ライフサイエンスコーパス: intron-containing

1 ed the ability of a formerly non-stimulating intron containing 11 copies of the sequence TTNGATYTG, w

2 uggest that there are at least two distinct, intron-containing 4CL genes, at least one of which is tr

3 of unmasked cryptic splice sites, including introns containing ADAR-dependent A-to-I editing cluster

4 When a shortened form of the intron containing all but the 3'-terminal six nucleotide

5 lleles, while minimizing cleavage at its own intron-containing allele.

6 donuclease from binding and cleaving its own intron-containing allele.

7 lts in unidirectional gene conversion to the intron-containing allele.

8 pts the endonucleases' recognition sequence, intron-containing alleles are immune to cleavage by thei

9 tic drift and weak mutation pressure against intron-containing alleles yields predictions consistent

10 efficiency and distinguishes intronless from intron-containing alleles.

11 U12-dependent introns containing alterations of the 3' splice site AC

12 his purpose two non-redundant samples of 719 intron-containing and 63 intron-lacking human genes were

13 a statistical analysis on these datasets of intron-containing and intron-lacking human coding sequen

14 AF1, and U2AF2-bind near active promoters of intron-containing and intronless genes, implying their a

15 inhibition was observed for mRNAs from both intron-containing and intronless histone genes.

16 an endothelial cells and megakaryocytes with intron-containing and intronless human vWF promoter-luci

17 I-BmoI binds intron-containing and intronless substrates with equal a

18 mes described here cleave one strand on both intron-containing and intronless targets at different di

19 ce with respect to the intron IS, binds both intron-containing and intronless TS-encoding substrates,

20 Eukaryotes have both 'intron containing' and 'intron less' genes.

21 by increasing the efficiency of splicing of introns containing branchpoint sequences with less than

22 AGO bind the nascent transcripts of not only intron-containing but also intronless genes on Drosophil

23 recruited to the export machinery or how the intron-containing but unspliced M1 mRNA bypasses the nor

24 eferentially binds and modulates splicing of introns containing CAG trinucleotides at their 3' splice

25 In an enhancer assay, the first intron containing cat construct exhibited a 5.4-fold inc

26 Although nuclear export of intron-containing cellular transcripts is restricted in

27 rerequisite for translation initiation on an intron-containing chloroplast RNA; and (3) a feedback co

28 monocistronic clpP mRNA and accumulation of intron-containing clpP transcripts in the chlorotic leav

29 e lowers the levels of spliced products from intron-containing constructs and can functionally replac

30 One or more intron-containing copies are retained in the Ssty-defici

31 We have now identified an intron-containing copy that is also present in multiple

32 of the gene may exist, only one full-length intron-containing copy was identified.

33 defects by an RNA gel blot assay, using the intron- containing CRY1 and ACT1 genes as hybridization

34 have previously demonstrated that unspliced intron-containing CTE RNA is efficiently exported to the

35 originated from a retrotransposed copy of an intron-containing DUX gene, DUXC.

36 ucture of the d3' hairpin of the Sc.ai5gamma intron containing EBS1 in its 11-nucleotide loop in comp

37 an essential step for the expression of all intron-containing eukaryotic genes.

38 Intron-containing expression cassettes were transfected

39 Furthermore, imaging of intron-containing FIV RNA showed that hCRM1 increased RN

40 Intron-containing fragments also accumulated in mutants,

41 pendently evolved the ability to distinguish intron-containing from intronless alleles while maintain

42 splicing isoforms were derived from 128 667 intron-containing full-length FLNC reads, including a la

43 We designed an intron-containing full-length KCNH2 gene construct to st

44 he U2AF2 protein also accumulates throughout intron-containing gene bodies and requires histone H3-ly

45 The intron-containing gene for human ribosomal protein RPL23

46 however, how a defective spliceosome affects intron-containing gene transcripts in human cells is lar

47 cing efficiency in 47% of the F. graminearum intron-containing gene transcripts that are involved in

48 f intron loss by replacement of an ancestral intron-containing gene with a reverse-transcribed DNA co

49 ruitment of RNA polymerase II (Pol II) to an intron-containing gene, which is rescued by spt8Delta.

50 ter expresses mitochondrial ferritin from an intron-containing gene.

51 dent on its origin from an intron-free or an intron-containing gene.

