ライフサイエンスコーパス: intrinsic factor

1 of isolated rat parietal cells also contain intrinsic factor.

2 rate 16 +/- 3.6% of parietal cells contained intrinsic factor.

3 ies comparable with those of haptocorrin and intrinsic factor.

4 tes are specified and maintained by distinct intrinsic factors.

5 s well as unrecognized brain-region-specific intrinsic factors.

6 a complex network of multiple extrinsic and intrinsic factors.

7 c variation can be generated by two parasite-intrinsic factors.

8 fluenced by a variety of other extrinsic and intrinsic factors.

9 -renewal is controlled by both extrinsic and intrinsic factors.

10 ast, is controlled by both niche signals and intrinsic factors.

11 on of SOD1 seems to be largely determined by intrinsic factors.

12 ogenitors is regulated by both extrinsic and intrinsic factors.

13 require thalamic inputs and is regulated by intrinsic factors.

14 y divisions is probably under the control of intrinsic factors.

15 ntalization is driven entirely by chromosome-intrinsic factors.

16 nsitions, tightly regulated by extrinsic and intrinsic factors.

17 insufficient adjustment on bacterial or host intrinsic factors.

18 y dynamic process dependent on extrinsic and intrinsic factors.

19 dulated both by environmental and by protein-intrinsic factors.

20 itment, which is influenced by extrinsic and intrinsic factors.

21 tion and is influenced by both extrinsic and intrinsic factors.

22 eference is affected by myriad extrinsic and intrinsic factors.

23 e influence of both environmental and T cell-intrinsic factors.

24 ous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smokin

25 Among the intrinsic factors, a number of proteins termed axonal gr

26 We propose that intrinsic factors act synergistically with extrinsic fac

27 defects induced by environmental and lineage intrinsic factors act together to reduce responses to Ag

28 he socket cell and the inner pupal case--and intrinsic factors--actin cytoskeleton assembly.

29 We here isolate the intrinsic factors affecting either electron or hole tran

30 e, and must instead be a consequence of cell-intrinsic factors, although we speculate that there may

31 was performed using antiserum against human intrinsic factor and H/K ATPase (a parietal cell marker)

32 llular and molecular characterization of the intrinsic factor and its receptor.

33 stric parietal cells, leading to the loss of intrinsic factor and reduced acid output.

34 a higher shape complementarity than those of intrinsic factor and transcobalamin.

35 ce of classical immune gastritis and of anti-intrinsic factor and/or antiparietal cell antibodies.

36 ion is stage dependent and regulated by both intrinsic factors and an extracellular signal, which is

37 ion is controlled by a combinatorial code of intrinsic factors and an extrinsic BMP signal.

38 perchlorate to examine the relative roles of intrinsic factors and axon-target interactions in the sp

39 ch reprogramming involves both extrinsic and intrinsic factors and can occur via three routes: pertur

40 tipotent progenitors is orchestrated by cell-intrinsic factors and cell-extrinsic environmental cues

41 a (MM) is driven by clonal plasma cell (cPC)-intrinsic factors and changes in the tumor microenvironm

42 pid heart growth during development, yet the intrinsic factors and environment governing these proces

43 Axon guidance is regulated by intrinsic factors and extrinsic cues provided by other n

44 Both intrinsic factors and extrinsic niche signals influence

45 egulatory network interactions between these intrinsic factors and extrinsic pathways, which ultimate

46 and temporally regulated through a number of intrinsic factors and extrinsic signaling pathways.

47 Here, we explore how tumor-intrinsic factors and immunological processes shape the

48 rolled by the interplay of neural crest cell-intrinsic factors and instructive cues from the surround

49 Skin pH is tightly regulated by intrinsic factors and limits the abundance of S aureus.

50 renewal and differentiation is controlled by intrinsic factors and niche signals.

51 rrant wound retention is due to myeloid cell intrinsic factors and not the local environment.

52 Several cell intrinsic factors and signaling pathways have been impli

53 trolled by the concerted action of stem cell-intrinsic factors and signals within the niche.

54 em cells are under strict regulation by both intrinsic factors and the microenvironment.

55 neration of Tfh cells depends on both T-cell intrinsic factors and the supporting function of B cells

56 by three transport proteins: transcobalamin, intrinsic factor, and haptocorrin (HC).

