ライフサイエンスコーパス: invention

1 vity are central pillars of human growth and invention.

2 rnment documents, news media and marketplace invention.

3 Necessity is the mother of invention.

4 g axis as a compelling realm for therapeutic invention.

5 uition to play a full role in the process of invention.

6 ces and evaluate the effectiveness of future inventions.

7 ces and evaluate the effectiveness of future inventions.

8 aryotic ancestor, with 40% likely eukaryotic inventions.

9 ity required a limited number of biochemical inventions.

10 rchin confirms a number of chordate specific inventions.

11 ems associated with patenting these sorts of inventions.

12 the issues that relate to patenting genomic inventions.

13 nt consequences for the supply and demand of inventions.

14 rship is important to maximize the impact of inventions.

15 nsfer of their discoveries, innovations, and inventions.

16 ric light is one of the most important human inventions.

17 Since its invention 10 years ago, PMCA has helped to answer fundam

18 it has not been made rechargeable since its invention(8-13).

19 Since its invention a decade ago, stimulated Raman scattering (SRS

20 man retellers given the high degree of novel inventions across retellings.

21 of increasing agricultural productivity and invention/adoption of military technologies (most notabl

22 f diverse pathways suggests that these gene "inventions" along the lineage leading to animals were li

23 As in general, technological inventions also drive the development in the field of to

24 The invention and advancement of biological microscopy depen

25 cles, and identify future challenges for the invention and application of non-equilibrium systems.

26 Her main contribution to the field was the invention and commercialization of a portable X-ray gene

27 This Review charts the recognition, invention and development of molecular ratchets, focussi

28 oto, David Huang, and Eric Swanson for their invention and development of optical coherence tomograph

29 ict between hosts and viruses has led to the invention and diversification of molecular arsenals, whi

30 The invention and evolution of modern ophthalmic lasers have

31 In research on early invention and innovation, technological "firsts" receive

32 Gero Miesenbock, and Georg Nagel 'for their invention and refinement of optogenetics'.

33 These changes reflected their invention and reinvention of the concept of a virus as i

34 ) hand anatomy, its associated grips and the invention and use of stone tools by early hominins.

35 he utility requirement for patenting protein inventions and consider the possible socioeconomic impac

36 reactions is discussed and how it relates to inventions and innovations.

37 essfully navigating the process of patenting inventions and licensing them to facilitate their use.

38 These synthetic inventions and mechanistic elucidations signify a transf

39 e minimum citation distance between patented inventions and prior scientific advances.

40 ration, physicochemical properties, patented inventions and recent advances of these micelles as effe

41 n memory: connecting concepts to form ideas, inventions, and artworks.

42 ife sciences, physical sciences and patented inventions, and using a hypergraph model that predicts r

43 biology and human health, a new stimulus for invention appeared.

44 Innovation and invention are urgently needed to develop the in situ ins

45 and technological change view discovery and invention as endogenous processes(1,2), wherein previous

46 d greater specialization and productivity at invention as individuals found it increasingly feasible

47 in amniote evolution and was not a mammalian invention as is usually supposed.

48 Antibiotics, however, are not a human invention as most of them are either natural products pr

49 help to accelerate the rate of discovery and invention as well as improve higher education and the tr

50 he indirect pathway is a recent evolutionary invention, as might be implied from its localization to

51 long-term performance and stability of these inventions awaits effective antioxidation strategies.

52 The invention builds on structural data indicating the prese

53 t only are women less likely to patent their invention, but each stage of examination individually co

54 avy-particle radiation therapy, is not a new invention, but it has gained considerable public attenti

55 ey are either a demonstration of independent invention by Neandertals or an indication that modern hu

56 has essentially remained unchanged since its invention by Zernike in the early 1930s.

57 Additionally, the novel invention can be considered as a 2D membrane for carbon

58 Synthetic invention can drive the investigation of the chemical sp

59 ht about a change in the way that biological inventions can be protected by patent laws.

