ライフサイエンスコーパス: intrinsically disordered

1 , but remarkably, many of these proteins are intrinsically disordered.

2 its oligomerization domain, is thought to be intrinsically disordered.

3 ions of these biomineralization proteins are intrinsically disordered.

4 a three-fingered LU domain and an N-terminal intrinsically disordered acidic domain.

5 atic intramolecular interactions between the intrinsically disordered acidic tracts and the positivel

6 d our structure of Cdc42 bound to ACK via an intrinsically disordered ACK region to guide an analysis

7 d that stabilization the N-terminal helix of intrinsically disordered ACTR accelerated its binding to

8 hat low-complexity domains (LCDs) tend to be intrinsically disordered and are relatively rare within

9 dynein light intermediate chain 1 (LIC1) is intrinsically disordered and contains two short conserve

10 ns leading to NUP98 gene fusions involve the intrinsically disordered and N-terminal region of NUP98

11 The structure is intrinsically disordered and therefore remains poorly ch

12 A substantial fraction of the proteome is intrinsically disordered, and even well-folded proteins

13 of molecular mass M that distinguish folded, intrinsically disordered, and urea-denatured biomolecule

14 es (CLKs) phosphorylate SR proteins on their intrinsically disordered Arg-Ser (RS) domains, mobilizin

15 Intrinsically disordered by itself, and previously uncha

16 uctural domains, these were characterized as intrinsically disordered by NMR spectroscopy.

17 We propose that the intrinsically disordered C terminus of cTnT directly int

18 rdiac troponin T (cTnT), in part through its intrinsically disordered C terminus, directly binds to W

19 Changing the length of the intrinsically disordered C-tail linker modifies the inte

20 Binding of the intrinsically disordered C-terminal arm of CcdA to the t

21 ular recognition element (alpha-MoRE) of the intrinsically disordered C-terminal domain of the measle

22 The large subunit of Pol II contains an intrinsically disordered C-terminal domain that is phosp

23 Z comprises a polymerizing GTPase domain, an intrinsically disordered C-terminal linker (CTL), and a

24 n the presence of glutamate and requires its intrinsically disordered C-terminal linker (IDL) region.

25 s egg extract to investigate the role of the intrinsically disordered C-terminal tail of the XRCC4-li

26 Here we show that Nopp140, an intrinsically disordered CB phosphoprotein, is required

27 zes" one of the conformational states of the intrinsically disordered Cdc25C protein partner and enha

28 entify AC9 (apical cap protein 9), a largely intrinsically disordered component of the Toxoplasma gon

29 y identified long-range interactions, and an intrinsically disordered connecting region.

30 ings indicate that a previously unrecognized intrinsically disordered domain located adjacent to the

31 lecular Recognition Feature (MoRF) within an intrinsically disordered domain of PopZ contributes to t

32 the back of the Kif14 molecular motor is an intrinsically disordered domain that gives it superpower

33 pronounced in the serine- and arginine-rich intrinsically disordered domain; these domains are known

34 s participation of RNA-binding proteins with intrinsically disordered domains (IDPs) in the DNA damag

35 ipheral channels, but some apparently extend intrinsically disordered domains containing nuclear loca

36 biophysics of proteins with low complexity, intrinsically disordered domains that have the capacity

37 usly showed that the interaction between two intrinsically disordered domains, NCBD and CID, likely e

38 ile both the FoxM1 NRD and TAD are primarily intrinsically disordered domains, they associate and ado

39 Phosphorylation of intrinsically disordered eIF4E binding proteins (4E-BPs)

40 her order structure self-assembly of the key intrinsically disordered EMPs, ameloblastin and amelogen

41 Thus, targeting the intrinsically disordered ensemble of alphaSyn offers a u

42 Native monomeric alphaSyn exists in an intrinsically disordered ensemble of interconverting con

43 uRIM was applied to probe the orientation of intrinsically disordered FG-repeat segments, providing i

44 Zwitterion (FITZ) complexes upon binding the intrinsically disordered FITZ Anionic Partner (FITZAP).

45 e GON7/LAGE3/OSGEP subcomplex shows that the intrinsically disordered GON7 protein becomes partially

46 acteria that is analogous to those formed by intrinsically disordered hub proteins in other kingdoms.