57 ere examined for immunolocalization of TFF2, intrinsic factor, and Mist1, and morphologically with el

58 of different cobalamins for transcobalamin, intrinsic factor, and nonintrinsic factor.

59 ree cobalamin-binding proteins: haptocorrin, intrinsic factor, and transcobalamin.

60 ecking antiparietal cell antibodies and anti-intrinsic factor antibodies to assist with the diagnosis

61 Antiparietal cell antibodies (APCAs), anti-intrinsic factor antibodies, and anti-H pylori antibodie

62 In both cohorts, anti-intrinsic factor antibody seroprevalence was less than 2

63 Anti-intrinsic factor antibody was positive in only 25% of ca

64 Extrinsic and intrinsic factors appeared to interact to affect breedin

65 Many extrinsic and intrinsic factors are critical for oocyte development an

66 In addition to environmental factors, intrinsic factors are important for maintaining the rege

67 observe significant changes, suggesting that intrinsic factors are likely responsible for determining

68 eactivity of His in proteins, especially the intrinsic factors are little known.

69 erable debate whether cell-extrinsic or cell-intrinsic factors are most important for triggering this

70 al cells within microbial populations due to intrinsic factors as well as equipping the organisms to

71 ce of stem or progenitor cell fate relies on intrinsic factors as well as local cues from the cellula

72 ave identified commensal dysbiosis as a host-intrinsic factor associated with metastatic disseminatio

73 HPV-infected women, suggesting that unknown intrinsic factors associated with the unique genetic/gen

74 nding of the interplay between extrinsic and intrinsic factors at the molecular level is one promisin

75 AIG associated with both H(+)K(+)ATPase and intrinsic factor autoantibody responses.

76 nation governed by niche signals and/or cell-intrinsic factors but how these regulatory mechanisms co

77 Next, we describe vascular intrinsic factors by which ageing promotes atherogenesis

78 suggest dysregulation of cell-extrinsic or -intrinsic factors can independently contribute to such i

79 n of Nodal signaling, indicating that tissue-intrinsic factors can restrict AVE differentiation.

80 s critical in eliminating tumors, but cancer-intrinsic factors can subvert this function.

81 The number of cells coexpressing intrinsic factor (chief cell marker), YFP (lineage marke

82 ctor-Cobalamin receptor (IFCR), binds to the intrinsic factor-cobalamin (IFCbl) complex with an assoc

83 kDa consisting of CUB domains 6-8 bound both intrinsic factor-cobalamin (vitamin B(12); Cbl) (IF-Cbl)

84 eptor that mediates intestinal absorption of intrinsic factor-cobalamin and selective protein reabsor

85 hat purified gp280 from rat kidney, like the intrinsic factor-Cobalamin receptor (IFCR), binds to the

86 orward sensory pathways but also depend upon intrinsic factors (collectively known as the network sta

87 d parallels to yeast, in which extrinsic and intrinsic factors combine to restrict meiotic initiation

88 ceptor for both the intestinal vitamin B(12)-intrinsic factor complex and the tubular reabsorption of

89 aired after immunization, but whether B cell-intrinsic factors contribute to this defect remains uncl

90 In search of intrinsic factors contributing to the immunogenicity of

91 This could be because of intrinsic factors controlling differentiation or an inab

92 The crystal bending kinetics depends on intrinsic factors (crystal size) and external factors (e

93 hindered in pernicious anemia (PA) owing to intrinsic factor deficiency.

94 within, healthy individuals, suggesting that intrinsic factors determine the magnitude of TLR4-mediat

95 Both extrinsic and intrinsic factors determine the severity of influenza.

96 However, unlike intracellular protein fate, intrinsic factors determining secreted protein aging and

97 roaches have provided fresh insight into the intrinsic factors determining the potency and duration o

98 -off, and how it is affected by latitude and intrinsic factors (development mode).

99 ternal environments, mechanisms regulated by intrinsic factors directly associated with the offspring

100 is more likely to occur (and progress) when intrinsic factor-driven absorption fails than when diet

101 the current understanding of the cancer cell-intrinsic factors driving immune evasion.

102 een breeding stages, pointing towards shared intrinsic factors driving sex-specific care.

