ライフサイエンスコーパス: invariably

1 Electrode used in lithium-ion battery is invariably a composite of multifunctional components.

2 challenging problem because the receptor is invariably a membrane protein, which represents an Achil

3 Human perception is invariably accompanied by a graded feeling of confidence

4 A further increase in Lac density was invariably accompanied by a substantial decrease in aggl

5 Background Heart failure (HF) is invariably accompanied by development of cardiac fibrosi

6 With ionizing radiation, immortalization is invariably accompanied by efficient biallelic deletion o

7 Tissue injury and regeneration is invariably accompanied by macrophage infiltration, but t

8 lly significant since substrate reduction is invariably accompanied by proton uptake.

9 of the altered environmental conditions that invariably accompany destructive disease?

10 However, MM patients invariably acquire resistance to these drugs.

11 asG12D/G12D,C181S compound heterozygous mice invariably acquired revertant mutations that restored cy

12 Conversely, amine ionization behaves invariably across the film.

13 us auditory and visual signals yet they will invariably activate the brain asynchronously due to diff

14 Invariably, acute leukemia diagnosed in the first trimes

15 These errors invariably affect downstream analysis/application and sh

16 However, kinks invariably affect numerous interhelical interactions, qu

17 12 independent clones were obtained and were invariably ALA-responsive, albeit to different extent fo

18 GFR tyrosine kinase inhibitors (TKIs) occurs invariably, and receptor tyrosine kinase (RTK) fusions h

19 hibitor (PARPi) therapy; however, resistance invariably arises in these patients and is a major clini

20 ble smoke invariably in As(III) form and ash invariably as As(V).

21 BPC1 with a dominant, mild skeletal myopathy invariably associated with a distinctive tremor.

22 These signalling patches are invariably associated with a ring of active SCAR/WAVE at

23 jamming was variable and transient, but was invariably associated with a thickening and stratificati

24 Infection and inflammation are invariably associated with activation of the blood coagu

25 Hepatocellular carcinoma (HCC) is almost invariably associated with an underlying inflammatory st

26 in head-restrained mice, eye movements were invariably associated with attempted head motion.

27 adiation of vertebrates, and that these were invariably associated with parallel changes in retinal t

28 ts for single words, on the other hand, were invariably associated with peak atrophy sites in the lef

29 Aneuploidy is invariably associated with poor proliferation of primary

30 M--mutations potentially arise first and are invariably associated with specific, high-fidelity oblig

31 ge cluster of genes in the E. coli genome is invariably associated with the high-pathogenicity island

32 the deadliest human malignancies, is almost invariably associated with the presence of an oncogenic

33 in compounds, Group I elements, for example, invariably assume the +1 oxidation state, and their chem

34 Interestingly, the primary sequence almost invariably avoids off-pathway aggregate formation, by fo

35 e doctrine that high-quality resonances must invariably be narrowband and providing the possibility o

36 of seizures with impaired awareness, as will invariably be the case in those having epilepsy surgery.

37 since large random ecological networks would invariably be unstable and thus should not be observed e

38 lation is highly active in quiescent oocytes invariably become repressed during meiotic re-entry, whe

39 malignancies, including gastric cancer, has invariably been associated with its canonical tyrosine p

40 /Cys(III)-Cys(VI) connectivities, which have invariably been associated with the inhibitor cystine kn

41 Primary epidemiological data have invariably been derived from cancer registries that are

42 However, the regulation of glycolysis has invariably been examined under conditions in which proli

43 tal effect approach has been applied, it has invariably been from a phytocentric perspective, focussi

44 ditionally, longitudinal studies have almost invariably been restricted to older adults, precluding t

45 ary adenomas expressing and secreting GH are invariably benign and exhibit DNA damage and a senescent

46 racterized by limited-stage presentation and invariably benign behavior despite often high-grade hist

47 SCNs of the pancreas are invariably benign entities.

48 The methylation reactions are almost invariably catalyzed by enzymes that use S-adenosylmethi

49 ically acting immunosuppressive drugs, which invariably cause severe side effects.