60 lly transmitted pathogens; fast tracking new inventions currently in the pipeline by intensifying sup

61 er science through discussion of several key inventions, described as "foundational devices." These d

62 eview we describe a holistic approach to the invention, development and optimisation of biotransforma

63 hropogenic values by midcentury will require invention, development, and deployment of schemes for ca

64 em was used for the collection of technetium inventions disclosed in patents and patent applications

65 cifying the identity of ovules, the landmark invention during the course of vascular plant evolution

66 Since its invention, ExM has been successfully applied to a wide r

67 ineers who had the tenacity to develop their inventions, followed by a series of technical innovation

68 sing incentives to differentiate the task of invention from that of commercializing new technologies

69 that initially arose and spread as cultural inventions had feedback effects on biological evolution

70 and increased in switching speed since their invention in 1947.

71 Since its invention in 2000, coronary fly-through or virtual angio

72 ngs identified a novel point for therapeutic invention in NSCLC that may be tractable to small-molecu

73 ss builds upon itself, with the expansion of invention in one domain propelling future work in linked

74 lar ratchet mechanisms in biology, and their invention in synthetic systems, is proving significant i

75 Since their invention in the 1950s, composite carbon electrodes have

76 of small fluorocarbon synthesis since their invention in the early 1930s by Thomas Midgley, Jr., and

77 Since its invention in the early 1990s, differential display (DD)

78 he most poisonous and sophisticated cellular inventions in animal evolution.

79 To what extent will KSR limit combination inventions in biotech?

80 The laser is one of the greatest inventions in history.

81 Vaccination is one of the most significant inventions in medicine.

82 ta about maternal characteristics, obstetric inventions (induction of labour, elective or emergency c

83 causes it to fail, to the development of an invention intended to assess, repair, or improve the pro

84 Invention is an investment in which the costs of the Res

85 npatentable natural phenomena and patentable inventions is crucial in preventing the patent laws from

86 hich scientific advances support marketplace inventions is largely unknown.

87 This Zeiss invention lacked only the slit illumination of today's i

88 Review, we highlight recent developments and inventions made by introducing the fourth dimension of t

89 These features and inventions made pre-Federal American paper currency an a

90 and physical capital required for effective invention, making it increasingly desirable for individu

91 Information relating to the source invention may be incomplete, and biological information

92 Expanding who gets credit for invention may boost participation in innovation.

93 e field and review contributions to reaction invention, mechanism, and application to complex molecul

94 arboxylation chemistries are an evolutionary invention mediated by complex metalloproteins.

95 A key component of this work is the invention of "borono-sclareolide", a terpenyl radical pr

96 Pioneered with the invention of (11)C-Pittsburgh compound B, amyloid-beta i

97 Since the invention of (18)F-FDG as a neurochemical tracer in the

98 Here we report the invention of a class of halogenating reagents based on a

99 enation that provides 1,3-enynes through the invention of a Co-catalyzed oxidation system.

100 In this article, the invention of a directing group to achieve such a transfo

101 orts to address these issues have led to the invention of a large number of protecting groups that te

102 The invention of a method for the synthesis of 1,3-diols fro

103 This required invention of a method to correct for the cell artifact a

104 This report details the invention of a method to enable syntheses of psychotrimi

105 Herein we report the invention of a new guanidine-based chlorinating reagent,

106 Herein, we report the invention of a new reagent (Zn(SO(2)CF(2)H)(2), DFMS) fo

107 amatic changes in function - essentially the invention of a new regulatory protein.

108 ment-based drug discovery) principles in the invention of a novel covalent Bruton's tyrosine kinase i

109 hese unique responsive dynamics motivate the invention of a series of optical devices triggered by mo

110 This study reports the invention of a simple maleate-derived blocking group for

111 and fluorescence microscopy have enabled the invention of a suite of spatial transcriptomics technolo

112 arise at all stages of innovation, from the invention of a technology through its selection, product

113 The invention of a WUS-like function within the WOX gene fam

114 Chao Valley, north coast of Peru) places the invention of adobe architecture before 5,100 calendar ye

115 pulation growth through time reveal that the invention of agriculture facilitated a fivefold increase

116 The invention of agriculture is widely assumed to have drive

117 The invention of agriculture is widely thought to have spurr

118 's Lasker Basic Science Award recognizes the invention of AlphaFold, a revolutionary advance in the h

119 Herein, we describe the invention of an amidoisoquinoline (IQ)-derived LRRK2 inh

120 Frequent re-invention of analogous architectures involving functiona

121 The Mangarevan invention of binary steps, centuries before their formal

122 Since the invention of biosensor, many ideas and methods have been

123 ses that the genetic code coevolved with the invention of biosynthetic pathways for new amino acids.

