ライフサイエンスコーパス: intrinsically

1 even though isolated MSNs do not burst fire intrinsically.

2 Such transport is intrinsically 3D and an accurate measurement must captur

3 cognitive flexibility may be associated with intrinsically abnormal functional connectivity of fronto

4 m the difference in the frequencies of their intrinsically accessible modes of motion.

5 r of 1.25, strongly suggesting that ACTIS is intrinsically accurate and that its accuracy is robust.

6 s for future immunotherapies, materials that intrinsically activate or suppress the immune system are

7 ing" of Cu NPs creates disordered structures intrinsically active for low overpotential C(2+) formati

8 Here, the design of a novel, intrinsically adhesive hydrogel and its use in developin

9 Intrinsically and fully stretchable active-matrix-driven

10 Although often overlooked, the interplay of intrinsically anionic POMs with organic and inorganic ca

11 ytic machinery for basal GTP hydrolysis, are intrinsically asymmetric.

12 re we describe a robust genetic program that intrinsically attenuates apoptosis competence in neurons

13 ther horizontal distances are expected to be intrinsically brighter and were found to be associated w

14 ECL emissions are intrinsically broad and lack the definition of other ava

15 IA increases plastic dendritic spines of the intrinsically bursting neurons and their interaction wit

16 eficits, and synaptic dysfunction to layer V intrinsically bursting pyramidal neurons in the prefront

17 The orbital angular momentum (OAM) intrinsically carried by vortex light beams holds a prom

18 It is intrinsically challenging to calculate NMR chemical shif

19 ar dynamics simulations of such ions bearing intrinsically charged labels reveal evidence of numerous

20 s compounds, in which the phosphorus atom is intrinsically chiral if R(1) != R(2).

21 In recent years, the colloidal synthesis of intrinsically chiral nanocrystals (NCs) of several chira

22 operties allowed us to prepare a persistent, intrinsically chiral, diradical which notably displayed

23 all-molecule additive (1-aza[6]helicene) and intrinsically chiral-sidechain polymers using a combinat

24 As a result, intrinsically compact and energy-efficient switching uni

25 echniques have made a number of designs with intrinsically complex geometries feasible to produce.

26 stance, tend to respond to small objects and intrinsically compute their direction of movement.

27 eport of the thermoelectric properties of an intrinsically conductive 3D MOF.

28 ry building unit and form cubic, porous, and intrinsically conductive structures, with electrical con

29 The rare combination of two intrinsically conflicting properties, i.e., backbone sta

30 rt at the plasma membrane and tonoplast, are intrinsically connected and communicate through this poo

31 Orientation is intrinsically coupled to position in microscopy imaging,

32 is coupling coefficients designed so far are intrinsically coupled, which inhibits their full impleme

33 s these confounders, and report thousands of intrinsically covarying gene pairs in mouse embryonic st

34 The CA hexamers are intrinsically curved, flexible and asymmetric, revealing

35 First, we applied hierarchical clustering to intrinsically define the functional boundaries of the MF

36 stances the template and/or strand structure intrinsically determines topology, which means that only

37 Intrinsically, detrimental defects accumulating at the s

38 llular complexity of brain-on-a-chip systems intrinsically develops cell type-specific phenotypes rel

39 gesting that their mechanisms of folding are intrinsically different from those observed in globular

40 s heterostructures present two versatile but intrinsically different platforms for exploring emergent

41 er, suggest that these forms of salience are intrinsically different, although the neural mechanisms

42 ution is similar in plants and animals or is intrinsically different.

43 oreceptors have cytoplasmic domains that are intrinsically disordered (i.e., have high configurationa

44 atic intramolecular interactions between the intrinsically disordered acidic tracts and the positivel

45 hat low-complexity domains (LCDs) tend to be intrinsically disordered and are relatively rare within

46 ns leading to NUP98 gene fusions involve the intrinsically disordered and N-terminal region of NUP98

47 The structure is intrinsically disordered and therefore remains poorly ch

48 Intrinsically disordered by itself, and previously uncha

49 ular recognition element (alpha-MoRE) of the intrinsically disordered C-terminal domain of the measle

50 s egg extract to investigate the role of the intrinsically disordered C-terminal tail of the XRCC4-li