50 ced hepatic arterial perfusion (HAP), and is invariably causing focal hepatic venous outflow obstruct

51 hat protein profiles of technical replicates invariably clustered; the protein profiles for distinct

52 ations of how the polarized structure arises invariably coalesce around somatic polarity, defined by

53 2s, yet this acidic loop (named for its four invariably conserved acidic residues) is critical for Cd

54 distal side of the loop collaborate with an invariably conserved histidine on the proximal side of t

55 The last C-terminal residue of uS9 is an invariably conserved, positively charged Arg that is bel

56 Photocatalysis has been invariably considered as an unselective process (especia

57 se clusters of up to 100 factors that almost invariably contain cohesins.

58 antly, neurites undergoing active elongation invariably contained a bright F-actin patch at the tip,

59 Brain tissue of Alzheimer's disease patients invariably contains deposits of insoluble, fibrillar agg

60 We observed that nascent disks are invariably continuous with the ciliary plasma membrane,

61 With each chain-extension step, monolignols invariably couple at their beta-positions, generating ch

62 ions in natural and artificial settings, and invariably couples elastic deformation fluid flow.

63 However, its surface is invariably covered with a dense aluminum oxide film, whi

64 Functional Polycomb recruiter sequences are invariably CpG-rich but require protection against DNA m

65 a human coronavirus (OC43), and this ability invariably depends upon the E3 ligase activity of TRIM56

66 patients with Lyme disease, the organism was invariably described as having spirochetal morphology.

67 trode sizes and current amplitudes, they are invariably described as small.

68 X-ray photoelectron spectroscopy invariably detected elemental contaminants associated wi

69 In frog hair cells, spectrin betaV was invariably detected near the apical junctional complex a

70 Even though TVCs normally migrate as an invariably determined leader-trailer polarized pair of a

71 mselves carry information, rather than being invariably detrimental.

72 atients with advanced prostate cancer almost invariably develop osseous metastasis.

73 treated with BRAF and MEK inhibitors almost invariably develop resistance that is frequently associa

74 eated with crizotinib, although all patients invariably develop resistance.

75 fect of sorafenib is transient, and patients invariably develop sorafenib resistance (SR).

76 However, these mice invariably developed esophageal achalasia, and the enter

77 ation-resistant prostate cancer (CRPC) which invariably develops after anti-androgenic therapy.

78 exerts a therapeutic effect, but resistance invariably develops through undefined mechanisms.

79 Resistance invariably develops to antiandrogen therapies used to tr

80 nase inhibitor (TKI) therapy, but resistance invariably develops, commonly within the CNS.

81 hibitors) such as crizotinib, but resistance invariably develops, often with progression in the brain

82 However, acquired resistance invariably develops.

83 Unfortunately, resistance almost invariably develops.

84 ay are used clinically, but tumor resistance invariably develops.

85 characterized by intracellular distributions invariably dictated by their hydrophilic/hydrophobic bal

86 However, mice with CHD invariably die prenatally/neonatally, causing CHD phenot

87 We found that null mutant animals invariably died at around the time of ecdysis, revealing

88 ones of the helices are in contact, and they invariably display networks of 4 to 8 weak hydrogen bond

89 ations that aim to test for voltage feedback invariably disrupt trophic signaling from synaptic trans

90 lenges the perspective that metastasis is an invariably disseminated process, and proposes a biologic

91 , serum and cystic fluid CA 19-9 levels were invariably elevated and the CA 19-9 level in the cystic

92 tes or phenotypically normal hepatocytes are invariably elevated compared to normal health subjects.

93 ells give rise to Blimp1(-) progeny that are invariably Elf5(+)ERalpha(-)PR(-).

94 However, drug-resistant tumour cells invariably emerge leading to disease progression.

95 arget AR signaling, but secondary resistance invariably emerges, and new therapies are urgently neede

96 orary and acquired resistance to these drugs invariably emerges.

97 These antibacterial effectors are invariably encoded with immunity proteins that protect c

98 ns varied from 35 kbp to 80 kbp in size, but invariably encompassed or interrupted only two genes: TG

99 risk of genome instability, since replisomes invariably encounter DNA lesions or other structures tha

100 xpertise for a class of stimuli, an observer invariably encounters novel exemplars from this class.

