ライフサイエンスコーパス: invasive phenotype

1 mbined loss of PTEN results in an aggressive invasive phenotype.

2 hen causes transition of these tumours to an invasive phenotype.

3 nt in melanoma and are known to regulate the invasive phenotype.

4 MMSET, responsible for the acquisition of an invasive phenotype.

5 formation to membrane ruffling to confer an invasive phenotype.

6 t, inhibition of Akt or mTOR exacerbated the invasive phenotype.

7 to drive cells to a more stem cell-like and invasive phenotype.

8 PAR1 resulted in a loss of the Mmp1a-driven invasive phenotype.

9 enoma-to-carcinoma transition and acquire an invasive phenotype.

10 ated malignant conversion and the associated invasive phenotype.

11 h cyclooxygenase-2 (COX-2) expression and an invasive phenotype.

12 redirected trophoblast differentiation to an invasive phenotype.

13 se MT1-MMP, thus affecting all aspects of an invasive phenotype.

14 expression of invadopodia components and an invasive phenotype.

15 ion of N-cadherin, and reversed their highly invasive phenotype.

16 cro-environment on the emergence of a motile invasive phenotype.

17 activity necessary for supporting the tissue-invasive phenotype.

18 ial-mesenchymal transition, indicative of an invasive phenotype.

19 se the effects of LOX, which promoted a more invasive phenotype.

20 ity increases matrix stiffness to promote an invasive phenotype.

21 h was necessary to generate and maintain the invasive phenotype.

22 which are associated with a less motile and invasive phenotype.

23 , we found these MMPs to be required for the invasive phenotype.

24 metrium and that Lkb1 loss promotes a highly invasive phenotype.

25 onal integrity, and promoted a migratory and invasive phenotype.

26 ta signaling and the RON pathway promotes an invasive phenotype.

27 n is often lost during progression to a more invasive phenotype.

28 senchymal transition (EMT) pathway, reducing invasive phenotype.

29 racene (DMBA) induces mammary tumors with an invasive phenotype.

30 ic cancers, have recently been implicated in invasive phenotype.

31 advanced melanoma cells contributes to their invasive phenotype.

32 K2alpha bitransgenic mice displayed a highly invasive phenotype.

33 a critical role in the establishment of the invasive phenotype.

34 ography, are critical for development of the invasive phenotype.

35 atin), suggesting a role of DPP4 in the cell invasive phenotype.

36 n of genes which might be associated with an invasive phenotype.

37 program of gene expression that defines the invasive phenotype.

38 with endothelial tubes, reverting to a less invasive phenotype.

39 breakdown of barrier function and acquire an invasive phenotype.

40 ity regulated by Src and contributing to the invasive phenotype.

41 thelial-to-mesenchymal transition and a less invasive phenotype.

42 (also known as ErbB2 and HER2) results in an invasive phenotype.

43 integrin is associated with a migratory and invasive phenotype.

44 th gestational age and differentiation to an invasive phenotype.

45 epithelial origin is associated with a more invasive phenotype.

46 is also important for the acquisition of an invasive phenotype.

47 enhanced gelatinase activity, typical of an invasive phenotype.

48 nes engineered to overexpress SPARC adopt an invasive phenotype.

49 that PKCbetaII activity is required for the invasive phenotype.

50 es in cell morphology consistent with a less invasive phenotype.

51 nduces cytotrophoblast differentiation to an invasive phenotype.

52 al-to-mesenchymal transition, and acquire an invasive phenotype.

53 n of hilA gene expression and the Salmonella invasive phenotype.

54 hilE superrepresses hilA expression and the invasive phenotype.

55 ity with in vitro passage, culminating in an invasive phenotype.

56 as and it is linked to the acquisition of an invasive phenotype.

57 the peritumoral normal tissue producing the invasive phenotype.

58 n and activity were necessary for the highly invasive phenotype.

59 icular in the control of angiogenesis in the invasive phenotype.

60 ession or function in tumors leads to a more invasive phenotype.

61 etic changes that may be responsible for the invasive phenotype.

62 d DPPIV, that are responsible for the tissue-invasive phenotype.

63 therapies directed toward inhibition of the invasive phenotype.

