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1  solutions in adjacent wells can be mixed by inversion.
2 ternal pump laser to maintain the population inversion.
3 id for mixing solutions in adjacent wells by inversion.
4 e large spread in estimates from atmospheric inversions.
5 a total of 220,452 insertions, deletions and inversions.
6 O(2) flux estimated by DGVMs and atmospheric inversions.
7 pe I R-M systems undergo invertase-catalyzed inversions.
8 nantly on gene duplications and large-effect inversions.
9  eightfold the number of previously reported inversions.
10 h members of one couple were identified with inversions.
11 ng eight with balanced translocations and 42 inversions.
12 re associated with CNV, LOH, and chromosomal inversions.
13 ith the accumulation of emissions underneath inversions.
14  late-replicating regions and correlate with inversions.
15 parametric empirical Bayes for optimal model inversion across both drug sessions, we identify the eff
16 rophy voltage criteria, long QTc, and T-wave inversion, all P<0.05) and predicted clinical worsening
17 ning of the VBS sequence, including sequence inversion, allow for an even more nuanced force response
18                                     Foldback inversions, also called inverted duplications, have been
19 ationic Hofmeister series dependency, charge inversion and a continuously decreasing variation in mob
20                                          The inversion and dense compaction of heterochromatin conver
21 tre of rotation of the subtalar joint during inversion and eversion motion.
22 onduction-band states caused by lack of both inversion and mirror symmetry, appear to be qualitativel
23                 In dynamic trajectories, the inversion and retention products are formed from the sam
24 ping of sister chromatid exchanges, germline inversion and to support global haplotype assembly.
25 bination will change over the lifetime of an inversion and within its area of distribution.
26 different approaches: "top-down" atmospheric inversions and "bottom-up" biosphere models.
27  inversion association analysis including 21 inversions and 25 obesity-related traits on a total of 4
28                       Our set of atmospheric inversions and biosphere models, which were adjusted for
29 pression differences reported before for two inversions and finding new candidate associations.
30  Balanced chromosomal rearrangements such as inversions and translocations can cause congenital disea
31 ron 15; producing partial gene duplications, inversions and translocations, and terminating transcrip
32 in or loss of genomic segments, for example, inversions and translocations, is a particularly challen
33 working interpretation that identifies fault inversion, and an oblique, anticlinal accommodation zone
34 ctrocardiography revealed nonspecific T-wave inversions, and a series of cardiac biomarkers were nega
35                The deep erosion, topographic inversions, and an absence of dunes on or near talus acr
36 signatures were preserved, with truncations, inversions, and translocations most conserved.
37 rbates are responsible for surface-potential inversions, and we find strong correlations between hydr
38 teristic spatial inversion symmetry and time inversion antisymmetry.
39 mongoose and other carnivores, although this inversion appears to be a feature of the Mustelidae fami
40 d ocean modelling) and top-down (atmospheric inversion) approaches to provide a comprehensive quantif
41 sis reveals that multiple translocations and inversions are responsible for the karyotype diversity o
42                                 Most studied inversions are widespread across continents, and their f
43              We further identify chromosomal inversion as a molecular mechanism that may shuffle more
44  recombination that generates reversible DNA inversions as a genetic mechanism mediating phase variat
45              Our data underscore the role of inversions as major genetic contributors to the joint su
46 ism has a similar response to magnetic field inversions as MTB.
47                                              Inversion associated allelic homologous recombination (A
48 yphoons" of high-JCN junctions and fold-back inversions associated with expressed protein-coding fusi
49                              We performed an inversion association analysis including 21 inversions a
50 g compounds (1 and 2) display a bowl-to-bowl inversion at room temperature.
51 were associated with multiple diseases while inversions at 8p23.1, 16p11.2, and 11q13.2 were strongly
52 ents" (ERCEs) was validated by deletions and inversions at additional domains.
53                      We identified 375 total inversions between 859 bp and 92 Mbp, increasing by eigh
54  depicts the most accurate fine-scale map of inversions between human and macaque using a two-pronged
55       Here we generated a genome-wide map of inversions between human and macaque, combining single-c
56 ng studies using methods such as atmospheric inversion, biogeochemical modeling, and field inventorie
57 with fruit shape, and a gene adjacent to the inversion breakpoint, PpOFP1, regulates flat shape forma
58 evious data, independent replicates and both inversion breakpoints, we demonstrate that the technique
59 ally, we identified 861 genes mapping at 156 inversions breakpoints, with some showing evidence of di
60 ty (DCMC) and natural optical activity in an inversion-broken tilted Weyl semimetal (WSM).