47 The intrinsically disordered human protein alpha-Synuclein (

48 r that ProTalpha, a small, widely expressed, intrinsically disordered human protein, enables up to ~1

49 oreceptors have cytoplasmic domains that are intrinsically disordered (i.e., have high configurationa

50 trate that the basic and SP-rich domains are intrinsically disordered in solution and significantly e

51 ic resonance (NMR) spectroscopy that Spp2 is intrinsically disordered in solution.

52 widely accepted that the SNARE proteins are intrinsically disordered in their monomeric prefusion fo

53 The prodomain region was found to be intrinsically disordered independent of the activation s

54 eactor where the interaction between M6A, an intrinsically disordered iron-binding domain, and an iro

55 f the energy landscape of a highly reactive, intrinsically disordered library peptide before and afte

56 binding, and coupled folding and binding of intrinsically disordered ligands to additional concepts

57 d by folded hubs and their interactions with intrinsically disordered ligands.

58 tion element whereas the C-terminus forms an intrinsically disordered linker (IDL) capped by a protei

59 erved ssDNA-binding domain, a less conserved intrinsically disordered linker (IDL), and a highly cons

60 tain a 9 residue acidic tip and a 56 residue intrinsically disordered linker (IDL).

61 However, the mechanisms by which the intrinsically disordered linker histone carboxy-terminal

62 We found that the intrinsically disordered linker region connecting the tw

63 ing Forkhead-associated domains joined by an intrinsically disordered linker with multiple phospho-ac

64 from the complex but remains tethered by an intrinsically disordered linker.

65 lation kinetics scale with the length of the intrinsically disordered linkers that join the enzyme an

66 Our findings highlight an important role of intrinsically disordered linkers to modulate RNA interac

67 nd that a probe inserted within the enzyme's intrinsically disordered loop samples multiple conformat

68 e membrane-anchoring C-terminal tail and the intrinsically disordered loop, and this has resulted in

69 on of phase diagrams for a set of archetypal intrinsically disordered low-complexity domains.

70 Gle1A isoform, six of which clustered in an intrinsically disordered, low-complexity N-terminal regi

71 Tau is an intrinsically disordered microtubule-associated protein

72 Tau is an intrinsically disordered, microtubule-associated protein

73 We found that the intrinsically disordered middle region and the folded PB

74 Here, we investigate the role of intrinsically disordered mixed-charge domains (MCDs) in

75 The transition of intrinsically disordered, monomeric alpha-synuclein into

76 probe the structuring and aggregation of the intrinsically disordered mutant Huntingtin (mHtt) vis-a-

77 nd comprise a beta-propeller core domain and intrinsically disordered N- and C-terminal tails.

78 Truncated XPA, lacking the intrinsically disordered N- and C-termini, loses specifi

79 himeras, we establish that engagement of the intrinsically disordered N-terminal extension of ClpS by

80 AFF4 consists of an intrinsically disordered N-terminal region that interact

81 Moreover, the 107-residue intrinsically disordered N-terminal segment of beta-cate

82 On the biopolymer side, microtubules possess intrinsically disordered, negatively charged C-terminal

83 iquid phase condensation of a pH-responsive, intrinsically disordered, oligopeptide repeat domain of

84 at divides the protein world into folded and intrinsically disordered ones.

85 n spliceosomal proteins were predicted to be intrinsically disordered or to contain disordered region

86 iced exons also overlap more frequently with intrinsically disordered peptide regions than constituti

87 The early events in the aggregation of the intrinsically disordered peptide, amyloid-beta (Abeta),

88 stically refining the structural ensemble of intrinsically disordered peptides (IDPs) facilitated by

89 eptide backbone conformational ensembles for intrinsically disordered peptides and proteins.

90 study demonstrates a role for phosvitin, an intrinsically disordered phosphoprotein, in chick embryo

91 The interaction of the intrinsically disordered polypeptide islet amyloid polyp

92 The intrinsically disordered, positively charged H4 histone

93 p27(Kip1) is an intrinsically disordered protein (IDP) that inhibits cyc

94 Is), those involving a folded protein and an intrinsically disordered protein (IDP), are prevalent in

95 nent regulatory protein in eukaryotes and an intrinsically disordered protein (IDP), regulates cell d

96 ed simulations of the self-organized polymer-intrinsically disordered protein (SOP-IDP) model of Abet

97 s (EB1 and PRC1) diffuse more slowly than an intrinsically disordered protein (Tau) on MTs.