64 l mechanism for neoplastic progression to an invasive phenotype.

65 ntially segregates with tumours that show an invasive phenotype.

66 ed the definition of consensus GEPs for each invasive phenotype.

67 y ZEB1 expression associated with gain of an invasive phenotype.

68 and adhesive activity to achieve a maximally invasive phenotype.

69 was associated with a pro-migratory and pro-invasive phenotype.

70 o increase cell proliferation and produce an invasive phenotype.

71 r metastases shed intact tumor cells with an invasive phenotype.

72 esenchymal splice variant of CD44 and a more invasive phenotype.

73 cellular architecture toward a migratory and invasive phenotype.

74 elial properties and acquire a migratory and invasive phenotype.

75 T and beta-catenin, leading to an attenuated invasive phenotype.

76 is an important factor in expression of the invasive phenotype.

77 1 from noninvasive cancer cells restored the invasive phenotype.

78 YAP/TEAD target genes, including Myc, and an invasive phenotype.

79 ontact inhibition and acquired migratory and invasive phenotype.

80 ted membrane protrusions, cell spreading and invasive phenotype.

81 induces cell transformation and promotes an invasive phenotype.

82 cal interactions facilitate transition to an invasive phenotype.

83 cts of human colorectal cancer, including an invasive phenotype.

84 propriately by DNA methylation to promote an invasive phenotype.

85 n coordinate and accelerate transition to an invasive phenotype.

86 he fibril fraction as compared to the highly invasive phenotype.

87 of alpha-catenin was sufficient to suppress invasive phenotype.

88 /pY654-beta-catenin complexes and develop an invasive phenotype.

89 phosphorylation and a more proliferative and invasive phenotype.

90 re it promotes aneuploidy and contributes to invasive phenotypes.

91 elial-mesenchymal transition, migratory, and invasive phenotypes.

92 tory potential and death on the emergence of invasive phenotypes.

93 subclones (29/46, 60%) share superficial and invasive phenotypes.

94 as increased proliferative, angiogenic, and invasive phenotypes.

95 he progression of colon cancer cells to more invasive phenotypes.

96 breast cancer progression from low to highly invasive phenotypes.

97 ntial molecular event for p53 mutant-induced invasive phenotypes.

98 orphological instabilities that may underlie invasive phenotypes.

99 A549 cells induced morphological changes and invasive phenotypes.

100 cells yet demonstrate distinct adhesive and invasive phenotypes.

101 8, but not T157, abolished the migratory and invasive phenotypes.

102 s of anchorage-dependent growth and acquired invasive phenotypes.

103 probing tumor heterogeneity and determining invasive phenotypes.

104 corresponding to melanoma proliferative and invasive phenotypes.

105 A-depleted cells resulted in reversal of the invasive phenotype, accompanied by sensitivity to apopto

106 ate that while matrilysin contributes to the invasive phenotype, activation of stromelysin-1 is a key

107 ary tumor burden, but induces a more locally invasive phenotype and causes seminal vesicle obstructio

108 tified as regulated during acquisition of an invasive phenotype and concomitant neuroendocrine transd

109 Trophoblast cells differentiate into an invasive phenotype and contribute to the transformation

110 The gastric tumors from the CIN mice had an invasive phenotype and formed liver and lung metastases.

111 MCF10DCIS.COM xenografts resulted in a more invasive phenotype and increased lung metastasis likely

112 ing late TGF-beta-responsive genes displayed invasive phenotype and increased tumor recurrence.

113 de transforming growth factor-beta1-mediated invasive phenotype and induced a more epithelial phenoty

114 des induced by Her-2/neu that promote a more invasive phenotype and may provide a novel avenue for tr

115 ion of mesenchymal properties linked with an invasive phenotype and metastasis of tumor cells.

116 GCB and Crohn's disease have an adherent and invasive phenotype and novel multilocus sequence types a

117 der cancer may prove useful for defining the invasive phenotype and provide targets for guiding thera

118 hree-dimensional type 1 collagen reverts the invasive phenotype and restores apicobasolateral polarit

119 Both the invasive phenotype and the progressive fibrosis were inh

120 C1 may regulate the basal-like breast cancer invasive phenotype and the propensity of these cancers t

121 impairs the ability of LOX-PP to inhibit the invasive phenotype and tumor formation of NF639 cells in

122 been known to promote metastasis by inducing invasive phenotype and tumor-initiating activity of canc

123 ng of how breast cancer cells progress to an invasive phenotype and underscore potential clinical int

124 endogenous EMX2 promoted cell proliferation, invasive phenotypes and canonical WNT signaling.