103 factor family 2/spasmolytic polypeptide and intrinsic factor dual-immunostaining cells significantly

104 ze of dendritic fields is determined by cell-intrinsic factors during development remains primarily u

105 However, genetic manipulation of intrinsic factors during hematopoietic differentiation h

106 hile root waving has been attributed to both intrinsic factors (e.g. circumnutation) and growth respo

107 On the other hand, the intrinsic factors (e.g., a limited number of basic resid

108 Plasticity can occur as a result of cell-intrinsic factors (e.g., genetic, transcriptional, or ep

109 pair are regulated by a complex interplay of intrinsic factors (e.g., transcription factors) and extr

110 e not been well-defined but may include both intrinsic factors (eg, the tendency to sickle) and extri

111 ressed by postmigratory germ cells, is a key intrinsic factor, enabling those cells to initiate meios

112 The intrinsic factors encompass regulators of cell cycle and

113 environment, suggesting that undefined host-intrinsic factors enhance early dissemination and the pr

114 These results suggest that intrinsic factors (evolutionary history) play more impor

115 studies are consistent with the concept that intrinsic factor expression is both predetermined in chi

116 l conditions could alter the distribution of intrinsic factor expression, two rodent models of chroni

117 Both leukemia cell-intrinsic factors favoring immune escape and poor CAR T-

118 entified the bag-of-marbles (bam) gene as an intrinsic factor for cystoblast fate in Drosophila germl

119 results demonstrate that NF-L is a critical intrinsic factor for dendritic growth in large motoneuro

120 preimplantation mammalian embryo depends on intrinsic factors for its development, but there is also

121 or sex, we detected a direct effect of these intrinsic factors for the majority of immune genes.

122 Our results highlight the importance of intrinsic factors for triggering neurogenesis, but they

123 A gene variant in exon 1 of GIF (Gastric Intrinsic Factor gene) was associated with a dramatic de

124 Cell-extrinsic and -intrinsic factors govern the capacity of cortical progen

125 Although both extrinsic and intrinsic factors have been identified that orchestrate

126 Although both external and intrinsic factors have been proposed as triggers of this

127 We found that both extrinsic and intrinsic factors have comparable influence within a giv

128 acultative niche exploitation, extrinsic and intrinsic factors, host associations, seasonal distribut

129 in the coding region of the gene for gastric intrinsic factor (IF) in an 11-year-old girl with severe

130 The structure of intrinsic factor (IF) in complex with cobalamin (Cbl) wa

131 st, dietary and biliary Cbl bound to gastric intrinsic factor (IF) presented apically to the ileal ab

132 The intrinsic factor (IF) vitamin B(12) ileum anchored recep

133 The question of whether gastric Intrinsic factor (IF), critical for B12 absorption in th

134 A functional candidate gene encoding the intrinsic factor (IF)-B12 receptor, cubilin, was recentl

135 Cubilin recognizes intrinsic factor (IF)-cobalamin and various other protei

136 Loss of CUBN, the intestinal intrinsic factor (IF)-vitamin B12 receptor, results in h

137 stration of [(57)Co]Cbl complexed to gastric intrinsic factor (IF).

138 d and not corrected by the administration of intrinsic factor (IF); if untreated, the disease is fata

139 At the bases of glands, intrinsic factor immunoreactive cells also were costaine

140 Extrinsic and intrinsic factors impact diversity.

141 Congenic controls expressed intrinsic factor in 8.9 +/- 3.8% (mean +/- SD) of pariet

142 It also resembled intrinsic factor in the composition of conserved residue

143 ed by concerted actions of niche signals and intrinsic factors in a variety of systems.

144 erted actions of extrinsic niche signals and intrinsic factors in a variety of systems.

145 tance of the interplay between extrinsic and intrinsic factors in determining disease dynamics is ill

146 ighlight the role of cell-extrinsic and cell-intrinsic factors in regulating the efficiency and kinet

147 To distinguish between extrinsic cues and intrinsic factors in the caudal migration of FBM neurone

148 ial skeleton depends on interactions between intrinsic factors in the skeletal precursors and extrins

149 rowth is well known, but the interference of intrinsic factors in these growth outcomes is not elucid

150 de immune destruction is governed by various intrinsic factors including their metabolic state.