124 Since the invention of cancer radiotherapy, its primary goal has b

125 lines the historical timeline leading to the invention of CAR-T cells, discusses the major achievemen

126 The invention of clay tiles was associated with the inceptio

127 n with earlier compounds and resulted in the invention of compound 18 (MK-8189), which is currently i

128 Similarly, the invention of cooking possibly affected the evolution of

129 omes to autosomes, which has resulted in the invention of diverse mechanisms to equilibrate gene expr

130 The invention of DNA cloning over 40 years ago marked the ad

131 Invention of DNA origami has transformed the fabrication

132 As the invention of DNA sequencing in the 70s, computational bi

133 This sub-discipline was galvanized by the invention of DNA shuffling, a procedure that randomly re

134 imarily from Arabidopsis has also led to the invention of effective gene knock-down technologies that

135 olar-to-fuel energy conversion relies on the invention of efficient catalysts enabling water oxidatio

136 Before the invention of electric lighting, humans were primarily ex

137 Following the invention of electron optics during the 1930s, lens aber

138 Although the invention of enantioselective variants is an ongoing cha

139 the optimization of existing enzymes and the invention of entirely new biocatalytic reactions that we

140 y demonstrated herein sets the stage for the invention of further multicomponent reactions in future.

141 e brought about by innovations that spur the invention of further, related, technology, and which occ

142 The rapid invention of genome-editing technologies over the past d

143 Slamon, and Axel Ullrich for their invention of Herceptin, the first monoclonal antibody th

144 Dennis J. Slamon, and Axel Ullrich for their invention of Herceptin, the first monoclonal antibody th

145 g genes, their isoforms and pseudogenes, the invention of high-throughput RNA sequencing and other te

146 Inspired by the invention of hydrogels and soft contact lenses by my men

147 of the process of transformation and to the invention of innovative preventive and therapeutic cance

148 The invention of inverse vulcanization provides great opport

149 ered" via a cultural stimulus, plausibly the invention of language.

150 Since the invention of laser scanning confocal microscopy in the 1

151 Since the invention of matrix-assisted laser desorption ionization

152 infection model and became the lead for the invention of MBLI clinical candidates.

153 The invention of metal-organic frameworks and zeolitic imida

154 Herein, we report the invention of MK-7845, a novel reversible covalent 3CLPro

155 -341 (bortezomib) in solid tumors led to the invention of MLN9708 (ixazomib), an orally bioavailable

156 (TMS) since the mid-1990s, shortly after the invention of modern TMS in 1985 by Barker.

157 ield of research that has benefited from the invention of multiple difluoromethylation reagents.

158 n goal of applying them to the discovery and invention of new and better medicines, especially in are

159 Cultural change occurs chiefly through invention of new behavioral variants combined with socia

160 ch in this field has largely focussed on the invention of new catalysts and the optimization of their

161 llenge to achieving this overall goal is the invention of new catalysts for the reductive and oxidati

162 llenges and opportunities for the design and invention of new chemical fuels to power synthetic molec

163 es of challenges, each of which required the invention of new chemistries.

164 between common families, as compared to the invention of new families and recombination among these,

165 uming, and often fails to keep pace with the invention of new materials.

166 e phase of terpene biosynthesis inspires the invention of new methodologies, since working with carbo

167 posed synthetic challenges that required the invention of new methodology.

168 ine to agriculture to materials science, the invention of new methods for the creation of carbon-fluo

169 to the discovery of reaction mechanisms, the invention of new methods, and the development of FDA-app

170 This necessity for invention of new molecules to improve human health and t

171 rs derived from Amerindian languages and the invention of new names for neotropical plants from Afric

172 ation of conserved enhancers rather than the invention of new ones.

173 uplication of existing genes rather than the invention of new ones.