125 probe tumor heterogeneity, discriminate more invasive phenotypes and correlate with biomarker express

126 -2 is able to reduce their proliferative and invasive phenotypes and decrease their level of matrix m

127 sting that 11a exon exclusion contributes to invasive phenotypes and leads to poor clinical outcomes.

128 as down-regulation of actopaxin reverted the invasive phenotypes and metastatic potential of metastat

129 y a significant role in the initiation of an invasive phenotype, and, equally, miR-200c overexpressio

130 ion of G2 is exclusively associated with the invasive phenotype; and 4) the two isoforms of sG may pr

131 ssion of EGFR and c-erbB-2 expression on the invasive phenotype, aneuploidy, and genotype of cultured

132 Mechanistically, the invasive phenotype appeared to be driven by an expansion

133 The downstream markers PODXL and DEL of the invasive phenotype are associated with a poor prognosis.

134 to study the transition from preinvasive to invasive phenotype as it may occur "spontaneously" in vi

135 Up-regulation of MT3-MMP is critical to the invasive phenotype as shown by small interfering RNA (si

136 t early step that precedes acquisition of an invasive phenotype, as we find decreased levels of BRE1A

137 this model, loss of Tgfbr2 induced a highly invasive phenotype associated with lymph node metastasis

138 bovine leukocytes induces proliferative and invasive phenotypes associated with activated signalling

139 mbination with a MEK inhibitor prevented the invasive phenotype, but only STAT3 inhibition caused cel

140 PSTT is characterized by a highly invasive phenotype, but the molecular mechanisms are poo

141 so shown to induce and maintain a motile and invasive phenotype by promoting gene transcription.

142 tion, reprogramming nonmalignant cells to an invasive phenotype by reducing the set point for stimula

143 expression of LIMK1 promotes acquisition of invasive phenotype by the benign prostate epithelial cel

144 ted Mig-7 expression before they acquired an invasive phenotype capable of pseudovasculogenesis.

145 t to recapitulate the increased motility and invasive phenotypes characteristic of transformed cells

146 epithelial cells is sufficient to induce an invasive phenotype characterized by membrane type-1 matr

147 lusion IDH-mutated glioblastomas have a less invasive phenotype compared with IDH wild type.

148 epithelial-mesenchymal transition (EMT) and invasive phenotype, compared to isogenic wild-type cells

149 hich breast cancer cells acquire an enhanced invasive phenotype contributing to metastasis.

150 The tumor invasive phenotype driven by seprase expression/activity

151 basis for emergence of a GAS strain with an invasive phenotype during human infection.

152 play a spectrum of phenotypical changes with invasive phenotypes evolving in lines resistant to the a

153 gradation of p53 by E6 may contribute to the invasive phenotype exhibited by cervical cells that cont

154 nolytic activity differentiates the collagen-invasive phenotype from bulk collagen degradation.

155 The initiation of the invasive phenotype has been linked to the aberrant expre

156 ibution of GBM stem-like cells (GSCs) to the invasive phenotype, however, has not been completely def

157 anced motility as cancer cells may evolve an invasive phenotype if the consequent cell movement is re

158 GDF11 promotes an epithelial, anti-invasive phenotype in 3D triple-negative cultures and in

159 n-regulation of E-cadherin and regulates the invasive phenotype in a RAC1-dependent manner.

160 adation, sarcosine dehydrogenase, induced an invasive phenotype in benign prostate epithelial cells.

161 N-cadherin expression has been linked to the invasive phenotype in bladder tumors yet a primary role

162 time, a role for FOXO3a in the inhibition of invasive phenotype in breast cancer cells with active ER

163 on and is required for the acquisition of an invasive phenotype in breast tumors.

