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1 phosphoinositides during endocytosis and at invadopodia.
2 tive pathway and suppresses the formation of invadopodia.
3 x by a mechanism independent of conventional invadopodia.
4 esion complexes involved in the formation of invadopodia.
5 phosphorylation of cortactin tyrosine 421 at invadopodia.
6 icle formation but enhances the formation of invadopodia.
7 to subcellular degradative structures termed invadopodia.
8 mediated knockdown inhibits the formation of invadopodia.
9 that UNC-60A disassembles actin filaments at invadopodia.
10 brane traffic in the transport of MT1-MMP to invadopodia.
11 domain to recruit a moesin-NHE-1 complex to invadopodia.
12 A (ADF/cofilin) as an essential regulator of invadopodia.
13 n cell migration, invasion, and formation of invadopodia.
14 d cell migration, invasion, and formation of invadopodia.
15 cell protrusions, including lamellipodia and invadopodia.
16 d functional characteristics associated with invadopodia.
17 the invasive protrusion and the cessation of invadopodia.
18 crease in the number and stability of mature invadopodia.
19 vels, activated EGFR and ERK1, and activated invadopodia.
20 dation and invasion through the formation of invadopodia.
21 ion enhances cofilin phosphorylation outside invadopodia.
22 gulating cofilin's phosphorylation status at invadopodia.
23 y is spatially confined to areas surrounding invadopodia.
24 understand how substrate rigidity regulates invadopodia.
25 t is important for the stability of actin in invadopodia.
26 cTNs are structural or functional analogs of invadopodia.
27 letal mechanisms and functions for McTNs and invadopodia.
28 a PKC site, contributes to its regulation at invadopodia.
29 containing scaffolds such as lamellipodin to invadopodia.
30 small actin-rich membrane protrusions called invadopodia.
31 protrusions, and increased AKT activation in invadopodia.
32 ed the mechanism by which PI3Kbeta regulates invadopodia.
33 e show that Vav2 promotes Rac3 activation at invadopodia.
34 rane targeting of MT1-MMP and its associated invadopodia.
36 shes the plasma membrane forward, whereas in invadopodia, actin polymerization couples with the extra
38 e and tumor cell results in the formation of invadopodia, actin-rich matrix degrading protrusions, im
39 sed a possible role for RalB in formation of invadopodia, actin-rich membrane protrusions that contri
40 cells from the primary tumor is mediated by invadopodia, actin-rich protrusive organelles that secre
41 MT1-MMP recycling compartments, required for invadopodia activity and invasion in a 3D collagen matri
42 o correlated with a commensurate increase in invadopodia activity in metastatic cells compared with n
43 f matrix stiffness on the mechanical mode of invadopodia activity of cancer cells cultured in three-d
44 more, there is an optimal rigidity range for invadopodia activity that may be limited by BM rigidity.
