ライフサイエンスコーパス: intronless

1 n-poor, as more than 80% of coding genes are intronless.

2 The DC3 gene, termed ODA14, is intronless.

3 where the protein-coding region is typically intronless.

4 Only five P450 genes are intronless.

5 ontains 10 introns whereas the hsp70 gene is intronless.

6 Herpes simplex virus genes are predominantly intronless.

7 In addition, five genes in the cluster are intronless.

8 CR5 mRNA isoform whose open reading frame is intronless.

9 ther insect globin genes reported so far are intronless.

10 RbTI gene was further confirmed as intronless.

11 explanation why most early zygotic genes are intronless.

12 ndicates that it contains an unusually long, intronless, 5'-untranslated leader sequence of 715 bp.

13 Unlike the intronless alcohol oxidases from methylotrophic yeasts,

14 coded endonuclease I-TevI, which cleaves the intronless allele 23 and 25 nucleotides upstream of the

15 mobile element capable of inserting into an intronless allele of the ltrB gene.

16 oming by making a double-strand break in the intronless allele within a sequence designated the homin

17 by initiating intron homing into its cognate intronless allele.

18 e site-specific insertion of the intron into intronless alleles ('homing').

19 They retrohome to intronless alleles and retrotranspose to ectopic sites,

20 ease that initiates intron homing to cognate intronless alleles by a double-strand-break (DSB) repair

21 oelements that insert site specifically into intronless alleles by a process called homing.

22 bility to distinguish intron-containing from intronless alleles while maintaining the same conserved

23 addition to "homing" to unoccupied sites in intronless alleles, group II introns transpose at low fr

24 d downstream of the intron insertion site of intronless alleles, preventing the endonuclease from bin

25 maximize the potential to spread to variant intronless alleles, while minimizing cleavage at its own

26 entered on the intron insertion site (IS) of intronless alleles.

27 We identified these intronless amphibian IFNs and their intron-containing pr

28 Histone mRNAs are naturally intronless and accumulate efficiently in the cytoplasm.

29 They are intronless and do not appear to encode a protein product

30 opy gene that was mapped to chromosome 19 is intronless and encodes a 92-kDa protein that has 77.5% o

31 One of these genes, aggst1-2, is intronless and has been described.

32 nd plant models by quantifying expression of intronless and intron-bearing reporter genes in vitro.

33 lthough Hpr1p is recruited similarly to both intronless and intron-containing genes, low Yra1p and Su

34 suggests that SR45 differentially regulates intronless and intron-containing SARs.

35 cifically required for the nuclear export of intronless and intron-poor mRNAs and lncRNAs.

36 ntified 33 such gene families that contained intronless and intron-poor sub-families.

37 tion as ctt-2beta and ctt-9.1; the fourth is intronless and lies between intron bearing genes.

38 tically enhanced SM-mediated accumulation of intronless and lytic viral transcripts.

39 In addition, an intronless and presumably non-coding, copy of the mESO3,

40 The chromosome 2 gene is intronless and would encode a protein 100% identical wit

41 regions from two fungal clones, a Mak1 cDNA (intronless) and a genomic (including three fungal intron

42 -families with genes that are intron-poor or intronless, and it remains unknown when and how these in

43 revealed by the sequence analysis: (a) it is intronless; (b) it has a single nucleotide deletion in t

44 ants, can rescue the said deficiencies under intronless background.

45 ermits efficient cytoplasmic accumulation of intronless beta-globin cDNA transcripts.

46 ce from an otherwise inefficiently expressed intronless beta-globin construct.

47 d between binding hnRNP L and enhancement of intronless beta-globin gene expression.

48 nd A-rich tract to increase the levels of an intronless beta-globin reporter RNA.

49 ced (i) the efficiency of polyadenylation of intronless beta-globin RNA in a cell-free polyadenylatio

50 completely sequenced and found to encode an intronless BHMT pseudogene (mBHMT-ps).

51 The intronless C/EBPbeta gene encodes a single mRNA that pro

52 ated intron-containing rhodopsin (sgRho) vs. intronless cDNA in ameliorating retinal disease phenotyp

53 (S) negatively regulates expression of su(s) intronless cDNA transgenes, and the ARMs are required fo

54 Thus intronless cDNA-the hallmark of reverse transcription-pr

55 h pre-mRNAs, introns, or mRNAs produced from intronless cDNAs.