98 ermination of conformational ensemble of the intrinsically disordered protein alpha-synuclein in the

99 erns, on the complex structural space of the intrinsically disordered protein alpha-synuclein.

100 Intrinsically disordered protein domains often have mult

101 alpha-Synuclein (AS) is an intrinsically disordered protein highly expressed in dop

102 yA binding protein-binding protein 1), is an intrinsically disordered protein implicated in stress gr

103 Within the intrinsically disordered protein interactome, the alpha-

104 elay of septum degradation requires Fir1, an intrinsically disordered protein localized to the cytoki

105 electron microscopy, we observed how a model intrinsically disordered protein phase-separates in liqu

106 ay utilizes damage-induced transcription and intrinsically disordered protein RBM14 for efficient rep

107 c analysis suggests that HVR-1 is a putative intrinsically disordered protein region.

108 s) or partially disordered segments known as intrinsically disordered protein regions (IDPRs).

109 atures (MoRFs) provide interaction motifs in intrinsically disordered protein regions to mediate dive

110 Such motifs, which frequently occur in intrinsically disordered protein regions, often bind par

111 ic interactions mediated by self-associating intrinsically disordered protein regions-are thought to

112 virus-1 viral infectivity factor (Vif) is an intrinsically disordered protein responsible for the ubi

113 several well-structured domains connected by intrinsically disordered protein segments are difficult

114 approach was applied to alpha-synuclein, an intrinsically disordered protein that aggregates in the

115 It is an intrinsically disordered protein that binds acidic phosp

116 alpha-Synuclein is an intrinsically disordered protein that can self-aggregate

117 alpha-Synuclein is an intrinsically disordered protein whose function in a hea

118 naptic protein alpha-synuclein (aSyn) is an 'intrinsically disordered protein' that is highly dynamic

119 RNAS PATHWAYS9 (CARP9), a nuclear-localized, intrinsically disordered protein, as a factor promoting

120 As an intrinsically disordered protein, monomeric alpha-synucl

121 re, we elucidated the mechanistic role of an intrinsically disordered protein, REPETITIVE PRO-RICH PR

122 quences of the proteins are based on a human intrinsically disordered protein, which has been appende

123 iquid-liquid phase separation of multivalent intrinsically disordered protein-RNA complexes is ubiqui

124 iled structural ensemble of a membrane-bound intrinsically disordered protein.

125 with the N terminus of CsoS2, a multivalent, intrinsically disordered protein.

126 ) interaction thus presents an example of an intrinsically disordered protein/ordered-protein interac

127 Intrinsically disordered proteins (IDPs) abound in cellu

128 Dynein light chain 8 (LC8) interacts with intrinsically disordered proteins (IDPs) and influences

129 Intrinsically disordered proteins (IDPs) and intrinsical

130 Intrinsically disordered proteins (IDPs) and membrane-le

131 tigating the drivers of LLPS have shown that intrinsically disordered proteins (IDPs) and nucleic aci

132 These interactions often involve intrinsically disordered proteins (IDPs) and protein bin

133 Intrinsically disordered proteins (IDPs) and their confo

134 Intrinsically disordered proteins (IDPs) are abundant in

135 Implicated in numerous human diseases, intrinsically disordered proteins (IDPs) are dynamic ens

136 Intrinsically disordered proteins (IDPs) are flexible bi

137 Intrinsically disordered proteins (IDPs) are well known,

138 Intrinsically disordered proteins (IDPs) as well as intr

139 Many intrinsically disordered proteins (IDPs) attain a well-d

140 signaling and regulation, are carried out by intrinsically disordered proteins (IDPs) binding to thei

141 Intrinsically disordered proteins (IDPs) can display a b

142 Intrinsically disordered proteins (IDPs) can form liquid

143 Phase separation of intrinsically disordered proteins (IDPs) commonly underl

144 ular structures that contain phase-separated intrinsically disordered proteins (IDPs) composed of seq

