive states.
263 are-earth orbital magnetism gives rise to an intrinsic spin-orbit coupling generating interfacial DMI
264 ed the impact of core destabilization on the intrinsic stability of the CA lattice in vitro and fates
265 is acid-mediated processes take advantage of intrinsic steric or electronic substrate bias to influen
266 symptotic resilience, initial resilience and intrinsic stochastic invariability) using first-order mu
267 guidance signaling systematically shapes the intrinsic, stochastic fluctuations of actin in the growt
269 ects of sUA and identify hyperuricemia as an intrinsic suppressor of innate immunity, in which sUA mo
270 f electrodes in different LHCEs indicate the intrinsic synergistic effects between the salt and the s
271 illustrate that an extrinsic cue modifies an intrinsic temporal program to increase neuronal diversit
272 that the ProQ NTD specifically recognizes 3' intrinsic terminators of RNA substrates, and that the di
275 ing clinical disease primarily to IS, either intrinsic to disease-related immune compromise or from t
276 Channeling morphogenic signaling gradients intrinsic to intestinal epithelial stem cells, Nikolaev
277 tachment sites and muscle/muscle matching is intrinsic to muscle identity and requires transcriptiona
280 trol and robustness against errors, which is intrinsic to stabilized macroscopic states, as well as t
281 of ferromagnetism and geometric frustration intrinsic to the kagome network of magnetic ions, giving
283 determine whether pioneer-factor function is intrinsic to the protein or whether pioneering activity
284 nonturnover redox peaks that are very likely intrinsic to the redox protein(s) performing the HET.
289 Therefore, the isolated fetal heart has intrinsic variability and carries a memory of adverse in
291 essure-sensing range of tactile sensors, the intrinsic viscoelasticity of soft polymeric materials re
292 charge fluctuation in the metallic phase of intrinsic VO(2) results in the formation of e(-) and h(+
293 us activity and visual stimulation reveal an intrinsic voltage-gated conductance that profoundly alte
294 reases in leaf-level intercellular CO(2) and intrinsic water use efficiency that track rising atmosph
295 m) scaled positively with photosynthesis and intrinsic water-use efficiency (TE(i) ), but not with st
296 eports on components of WUE(plant) , such as intrinsic water-use efficiency (WUE(i) , the rate of lea
298 which antiviral effects of IRF-1 are B cell intrinsic, we generated mice with conditional IRF-1 defi
299 otype in tumor cells without affecting tumor-intrinsic Wnt signaling, suggesting involvement of nonim