56 The small, compact and intronless chloroplast genome (cpDNA) of V. peltata show

57 Expression of an intronless ckx1 in Pichia pastoris allowed production of

58 This structure differs from the intronless coding region for a homologous receptor, Edg1

59 nlike other known Kv1 family genes that have intronless coding regions, the protein-coding region of

60 r export, whereas the control reporter is an intronless complementary DNA expression cassette.

61 d into the 5'-UTR and coding sequences of an intronless construct, demonstrating that splicing is not

62 he activities of the PAN-ENE are specific to intronless constructs, since inserting the PAN-ENE into

63 rter enzyme activity 40-fold relative to the intronless control by introducing 11 copies of the more

64 imulate gene expression ~eight-fold above an intronless control, at both mRNA and protein levels, sug

65 nce of processed pseudogenes: nonfunctional, intronless copies of real genes found elsewhere in the g

66 long arm (Yq) carries hundreds of supposedly intronless copies of Ssty, for which no protein has hith

67 ntrons are lost through gene conversion with intronless copies of the gene.

68 Reexpression of the intronless copy of dE2F2 in B52-deficient cells restores

69 stigate the mechanism of export of NORAD, an intronless cytoplasmic long noncoding RNA (lncRNA).

70 equence M10 strongly inhibited the export of intronless dihydrofolate reductase mRNA.

71 stence of higher synonymous mutations in the intronless divergents of ReCHS.

72 ene 5.3 of phage T3, located adjacent to its intronless DNA polymerase gene, is a homologous homing e

73 Both of these endonucleases cleave intronless DNA polymerase genes at identical positions.

74 g, the intron reverse splices into a cognate intronless DNA site.

75 A encode endonuclease activities that cleave intronless DNA target sites to initiate mobility by targ

76 Certain group I introns insert into intronless DNA via an endonuclease that creates a double

77 homing" endonucleases cleave both strands of intronless DNA; subsequent repair results in unidirectio

78 nomic DNA, HUSH recognizes long single-exon (intronless) DNA, the essential hallmark of reverse trans

79 Numerous additional intronless eIF4E pseudogenes were found, but unlike EIF4

80 six introns, but the other gene (EIF4E2) was intronless, flanked by Alu sequences and 14-base pair (b

81 nt for cleavage efficiency and distinguishes intronless from intron-containing alleles.

82 but use different strategies to distinguish intronless from intron-containing substrates.

83 haracterised, DNA ligase IV is encoded by an intronless gene (LIG4).

84 n chromosome 10 encodes Supt4h2, a processed intronless gene (with a polyA tail and a tandemly-duplic

85 sequenced in its entirety and shown to be an intronless gene encoding a predicted 130-amino-acid prot

86 Lem1 was found to be a single intronless gene encoding an acidic 102 amino acid protei

87 C/EBPbeta is an intronless gene encoding three protein isoforms--LAP1, L

88 The cDNA was found to be identical to the intronless gene found in platelets.

89 oftness protein-1 (Gsp-1) is a small, 495-bp intronless gene found throughout the Triticeae tribe at

90 y general transcription factor encoded by an intronless gene identified thus far.

91 R9AP is encoded by one intronless gene in both human and mouse.

92 data demonstrate expression of the CKIIalpha intronless gene in megakaryocytes and platelets.

93 have also investigated the expression of the intronless gene in several other cell lines.

94 In humans, DAMAGE is encoded by an intronless gene located at chromosome Xq13.1, a locus th

95 Cetn1 is an intronless gene located on chromosome 18A2 that encodes

96 STH is an intronless gene that encodes a 128-aa protein with no cl

97 We found that CRIPak is an intronless gene that localized to chromosome 4p16.3.

98 te the cytoplasmic accumulation of naturally intronless gene transcripts.