174 As such, the invention of new reactions between carboxylic acid deriv

175 the power of halogenation rely on either the invention of new reagents or activating commercially ava

176 The invention of new strategies for the design of protein-mi

177 ng of core T cell subset definitions and the invention of new subset designations that have not been

178 These findings, together with the invention of new tools to study persisters, could have i

179 onic properties to a metal, will support the invention of new transformations not previously possible

180 The invention of next-generation sequencing technology has m

181 Modifications of 1 ultimately led to the invention of nirmatrelvir 14, the M(pro) inhibitor compo

182 and materials sciences have resulted in the invention of numerous hybrid molecules that possess stre

183 The invention of oxygenic photosynthesis by cyanobacteria 2.

184 The invention of paper as writing materials has greatly cont

185 Prior to the invention of pars plana vitrectomy, such surgery was inn

186 reclinical discovery efforts that led to the invention of PF-07321332 (nirmatrelvir, 14), a potent an

187 Since the invention of polymer networks such as cross-linked natur

188 ic periods from the first use of fire to the invention of pottery.

189 liest villages were established prior to the invention of pottery.

190 ge-specific proteins rather than large-scale invention of protein-coding capacity.

191 Since the invention of quantum mechanics, even the simplest exampl

192 y' methodology in the 1970s, followed by the invention of recombinant protein-based therapeutic agent

193 k on Neisseria meningitidis B, reporting the invention of Reverse Vaccinology (RV), which allows to i

194 heir medicinal properties and facilitate the invention of safe, efficacious, metabolically stable, an

195 Before the invention of secondary LIBs, the primary lithium-thionyl

196 electivity of the process was enabled by the invention of ShabyDACH, a novel C(1)-symmetric diaminocy

197 The invention of signals decreasing uncertainty about relati

198 The invention of single molecule localization microscopy (SM

199 Our previous invention of sub-micron-thin imperceptible graphene e-ta

200 The recent invention of super-resolution fluorescence microscopy br

201 The recent invention of superresolution microscopy has brought up m

202 Here, we suggest that the invention of synthetic ligand--GPCR pairs (aka DREADDs,

203 uorination reagents, and contributing to the invention of synthetic methods capable of enabling radio

204 It has been almost 30 years since the invention of Systematic Evolution of Ligands by Exponent

205 omes during molecular evolution required the invention of telomeres.

206 The invention of the (3)He/(4)He dilution refrigerator opene

207 ounds was added to the main subjects and the invention of the atomic force microscope provided new wa

208 The invention of the daguerreotype was publicly announced in

209 ral conditions were developed long after the invention of the electric devices suspected of delaying

210 The invention of the esophagoscope confirmed that GERD was a

211 ack-Band Model (slCBM), inspired by the 2020 invention of the gap test, prevented spurious damage loc

212 These data also strengthen the argument for invention of the genetic code in an RNA world and for th

213 The invention of the Kalman filter is a crowning achievement

214 has been the desire of scientists since the invention of the laser 40 years ago.

215 The invention of the laser generated great excitement, becau

216 The invention of the laser has resulted in many innovations,

217 Since the invention of the laser more than 50 years ago, scientist

218 e preserving single-mode operation since the invention of the laser six decades ago(1-8).

219 ork of multiple investigators leading to the invention of the laser, its biophysical effects on ocula

220 Since the invention of the laser, nonlinear effects such as filame

221 The invention of the maser stimulated revolutionary technolo

222 Since the 2002 invention of the microfluidic fuel cell, the research fi

223 he foot colliding with the ground before the invention of the modern shoe.

224 nuclease CRISPR-Cas9 and CRISPR-Cas12a, the invention of the nuclease-dead Cas molecules (dCas9 and

225 targeted the phonon laser (saser) since the invention of the optical laser over 50 years ago.

226 Nearly 40 years have elapsed since the invention of the PCR, with its extremely sensitive and s

227 The invention of the placenta facilitated the evolution of m

228 The invention of the scanning tunnelling microscope revoluti

229 The invention of thermally resistant ceramic cooking vessels

230 Since the invention of transistors, the flow of electrons has beco

231 that prehistoric transaction records and the invention of writing for recordkeeping were linked to in

232 rmation of the human diet resulting from the inventions of agriculture and animal husbandry.