51 entify AC9 (apical cap protein 9), a largely intrinsically disordered component of the Toxoplasma gon

52 lecular Recognition Feature (MoRF) within an intrinsically disordered domain of PopZ contributes to t

53 the back of the Kif14 molecular motor is an intrinsically disordered domain that gives it superpower

54 pronounced in the serine- and arginine-rich intrinsically disordered domain; these domains are known

55 s participation of RNA-binding proteins with intrinsically disordered domains (IDPs) in the DNA damag

56 ipheral channels, but some apparently extend intrinsically disordered domains containing nuclear loca

57 usly showed that the interaction between two intrinsically disordered domains, NCBD and CID, likely e

58 Phosphorylation of intrinsically disordered eIF4E binding proteins (4E-BPs)

59 acteria that is analogous to those formed by intrinsically disordered hub proteins in other kingdoms.

60 ic resonance (NMR) spectroscopy that Spp2 is intrinsically disordered in solution.

61 eactor where the interaction between M6A, an intrinsically disordered iron-binding domain, and an iro

62 f the energy landscape of a highly reactive, intrinsically disordered library peptide before and afte

63 binding, and coupled folding and binding of intrinsically disordered ligands to additional concepts

64 tion element whereas the C-terminus forms an intrinsically disordered linker (IDL) capped by a protei

65 erved ssDNA-binding domain, a less conserved intrinsically disordered linker (IDL), and a highly cons

66 We found that the intrinsically disordered linker region connecting the tw

67 lation kinetics scale with the length of the intrinsically disordered linkers that join the enzyme an

68 Our findings highlight an important role of intrinsically disordered linkers to modulate RNA interac

69 nd that a probe inserted within the enzyme's intrinsically disordered loop samples multiple conformat

70 e membrane-anchoring C-terminal tail and the intrinsically disordered loop, and this has resulted in

71 on of phase diagrams for a set of archetypal intrinsically disordered low-complexity domains.

72 Here, we investigate the role of intrinsically disordered mixed-charge domains (MCDs) in

73 probe the structuring and aggregation of the intrinsically disordered mutant Huntingtin (mHtt) vis-a-

74 Truncated XPA, lacking the intrinsically disordered N- and C-termini, loses specifi

75 himeras, we establish that engagement of the intrinsically disordered N-terminal extension of ClpS by

76 n spliceosomal proteins were predicted to be intrinsically disordered or to contain disordered region

77 iced exons also overlap more frequently with intrinsically disordered peptide regions than constituti

78 The early events in the aggregation of the intrinsically disordered peptide, amyloid-beta (Abeta),

79 nent regulatory protein in eukaryotes and an intrinsically disordered protein (IDP), regulates cell d

80 ed simulations of the self-organized polymer-intrinsically disordered protein (SOP-IDP) model of Abet

81 s (EB1 and PRC1) diffuse more slowly than an intrinsically disordered protein (Tau) on MTs.

82 erns, on the complex structural space of the intrinsically disordered protein alpha-synuclein.

83 Intrinsically disordered protein domains often have mult

84 ay utilizes damage-induced transcription and intrinsically disordered protein RBM14 for efficient rep

85 c analysis suggests that HVR-1 is a putative intrinsically disordered protein region.

86 ic interactions mediated by self-associating intrinsically disordered protein regions-are thought to

87 It is an intrinsically disordered protein that binds acidic phosp

88 alpha-Synuclein is an intrinsically disordered protein that can self-aggregate

89 RNAS PATHWAYS9 (CARP9), a nuclear-localized, intrinsically disordered protein, as a factor promoting

90 As an intrinsically disordered protein, monomeric alpha-synucl

91 re, we elucidated the mechanistic role of an intrinsically disordered protein, REPETITIVE PRO-RICH PR

92 iquid-liquid phase separation of multivalent intrinsically disordered protein-RNA complexes is ubiqui

93 iled structural ensemble of a membrane-bound intrinsically disordered protein.

94 with the N terminus of CsoS2, a multivalent, intrinsically disordered protein.