99 Expression of the intronless gene was only found in cell line MEG-01.

100 alysis demonstrates that AtZFP1 is a unique, intronless gene which encodes a 1100 nucleotides mRNA hi

101 cture-functional characterization of a novel intronless gene, BRCC2, located on human chromosome 11q2

102 Ier5 is an intronless gene, encoding a serum- and growth factor-ind

103 ound to be 99.7% homologous to the CKIIalpha intronless gene, having the same characteristic amino ac

104 POU3F3 is an intronless gene, insensitive to nonsense-mediated decay,

105 Despite the compact nature of this intronless gene, local linkage disequilibrium between a

106 n two primary tumors we found that Alpha, an intronless gene, rearranges with the first intron of TFE

107 TUSC1 (tumor suppressor candidate 1), is an intronless gene.

108 236 (Arg --> His), which is not found in the intronless gene.

109 use Insm1 genomic DNA revealed that it is an intronless gene.

110 criptional arrest and is encoded by a 2.5-kb intronless gene.

111 mitrella patens, ADF is encoded by a single, intronless gene.

112 terrupted open reading frame and is the only intronless general transcription factor identified so fa

113 We also isolated two highly related intronless genes and determined their chromosomal locati

114 both SM-responsive as well as nonresponsive intronless genes and increases the nuclear accumulation

115 ipt- and genome-level DNA alignments between intronless genes and their corresponding intron-containi

116 dition to Pfam domains; (iii) information on intronless genes are now included in the database; (iv)

117 Moreover, intronless genes are often associated with promoter-asso

118 Bioinformatic analysis showed human intronless genes are significantly enriched for MAE.

119 the Acam gene is part of a cluster of three intronless genes arranged in a head-to-tail manner.

120 Intronless genes can arise by germline retrotranspositio

121 ic analysis revealed ACTL7A and ACTL7B to be intronless genes contained on a common 8-kb HindIII frag

122 we examined the alternative possibility that intronless genes could be generated by partial DNA-based

123 Intronless genes encoding a leucyl aminopeptidase (lap)

124 rease from the 5' to the 3' ends of the four intronless genes examined.

125 mic export, PPE-like elements from naturally intronless genes facilitate polyadenylation as well.

126 H binds and represses a subset of endogenous intronless genes generated through retrotransposition of

127 Intronless genes have often been considered to be retrop

128 ns unknown when and how these intron-poor or intronless genes have originated and evolved, and what t

129 the additional genomic clones identified two intronless genes homologous to hPTTG.

130 In contrast to intron-rich genes, intronless genes in intron-poor sub-families occurred la

131 ich genes in the same gene families, whereas intronless genes in the B_lectin and S_locus_glycop gene

132 The silencing of intronless genes is initiated independently of the piRNA

133 Both hFRAT1 and hFRAT2 are intronless genes localized to the same portion of chromo

134 active and compact, comprising mostly short, intronless genes near neighboring genes of opposite sens

135 ripts of not only intron-containing but also intronless genes on Drosophila polytene chromosomes.

136 Intronless genes seemed to have first emerged in early l

137 C/EBPalpha and C/EBPbeta are intronless genes that can produce several N-terminally t

138 emained unclear whether mRNAs generated from intronless genes use specific machinery to promote their

139 These results suggest that viral intronless genes utilize a similar strategy for intron-i

140 are mobile retroelements that invade cognate intronless genes via retrohoming, where the introns reve

141 For example, all differentially expressed intronless genes were downregulated, including ATXN7L3B,

142 dditionally, stop codon-gain variants in two intronless genes were not expressed, an unexpected outco

143 rystallins are encoded in three very similar intronless genes with markedly different 5' flanking seq

144 Unlike other intronless genes, 3'end processing of the MC4R primary t

145 ays an unexpected role in mRNA processing of intronless genes, and numerous ABA signaling genes are t

146 ons of intron-containing yeast genes than in intronless genes, and significantly higher folding poten

147 The PRE, PPE and CJE from naturally intronless genes, but not the CTE or RRE from intron-con

148 t of random insertion events into previously intronless genes, on the one hand, or the result of rand

149 In intronless genes, the 3' boundary displays gene-specific

150 ntaining genes may have different utility in intronless genes, these can be reduced or increased in d

151 created four different carboxy ends of these intronless genes, two of which are within the 2q13 locus

152 translated regions [UTRs]) of transcripts of intronless genes.