52 at the last intervening sequence of multiple intron containing genes is a principal determinant of th

53 tion, as exonic splice enhancers resident in intron containing genes may have different utility in in

54 of U1 snRNP and its associated components to intron-containing genes (ICGs).

55 equired for protein expression of ~714 minor intron-containing genes (MIGs) crucial for cell-cycle re

56 or excess intron retention outliers in minor intron-containing genes (MIGs).

57 e that the SM protein inhibits expression of intron-containing genes and activates expression of intr

58 neral exon database comprising all available intron-containing genes and exon databases from 10 eukar

59 Gcn5 associates throughout intron-containing genes and, in the absence of the histo

60 We conclude that all multi-intron-containing genes are alternatively spliced and th

61 Intron-containing genes are generally expressed more eff

62 Intron-containing genes are often transcribed more effic

63 he Bubarida TS-associated contigs consist of intron-containing genes homologous to sponge genes and f

64 Yra1 associates with introns of intron-containing genes in a splicing-dependent manner.

65 suggests that at least approximately 42% of intron-containing genes in Arabidopsis are alternatively

66 Here we show that splicing of intron-containing genes in cells lacking H2A.Z is impair

67 The expression of intron-containing genes in eukaryotes requires generatio

68 decreases the expression of a subset of U12 intron-containing genes in mammalian cells and Drosophil

69 enerated by partial DNA-based duplication of intron-containing genes in the fruitfly genome.

70 find aberrant minor intron splicing in minor intron-containing genes involved in cell cycle regulatio

71 to differential expression analysis of minor intron-containing genes is applicable to other diseases

72 the long production time required for large intron-containing genes is significant for the behavior

73 om genomewide studies on yeast revealed that intron-containing genes produce more RNA and more protei

74 e ontology term enrichment analysis on minor intron-containing genes reveals that the cilium assembly

75 hancing mRNA expression of hundreds of minor intron-containing genes that are otherwise suppressed by

76 to elevated minor intron retention in minor intron-containing genes that regulate cell cycle.

77 ate the recombination of their corresponding intron-containing genes through a mechanism known as int

78 large databases of animal, plant, and fungal intron-containing genes to a 20% similarity level and th

79 Pre-mRNAs from over 60% of intron-containing genes undergo AS to produce a vast rep

80 Whether metazoan species with long, intron-containing genes utilize a similar mechanism has

81 scent mRNAs and are retained specifically at intron-containing genes via RNA-dependent interactions.

82 Strikingly, intron-containing genes were most susceptible to CHD1 lo

83 Some intron-containing genes were not bound by the spliceosom

84 To extend these studies, we analyzed intron-containing genes with different second exon lengt

85 round of export if the tRNAs are encoded by intron-containing genes, and for these tRNAs Msn5 functi

86 We targeted other essential intron-containing genes, and observed a similar phenotyp

87 es was assessed by RT-PCR in a subset of 166 intron-containing genes, and those with confirmed testis

88 g enough to cover exon-exon junctions of the intron-containing genes, and thus intron loss events can

89 ntified debranched lariat intermediates from intron-containing genes, demonstrating a significant dis

90 s recruited similarly to both intronless and intron-containing genes, low Yra1p and Sub2p levels are

91 In intron-containing genes, R-loops are bounded between the

92 On some intron-containing genes, retention and/or transfer of Yr

93 ntronless genes, but not the CTE or RRE from intron-containing genes, significantly enhanced stabilit

94 Second, although most SARs are derived from intron-containing genes, surprisingly, 340 SARs are deri

95 Gs) are highly overrepresented in the set of intron-containing genes, we tested the hypothesis that s

96 and Sub2p levels are present on a subset of intron-containing genes.

97 ontrol the level of mRNA produced from these intron-containing genes.

98 m intronless mRNAs can trans-silence cognate intron-containing genes.

99 eading to splicing inhibition for downstream intron-containing genes.

100 e, which has been reported to harbor only 26 intron-containing genes.

101 tion causes a defect in the transcription of intron-containing genes.

102 About 20% of yeast tRNAs are encoded by intron-containing genes.

103 ate unspliced RNAs from the vast majority of intron-containing genes.

104 Several databases are available for 'intron containing' genes in eukaryotes.

105 gene evolution in a much simpler way unlike 'intron containing' genes.