151 e dependence of dissociation is regulated by intrinsic factors, including molecular sensitivity to fo

152 metabolic phenotypes are the combination of intrinsic factors, including mutation status or tissue o

153 eration, which depends on both extrinsic and intrinsic factors, including the PTEN-Akt pathway that i

154 messenger RNA were reduced, whereas those of intrinsic factor increased.

155 Both dietary and host-intrinsic factors influence community structure and the

156 Knowledge about how intrinsic factors influence solubility is limited due to

157 ng apart the relative roles of extrinsic and intrinsic factors influencing transmission.

158 rrow chimerism experiments demonstrated that intrinsic factors inhibited the pathogenic activity of N

159 o quantify the extent to which extrinsic and intrinsic factors interact to influence owl reproductive

160 How extrinsic stimuli and intrinsic factors interact to regulate continuous neurog

161 rinsic factors (buffer environment) and cell-intrinsic factors (interferon-inducible transmembrane pr

162 Intrinsic factor is produced primarily by chief cells in

163 These intrinsic factors known as temporal factors dictate timi

164 lish lung T(RM); however, the role of T cell-intrinsic factors like TCR signal strength have not been

165 n of residence, with longevity influenced by intrinsic factors like the immunoglobulin isotype.

166 regulated by a combination of 1) mesodermal intrinsic factors MAB-5, HLH-1 and FOZI-1, 2) differenti

167 by broad synaptic blockade, suggesting that intrinsic factors may dominate the ISI distribution duri

168 ous, and it is currently unclear how patient-intrinsic factors may relate to coronavirus disease 2019

169 Our results substantiate that COUP-TFI, an intrinsic factor, may work in concert with Pax6 and Emx2

170 te malabsorption engendered by disruption of intrinsic factor-mediated absorption.

171 ntification of commensal dysbiosis as a host-intrinsic factor mediating evolution of metastatic breas

172 st; thus, a better understanding of how cell-intrinsic factors modulate the outcome of infection is o

173 y and indoor/outdoor trapping location) than intrinsic factors (namely, the (sibling) species of the

174 als from the embryonic testis, the germ cell intrinsic factor NANOS2 coordinates a transcriptional pr

175 ibitory CNS environment and the loss of cell-intrinsic factors necessary for regeneration.

176 this study supports the hypothesis that the intrinsic factors Neurog2 and Ascl1 regulate the tempora

177 nnection probabilities, suggesting that cell-intrinsic factors, not proximity, determine connectivity

178 ptides contained in complex Ags is due to an intrinsic factor of the peptide, based upon the affinity

179 timing results from the minimization of the intrinsic factors of effort and variance due to constant

180 and exemplifies the effect of extrinsic and intrinsic factors on evolution in ruminants.

181 ribes the combinatorial effect of lymphocyte-intrinsic factors on the homeostasis, activation and hom

182 ore the interactive effects of extrinsic and intrinsic factors on tool production and deployment.

183 phases show significant coercivities due to intrinsic factors only, hinting at their huge potential

184 However, how these intrinsic factors orchestrate the spatiotemporal express

185 Recently, two such intrinsic factors, Pax6 and Emx2, have been identified.

186 d in the absence of XBP1 induced ZC markers (intrinsic factor, pepsinogen C) but showed abnormal rete

187 lability and intra-specific competition) and intrinsic factors (population, sex and breeding outcome)

188 After 4 and 8 weeks of infection, intrinsic factor-positive parietal cells increased from

189 kin-1beta demonstrated a twofold increase in intrinsic factor-positive parietal cells.

190 rietal cell marker), counting the percent of intrinsic factor-positive parietal cells.

191 ucus-producing pit cells, and pepsinogen and intrinsic factor-producing zymogenic cells) is accuratel

192 In the Drosophila melanogaster ovary, some intrinsic factors promote germline stem cell (GSC) self-

193 onchial cell line, Calu-3, expresses the B12-intrinsic factor receptor, the transcobalamin II recepto

194 Many extracellular and intrinsic factors regulate oligodendrocyte development,

195 Although both extrinsic and intrinsic factors regulate this process, little is known

196 ntial utility of our system for the study of intrinsic factors regulating genetic variation in HCV.