153 s to the protein-encoding potential of these intronless genes.

154 ll members of a small gene family are active intronless genes.

155 nes, surprisingly, 340 SARs are derived from intronless genes.

156 DNA strand, mainly associated with short and intronless genes.

157 GeneTack for ab initio frameshift finding in intronless genes.

158 which ORF57 promotes the expression of viral intronless genes.

159 The SS gene sets were enriched with intronless genes.

160 high GC content class is also enriched with intronless genes.

161 tor in expression of these relatively short, intronless genes.

162 re encoded by an unlinked, redundant pair of intronless genes.

163 d transcriptionally repress a broad range of intronless genetic elements.

164 The near-intronless genome of the kinetoplastid Leishmania exhibi

165 important for transmission of intron DNA to intronless genomes ("homing"), and are implicated in hor

166 g3 is localized in the 3'UTR of Peg3 with an intronless genomic structure.

167 TP gene in Pan troglodytes and establish the intronless GLTP as a primate-specific, processed pseudog

168 Orthologs of the intronless GLTP gene were observed in primates but not i

169 by 19 nucleotides, are transcribed from the intronless glutathione S-transferase D21 gene in Drosoph

170 required for the cytoplasmic accumulation of intronless HBV RNAs.

171 ment (PRE) by inducing the expression of the intronless HBV surface message.

172 No analogous intronless hDIPP2alpha gene was detected by analysis of

173 Two BACs containing distinct, but intronless, hDIPP2beta genes were cloned.

174 f two endogenous heat-inducible transcripts--intronless heat-shock protein 70 (HSP70) and intron-cont

175 A similar defect in intronless hemagglutinin (HA) mRNA nuclear export was se

176 We identified cis-acting elements in the intronless herpes simplex virus type 1 thymidine kinase

177 ter ovary cells showed that expression of an intronless HEXA minigene harboring the frameshift mutati

178 ed for mRNAs from both intron-containing and intronless histone genes.

179 NA sequence polymorphisms, as is the case in intronless homing of free-standing endonuclease genes [3

180 100-fold reduced efficiency relative to the intronless homing site.

181 own three-dimensional structures, which have intronless homologues in bacteria and intron-containing

182 , it was demonstrated that ICP27 bound seven intronless HSV-1 transcripts in both the nucleus and the

183 The intronless ht-WNT10B resembles a long non-coding RNA (ln

184 nd megakaryocytes with intron-containing and intronless human vWF promoter-luciferase constructs.

185 in vertebrates and evolutionary dominance of intronless IFN genes in amniotes is a signature event in

186 nes is evident in amphibians, shown by 24-37 intronless IFN genes in each frog species.

187 we show that the emergence and expansion of intronless IFN genes is evident in amphibians, shown by

188 In contrast to MCHR1, which is intronless in the coding region and is located at the ch

189 analysis suggests that ORF57 recruits PYM to intronless KSHV mRNA and PYM then facilitates the associ

190 which raises the intriguing question of how intronless KSHV transcripts are efficiently translated.

191 directly with PYM to enhance translation of intronless KSHV transcripts.

192 RIPD genes identified here were enriched for intronless loci, with a non-uniform distribution that in

193 of which contain novel ORFs, were typically intronless, <2 Kb in length, expressed early during vira

194 tive effect on the cytoplasmic expression of intronless luc RNA, and ribosomal profile analysis demon

195 criptionally activates expression of certain intronless lytic EBV genes.

196 we described several members of a family of intronless mammalian genes encoding a novel class of zin

197 ired for cleavage and polyadenylation in the intronless melanocortin 4 receptor (MC4R) pre-mRNA.

198 Contrary to the prevailing concept of intronless mitochondria, here we present evidence that m

199 ype of the cox24 mutant in the background of intronless mitochondrial DNA, however, suggests that in

200 ation codon (PTC; UAA, UAG or UGA) within an intronless mRNA and U36 of the anticodon of a matching t

201 ta suggest that the CAR-E promotes export of intronless mRNA by sequence-dependent recruitment of the

202 The intronless mRNA level remains unchanged with or without

203 Surprisingly, two other described intronless mRNA transport elements (from the herpes simp

204 ompt us to suggest that a general feature of intronless mRNA transport elements might be a collection

205 x is recruited during splicing; however, for intronless mRNA, recruitment is sequence dependent.