106 er, analysis of EWG expression elicited from intron-containing genomic transgenes and cDNA minitransg

107 cognate cDNA revealed seven exons, with all introns containing GT/AG splicing donor/acceptor site.

108 An intron-containing hairpin RNA-mediated gene silencing wa

109 Unregulated splicing of introns containing hairpins may adversely impact Dicer/A

110 to examine the intranuclear distributions of intron-containing HIV RNAs and to determine their spatia

111 nt manner to enhance polysome association of intron-containing HIV-1 gag RNA and also nonviral luc RN

112 The nuclear export of intron-containing HIV-1 RNA is critically dependent on t

113 ellular cofactor for Rev-dependent export of intron-containing HIV-1 RNA.

114 In the absence of Rev, these intron-containing HIV-1 RNAs are retained in the nucleus

115 h have intronless homologues in bacteria and intron-containing homologues in the eukaryotes, with a c

116 H to distinguish invading retroelements from intron-containing host genes.

117 intronless heat-shock protein 70 (HSP70) and intron-containing HSP83--and identify novel export facto

118 Delivery of synthetic intron-containing HSV-TK constructs to leukemia, breast

119 introduced into cells, or when a full-length intron-containing human beta-globin transcript is expres

120 sive element (RRE)-independent expression of intron-containing human immunodeficiency virus type 1 (H

121 Nuclear export of intron-containing human immunodeficiency virus type 1 RN

122 expression and regulation of spliced versus intron-containing ICP0 transcripts in latently infected

123 riptase-PCR assays that detected spliced and intron-containing ICP0 transcripts in mouse ganglia late

124 There were fewer spliced than intron-containing ICP0 transcripts on average, with cons

125 however, appear to express reduced levels of intron-containing ICP0 transcripts.

126 ow that strong constitutive expression of an intron-containing JAZ10 genomic clone is sufficient to r

127 also needed for splicing of a small group of intron-containing lincRNAs.

128 Humans have a single intron-containing locus, EEF1B2, which maps to 2q33, and

129 The reporter, consisting of a destabilized, intron-containing luciferase expressed from a short-live

130 Bz2 seems to be specific: splicing of other intron-containing maize genes, including a maize actin g

131 The expression of intron-containing messages has been shown to occur in a

132 However, it is unknown whether these intron-containing messages result in protein production

133 is or in therapeutic intervention of group I intron-containing microorganisms.

134 Our studies indicate that (1) intron-containing miRNAs (inc-miRs) can be efficiently s

135 hlights variants preferentially occurring on intron-containing molecules, possibly resulting from alt

136 The intron-containing mRNA encodes a truncated 156-amino-aci

137 f an endogenous BK(Ca) channel alpha-subunit intron-containing mRNA in the cytoplasm of hippocampal n

138 We show that intron-containing mRNA precursors template siRNA synthes

139 s mimicking nonsense-mediated decay of minor intron-containing mRNA species converged on LZTR1, a reg

140 estrict the nuclear export and expression of intron-containing mRNA.

141 an element that enables export of unspliced, intron-containing mRNA.

142 Intron-containing mRNAs are subject to restricted nuclea

143 ficiency virus type 1 (HIV-1) are encoded by intron-containing mRNAs that normally are retained in th

144 hCRM1 regulates the nuclear export of viral intron-containing mRNAs through the activity of the vira

145 Because maturation of 11 other intron-containing mRNAs was unaffected in the chlorotic

146 Interestingly, translation of intron-containing mRNAs was up-regulated.

147 cycle by facilitating the nuclear export of intron-containing mRNAs, yet their activities have rarel

148 A retained intron containing multiple translation stop codons that

149 ut in the mutants in vivo both by monitoring intron-containing nascent transcript levels and (14)C-ur

150 This pathway furthermore protects most intron-containing nascent transcripts from the effects o

151 -like sequence may have been derived from an intron-containing nuclear tRNA gene or it may serve some

152 -like sequence may have been derived from an intron-containing nuclear tRNA gene or it may serve some

153 Furthermore, we propose that the intron-containing ORF 57 gene downregulates itself by th

154 Furthermore, each of a series of introns containing overlapping deletions that together s

155 een intronless genes and their corresponding intron-containing paralogs, we found that alignments do

156 n been considered to be retroposed copies of intron-containing paralogs.