45 rmal growth factor receptor (EGFR) modulates invadopodia activity through phosphorylation of the acti
47 s promotes the formation of matrix degrading invadopodia, adhesion structures linked to invasive migr
48 fness, cells form shorter and more transient invadopodia and are less likely to extend invadopodia ov
50 in resulted in a decrease in cytosolic pH at invadopodia and blocked cofilin-dependent actin polymeri
52 of invasive dynamics including formation of invadopodia and cell-membrane protrusions, and removal o
53 ell invasion by regulating actin dynamics at invadopodia and enhancing focalized extracellular matrix
57 t time, how RhoC activation is controlled at invadopodia and how this activation regulates cofilin ph
58 ation of cofilin leads to destabilization of invadopodia and impairs cell invasion, although the acti
62 formation but does cause decreases in mature invadopodia and matrix degradation, whereas SHIP2 overex
63 e role of c-Src activity on the formation of invadopodia and may provide insight into the mechanisms
66 sembled that of similar structures (that is, invadopodia and podosomes) described in other cell types
69 ranched radial F-actin fibers emanating from invadopodia and rosettes, which may facilitate rosette f
70 e that SHIP2 recruits Mena, but not VASP, to invadopodia and that disruption of SHIP2-Mena interactio
71 ity of KRAS mutant PDAC cell lines exhibited invadopodia and that expression of activated K-Ras is bo
72 show that fascin is an integral component of invadopodia and that it is important for the stability o
74 Vav2 SH2 domain disrupts its recruitment to invadopodia, and an SH2-domain mutant form of Vav2 canno
77 ructures, including lamellipodia, filopodia, invadopodia, and membrane blebs, as well as on cell-cell
78 protein-lipid complexes, receptor complexes, invadopodia, and other cellular structures in the malign
79 nsitive structures, such as focal adhesions, invadopodia, and podosomes, that are directly implicated
93 oreover, Abl kinases are readily detected at invadopodia assembly sites and their inhibition prevents
96 We report podoplanin as a novel component of invadopodia-associated adhesion rings, where it clusters
98 that span kPa-GPa moduli, we found a peak of invadopodia-associated extracellular matrix degradation
99 uced calpain-mediated cleavage of the FA and invadopodia-associated proteins talin, focal adhesion ki
100 n is required for its proper localization in invadopodia at the leading edge of breast cancer cells d
101 HNSCC mediates invasion in part through invadopodia-based proteolysis of the extracellular matri
103 ollagen (HDFC) matrix is a potent inducer of invadopodia, both in carcinoma cell lines and in primary
104 work showed that beta1 integrin localizes to invadopodia, but its role in regulating invadopodial fun
110 Released HB-EGF induced the formation of invadopodia, cellular structures that aid cancer cell in
111 trix metalloproteinase (MT1-MMP), a critical invadopodia component required for matrix degradation.
112 ma, including up-regulated expression of the invadopodia component Tks5long, the embryonal proto-onco
115 loss of function experiments, we determined invadopodia contain receptors involved in chemotaxis, na
116 of PI4KIIbeta also induced the formation of invadopodia containing membrane type I matrix metallopro
117 /Arg(-/-) fibroblasts produced ECM degrading invadopodia containing pY421 cortactin, indicating that
119 n promotes visceral metastases via increased invadopodia-dependent invasion and anchorage-independent
120 bstantially more effective than conventional invadopodia, distinct in structural organization and reg
123 ezrin in regulating focal adhesion (FA) and invadopodia dynamics, two key processes required for eff
124 of Src to phosphorylate cortactin, promoting invadopodia ECM degradation activity and thus assigning
125 m HNSCC cells, where soluble HB-EGF enhanced invadopodia ECM degradation in HNSCC but not in MDA-MB-2
127 rylation, triggering actin polymerization in invadopodia, ECM degradation, and matrix proteolysis-dep
129 of actin-rich degradative protrusions called invadopodia, enabling tumor cells to degrade and break t
130 hat increased stiffness physically restricts invadopodia extension and cell migration in three-dimens
131 tivation, leading to actin polymerization in invadopodia, extracellular matrix degradation, and tumor
133 alloproteinases or actin regulators and lack invadopodia, F-actin-rich membrane protrusions that faci
135 se actin-rich membrane protrusions, known as invadopodia, for efficient ECM degradation, which involv
140 nphosphorylable mutants blocks SrcYF-induced invadopodia formation and ECM degradation, while the ove
143 bl kinase signaling plays a critical role in invadopodia formation and function, and have far-reachin
147 drives deposition of MT1-MMP at the site of invadopodia formation and is critical for metastasis in
148 Invasive 3D cancer cell migration as well as invadopodia formation and matrix degradation was impaire
150 Mechanistically, this is due to increased invadopodia formation and matrix metalloproteinase secre