95 Intrinsically disordered proteins (IDPs) abound in cellu

96 Dynein light chain 8 (LC8) interacts with intrinsically disordered proteins (IDPs) and influences

97 Intrinsically disordered proteins (IDPs) and intrinsical

98 tigating the drivers of LLPS have shown that intrinsically disordered proteins (IDPs) and nucleic aci

99 These interactions often involve intrinsically disordered proteins (IDPs) and protein bin

100 Intrinsically disordered proteins (IDPs) can display a b

101 Intrinsically disordered proteins (IDPs) can form liquid

102 Phase separation of intrinsically disordered proteins (IDPs) commonly underl

103 Intrinsically disordered proteins (IDPs) constitute an i

104 Many intrinsically disordered proteins (IDPs) have been deter

105 Phase separation of intrinsically disordered proteins (IDPs) is a remarkable

106 Intrinsically disordered proteins (IDPs) or regions of i

107 Many properties of intrinsically disordered proteins (IDPs), or protein reg

108 olecular interactions of a set of artificial intrinsically disordered proteins (IDPs), we have create

109 Intrinsically disordered proteins (IDPs), which in isola

110 mineralization processes and the function of intrinsically disordered proteins (IDPs).

111 ite many previous studies on condensation of intrinsically disordered proteins and low complexity dom

112 ly, whereas disorder-to-order transitions of intrinsically disordered proteins appear to follow rules

113 Intrinsically disordered proteins are proteins whose nat

114 rated--functional activation of supercharged intrinsically disordered proteins by low concentrations

115 Highly charged intrinsically disordered proteins can form complexes wit

116 Intrinsically disordered proteins control cell elongatio

117 relationships in conformational ensembles of intrinsically disordered proteins derived using experime

118 Intrinsically disordered proteins function as flexible s

119 commonly observed in signal transduction by intrinsically disordered proteins in biology.

120 performance of force fields recommended for intrinsically disordered proteins in molecular dynamics

121 scriptome-wide analysis of mRNAs that encode intrinsically disordered proteins revealed that each has

122 ng for analysis by other techniques, such as intrinsically disordered proteins, amyloidogenic protein

123 ecently to be well suited for simulations of intrinsically disordered proteins.

124 using an explicit water model optimized for intrinsically disordered proteins.

125 important for the activity and misfolding of intrinsically disordered proteins.

126 to conformational biases in the ensembles of intrinsically disordered proteins.

127 ins fail to properly reproduce properties of intrinsically disordered proteins.

128 define its molecular determinants acting on intrinsically disordered proteins.

129 rging features of binding-induced folding of intrinsically disordered proteins.

130 Intrinsically disordered proteins/regions (IDPs/IDRs) co

131 The C-terminal intrinsically disordered region (C-IDR), remaining disor

132 GCNA contains an acidic intrinsically disordered region (IDR) and a protease-lik

133 In parallel, we have identified the intrinsically disordered region (IDR) at the N-terminal

134 Here, we find that the intrinsically disordered region (IDR) of APC, which cont

135 found that its N-terminal half comprises an intrinsically disordered region (IDR) that facilitates i

136 scattering, we show that the long N-terminal intrinsically disordered region and the linker connectin

137 An intrinsically disordered region in the outer coat protei

138 he scaffold protein Lge1, which possesses an intrinsically disordered region that phase-separates via

139 1 phosphorylates ORE1 at a hotspot within an intrinsically disordered region.

140 es in vitro, and truncation mutations in the intrinsically disordered regions (IDR) of EloA interfere

141 certain sequence characteristics, including intrinsically disordered regions (IDRs) and prion-like d

142 The nuclear pore complex (NPC) employs the intrinsically disordered regions (IDRs) from a family of

143 e show that interplay between three distinct intrinsically disordered regions (IDRs) in G3BP1 regulat

144 RM2 or depletion of SON in a cell-line where intrinsically disordered regions (IDRs) of SRRM2 are gen

145 inherited human disorders, and many occur in intrinsically disordered regions (IDRs) of transcription

146 stantial portion of the proteome consists of intrinsically disordered regions (IDRs) that do not fold

147 Robust LLPS with RNA requires two intrinsically disordered regions (IDRs), the N-terminal

148 RD4S nuclear condensation is mediated by its intrinsically disordered regions and binding of its brom

149 that are able to undergo LLPS often contain intrinsically disordered regions and remain dynamic in s

150 al proteins in Mtb, several of which contain intrinsically disordered regions at their termini.