157 wheat GstA1 promoter in combination with an intron-containing part of the wheat WIR1a gene was found

158 ycan hydrolase sequences, three new putative intron-containing phage endolysin genes were identified

159 rk reveals that nab2 mutant cells accumulate intron-containing pre-mRNA in vivo We extend this analys

160 ivo, with a preference for exon 2 regions of intron-containing pre-mRNAs and poly(A) proximal sites.

161 irect Prp8-binding sites on U5, U6 snRNA and intron-containing pre-mRNAs identified using site-direct

162 is of short-lived non-coding RNAs as well as intron-containing pre-mRNAs in wild-type yeast.

163 First, intron-containing pre-mRNAs in yeast are detectably boun

164 is associated with nad1 i4 and several other intron-containing pre-mRNAs.

165 cing Endonuclease (SEN) during processing of intron-containing pre-tRNAs and by Ire1 cleavage of HAC1

166 Both intron-containing pre-tRNAs and spliced tRNAs, regardles

167 Our studies of the location of intron-containing pre-tRNAs in the rna1-1 mutant rule ou

168 execute nuclear export of newly transcribed intron-containing pre-tRNAs.

169 ays a critical function in the maturation of intron-containing pre-tRNAs.

170 complexes with members of the 10 families of intron-containing pre-tRNAs.

171 f the transgene is inhibited at the level of intron-containing precursor mRNA.

172 enome assembly is comprised of nearly 14,000 intron-containing predicted genes, and 13,500 intron-les

173 Finally, we show that intron-containing pri-miRNAs and pre-mRNAs exhibit a glo

174 er of the Pabp2 gene is not derived from its intron-containing progenitor, Pabp1.

175 ed these intronless amphibian IFNs and their intron-containing progenitors, and functionally characte

176 cteriophage T4 and is encoded adjacent to an intron-containing psbA gene [5, 6].

177 te spans the IIS, and it is unable to cleave intron-containing psbA genes.

178 tween the TIRs reside tail-to-tail-oriented, intron-containing RAG1-like and RAG2-like genes.

179 eved in a slow-growing mycobacterium with an intron-containing RecA.

180 ot spliced and six predictions identified an intron-containing region but failed to specify the corre

181 instead promoting the retention of flanking introns containing repeated SRSF7 binding sites.

182 preferentially increased the translation of intron-containing reporters via the EJC, whereas silenci

183 d the efficacy of nanoparticle (NP)-mediated intron-containing rhodopsin (sgRho) vs. intronless cDNA

184 We introduce intron-containing ribosomes into the E. coli genome and

185 that de novo cytoplasmic expression of HIV-1 intron-containing RNA (icRNA) in macrophages and microgl

186 IF4E is readily detected in association with intron-containing RNA and the C-terminal domain of RNA p

187 Intron-containing RNA expressed from the HIV-1 provirus

188 te immune receptor required for detection of intron-containing RNA expressed from the HIV-1 provirus,

189 that IFIH1 is the innate immune receptor for intron-containing RNA from the HIV-1 provirus and that I

190 ssion in all retroviruses is that unspliced, intron-containing RNA is exported to the cytoplasm despi

191 In complex retroviruses, the export of intron-containing RNA is mediated by specific viral regu

192 ate that Tap regulates expression of its own intron-containing RNA through a CTE-mediated mechanism.

193 F1 gene also regulates expression of its own intron-containing RNA through the use of a functional CT

194 t signal function and redirect the export of intron-containing RNA to a CRM1-independent pathway.

195 out the gamma-globin intron by targeting the intron-containing RNA via microRNA 30 (miR30)-based shor

196 Retroviruses carry a genomic intron-containing RNA with a long structured 5'-untransl

197 ell restriction on cytoplasmic expression of intron-containing RNA.

198 by inducing the cytoplasmic accumulation of intron-containing RNA.

199 s as an autonomous nuclear export signal for intron-containing RNA.

200 t can also facilitate the export of cellular intron-containing RNA.

201 of spliceosomes from this abundant class of intron-containing RNAs (the ribosomal protein genes) to

202 translation repression, and are enriched in intron-containing RNAs and splicing factors.

203 Indeed, intron-containing RNAs are typically retained in the nuc

204 Together, our results show that binding to intron-containing RNAs stabilizes and regulates the acti

205 of spliceosomes from this abundant class of intron-containing RNAs to otherwise poorly spliced trans

206 Moreover, 144 minor intron-containing RNAs were differentially expressed, in

207 taining RNAs cofactors normally recruited to intron-containing RNAs.