206 -E) functions in cytoplasmic accumulation of intronless mRNA, we multimerized the most conserved CAR-

207 taining whereas Sp1 preferentially increases intronless mRNA.

208 nds U2 snRNP, although it is derived from an intronless mRNA.

209 e requirements for export of three naturally intronless mRNAs (HSPB3, IFN-alpha1, and IFN-beta1).

210 nd cytoplasmic localization on the naturally intronless mRNAs and a cDNA transcript, which is normall

211 nts SRm160 or RNPS1 boosts the expression of intronless mRNAs but not of spliced mRNAs.

212 Small RNAs amplified from intronless mRNAs can trans-silence cognate intron-contai

213 We conclude that naturally intronless mRNAs contain specific sequences that result

214 is essential for stable accumulation of the intronless mRNAs in the cytoplasm.

215 e required for accumulation of the naturally intronless mRNAs in the cytoplasm.

216 led that nuclear export of a large number of intronless mRNAs is impaired in Drosophila-cultured cell

217 ciated herpesvirus (KSHV) expresses numerous intronless mRNAs that are unable to access splicing-depe

218 omplexes showed that dU2AF50 associates with intronless mRNAs.

219 inding motifs that promote nuclear export of intronless mRNAs.

220 cing factor dU2AF50 in the nuclear export of intronless mRNAs.

221 rotein ICP27 facilitates the export of viral intronless mRNAs.

222 in the nucleus, mediates RNA export of viral intronless mRNAs.

223 nt cis-acting mode of silencing also acts on intronless mRNAs.

224 factors results in nuclear retention of the intronless mRNAs.

225 ccharomyces cerevisiae with either normal or intronless mtDNA background.

226 cause disruption of MNE1 in cells containing intronless mtDNA does not lead to a respiratory growth d

227 homologue of the yeast gene, from which the intronless mUtp14b has been derived by retrotranspositio

228 Eukaryotic genes can be classified into intronless (no introns), intron-poor (three or fewer int

229 AC115 is a small, novel, intronless nuclear gene which encodes a protein of 113 a

230 aba1 gene was found to consist of a single, intronless open reading frame (ORF) of 34,980 bp, encodi

231 The 40 kb intronless open reading frame (ORF) predicts a single po

232 Its eyes are supported by highly diverse, intronless opsins expanded by retroposition for broadene

233 on RNA-seq analyses in Arabidopsis and rice, intronless or intron-poor genes in AP2, EF-hand_7, bZIP,

234 ces or neighboring genes are included in the intronless paralog.

235 posed copies (RPCs) of genes are functional (intronless paralogs) or nonfunctional (processed pseudog

236 ng locus, EEF1B2, which maps to 2q33, and an intronless paralogue expressed only in brain and muscle

237 inguishing between processed pseudogenes and intronless paralogues.

238 the two stimulated both intron-retaining and intronless PNMT mRNA and PNMT protein, but to different

239 nt cis-acting element, the ENE, which allows intronless polyadenylated transcripts to accumulate to h

240 cated 3.7 kb upstream of sid1 and encodes an intronless polypeptide of 3,947 amino acids with three i

241 at least in part, by directly recruiting to intronless PPE-containing RNAs cofactors normally recrui

242 4) in the human genome, containing the intronless protein coding sequence of Rac1.

243 We used transformation of an intronless-psbA strain (IL) to test whether these intron

244 forms, we isolated the mouse PAP gene and an intronless pseudogene from a mouse liver genomic library

245 In addition to ESO3, an intronless pseudogene highly homologous to ESO3 was foun

246 f PPP1R2 on chromosome 5 is identified as an intronless pseudogene.

247 One such locus, GGTA1P, a processed (intronless) pseudogene (PPG), is present in platyrrhines

248 In addition, three other intronless pseudogenes of Rac1 on chromosomes 4, 13 and

249 maps to human chromosome 17, with candidate intronless pseudogenes on chromosomes 2, 12, and 20.

250 he td intron endonuclease I-TevI cleaves the intronless recipient 23 and 25 nucleotides upstream of t

251 ose encoding cilia components as well as the intronless replication-dependent histones.