151 e features of FoxP1 provide a glimpse of how intrinsically disordered regions can facilitate domain s

152 ven by RNA-binding proteins that harbor long intrinsically disordered regions in addition to folded R

153 Our study establishes the importance of intrinsically disordered regions in p47 for the formatio

154 rization of modular proteins containing long intrinsically disordered regions intercalated with folde

155 FLs) are abundant and functionally important intrinsically disordered regions that connect protein do

156 Intrinsically disordered proteins (IDPs) and intrinsically disordered regions within proteins (IDRs)

157 udies have shown that LCRs may co-occur with intrinsically disordered regions, are highly conserved i

158 cs, and more likely to contain proteins with intrinsically disordered regions, implying that environm

159 eir structure, possibly by intercalating its intrinsically disordered regions.

160 nce motifs found in numerous proteins within intrinsically disordered regions.

161 sperse oligomeric ensembles and contain long intrinsically disordered regions.

162 separation, we characterized variants of the intrinsically disordered RGG domain from LAF-1, a model

163 ism of activation and transport, the role of intrinsically disordered segments, and allostery and coo

164 ty of information that can be obtained about intrinsically disordered sequences.

165 ed to study the membrane interactions of the intrinsically disordered SH4 and Unique domains of the S

166 ic patch on the nucleosome, we find that the intrinsically disordered SIRT6 C-terminus promotes bindi

167 small molecules is challenging due to their intrinsically disordered state.

168 However, the Delta11 variant alters an intrinsically disordered tail in CRY1 downstream of the

169 The aggregation of the intrinsically disordered tau protein into highly ordered

170 On the biopolymer side, microtubules possess intrinsically disordered, negatively charged C-terminal

171 The intrinsically disordered, positively charged H4 histone

172 ery that a large fraction of the proteome is intrinsically disordered, while being functional, has re

173 ions of these biomineralization proteins are intrinsically disordered.

174 P granules and stress granules and identify intrinsically-disordered proteins as drivers of RNA cond

175 ne sulfonate) (PEDOT:PSS), in which PEDOT is intrinsically doped due to inclusion of PSS.

176 hanges in cytoarchitecture and mechanics are intrinsically driven by topographical confinement rather

177 We find that OCD distortion is intrinsically due to S6 kinase 1 (S6K1) activation.

178 Supramolecular systems are intrinsically dynamic and sensitive to changes in molecu

179 the fitness landscape of strategies becomes intrinsically dynamic due to species-environment feedbac

180 nt SPION (EuSPION) core and the silica-based intrinsically emitting shell of the core-shell MSN.

181 Mechanistically, PTGES/PGE(2) signaling intrinsically endows tumor cells resistant to T-cell cyt

182 pon proper design, the poor light absorption intrinsically featured by lanthanides is compensated by

183 Proteins are intrinsically flexible macromolecules that undergo inter

184 r hand, flexible and printed electronics use intrinsically flexible materials and printing techniques

185 The intrinsically flexible Thumb domain seems to play a majo

186 these results describe SWG as a specific and intrinsically fluorescent pharmacological tool for disse

187 velop bisaminoquinoline derivatives that can intrinsically form nanoassemblies.

188 ooperation can emerge and persist despite an intrinsically fragmented population structure.

189 It arises intrinsically from the archetypal many-body states of th

190 These gB chimeras were intrinsically fusion active and led to the formation of

191 Native mass spectrometry, an intrinsically gas-phase method, has recently been demons

192 In the auditory system, intrinsically generated activity arises within the cochl

193 dies in isolated cochleae revealed that this intrinsically generated activity is initiated by ATP rel

194 that human cerebellum may become capable of intrinsically generating epileptic activity.

195 immune microenvironment of advanced HGSOC is intrinsically heterogeneous and that chemotherapy induce

196 el slope: 54 mV dec(-1)), thus indicating an intrinsically high activation of the TMD GBs.

197 s for electrocatalysis, noble metals exhibit intrinsically high activity and excellent durability.

198 Biomolecular simulations are intrinsically high dimensional and generate noisy data s

199 C electrodes hold distinct advantages: i) an intrinsically high flexural strength that enables their

200 perates as a built-in agonist, conferring an intrinsically high level of basal activity to GPR52(3).

201 near-infrared (NIR) fluorescent probes with intrinsically high signal-to-background ratio.