151 comprising TKS5, FGD1, and CDC42, directing invadopodia formation and the polarization of MT1-MMP re
153 ition impairs matrix protein degradation and invadopodia formation associated with significantly fast
154 ignaling pathways involved in collagenolytic invadopodia formation downstream of TKS4 or TKS5 in brea
155 ental cues and signaling factors that induce invadopodia formation during extravasation remain unclea
157 paxillin phosphorylation, cell motility, and invadopodia formation in a manner dependent upon upstrea
158 role of Src and Abl kinases to regulate also invadopodia formation in cancer cells, our findings sugg
159 ates podosome formation in myeloid cells and invadopodia formation in cancer cells, we addressed whet
160 f Tks5, a Src substrate that is required for invadopodia formation in mammalian cells blocked formati
161 lar matrix-coated coverslips showed enhanced invadopodia formation in response to VEGF that was HEF1-
162 odel stroma and BM, we expected to find more invadopodia formation on the stroma, and this was verifi
165 its activated state, is a potent inducer of invadopodia formation through Cdc42, even in the absence
166 ha and HIF2alpha drive melanoma invasion and invadopodia formation through PDGFRalpha and focal adhes
167 ty, matrix metalloproteinase expression, and invadopodia formation via the phosphatidylinositol 3-kin
168 ration, invasion, anchorage independence and invadopodia formation, and dystrophin inactivation was f
171 s a critical mediator of TGF-beta-stimulated invadopodia formation, cell migration, and invasion.
172 binding protein 1 (MTCBP-1) with respect to invadopodia formation, matrix remodeling, and invasion b
178 ic invadopodia, which differ from dotty-like invadopodia forming on the gelatin substratum model.
180 re, they identify Arg as a novel mediator of invadopodia function and a candidate therapeutic target
181 doplanin has a key role in the regulation of invadopodia function in SCC cells, controlling the initi
183 Furthermore, Rac1 activation is required for invadopodia function, while its inactivation promotes Rh
187 n understanding of the mechanisms regulating invadopodia has been hindered by the difficulty of exami
189 the formation of invasive structures called invadopodia; however, it is unclear how Stx4 function is
191 Cancer cell invasion and metastasis rely on invadopodia, important extensions of the cytoskeleton th
193 e formation of mature, degradation-competent invadopodia in both two- and three-dimensional matrices
196 f PI(3,4)P2, which correlated with increased invadopodia in epidermal growth factor (EGF)-stimulated
200 eriments demonstrated that Tks5long promoted invadopodia in vitro and increased metastasis in transpl
202 ntly enhanced McTN formation, but suppressed invadopodia, including the appearance of F-actin cores a
203 r Hic-5 in orchestrating the organization of invadopodia into higher-order rosettes, which may promot
204 cidated, little is known about maturation of invadopodia into structures competent for ECM proteolysi
205 of phosphatidylinositol(3,4)-bisphosphate at invadopodia is a key determinant for invadopodia maturat
207 whose recycling to form dynamic, functional invadopodia is dependent on localized F-actin disassembl
211 d for the development of focal adhesions and invadopodia, key machineries for cell migration and inva
212 nd cofilin-dependent barbed-end formation at invadopodia, leading to a significant decrease in the nu
213 ECM degradation associated with formation of invadopodia-like feature, suggesting that TIMP2 is a neg
215 ssed, noncancerous cells developed prominent invadopodia-like protrusions and showed increased matrix
218 ever, at higher stress values, cells utilize invadopodia-like structures to mediate protease-dependen
219 trusions within the epithelium that resemble invadopodia, matrix-degrading protrusions present in inv
220 regulation and the roles of this pathway in invadopodia maturation and cell invasion are not fully u
222 trate that this occurs through inhibition of invadopodia maturation and shedding of membrane-derived
223 ly, we demonstrate that podoplanin regulates invadopodia maturation by acting upstream of the ROCK-LI
225 rtactin phosphorylation is a key step during invadopodia maturation, regulating Nck1 binding and cofi
232 Surprisingly, we observed another peak in invadopodia numbers at 2 GPa as well as gene expression
235 work was required for efficient induction of invadopodia on dense fibrillar collagen and for local de
236 ctivity, and cells do not form fully matured invadopodia or migrate in the direction of the invadopod
237 t phenotypes and the degradative activity of invadopodia, our findings show that increased stiffness
239 nt invadopodia and are less likely to extend invadopodia overall, contrasting with results from 2D st
240 CC cells treated with inhibitors of the EGFR-invadopodia pathway indicated that EGFR and Src are requ
241 nase c-Src is necessary for the formation of invadopodia, phosphotyrosine-rich structures which degra
242 dings present the first direct evidence that invadopodia play a role in tissue cell invasion in vivo.