145 Intrinsically disordered proteins (IDPs) constitute an i

146 Many intrinsically disordered proteins (IDPs) have been deter

147 Intrinsically disordered proteins (IDPs) have fluctuatin

148 Intrinsically disordered proteins (IDPs) have roles in m

149 Phase separation of intrinsically disordered proteins (IDPs) is a remarkable

150 eterogeneity, structural characterization of intrinsically disordered proteins (IDPs) is very challen

151 s and mutations that change charge states in intrinsically disordered proteins (IDPs) is well-establi

152 Intrinsically disordered proteins (IDPs) often fold into

153 Intrinsically disordered proteins (IDPs) or regions (IDR

154 less organelles form via phase separation of intrinsically disordered proteins (IDPs) or regions (IDR

155 Intrinsically disordered proteins (IDPs) or regions of i

156 nt (LEA) proteins are mostly predicted to be intrinsically disordered proteins (IDPs) that are induce

157 Intrinsically disordered proteins (IDPs) that lack a uni

158 dimensions that unfolded proteins, including intrinsically disordered proteins (IDPs), adopt in the a

159 Many properties of intrinsically disordered proteins (IDPs), or protein reg

160 olecular interactions of a set of artificial intrinsically disordered proteins (IDPs), we have create

161 Intrinsically disordered proteins (IDPs), which in isola

162 es in the functional mechanisms exploited by intrinsically disordered proteins (IDPs).

163 mineralization processes and the function of intrinsically disordered proteins (IDPs).

164 Here we show that tardigrade-specific intrinsically disordered proteins (TDPs) are essential f

165 scussing examples from evolutionary biology, intrinsically disordered proteins and current biomedical

166 ite many previous studies on condensation of intrinsically disordered proteins and low complexity dom

167 flexibility and binding properties of these intrinsically disordered proteins and probably exemplifi

168 d recognition of the prevalence and roles of intrinsically disordered proteins and protein regions (I

169 Intrinsically disordered proteins and proteins with intr

170 Liquid granules rich in intrinsically disordered proteins and RNA play key roles

171 ly, whereas disorder-to-order transitions of intrinsically disordered proteins appear to follow rules

172 Intrinsically disordered proteins are crucial elements o

173 amplitudes of conformational fluctuations of intrinsically disordered proteins are governed, in part,

174 Protein-protein interactions involving intrinsically disordered proteins are important for cell

175 Intrinsically disordered proteins are proteins whose nat

176 rated--functional activation of supercharged intrinsically disordered proteins by low concentrations

177 Highly charged intrinsically disordered proteins can form complexes wit

178 Intrinsically disordered proteins control cell elongatio

179 relationships in conformational ensembles of intrinsically disordered proteins derived using experime

180 Intrinsically disordered proteins function as flexible s

181 Data indicate that the intrinsically disordered proteins have a similar behavio

182 Intrinsically disordered proteins have been reported to

183 commonly observed in signal transduction by intrinsically disordered proteins in biology.

184 performance of force fields recommended for intrinsically disordered proteins in molecular dynamics

185 between these marginally stable proteins and intrinsically disordered proteins in order to fully unde

186 Liquid-liquid phase separation of intrinsically disordered proteins into mesoscopic, dynam

187 Intrinsically disordered proteins often play an importan

188 Intrinsically disordered proteins organize interaction n

189 Intrinsically disordered proteins play important roles t

190 scriptome-wide analysis of mRNAs that encode intrinsically disordered proteins revealed that each has

191 The NPC passageway is lined by intrinsically disordered proteins that contain hydrophob

192 The results indicate that, in the case of intrinsically disordered proteins too, the folding mecha

193 Intrinsically disordered proteins with stickers uniforml

194 The sugar trehalose and hydrophilins (small intrinsically disordered proteins) had also been propose

195 ng for analysis by other techniques, such as intrinsically disordered proteins, amyloidogenic protein

196 Dehydrins are intrinsically disordered proteins, generally expressed i

197 Finally, we implicate intrinsically disordered proteins, key components in mRN

198 Intrinsically disordered proteins, like tau, are enriche

199 hich has acquired a state similar to that of intrinsically disordered proteins, resulting in a predom

200 ntrast, it has recently been discovered that intrinsically disordered proteins, which lack a defined

201 to conformational biases in the ensembles of intrinsically disordered proteins.