202 In contrast, iSPNs, but not dSPNs, were intrinsically hyperexcitable due to reduced function of

203 Our data suggests that newborn monocytes are intrinsically impaired in extravasation through quiescen

204 Class F receptor signaling is intrinsically important for embryonic development and it

205 es claim that cortical activity is generated intrinsically, independent of movement [3, 4].

206 proteins, SHTN1's actin binding activity is intrinsically inhibited by a putative coiled-coil domain

207 sired upconverted thermal noise, no noise is intrinsically introduced by efficient electro-optic modu

208 15 g PRO), 30 (30 g PRO), or 45 (45 g PRO) g intrinsically l-[1-13C]-phenylalanine and l-[1-13C]-leuc

209 edly 4 h after a standardized meal including intrinsically labeled whey protein concentrate and calci

210 Owing to its intrinsically large and electrically tunable nonlinear o

211 ng kinetochores, low-tension attachments are intrinsically less stable than those under higher tensio

212 upercooling preservation to human organs was intrinsically limited because of volume-dependent stocha

213 e IR microspectrometer spatial resolution is intrinsically limited by diffraction (a few micrometers)

214 ical emission on plasmonic nanostructures is intrinsically limited by the distance between the emitte

215 Mechanistically, NRP1 cell-intrinsically limited the self-renewal of the CD44(+)PD1

216 However, the use of D-A blends intrinsically limits the photovoltage and introduces mor

217 hat undernutrition, obesity, and DR-NCDs are intrinsically linked through early-life nutrition, diet

218 The population coupling is intrinsically linked to fractal fluctuations: neurons sh

219 s disease transmission-that future cases are intrinsically linked to past reported cases-and are opti

220 he electrolyte at the positive electrode are intrinsically linked to surface reactivity of the active

221 cortex architecture and function, which are intrinsically linked to the development of major depress

222 cluding the recognition that PRS validity is intrinsically linked to the methodological and analytica

223 Meanwhile, DNA replication is intrinsically linked to the process of chromatin duplica

224 Cell death is intrinsically linked with immunity.

225 immune activation increases the turnover of intrinsically long-lived provirus-containing CD4(+) T ce

226 armonicity and Ag disorder are the origin of intrinsically low [Formula: see text] The breakdown of s

227 Intrinsically low lattice thermal conductivity ([Formula

228 een chemical bonding and lattice dynamics in intrinsically low thermal conductive crystalline solids

229 Because of the land constraint, the intrinsically low yields of energy per unit of land area

230 osed experimental approach to foods that are intrinsically made of both proteins and lipids.

231 The discoveries of intrinsically magnetic topological materials, including

232 och states(4-9), excitonic bound states from intrinsically many-body localized states are rare.

233 ve zeros, over-dispersion, compositionality, intrinsically microbial correlations and variable sequen

234 ates that the rhomboid transmembrane core is intrinsically monomeric.

235 talysts containing well-defined sites may be intrinsically more active and selective towards CO(2) co

236 that macrophages derived from male mice are intrinsically more migratory.

237 Yeast prion systems are intrinsically multi-scale: the molecular chemical proces

238 actical applications is severely hindered by intrinsically narrow band performance.

239 NFAT5 has three intrinsically ordered (ID) activation domains (ADs).

240 Uniquely, the nanorods are intrinsically photoacoustic and photothermal, enabling m

241 , a small population of RGCs are in addition intrinsically photosensitive (ipRGCs) and project to uni

242 The M4 and M5 melanopsin-expressing, intrinsically photosensitive retinal ganglion cell (ipRG

243 Melanopsin-expressing, intrinsically photosensitive retinal ganglion cells (ipR

244 These intrinsically photosensitive retinal ganglion cells (ipR

245 nd the intergeniculate leaflet (IGL) through intrinsically photosensitive retinal ganglion cells (ipR

246 While the melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipR

247 In the years following, many types of these intrinsically photosensitive retinal ganglion cells (ipR

248 Melanopsin-expressing intrinsically photosensitive retinal ganglion cells are

249 identified a subset of melanopsin-expressing intrinsically photosensitive RGCs (ipRGCs) in mice that

250 ough the molecular cation CH(3) NH(3) (+) is intrinsically polar, it is heavily disordered and this c

251 They are intrinsically polarized, and when compared to their nons

252 mammalian central nervous system axons have intrinsically poor regenerative capacity, so axonal inju

253 Here we report a new family of intrinsically porous frameworks made from rare-earth nit

254 n the porosity and analyte uptake ability of intrinsically porous molecular nanocarbons.