101 The DNA replication machinery invariably encounters obstacles that slow replication fo

102 nitially effective in cancer patients nearly invariably engender resistance at some stage, an inheren

103 on and mitochondrial protein acetylation are invariably enhanced in this dietary milieu.

104 formed by admixing of seawater, however, are invariably enriched in CH3SH (up to approximately 10(-6)

105 Tumor cells nearly invariably evolve sustained PI3K/Akt signaling as an eff

106 that complexin-deficient DKD and DKO neurons invariably exhibit a ~50% decrease in vesicle priming.

107 lighting from a large petrochemical complex invariably exhibited a visually based foraging behaviour

108 , once animal germ cells are specified, they invariably express a number of highly conserved genes.

109 est ants are sufficient to kill raiders that invariably exterminate host nests without a cohabiting g

110 merging evidence indicates that OXT does not invariably facilitate social bonding but also produces n

111 th actual tumor mass shrinkage, this therapy invariably fails and the cancer reappears as castration-

112 ceptor (ER)-positive breast cancer, but this invariably fails with cancers becoming refractory to tre

113 g in amyotrophic lateral sclerosis (ALS), an invariably fatal and clinically heterogeneous neuromuscu

114 us protein-only infectious agents that cause invariably fatal brain diseases following silent incubat

115 Glioblastoma multiforme (GBM) remains almost invariably fatal despite optimal surgical and medical th

116 a genomically diverse, prevalent, and almost invariably fatal malignancy.

117 reutzfeldt-Jakob disease (CJD) is a rare but invariably fatal neurodegenerative disease caused by mis

118 ey role in amyotrophic lateral sclerosis, an invariably fatal neurodegenerative disease.

119 treatment for a disease that was considered invariably fatal once clinical signs develop.

120 -Gilford progeria syndrome (HGPS) is a rare, invariably fatal premature aging disorder.

121 of rabbit PrP.IMPORTANCE Prion disorders are invariably fatal, untreatable diseases typically associa

122 ckable-turned-shockable OHCA is poor but not invariably fatal.

123 were used; however, significant differences invariably favored the bivalent vaccine.

124 hour) of rapid phagocytosis, which was then invariably followed by a sharp reduction in phagocytic a

125 cated into the cytosolic leaflet of the BCV, invariably followed by cytosolic exposure of glycans, wh

126 sults in dramatic tumor regression but it is invariably followed by drug resistance.

127 urvival rates, with initial responses nearly invariably followed by rapid recurrence of therapy-resis

128 Aspartate release invariably follows that of a sodium ion located near the

129 beta-hairpin-containing conformers, instead, invariably form very stable dimers when their side chain

130 Products invariably formed in good yields, with rigorous chemo-,

131 nent of microbial networks throughout and we invariably found fungi to act as keystone species in all

132 ess, when examined, miRNA targeted mRNAs are invariably found to be polysome associated; observations

133 siRNA release occurred invariably from maturing endosomes within ~5-15 min of e

134 icient, whereas the wild-type allele of Tp53 invariably gained point mutations.

135 he thyroid carcinoma cells investigated were invariably gal-3-positive while presenting low or lost N

136 ne zipper (GILZ) is a rapidly, potently, and invariably GC-induced gene.

137 configurations are thermally activated, they invariably give rise to a softening of the bulk modulus

138 rostate tumor xenografts, delta-catenin gene invariably gives rise to mutations, leading to sequence

139 As fatigue limits are invariably governed by the local arrest of microscopical

140 -cell ontogeny develop thymic lymphomas that invariably harbor a reciprocal translocation involving t

141 that colorectal cancer progression specimens invariably harbored lesions in elements of the RAS-RAF-M

142 The resulting tumours invariably harbour the Eml4-Alk inversion, express the E

143 ailure to maintain these physiologic rhythms invariably has pathologic consequences.

144 Patients almost invariably have prominent extrapyramidal movement abnorm

145 However, illumination invariably heats tissue, and many physiological processe

146 r 6 months), decreasing with age, and almost invariably heterotypic, indicative of lasting type-speci

147 Similarly, DAAM mutants express invariably high levels of Ena in vitro.

148 The targets whose vulnerabilities are invariably high might be more universally acceptable tar

149 ions were detected in 79% of patients, being invariably identified in those with a confirmed diagnosi

150 whereas combustion produces respirable smoke invariably in As(III) form and ash invariably as As(V).