233 that followed for thousands years until the inventions of agriculture?

234 esis posits that DNA and proteins were later inventions of early life, or the chemistry that gave ris

235 The issue of patents on inventions of genomic research is the subject of intense

236 Reading, one of the most important cultural inventions of human society, critically depends on poste

237 Crop biodiversity is one of the major inventions of humanity through the process of domesticat

238 in himself and others, civic activities, and inventions of medical devices.

239 he Haber Bosch process is among the greatest inventions of the 20th century.

240 evolve cell designs is a product of communal invention, of the universal HGT field, not intralineage

241 This invention offers a simple but practical strategy to redu

242 mammals and zebrafish, rather than a de novo invention on the tetrapod lineage.

243 Since its invention, optical frequency comb has revolutionized a b

244 Like the two sides of a coin, any new invention or discovery also possess their two faces.

245 The role of creativity in the discovery and invention processes is also discussed.

246 Biotechnology inventions raise both moral and technical dilemmas.

247 proceeded largely by gene duplication and/or invention rather than by modification of extant proteins

248 posure to relevant ways of thinking, and the invention's utility.

249 Since its invention, SAGE has been widely applied to analyzing gen

250 s an ancient and highly conserved eukaryotic invention, self-incompatibility systems such as mating t

251 mental illness, some group-level anti-stigma inventions show promise and merit further assessment; (3

252 ible for thousands of missing female-focused inventions since 1976.

253 nology, represents one of the most momentous inventions since the industrial revolution.

254 ver, notwithstanding eukaryote-specific gene inventions, single-gene phylogenies have never traced eu

255 , during the concept generation phase of the invention step, we integrated the results from the VOC i

256 rs mediating tumor outgrowth and therapeutic invention strategies against lymphoma.

257 The patent system was developed to protect inventions such as the Spinning Jenny and Stevenson's Ro

258 and some of them presaged later dinosaurian inventions, such as thickened skull roofs.

259 ith implications for the definition of novel invention targets (e.g., activin A and CD36) to prevent

260 omen engage in less commercial patenting and invention than do men, which may affect what is invented

261 paradoxical, given that reading is a recent invention that could not have influenced the genetic evo

262 g patent applications directed to biological inventions that are claimed in more conventional terms.

263 ade has seen a diverse range of breakthrough inventions that are derived from gold complexes, includi

264 served non-coding elements (CNEs) are recent inventions that postdate the divergence of Eutheria and

265 However, the inventions that underlie most forensic science disciplin

266 within our culture that it has become a meta-invention-that is, it is a tool that allows other invent

267 Two decades after its invention, the classic self-referenced frequency comb la

268 In the 25-year period since its invention, the STM has helped uncover a wealth of phenom

269 databases continue to yield new insights and inventions, the commercial incentive to conflate race an

270 vings now underway can be traced to a single invention--the blue light-emitting diode.

271 Since their invention, tissue expanders, which are designed to trigg

272 f the human brain and represents evolution's invention to enable the nervous system to escape the res

273 and animal kingdoms, DRP5B is a plant/algal invention to facilitate the division of their organelles

274 milestones in CAR-T cell evolution, from its invention to its clinical applications.

275 tion-that is, it is a tool that allows other inventions to be realized, most recently enabling the bi

276 d 190 scenarios of different combinations of inventions to calculate the incremental cost-effectivene

277 tions to ensure that they can bring exciting inventions to the public.

278 tion is mandated to move from pure technical inventions to true innovations addressing key current an

279 ecognized by the 2007 ACS Award for Creative Invention, we discuss the discovery of a new synthetic r

280 evement of a high level of specialization at invention well before the rise of large-scale research l

281 ocation and duration of disease, and medical inventions were analyzed.

282 now seek to protect certain aspects of their inventions, which include software, methods of doing bus

283 multiple times due to the filing of the same invention with multiple patent offices, or the use of th

284 summarize and analyze data concerning these inventions with the ultimate goal to find a promising co

285 Since their invention, XTEN polypeptides have been utilized to exten