164 ly, ectopic expression of Mmp1a conferred an invasive phenotype in epithelial cells that do not expre

165 Notably, RelB promoted a more invasive phenotype in ERalpha-negative cancers via induc

166 n important role in the observed reversal of invasive phenotype in ERalpha-positive breast cancer cel

167 ted access to the stromal ECM may trigger an invasive phenotype in follower epithelial cells that cou

168 d FBXW7 expression is associated with a more invasive phenotype in gastric cancer cell lines.

169 receptor, CXCR4, with the development of an invasive phenotype in malignant glioblastoma.

170 rotubules and the LINC complex to promote an invasive phenotype in melanoma cells.

171 the ability to switch to a dedifferentiated, invasive phenotype in response to multiple stimuli.

172 ADAM9-S induced a highly invasive phenotype in several human tumor cell lines in

173 forced MMP9 or MMP13 expression rescued the invasive phenotype in SPDEF expressing PC3 cells in vitr

174 work identifies HLH-2 as a regulator of the invasive phenotype in the AC, adding to our understandin

175 dasatinib, we identified a switch to a more invasive phenotype in the BRAF-mutant cells as a potenti

176 expression of Foxa2 was associated with the invasive phenotype in the primary prostate cancer.

177 progression of gliomas that leads to a more invasive phenotype in these cells.

178 her ErbB2 or CSF-1R/CSF-1 induced a dramatic invasive phenotype in three-dimensional cultures.

179 pe with increased growth in soft agar and an invasive phenotype in three-dimensional organotypic cult

180 nd selectively mitigated a miR-21-associated invasive phenotype in triple-negative breast cancer cell

181 d the IGF-IR may play a critical role in the invasive phenotype in urothelial neoplasia.

182 a critical role in the establishment of the invasive phenotype in urothelial neoplasia.

183 147 (emmprin; basigin) is associated with an invasive phenotype in various types of cancers, includin

184 elates with increased cell proliferation and invasive phenotypes in endometrial adenocarcinoma cells,

185 scriptional regulation promoting cancer cell invasive phenotypes in lung adenocarcinoma, lung squamou

186 in mitochondrial dynamics and acquisition of invasive phenotypes in normal epithelial cells.

187 chondria-to-nucleus stress signaling induces invasive phenotypes in otherwise non-invasive C2C12 myob

188 te to the development of drug resistance and invasive phenotypes in PDAC.

189 ted WM239A clusters and single cells adopted invasive phenotypes in the hDF coculture model, which in

190 ications illustrated by its ability to block invasive phenotypes in vitro and metastatic properties i

191 e because CCN5/WISP-2 silencing augments the invasive phenotypes in vitro.

192 ced aberrantly expressed Ror2, leading to an invasive phenotype, in several cancers including renal c

193 cell migration, a necessary component of the invasive phenotype, in two human cancer cell lines; UMUC

194 nced the CCN5/WISP-2 expression and enhanced invasive phenotypes, including the induction of morpholo

195 expression suppressed cell proliferation and invasive phenotypes, inhibited canonical WNT signaling,

196 iated lamellipodia formation, countering the invasive phenotype initiated by oncogenic Ras.

197 tality, and the acquisition of migratory and invasive phenotype is a key factor in initiation of mali

198 We have further shown this more invasive phenotype is accompanied by alterations in the

199 Acquisition of an invasive phenotype is accompanied by changes in gene exp

200 ucing tumor cell infiltration, and that this invasive phenotype is caused by activation of MMP-2.

201 Finally, we demonstrate that this invasive phenotype is specific to WASF3 as depletion of

202 cterizing this heterogeneity and identifying invasive phenotype may provide possibility to improve ch

203 ng RNA led to a decrease in the gastric cell-invasive phenotype mediated by the infection.

204 n-refractory prostate cancer and that a more invasive phenotype might develop through AR activation d

205 rs paradoxically exhibit (given their highly invasive phenotype) normal cell polarity and apical diff

206 Conversely, the invasive phenotype observed in ErbB2-positive cancer mod

207 xpression and phosphorylation status and the invasive phenotype of aggressive human tumors.

208 ic mechanisms that underlie the particularly invasive phenotype of astrocytic tumor cells are unclear

209 udy factors that determine progression to an invasive phenotype of bladder cancer.