202 ins fail to properly reproduce properties of intrinsically disordered proteins.

203 define its molecular determinants acting on intrinsically disordered proteins.

204 rging features of binding-induced folding of intrinsically disordered proteins.

205 ted in the liquid-liquid phase separation of intrinsically disordered proteins.

206 lationship between sequence and structure of intrinsically disordered proteins.

207 etheless poorly understood, particularly for intrinsically disordered proteins.

208 ecently to be well suited for simulations of intrinsically disordered proteins.

209 using an explicit water model optimized for intrinsically disordered proteins.

210 important for the activity and misfolding of intrinsically disordered proteins.

211 Intrinsically disordered proteins/regions (IDPs/IDRs) co

212 P granules and stress granules and identify intrinsically-disordered proteins as drivers of RNA cond

213 proteins have some features in common with "intrinsically disordered" proteins.

214 The C-terminal intrinsically disordered region (C-IDR), remaining disor

215 GCNA contains an acidic intrinsically disordered region (IDR) and a protease-lik

216 In parallel, we have identified the intrinsically disordered region (IDR) at the N-terminal

217 Here, we find that the intrinsically disordered region (IDR) of APC, which cont

218 multiple-chain simulations of the N-terminal intrinsically disordered region (IDR) of DEAD-box helica

219 found that its N-terminal half comprises an intrinsically disordered region (IDR) that facilitates i

220 CA512 RESP18HD residues 91-131 encode for an intrinsically disordered region (IDR), which in vitro ac

221 at the conserved residues of CBX2 within the intrinsically disordered region (IDR), which is the regi

222 l F-BAR domain linked to an SH3 domain by an intrinsically disordered region (IDR).

223 ences of charge patterning on the C-terminal intrinsically disordered region (p27 IDR) of the cell cy

224 scattering, we show that the long N-terminal intrinsically disordered region and the linker connectin

225 An intrinsically disordered region in the outer coat protei

226 the inhibitory activity and suggest that the intrinsically disordered region makes its inhibitory pot

227 his study reveals the mechanistic role of an intrinsically disordered region of a transmembrane recep

228 We conclude that helix 1 in the intrinsically disordered region of LIC provides a conser

229 nd tightly to a long acidic tract within the intrinsically disordered region of NPM1, altering its ph

230 The intrinsically disordered region of SSB is required for a

231 he scaffold protein Lge1, which possesses an intrinsically disordered region that phase-separates via

232 nally, the eIF4E4 N-terminal extension is an intrinsically disordered region that transitions to a pa

233 restin's C-terminal, specifically within the intrinsically disordered region, we sought to delete the

234 X-isoleucine-proline) which exists within an intrinsically disordered region.

235 1 phosphorylates ORE1 at a hotspot within an intrinsically disordered region.

236 es in vitro, and truncation mutations in the intrinsically disordered regions (IDR) of EloA interfere

237 certain sequence characteristics, including intrinsically disordered regions (IDRs) and prion-like d

238 Intrinsically disordered regions (IDRs) are often fast-e

239 Intrinsically disordered regions (IDRs) are present in a

240 The nuclear pore complex (NPC) employs the intrinsically disordered regions (IDRs) from a family of

241 e show that interplay between three distinct intrinsically disordered regions (IDRs) in G3BP1 regulat

242 ically disordered proteins (IDPs) as well as intrinsically disordered regions (IDRs) of complex prote

243 RM2 or depletion of SON in a cell-line where intrinsically disordered regions (IDRs) of SRRM2 are gen

244 inherited human disorders, and many occur in intrinsically disordered regions (IDRs) of transcription

245 Intrinsically disordered regions (IDRs) play important r

246 stantial portion of the proteome consists of intrinsically disordered regions (IDRs) that do not fold

247 We find that ORC, Cdc6, and Cdt1 contain intrinsically disordered regions (IDRs) that drive LLPS

248 es of full-length kinases and to address the intrinsically disordered regions (IDRs) that typically f

249 T, TGF-beta, and JAK/STAT pathways use their intrinsically disordered regions (IDRs) to enter and con

250 Robust LLPS with RNA requires two intrinsically disordered regions (IDRs), the N-terminal

251 gomerization domain (Pcore) flanked by large intrinsically disordered regions (IDRs).