208 The intron-containing RPL23A gene was mapped to cytogenetic

209 SR45 differentially regulates intronless and intron-containing SARs.

210 evious RNA analysis of lesions within the 15 intron-containing Sh2 (shrunken2) gene of maize (Zea may

211 rotein 1 gene (MKRN1), a highly transcribed, intron-containing source for this family of genes.

212 sition of a cDNA originating as mRNA from an intron-containing source gene.

213 ges in a unique BK(Ca) channel alpha-subunit intron-containing splice variant mRNA can greatly impact

214 The experiments reveal that these intron-containing splice variants remain within the nucl

215 56-bp region of the mouse alpha-actin first intron containing SRF, NFAT, and AP-1 sites (SNAP) acted

216 n the level of gene expression as long as an intron containing stimulatory sequences was included.

217 nt strategies to distinguish intronless from intron-containing substrates.

218 trotransposons, Ctr1 functions in processing intron-containing telomerase RNA.

219 a second, the beta form, in which a cryptic intron containing the potential DNA binding domain is sp

220 expression plasmids, we show that miniature introns containing the splice sites along with short ( a

221 f the glycoprotein hormone receptors and the intron-containing TM/C module of the CRFR is suggested b

222 educed endogenous cytoplasmic levels of this intron-containing transcript by RNA interference without

223 hat is not inhibited by LMB and programs the intron-containing transcript for translational enhanceme

224 d increase in the presence of the unspliced, intron-containing transcript.

225 redominantly results in nuclear detention of intron-containing transcripts and the production of non-

226 Primer extension analysis of intron-containing transcripts in prp40 temperature-sensi

227 preliminary analysis of the splicing of all intron-containing transcripts in Saccharomyces cerevisia

228 After splicing of intron-containing transcripts, all three RLuc mRNAs had

229 RNAs but also inhibits expression of several intron-containing transcripts.

230 e and the cDNA of the transgene, but not the intron-containing transgene.

231 In Trypanosoma brucei, the single intron-containing tRNA (tRNA(Tyr)GUA) is responsible for

232 s in mutant mice, numerous other products of intron-containing tRNA genes were dysregulated, with pre

233 s tRNA splicing, we profiled the products of intron-containing tRNA genes.

234 Splicing of eukaryal intron-containing tRNAs requires the action of the heter

235 nspliced tRNA fragments, depletion of mature intron-containing tRNAs, and ribosome stalling at codons

236 e tRNA, but not splicing of any of the other intron-containing tRNAs, controls the ISR.

237 protein complex, involved in the cleavage of intron-containing tRNAs.

238 in vivo splicing of the Haloferax volcanii, intron-containing tRNATrp RNA.

239 ependent U6atac modulation can control minor intron-containing tumor suppressor PTEN expression and c

240 ) RNA element mediates the nuclear export of intron containing viral RNAs by forming an oligomeric co

241 ilitates the cytoplasmic accumulation of the intron-containing viral gag-pol and env mRNAs and is req

242 ion of both intronless viral ORF59 genes and intron-containing viral K8 and K8.1 genes.

243 tions are necessary for nuclear export of an intron-containing viral mRNA in vivo.

244 All five forms of 3'UTRs can assist intron-containing viral mRNA nuclear export, with simila

245 ev protein is required for nuclear export of intron-containing viral mRNA transcripts.

246 During HIV infection, intron-containing viral mRNAs are exported from the cell

247 lls, the HIV-1 Rev protein recruits hCRM1 to intron-containing viral mRNAs encoding the Rev response

248 otein that facilitates the nuclear export of intron-containing viral mRNAs.

249 nuclear export steps to allow the export of intron-containing viral RNA transcripts to the cytoplasm

250 retroviruses act to facilitate the export of intron-containing viral RNAs.

251 s in the pdg coding regions (exons) from the intron-containing viruses are 84 to 100% identical.

252 lear ribonucleoprotein particles (snRNPs) to intron-containing yeast (S. cerevisiae) genes.

253 tinguish spliced from unspliced RNA for each intron-containing yeast gene and measured genomewide eff

254 dary structure bias in the coding regions of intron-containing yeast genes than in intronless genes,

255 method, we applied this approach to a set of intron-containing yeast genes, where we easily identifie