210 gh expression of MLK4 promotes migratory and invasive phenotype of breast cancer and may represent a

211 f EphB6, a kinase-deficient receptor, in the invasive phenotype of breast cancer cell lines.

212 way could be important to control the highly invasive phenotype of breast cancer cells.

213 the alpha(5)beta(1)-induced, MMP-1-dependent invasive phenotype of breast cancer cells.

214 -dynein-dynactin-kinesin-1 axis promoting an invasive phenotype of breast cancer cells.

215 during tumor progression contributes to the invasive phenotype of cadherin-deficient carcinomas and

216 contributor to the increase in the migratory/invasive phenotype of cancer cells that results when GnT

217 E3 results in a significant reduction in the invasive phenotype of cancer cells, which is specific to

218 expression correlates with the migratory and invasive phenotype of cancer cells.

219 as a tumor suppressor lncRNA by reducing the invasive phenotype of cancer cells.

220 are critical determinants of the motile and invasive phenotype of cancer cells.

221 okines from epithelial cells may reflect the invasive phenotype of F. nucleatum and contribute to the

222 d gene, to be required for the migratory and invasive phenotype of GBM cells.

223 2 by a specific MMP-2 inhibitor reversed the invasive phenotype of glioma cells overexpressing FoxM1.

224 ge factor (GEF), are evidently linked to the invasive phenotype of glioma cells.

225 extracellular region, consistent with a more invasive phenotype of LGSCs compared with BSTs.

226 Thus, LOX-PP potently inhibits invasive phenotype of lung and pancreatic cancer cells,

227 MCV sT was shown to induce the migratory and invasive phenotype of MCC cells through the transcriptio

228 as well as RNA silencing, we found that the invasive phenotype of MDA-MB-231 cells is mediated by PL

229 The invasive phenotype of metastatic cancer cells is accompa

230 EGCG treatment similarly inhibited invasive phenotype of mouse mammary tumor cells driven b

231 ain, which inhibited tumor formation and the invasive phenotype of NF639 breast cancer cells driven b

232 nic conversion and further progression to an invasive phenotype of non-tumorigenic benign prostate ep

233 ports the effect of elevated pressure on the invasive phenotype of patterned three-dimensional (3D) a

234 xpression of active RhoC is required for the invasive phenotype of PC-3 cells.Oncogene advance online

235 in regulating the differentiation state and invasive phenotype of PDAC cells.

236 ndent of cellular alterations leading to the invasive phenotype of RA-synovial fibroblasts.

237 he Shigella surface and thus compromises the invasive phenotype of S. flexneri.

238 f catalase, indicating that the promigratory/invasive phenotype of Sod2-expressing cells is H(2)O(2)

239 activity contributes to the hyperplastic and invasive phenotype of synoviocytes that leads to cartila

240 nel of genes potentially associated with the invasive phenotype of the neoplasms.

241 These results demonstrate the invasive phenotype of the serotype 14 variant of the Spa

242 ed the cases according to the dysplastic and invasive phenotype of theIPMTs.

243 f Ack1 in cancer cell lines can increase the invasive phenotype of these cells both in vitro and in v

244 asma membrane and this may contribute to the invasive phenotype of these tumors.

245 nase (MMP)-9 is thought to contribute to the invasive phenotype of tumor cells.

246 re the diffusion-tensor (DT) imaging-defined invasive phenotypes of both isocitrate dehydrogenase (ID

247 e cancers and gene ablation can suppress the invasive phenotypes of many tumor cell lines.

248 partner c-Jun inhibits the proliferative and invasive phenotypes of TNBC cells in vitro.

249 Ibeta was sufficient to confer an aggressive invasive phenotype on minimally invasive HeLa and MCF-7

250 ession of AEP and ICAM1 did not result in an invasive phenotype or murine CNS disease.

251 ic ductal epithelial cells led to a markedly invasive phenotype (P < 0.0001) and near total down-regu

252 /16), were significantly associated with the invasive phenotype (P < 0.001).

253 ole in repressing hilA transcription and the invasive phenotype, particularly in response to osmolari

254 r events surrounding the acquisition of this invasive phenotype remain incompletely understood.