151 udy suggests that rising temperatures do not invariably increase CO2 emissions from aquatic ecosystem

152 We now know that IgE levels are invariably increased in patients affected by atopic cond

153 The results show that translation invariably initiates off the thylakoid membrane and that

154 singlet oxygen in solution-phase systems is invariably invoked when explaining the biological antiox

155 bserved following caecum implantation, which invariably involves peritoneal carcinomatosis.

156 Cytoplasm sharing invariably involves plasma membrane breaches.

157 It invariably involves specific and detailed sequences of d

158 rmine why VZV, when grown in cultured cells, invariably is more cell associated and has a lower titer

159 n microscopy (TEM) can resolve nanowires but invariably lacks the facility for direct observation of

160 ver, largely relies on manual efforts, which invariably lag behind the increasingly automated generat

161 The business-as-usual scenarios invariably lead to a peak of primary production by the m

162 (i.e. hemispherectomies or hemispherotomies) invariably lead to contralateral hemiparesis.

163 Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional programs

164 DSB formation did not invariably lead to nucleosome dissolution, and in some c

165 Chemical inducers of ER stress invariably lead to pain behavior that is reversed by a c

166 ardiac electrophysiological alterations that invariably lead to premature aging and death.

167 regulation of cell cycle progression in HSCs invariably lead to the development of hematologic malign

168 my 21) (DS) is a neurodevelopmental disorder invariably leading to early-onset Alzheimer's disease (A

169 ision clearly deviates from this rule, which invariably leads to asymmetric cell division.

170 can sometimes attenuate size variations, it invariably leads to higher-order moments growing unbound

171 nd positive changes in population size, this invariably leads to questions about whether favorable cl

172 However, ART interruption almost invariably leads to rebound viremia in infected individu

173 o invade into normal brain parenchyma, which invariably leads to tumor recurrence and patient death.

174 ting duct cells, enhanced apical Na(+) entry invariably led to increased basolateral Na,K-ATPase expr

175 sential to successfully treating this almost invariably lethal disease.

176 fibrosis (IPF) is a common, progressive, and invariably lethal interstitial lung disease with no effe

177 entifying a clinical distinction between the invariably lethal prion disease Creutzfeldt-Jakob diseas

178 jor neurological symptoms, compared with the invariably lethal wild-type virus.

179 and other nonspecific therapies, and almost invariably lethal.

180 rugs can produce dramatic responses that are invariably limited by the emergence of drug-resistant ce

181 Drug resistance invariably limits the clinical efficacy of targeted ther

182 trol of infection, and Sb's efficacy are not invariably linked expressions of the same T cell-depende

183 tional behaviour, and that such coherence is invariably linked to the development of ensemble represe

184 ng that PSEN1 FAD causing mutations generate invariably long Abeta and seed amyloid.

185 eneficial endosymbiotic lifestyle, it almost invariably loses a large fraction of its genome [1, 2].

186 of origin Sonic hedgehog (Shh) expression is invariably lost during progression to invasive urothelia

187 Post-extinction survival faunas are invariably low diversity, especially benthic communities

188 aluminium content of 191 tissue samples was invariably low with over 80% of tissues having an alumin

189 Analysis of invariably methylated transposons and genes across this

190 The daughter centriole invariably migrated ahead of the MC from the center to t

191 ntreated tumors confirmed that C2 cells were invariably more abundant than C3 cells.

192 However, the natural cellular membrane is invariably more complex than the proteoliposomes most of

193 linical human cytomegalovirus (HCMV) strains invariably mutate when propagatedin vitro Mutations in g

194 s that prioritize investment across a region invariably navigate trade-offs among multiple objectives

195 ossible adverse effects, and adjustments are invariably needed along the way.

196 sh the viral genome hypermethylation that is invariably observed in asymptomatic, recovered tissues.