243 ruitment of the metalloproteinase MT1-MMP to invadopodia plays a critical role in this invasive proce
245 omotes actin polymerization at newly-forming invadopodia, promoting their maturation to matrix-degrad
248 a unique interplay between AXL and ERBB3 in invadopodia regulation that points to the need for combi
249 naling pathway, which can also activate core invadopodia regulators and enhance invadopodia function.
251 are mediated in part by PAK1 which controls invadopodia responsiveness to ligands such as GABA and E
254 nisms and suggest that targeting of multiple invadopodia signaling networks may serve as a potential
257 doplanin downregulation in SCC cells impairs invadopodia stability, thereby reducing the efficiency o
260 involved in the formation and maturation of invadopodia, such as integrin beta1, cortactin, neuronal
261 pecializations of the plasma membrane termed invadopodia that act both to sequester and release matri
262 binding is regulated by local pH changes at invadopodia that are mediated by the sodium-hydrogen exc
264 ed by the proto-oncogene Src form individual invadopodia that can spontaneously self-organize into la
265 uss several key components and regulators of invadopodia that have been uniquely implicated in tumor
266 of stiffness, we find that cells form mature invadopodia that often precede migration in the directio
267 that this interaction displaces MT1-MMP from invadopodia, thereby attenuating their number and functi
271 te RhoC, whereas p190RhoGAP localizes inside invadopodia to deactivate the GTPase within the structur
272 e specialized, actin-rich protrusions called invadopodia to degrade and invade through the extracellu
273 tin polymerization-driven protrusions called invadopodia to degrade and possibly invade through the e
274 switch between the use of microvesicles and invadopodia to facilitate invasion through the extracell
275 use invasive finger-like protrusions termed invadopodia to invade into and degrade extracellular mat
277 ites lack the punctate shape of conventional invadopodia to spread along the cell base and are reticu
278 is critical for integrating the adhesion of invadopodia to the extracellular matrix (ECM) with their
280 the formation and function of adhesions and invadopodia, two key cellular structures required for br
281 of proteolytic cellular protrusions known as invadopodia, undergoes an isoform switch during metastat
282 ling, as demonstrated by a rapid decrease in invadopodia upon inhibition of autocrine HBEGF/EGFR sign
283 noma cells, HDFC matrix induced formation of invadopodia via a specific integrin signaling pathway th
284 hosignaling mechanism regulates cell surface invadopodia via kindlin2 for local proteolytic remodelin
286 ar invadosomes." Interestingly, podosomes or invadopodia were replaced by linear invadosomes upon con
287 matrix degradation and the number of mature invadopodia were significantly decreased with APOE knock
291 e identified L-plastin as a new component of invadopodia, where it contributes to degradation and inv
292 ed protrusions of the plasma membrane called invadopodia, where the trans-membrane type 1 matrix meta
293 Rac3 knockdown reduces matrix degradation by invadopodia, whereas a constitutively active Rac3 can re
294 adative protrusions (invasive pseudopods and invadopodia), which allows their efficient dispersal dur
295 s accompanied by the formation of actin-rich invadopodia, which adhere to the extracellular matrix an
296 ollagen fibers form elongated collagenolytic invadopodia, which differ from dotty-like invadopodia fo
297 can partially rescue actin polymerization in invadopodia while Src overexpression cannot compensate f
300 to the capacity of AXL to directly stimulate invadopodia, yet its suppression upregulates the ERBB3 s