255 s selected as a conceptually simple class of intrinsically porous nanocarbons to serve as a platform

256 unorthodox - it proposes that noise, that is intrinsically present in a system or is extrinsically ad

257 ion is common in humid soils, so Fe does not intrinsically protect OM; rather reactive Fe phases requ

258 entration of the reaction components but not intrinsically quantitative.

259 functionalization, even when the C-H bond is intrinsically reactive.

260 However, whether BATF3 intrinsically regulates CD8 T cell responses is not well

261 The properties of a polymer are known to be intrinsically related to its molecular weight distributi

262 nclear which type of impulsivity, if any, is intrinsically related to TD and specifically to the seve

263 These results suggest that AFNs are intrinsically related to vagal innervation.

264 cancer patients have tumors that are either intrinsically resistant or develop resistance.

265 ugs that can benefit patients who are either intrinsically resistant or have acquired resistance to t

266 MYC and a key enzyme in glutaminolysis, are intrinsically resistant to platinum-based chemotherapy a

267 to which E. coli would usually be considered intrinsically resistant.

268 tory receptor neurons (ORNs) that consist of intrinsically rhythmically active 'bursting' ORNs (bORNs

269 Our results suggest that both intrinsically rhythmogenic neurons and neurons entrained

270 Protein kinases intrinsically sample a number of conformational states w

271 efficient, hierarchical structures that are intrinsically scaling, as well as biological catalysts t

272 Whether parental animals are intrinsically sensitive to neonatal vocalizations, or in

273 plete tumor regressions in some mice; tumors intrinsically sensitive to SHP2 inhibition or checkpoint

274 These reactions are intrinsically slow because, although the precursorsare "

275 -S) batteries are the cornerstone to enhance intrinsically sluggish reaction kinetics but the true ac

276 However, fabricating intrinsically stable SACs on traditional supports (N-dop

277 nd that switching near the critical point is intrinsically stochastic and provide evidence that contr

278 ertoires is achieved by a combination of two intrinsically stochastic steps: random receptor generati

279 the development of chemically-orthogonal and intrinsically stretchable dielectric materials.

280 aterial is implemented in the first reported intrinsically stretchable organic thermoelectric module.

281 n overview of the recent developments in new intrinsically stretchable piezoelectric materials and ri

282 cryopolymerization strategy for preparing an intrinsically stretchable, compressible and bendable ani

283 Results: The FERM nanoemulsion was intrinsically taken up by phagocytic immune cells, parti

284 h temperature are desirable because they are intrinsically thermally insulating while retaining usefu

285 Polynitrides are intrinsically thermodynamically unstable at ambient cond

286 he bipolar cell population, rather than cell-intrinsically, to control VGluT3 cell number.

287 oustic-optical phonon coupling results in an intrinsically ultralow kappa(L) value in the all-inorgan

288 Here, we discover intrinsically ultralow lattice thermal conductivity (kap

289 easily compromised during plating, making it intrinsically unable to protect Li.

290 by exponentially growing dynamics, which are intrinsically unpredictable.

291 ut rather structural and reactive control of intrinsically unstable carbocations in order to guide th

292 lipid accumulation in caveolae generates an intrinsically unstable domain prone to scission if not r

293 d simultaneously promotes the degradation of intrinsically unstable KIF1A proteins by proteasomes in

294 t KIF1A, unlike other axonal kinesins, is an intrinsically unstable protein prone to proteasomal degr

295 A flanking the RNA-5' side of R-loops is not intrinsically unstable.

296 MoCl(4)(THF)(2)] itself was also found to be intrinsically unstable; remarkably, this substrate conve

297 ing, we explicate the mechanism by which the intrinsically unstructured N-terminal translocation doma

298 the burgeoning population of older adults is intrinsically vulnerable to cardiovascular disease, the

299 ey do so using catalytic mechanisms that are intrinsically vulnerable to oxygen.

300 rt stem and small terminal loop render it an intrinsically weak Microprocessor substrate.