197 ) and very low (0.007-0.009) Na/K ratio were invariably obtained across landraces, contrasted by sign

198 a member of the beta-herpesvirus family that invariably occupies hosts for life despite a consistent

199 that (i) accounts for intrinsic changes that invariably occur in the optical baseline of the EA-IOW d

200 Fatal tachyarrhythmias invariably occurred in the presence of severe metabolic

201 ry FLT3-ITD(+) AML, but leukemia progression invariably occurs.

202 erpreting clinical datasets in which signals invariably originate from hundreds to thousands of cells

203 Prostate tumors invariably overexpress prostate surface membrane antigen

204 We observed that dicentric chromosomes invariably persisted through mitosis and developed into

205 on malignant primary brain tumor, carries an invariably poor prognosis.

206 iviral therapy, the finding that IFN-lambda3 invariably possesses the highest activity among type III

207 matic colonization of the nasopharynx almost invariably precedes disease, the critical determinants e

208 )(4)-specific T cells, but graft destruction invariably predated their recruitment.

209 Whereas NBO analysis at the B3LYP DFT level invariably predicts a propargylic electronic structure,

210 asculopathy and hydrocephalus, and is almost invariably prenatally fatal.

211 Myelopoiesis is invariably present and contributes to pathology in anima

212 These nephropathies invariably present with microscopic hematuria and freque

213 tations, +12, and subset 8 BCR configuration invariably primes CLL transformation into Richter syndro

214 ional GABs, filament elongation on a surface invariably proceeded with the same rate as with the VASP

215 isms, crocidolite or applied Fe(3+)/H(2)O(2) invariably produced oocyte cell death.

216 r concentration of 0.1%, all the emulsifiers invariably produced stable nanodispersions with small pa

217 Unlike the invariably progressive deterioration of the disease, 8 m

218 Thus, the MD does not invariably project out into solution as in one structura

219 this effect, as A + T-rich sequence settings invariably provoke de novo DNA methylation leading to lo

220 inly limited to radical reactions, which are invariably racemic.

221 resistant variants, which would explain the invariably rapid emergence of stem-like resistant cells.

222 mors with full penetrance and the tumors are invariably Rb1(-/-), modeling tumorigenesis by two-hit l

223 several potent proteins and lipids that are invariably recognized as foreign by immune system cells.

224 nce-specific interactions, these experiments invariably record a contribution due to proximity FRET,

225 hways, attachment of cargo molecules to CPPs invariably reduces their cellular uptake.

226 nomes, the top enriched function for each is invariably reflective of their very different medical hi

227 infection by EBV is often subclinical; this invariably reflects the necessity of the virus to preser

228 y unable to decode male courtship and almost invariably reject males.

229 d treatment for metastatic PCa, but patients invariably relapse despite castrate androgen levels (cas

230 Mice invariably relapsed after treatment with drug-resistant

231 Undisturbed sites invariably released modern DOC and POC (<20 years old),

232 hat the ceramic aragonite platelets in nacre invariably remain shielded from the propagating crack.

233 to human cells on an SV40-based episome were invariably repaired, this process induced mutations in f

234 r database, a decision that published papers invariably report but do not discuss.

235 While calpains are invariably reported to be exclusively intracellular (exc

236 tive cases, we demonstrate that relapsed AML invariably represents re-emergence or evolution of a fou

237 Previously developed methodologies invariably require activated, electronically engineered

238 These processes invariably require that reactivity be relayed from inter

239 king is more complex because patients almost invariably require valve replacement.

240 Profiling ctDNA almost invariably requires prior knowledge of what genomic alte

241 erapy, including intravenous amiodarone, but invariably responded to quinidine therapy.

242 vation of PI3K mediated by p110beta does not invariably restore AKT phosphorylation, demonstrating th

243 icate this feat in artificial systems almost invariably result in bubble formation, except under high

244 This will invariably result in higher melt rates.

245 ever, alleviating growth inhibition does not invariably result in increased production.

246 enital disorders of ganglioside biosynthesis invariably result in intellectual disability and are oft

247 ted with autosomal recessive (AR) conditions invariably result in loss-of-function.

248 induced a change in membrane potential that invariably resulted in cellular senescence.

249 t a high concentration (10 microM), baclofen invariably resulted in hyperpolarization, at low concent

250 ions within the zinc finger region of ZBTB7A invariably resulted in loss of function.