197 cus on cancer metastasis has centered on the intrinsic factors regulating the cell autonomous homing

198 h cell-extrinsic stochastic factors and cell-intrinsic factors related to T cell antigen receptor (TC

199 The extent of contraction may be dictated by intrinsic factors related to the number of prior cell di

200 ify a molecular logic by which a single cell-intrinsic factor represses multiple extrinsic pathways t

201 pecialized microenvironments, or niches, and intrinsic factors required for execution of context-appr

202 atostatin (SST)-expressing interneurons, the intrinsic factors required for the terminal differentiat

203 double-knockout implicated cardiac myocytes intrinsic factors responsible for observed phenotype.

204 These comprehensive data argue that intrinsic factors shape niche breadth variation in micro

205 ighlights the role of both environmental and intrinsic factors shaping the population-level variation

206 hymus growth by provision of growth factors, intrinsic factors such as a proliferative restriction of

207 In recent years, intrinsic factors such as alignment, strength, laxity, a

208 s genotoxic and oxidative stress, as well as intrinsic factors such as mutations in DNA repair genes.

209 re expected to vary among individuals due to intrinsic factors such as sex, age or feeding proficienc

210 across the body, but the importance of cell intrinsic factors such as stem cell function in determin

211 Additionally, whether cell-intrinsic factors such as TCR usage influence CD4(+) T c

212 Cigarette smoke (CS) exposure and intrinsic factors such as the NADPH oxidases produce hig

213 Cell intrinsic factors such as the proneural basic helix-loop

214 through single-file channels is affected by intrinsic factors such as their size and polarity and by

215 ors (such as perisynaptic astroglia) and the intrinsic factors (such as core subcellular organelles)

216 Our understanding of the impact of host-intrinsic factors (such as the host genome, epigenome, a

217 uch as signaling from neighboring cells, and intrinsic factors, such as chromatin structure.

218 The PNIR assessment model incorporates intrinsic factors, such as patient severity of illness,

219 Pest movement is affected by a suite of intrinsic factors, such as population age structure and

220 on of the aggregation process should include intrinsic factors, such as sequence variation, and extri

221 mbined activities of genes encoding mesoderm-intrinsic factors, such as Tinman (Tin), and spatially r

222 differentiated chief cell markers, Mist1 and intrinsic factor, suggesting that SPEM derived from tran

223 ts and controlled by extrinsic (but not cell-intrinsic) factors, suggesting that sepsis-induced chang

224 These results identify Lin-28 as a stem cell intrinsic factor that boosts insulin signaling in intest

225 istone demethylase UTX was an essential cell-intrinsic factor that controlled an iNKT-cell lineage-sp

226 this study, we identify an oligodendroglial-intrinsic factor that controls OL maturation specificall

227 sults indicate that MALT1 is a central, cell-intrinsic factor that determines the encephalitogenic po

228 the length of the C-terminus is an important intrinsic factor that directly correlates with the therm

229 curiosity has been suggested as an important intrinsic factor that enhances learning, whereas in dome

230 id cells identified Selplg as a myeloid cell intrinsic factor that is deregulated in chronic wounds.

231 he transcriptional repressor, Blimp-1, is an intrinsic factor that predisposes CD4(+) memory T cells

232 Our study identifies Pals1 as a novel intrinsic factor that regulates the generation of cerebe

233 However, our limited knowledge of the intrinsic factors that act along the secretory pathway,

234 ted to address a real-world issue of finding intrinsic factors that affect drugs' clinical exposure w

235 gms of ENaC regulation include extrinsic and intrinsic factors that affect the expression, single-cha

236 how water sorption behavior is influenced by intrinsic factors that are related to structural propert

237 Moreover, identification of myeloid cell intrinsic factors that contribute to chronic inflammatio

238 In search of intrinsic factors that contribute to the distinctively s

239 In search of intrinsic factors that control collateral branch develop

240 Little is known about common cell-intrinsic factors that control the development of such d

241 However, the extrinsic and intrinsic factors that control the recognition and rejec

242 Moreover, the intrinsic factors that control the timing of neurogenesi

243 The cell intrinsic factors that determine whether a neuron regene

244 e been implicated, little is known about the intrinsic factors that direct this process.

245 However, the tumor-intrinsic factors that drive chemokine production and TI

246 The intrinsic factors that drive reactive neutrophilias and

247 To better understand the intrinsic factors that drive these interactions, we have

248 The intrinsic factors that endow epiblast cells with the com

249 and what remains to be understood about the intrinsic factors that form the first line of defence ag

250 me host animal suggests that there are tumor-intrinsic factors that influence metastatic seeding.