61  as a topological magneto-electric effect of inversion-broken tilted WSMs.
62 e breakpoints of large (>100 kilobases (kb)) inversions but not smaller events.
63 (n = 1,069) of previously reported great ape inversions by using single-cell DNA template strand and
64 red to date, with a barrier (DeltaG) to ring inversion calculated at 27 kcal mol(-1) .
65 symmetry elements of olanzapine crystals, an inversion centre, emerges in solute dimers extant in sol
66 ly chiral when it lacks mirror planes, space-inversion centres or rotoinversion axes(1).
67 MS method utilizing gas-phase ion/ion charge inversion chemistry that provides near-complete GPL stru
68 l rearrangements (GCRs) mediated by foldback inversions combined with whole-genome sequencing to stud
69             Four of these represent megabase inversions confirmed by long read sequencing.
70 e large interspersed segmental duplications, inversions, deletions, and translocations using linked-r
71 detailed analyses we found (i) a robust face inversion effect across the parafovea, while for houses
72  visible-light-driven, reversible handedness inversion, enabled by a halogen bond donor molecular swi
73 nd senescence of the cell and during nuclear inversion events.
74                              Among these, 19 inversions flanked by segmental duplications overlap wit
75  prior emissions and other parameters of the inversion framework.
76  At 1 mM indole and higher, a time-dependent inversion from a repellent to an attractant response was
77 generated genotypes have allowed us to check inversion functional effects, validating gene expression
78              Finally, we found that foldback inversion GCRs were stabilized by secondary rearrangemen
79 tion of homologous strains (defined by field-inversion gel electrophoresis banding pattern), emm type
80 s at its boundary, instead of the chromosome inversion generally assumed for suppressing sex-linked r
81     In this species, a series of chromosomal inversions has formed a supergene that segregates with a
82  the Y chromosome, consistent with the three inversions identified by our previous cytogenetic analys
83 and theoretically investigated, revealing an inversion in energy of the singly occupied molecular orb
84                                       T wave inversion in infero-lateral and left precordial leads we
85  cessation was found associated with a large inversion in only one of the four linkage events.
86 ering induces the targeted gene deletion and inversion in situ We found the inverted ORF57 gene in th
87  this interaction is disrupted by the -31CBS inversion in T-ALL cells.
88 ion" in diamino-o-carborane (1) causes rapid inversion in the amine, which results in the observation
89 us rhythm, right bundle branch block, T-wave inversion in V6, and evidence of right atrial dilatation
90 highlighted by large paracentric/pericentric inversions in 14 chromosomes.
91 kely played a fundamental role in generating inversions in humans and great apes, creating architectu
92 erial phyla, which potentially catalyze hsdS inversions in the epigenetic invertons.
93 of large regions of differentiation owing to inversions in the history of Atlantic codfish.
94  islets indicated the potential mechanism of inversions in the susceptibility of diabetes by disrupti
95                     We further verified hsdS inversions in the Type I R-M systems of four representat
96 stence of pressure-induced polarity (red-ox) inversions in various alloys.
97  European, and East Asian individuals for 16 inversions, including four already validated variants wi
98 ate and sensitive detection of excisions and inversions independent of length.
99                              Here we develop inversion-induced joined neoantigen (NINJA), using RNA s
100 ry calculations, it is ascertained that band inversion induces a topologically nontrivial ground stat
101                                   Two of the inversions interrupt protein-coding genes, resulting in
102                                        Phase inversion introduced by d orbitals renders the Pd-cataly
103  to the benzodipyrrole moiety, attained ring inversion (inverted sapphyrins), whereas the selenophene
104  androgen synthesis, and an intrachromosomal inversion involving the pro-testicular growth factor gen
105                       In addition, a 1.67 Mb inversion is highly associated with fruit shape, and a g
106 e no functional sequelae are suggested, this inversion is likely to result from the altricial birth o
107 t is demonstrated that the combination of an inversion layer, induced by holes (or electrons) at the
108 r of anterior and inferior leads with T-wave inversion, left and right ventricular ejection fraction.
109          The nanoemulsion developed by phase inversion method was characterized and stable under ther
110 keleton in the firm sediment during the body inversion moult procedure.