251 inherent to the system being studied, which invariably results from the non-linear nature of biologi

252 subunit contacts by amino-acid substitutions invariably results in accelerated catalysis, slowed-down

253 Such rejection invariably results in allosensitization and accelerated

254 dministered, and therapy interruption almost invariably results in robust viral rebound.

255 Unfortunately, interruption of ART almost invariably results in viral rebound, attributed to a poo

256 ies of the normally episomal HPV genome that invariably retain intact forms of the two HPV oncogenes

257 nsiently suppresses virus replication, which invariably returns to pre-treatment levels and results i

258 PRRT-induced myelosuppression is almost invariably reversible and rarely requires clinical measu

259 Environmental limits of animal life are invariably revised when the animals themselves are inves

260 with decompensated cirrhosis, who are almost invariably sarcopenic.

261 N invariably scales sublinearly to V (b < 1), making large

262 circuit that may cause the AD-like pathology invariably seen in DS that could help to identify mechan

263 ts in the form of lung hypoplasia are almost invariably seen in patients with CDH and frequently in a

264 d that TKI-resistant low-level mutations are invariably selected if the patients are not switched to

265 sRNAPs are highly conserved in evolution and invariably share a approximately 400 kDa five-subunit ca

266 efficacy in melanoma patients, response is, invariably, short lived.

267 ant:sensitive) ratio and the tolerant plants invariably showed normal grain filling.

268 cell membrane is disrupted, while the CTL is invariably spared.

269 ChR2-EYFP-expressing neurons almost invariably stained for tyrosine hydroxylase, identifying

270 olar fuel) through photocatalytic processes, invariably starts with photoinduced generation of energy

271 We define how Hsp104(DeltaN) invariably stimulates Sup35 prionogenesis by fragmenting

272 isk, hazard, or alternatives assessment, one invariably struggles with the task of reconciling multip

273 with pancreatic ductal adenocarcinoma (PDAC) invariably succumb to metastatic disease, but the underl

274 op metastatic castration-resistant PC (CRPC) invariably succumb to the disease.

275 castration-resistant prostate cancer (CRPC) invariably succumb to the disease.

276 trast, single-molecule FRET (smFRET) studies invariably suggest that protein unfolded states contract

277 idence/models that support one theory almost invariably supports other theories as well.

278 Patients treated with quinidine invariably survived to hospital discharge.

279 Molecular weight, almost invariably the defining characteristic of "beyond the ru

280 Invariably, the rates of benzoic acid oxidation with dif

281 Invariably, this has required enzymatic incubation at 37

282 ription factors that reprogram cell fate are invariably those that are crucial for the initial cell p

283 the transcription start site and to produce invariably tight repression of all of the strong viral/m

284 t-onset neurodegenerative disease that leads invariably to fatal paralysis associated with motor neur

285 al connections, but their ultimate effect is invariably to minimize arterial PCO2 fluctuations.

286 New spacers are added invariably to the 5' end of the array; therefore, the fi

287 Colonies arising with STEMCCA-loxP were invariably TRA-1-60(+), yielding 5.3 +/- 2.8 iPSC coloni

288 oblastoma (GBM) responses to bevacizumab are invariably transient with acquired resistance.

289 The polymorphic VT events were invariably triggered by extrasystoles with short (364+/-

290 ointingly, the phosphorescence quantum yield invariably turned out to be very low, about 0.02 - 0.04%

291 ng resistance to MET oncogene-targeted drugs invariably underwent NRP2 loss, a step required for EGFR

292 FITs are invariably used in a dichotomous manner using pre-specif

293 In addition, the term "lone AF" is not invariably useful in making treatment decisions, and oth

294 These analyses, however, invariably using extracellular recordings, are greatly h

295 ulation sizes at the time of measurement are invariably very large and mutation rates are low.

296 e, and first thoracoabdominal metastases are invariably visible on abdominal images.

297 IgE sensitization started almost invariably with group A molecules and expanded sequentia

298 of different colloidal crystals, but almost invariably with the restriction that the particles must

299 However clinically, ND is associated invariably with well-centered in-the-bag IOLs.

300 ch in starch and other polysaccharides, they invariably yield less and poor quality RNA.