251 However, the cell-intrinsic factors that influence the induction of cell d

252 m can be influenced by diverse extrinsic and intrinsic factors that influence the risk of disease.

253 their fitness may be reduced by external and intrinsic factors that may limit their success and sugge

254 purpose of this review is to highlight niche intrinsic factors that may promote or support malignant

255 This progression is mediated by clonal intrinsic factors that mediate tumor invasiveness as wel

256 The role of tissue-intrinsic factors that might contribute to regulation of

257 at can be initiated by numerous extrinsic or intrinsic factors that promote an unstable and hyperosmo

258 elta mice provide a model to identify B cell-intrinsic factors that promote T cell-dependent immune r

259 epted that the primary size determinants are intrinsic factors that regulate and coordinate cell prol

260 However, the intrinsic factors that regulate muscle pre-patterning re

261 The intrinsic factors that regulate muscle-specific characte

262 nitrogen compounds in the environment and by intrinsic factors that regulate the frequency and patter

263 a complex microenvironment of extrinsic and intrinsic factors that regulate the self-renewing and as

264 Little is known of the tumor-intrinsic factors that regulate these mechanisms.

265 Beyond cancer-cell intrinsic factors, the immune status of the host has a p

266 Like intrinsic factors, the trout cobalamin-binding protein w

267 cause holobionts are biologically different (intrinsic factors), they were exposed to different envir

268 specific rescue show that it functions as an intrinsic factor to control GSC self-renewal.

269 ulated by a number of environmental and cell-intrinsic factors to adapt to environmental changes.

270 r, the relative contribution of myeloid cell-intrinsic factors to chronic inflammation versus aberran

271 However, memory CD8+ T cells relied on intrinsic factors to control differentiation upon challe

272 rically, sequentially expressing a series of intrinsic factors to generate a diversity of neuron type

273 uggest that early signals can modulate these intrinsic factors to influence the timing of neurogenesi

274 relative contribution of systemic and brain-intrinsic factors to neurovascular function.

275 the relative contribution of synaptic versus intrinsic factors to the temporal dispersion of spikes i

276 strate that, in mouse embryos, extrinsic and intrinsic factors together regulate meiotic initiation.

277 increased numbers of cells that coexpressed intrinsic factor, trefoil factor 2, and Griffonia (Bande

278 (HSCs) is finely regulated by extrinsic and intrinsic factors via various signaling pathways.

279 nt study we investigated contribution of the intrinsic factor VIII (fVIII)-dependent pathway.

280 he recently described endocytic receptor for intrinsic factor-vitamin B(12).

281 ted that Cubilin, the endocytic receptor for intrinsic factor-vitamin B12, albumin and apolipoprotein

282 The search for intrinsic factors, which account for a protein's capabil

283 ral, regulation of these elements depends on intrinsic factors with little direct input from the host

284 The remaining 60-80% is shaped by intrinsic factors, with age being the predominant factor

285 CMV control shaped by both viral and tissue-intrinsic factors, with global effects on homeostasis of

286 ults from interactions between extrinsic and intrinsic factors, with important implications for popul

287 t of the cellular respiratory rate is due to intrinsic factors within the myofibre.

288 Local intrinsic factors within the neighboring DNA that determ

289 hospholipid vesicles promote assembly of the intrinsic factor X (FX) activating complex by presenting

290 r of native Factor IXa for assembly into the intrinsic Factor X activation complex, Factor IXai, was

291 increase the affinity of factor IXa for the intrinsic factor X activation complex.

292 Intrinsic factor X activation is accelerated >10(7)-fold

293 been shown to be a specific inhibitor of the intrinsic factor X-(FX)-activating complex.

294 Activated platelets promote intrinsic factor X-activating complex assembly by presen

295 alue similar to its Ki for inhibition of the intrinsic factor Xase (105 microM).

296 The intrinsic factor Xase complex (FXase) is comprised of a

297 ith fIXa results in potent inhibition of the intrinsic factor Xase complex.

298 ivates the cofactor at two levels within the intrinsic factor Xase complex.

299 ly response; and 3) in normal hemostasis the intrinsic factor Xase function contributes to the durabi

300 activation after resupply; 2) impairments in intrinsic factor Xase function, i.e. hemophilias A and B