255 in MCF-7 cells induced a hormone-refractory, invasive phenotype representative of advanced basal-like

256 sition underlying the attainment of a highly invasive phenotype specifically driven by Fbxw7.

257 logy and promotes key characteristics of the invasive phenotype such as lumen-filling and basement me

258 -mediated adhesion enabled acquisition of an invasive phenotype, suggesting that maintenance of inter

259 integration of programs leading to migratory/invasive phenotypes, survival and resistance to environm

260 (MITF) is a hallmark of the proliferative-to-invasive phenotype switch, although how MITF promotes pr

261 ells transfected with Rap1GAP exhibit a more invasive phenotype than corresponding vector-transfected

262 clones, which displayed more aggressive and invasive phenotype than cyclin D1-expressing clones.

263 s also express markers of EMT and exhibit an invasive phenotype that can be interpreted as consistent

264 we show that RIE/PKCbetaII cells acquire an invasive phenotype that is blocked by the PKCbeta inhibi

265 ts with the v-fos oncogene produces a highly invasive phenotype that is mediated by changes in gene e

266 isolated from patients with IPF exhibited an invasive phenotype that was also dependent on HAS2 and C

267 ndings implicate AIM1 as a key suppressor of invasive phenotypes that becomes dysregulated in primary

268 ating a dependency of preloaded lipids on an invasive phenotype, the authors then establish that onco

269 vestigate the mechanism(s) leading to a less invasive phenotype, the effects of the green tea polyphe

270 and prfA G155S strains were similar in their invasive phenotypes, the infection of epithelial cells w

271 etween the tumor boundary morphology and the invasive phenotype, this work provides a quantitative to

272 single-agent Src inhibition promotes a more invasive phenotype through an IL-1beta>FAK>p130Cas>c-Jun

273 environment trigger cancer cells to adopt an invasive phenotype through epithelial-mesenchymal transi

274 at integrin alpha6beta4 confers a motile and invasive phenotype to breast carcinoma cells by regulati

275 e specific gene targets/pathways driving the invasive phenotype to develop more effective therapeutic

276 Y. enterocolitica genes that could confer an invasive phenotype to Escherichia coli.

277 beta1 signaling via PTEN confers a migratory/invasive phenotype to fibrotic lung fibroblasts.

278 mentation of the mutant reestablished Caco-2 invasive phenotype to wild-type levels.

279 estigated how RASSF1A inactivation conferred invasive phenotypes to human bronchial cells.

280 in ovarian carcinomas that transform into an invasive phenotype under hypoxic conditions.

281 The vascular invasive phenotype was associated with a YAP-dependent u

282 The induction of this invasive phenotype was associated with loss of basement

283 ith a side length <900 mum, transition to an invasive phenotype was blocked in 20 of 20 experiments,

284 The invasive phenotype was determined by using previously pu

285 Notably, this invasive phenotype was further enhanced by exposure to C

286 at are greatly enriched in Gb(3) and have an invasive phenotype was identified in human colon cancer

287 The invasive phenotype was in part modulated by the activati

288 The invasive phenotype was linked to enhanced PIP(3) product

289 orrelated to Sod2 expression levels and this invasive phenotype was similarly observed in 253J bladde

290 nt changes in transition from preinvasive to invasive phenotype, we performed attribute profile clust

291 The vascular invasive phenotypes were reversible.

292 eonectin and osteoactivin, acquired a highly invasive phenotype when implanted intracranially in immu

293 erexpressing S1P(2) or S1P(3) exhibit a more invasive phenotype, when compared to control cells.

294 ls of gene transcription responsible for the invasive phenotype, where first-tier genes are controlle

295 ibitor U0216 reduced growth in soft agar and invasive phenotype, whereas the combination of EGCG and

296 ial tumors, but all tumors have an initially invasive phenotype, which complicates therapy.

297 ODC-overexpressing keratinocytes acquire an invasive phenotype with additional expression of either

298 HB-EGF in human KCs triggers a migratory and invasive phenotype with many features of epithelial-mese

299 d human bladder cancer cell lines with known invasive phenotypes with either wild-type PTEN construct

300 ression of mesenchymal genes and promoted an invasive phenotype without impacting cell proliferation.