252 ay (NMD) factors Upf1, Upf2, and Upf3b to an intronless reporter mRNA.

253 These sequences are intronless retroposons, which appear to be paralogues of

254 ded locus and several X-linked and autosomal intronless retroposons, which, apparently, comprise both

255 1 expression does not alter the abundance of intronless RNA transcripts or suppress the Ts phenotypes

256 s a major driver of RNA nuclear export, many intronless RNAs are efficiently exported to the cytoplas

257 and that Aly/REF stimulates export of viral intronless RNAs but does not cross-link to these RNAs.

258 he histone H2a gene to promote the export of intronless RNAs in both mammalian cells and Xenopus oocy

259 otes expression of a selection of KSHV viral intronless RNAs, it is not a bona fide export factor.

260 0, previously shown to promote the export of intronless RNAs.

261 recruits Aly/REF from spliceosomes to viral intronless RNAs.

262 factor that promotes the transport of HSV-1 intronless RNAs.

263 Rh1, the intronless rod opsin gene, first emerged in ancestral Ac

264 ical, noncoding cellular introns, so a long, intronless sequence of DNA is the abnormal molecular pat

265 with genomic sequence showed that PKDREJ is intronless; sequencing the mouse orthologue revealed a s

266 The mRNA of the intronless, single-copy CCAAT/enhancer-binding protein-b

267 We observed this effect particularly in intronless small genes, many of which are expressed retr

268 otein was produced by a strongly transcribed intronless Ssty transgene, raising doubts as to the prot

269 associated with the COX1 mRNA even within an intronless strain.

270 ing substrates, but efficiently cleaves only intronless substrate.

271 stretch of TS-encoding DNA and cleave their intronless substrates in very similar positions.

272 I-BmoI binds intron-containing and intronless substrates with equal affinity but can nevert

273 We report the identification of a novel intronless SUMO gene, SUMO-4, that encodes a 95-amino ac

274 The enzyme cleaves an intronless sunY gene near the exon I-exon II junction, t

275 e assay and scanning deletion mutants of the intronless target site, the minimal recognition site was

276 ave one strand on both intron-containing and intronless targets at different distances from their com

277 serted via homologous recombination into the intronless thrombomodulin locus of murine embryonic stem

278 An evolutionary link between the intronless TM/C module of the glycoprotein hormone recep

279 PURG-A mRNA consists of a single intronless transcript of approximately 3 kb.

280 Strikingly, an intronless transcript, HSP104, also accumulates in nucle

281 he RSL was essential for its activity on the intronless transcript.

282 Unspliced pre-mRNAs and intronless transcripts are thus inherently poorly expres

283 ting element that increases RNA abundance of intronless transcripts but inhibits assembly of an expor

284 facilitates the cytoplasmic localization of intronless transcripts.

285 redicated on the recent discovery that human intronless transgenes and native retrogenes can be expre

286 scriptionally repress a broad range of long, intronless transgenes.

287 I-Ssp6803I cleaves each strand of the intronless tRNA(fMet) gene adjacent to the anticodon tri

288 intron IS, binds both intron-containing and intronless TS-encoding substrates, but efficiently cleav

289 e kinetics of nucleocytoplasmic export of an intronless variant of adenovirus major late leader regio

290 ranscripts synthesized in CV-1 cells from an intronless variant of the human beta-globin gene when pr

291 identified here, to enable expression of an intronless variant of the human beta-globin gene.

292 essential for the homing of Ll.ltrB into an intronless version of ltrB are found exclusively at posi

293 Expression of an intronless version of sororin and depletion of the cohes

294 sed more effectively in human cells than are intronless versions of the same gene.

295 ICP27 dramatically stimulates the export of intronless viral mRNAs, but has no effect on the export

296 HV) ORF57 facilitates the expression of both intronless viral ORF59 genes and intron-containing viral

297 The gene is intronless which may facilitate transcription during cel

298 c level they show differences with one being intronless, while others contain two introns.

299 protein alpha (C/EBPalpha) and C/EBPbeta are intronless, yet can create various N-terminally truncate

300 The intronless ZNF127 gene is expressed ubiquitously, but th