252 We show here that N- and C-terminal intrinsically disordered regions account for 80% of the

253 RD4S nuclear condensation is mediated by its intrinsically disordered regions and binding of its brom

254 y motor and structural proteins that contain intrinsically disordered regions and coiled coil domains

255 r proteins, however 14-3-3 complexes feature intrinsically disordered regions and often a transient t

256 that are able to undergo LLPS often contain intrinsically disordered regions and remain dynamic in s

257 al proteins in Mtb, several of which contain intrinsically disordered regions at their termini.

258 e features of FoxP1 provide a glimpse of how intrinsically disordered regions can facilitate domain s

259 ven by RNA-binding proteins that harbor long intrinsically disordered regions in addition to folded R

260 Our study establishes the importance of intrinsically disordered regions in p47 for the formatio

261 rization of modular proteins containing long intrinsically disordered regions intercalated with folde

262 Intrinsically disordered regions make up a large part of

263 lignment between exons and the boundaries of intrinsically disordered regions of proteins is not a ge

264 , may generally promote interactions between intrinsically disordered regions of proteins.

265 e of cysteine reactive inhibitors, targeting intrinsically disordered regions of transcription factor

266 cause RPs are often highly basic and contain intrinsically disordered regions prone to nonspecific in

267 FLs) are abundant and functionally important intrinsically disordered regions that connect protein do

268 t of transcription regulators that use their intrinsically disordered regions to remodel transcriptio

269 We demonstrate that intrinsically disordered regions with similar evolutiona

270 rescue function in vivo, and that groups of intrinsically disordered regions with similar evolutiona

271 Intrinsically disordered proteins (IDPs) and intrinsically disordered regions within proteins (IDRs)

272 y motifs (alpha-helixes and beta-sheets) and intrinsically disordered regions), to function (activity

273 ically disordered proteins and proteins with intrinsically disordered regions, although extremely imp

274 udies have shown that LCRs may co-occur with intrinsically disordered regions, are highly conserved i

275 cs, and more likely to contain proteins with intrinsically disordered regions, implying that environm

276 nce motifs found in numerous proteins within intrinsically disordered regions.

277 contain BAR domains often also contain large intrinsically disordered regions.

278 nteractions, often mediated by proteins with intrinsically disordered regions.

279 d in the amino acid sequences of orthologous intrinsically disordered regions.

280 erent interacting partners that bind through intrinsically disordered regions.

281 sperse oligomeric ensembles and contain long intrinsically disordered regions.

282 eir structure, possibly by intercalating its intrinsically disordered regions.

283 re characterized by three to five conserved, intrinsically disordered repeat regions that mediate ele

284 e also show that most proteins designated as intrinsically disordered retain their unfolded structure

285 separation, we characterized variants of the intrinsically disordered RGG domain from LAF-1, a model

286 The model includes an RNA element called an intrinsically disordered RNA region (IDRR).

287 ism of activation and transport, the role of intrinsically disordered segments, and allostery and coo

288 ty of information that can be obtained about intrinsically disordered sequences.

289 transcription factor ETS1 is regulated by an intrinsically disordered serine-rich region (SRR) that t

290 ed to study the membrane interactions of the intrinsically disordered SH4 and Unique domains of the S

291 t Acinetobacter baumannii, is mediated by an intrinsically disordered short linear motif and a beta-h

292 ic patch on the nucleosome, we find that the intrinsically disordered SIRT6 C-terminus promotes bindi

293 small molecules is challenging due to their intrinsically disordered state.

294 yoelectron microscopy, revealed that several intrinsically disordered tail domains of two NP pentamer

295 However, the Delta11 variant alters an intrinsically disordered tail in CRY1 downstream of the

296 The aggregation of the intrinsically disordered tau protein into highly ordered

297 Intrinsically disordered transcription factor transactiv

298 ery that a large fraction of the proteome is intrinsically disordered, while being functional, has re

299 The removal of the intrinsically-disordered YAP transcription activation do

300 at the N-terminal inhibitory domain (NID) is intrinsically disordered, yet utilizes transient intramo