111 g in tellurabenzosapphyrin did not show ring inversion (normal sapphyrins).
112 at under weak spin-orbit interaction, a band inversion occurs.
113                                              Inversion of -31CBS in Jurkat cells alters chromatin acc
114 (IR) size of 37.4 kb, suggesting large-scale inversion of 13.8 kb within the expanded IR regions.
115                             The deletion and inversion of a CTCF site located near these regulatory s
116 ribe here a metasurface based upon geometric inversion of a set of conformal mapping contours.
117                       Reactions facilitating inversion of alkene stereochemistry are rare, sought-aft
118 eoxygenation process that results in overall inversion of alkene stereochemistry.
119 ducts showed that the reaction proceeds with inversion of configuration for these substrates.
120 n at the quaternary carbon center, with pure inversion of configuration, to provide the acyclic produ
121 ium on carbon (Pd/C) generally proceeds with inversion of configuration.
122  of tetrahedral amorphous semiconductors via inversion of diffraction data.
123 hedral amorphous semiconductors obtained via inversion of diffraction data.
124 tion of the cell divisions, even enabling an inversion of division order at the two-cell stage.
125 isoform of CaMKII controls the bidirectional inversion of plasticity at parallel fibre (PF)-Purkinje
126    In the representative case study of 2, an inversion of potential in both of the two-electron proce
127                                Umbrella-like inversion of pyramidalized amines proceed through a plan
128 ents on the Cascadia megathrust based on the inversion of surface deformation measurements between 20
129  acid residues that are responsible for this inversion of the allosteric effect, all 6 evolutionary T
130                                         This inversion of the competitive hierarchy is caused by acti
131 air effect of the outer electrons leading to inversion of the conduction and valence bands, and spin-
132                           This occurs via an inversion of the conformation of the loops that define t
133 between the species studied was the physical inversion of the dorsal lateral geniculate nucleus, as w
134                                              Inversion of the phosphate in these holoenzyme-product c
135                                              Inversion of the phosphorus configuration through stereo
136  The metasurface is derived from a geometric inversion of the Rhodonea, or more commonly called four-
137                           Here, we reveal an inversion of this paradigm where a putative histone deme
138 ology and geophysics (BMKG) in Indonesia and inversions of global positioning system (GPS) data revea
139  shifts in operational range, and a complete inversion-of-function from activation to repression.
140 in regions, and eQTL analyses highlighted an inversion on chromosome 17 plus two brain-specific eQTLs
141 X chromosome is most enriched (2.5-fold) for inversions, on the basis of its size and duplication con
142 lecular laser based on rotational population inversions optically pumped by a quantum cascade laser.
143 sulting beta-aminoalcohol, leading to either inversion or retention of the configuration depending on
144 ile concurrently subject to looped selective inversion or selective saturation procedures.
145                         The presence of both inversion (P) and time-reversal (T) symmetries in solids
146                                              Inversions play an important role in disease and evoluti
147                 We discovered abundant large inversion polymorphisms and analysed in detail two inver
148 has occurred following the appearance of the inversions, potentially mitigating the evolutionary dege
149                    Of those, we validated 13 inversions predicted by different genome-wide techniques
150 on sequencing data generated using molecular inversion probe (MIP) capture.
151  from surrounding countries, using molecular inversion probes - a high-throughput genotyping tool.
152        We designed single-molecule molecular inversion probes for target selection and used next gene
153 y next generation sequencing using molecular inversion probes that targeted mainly coding regions.
154                               The tub-to-tub inversion proceed through the successive bending of the
155 photonic crystal (PhC) through a double-band-inversion process.
156 ons estimation through the atmospheric CO(2) inversion process.
157  gives rise to predominant but not exclusive inversion products.
158        The older patient had anterior T wave inversions, prolonged terminal activation duration (TAD)
159 -interest signal and corrected for imperfect inversion pulse efficiency.
160 oplet digital PCR (ddPCR) assays to study 20 inversions ranging from 3.1 to 742 kb flanked by inverte
161 affecting recurrence levels and estimate the inversion rate across the genome.
162 n lycophyte plastomes occurs via overlapping inversions rather than transposase/recombinase-mediated
163 show that as a consequence of this signaling inversion, Rb inactivation replaces APC/C(CDH1) inactiva
164  This process is demonstrated via the charge inversion reaction of phosphatidylcholine (PC) lipid cat
165  the mass spectrometer via an ion/ion charge inversion reaction with tris-phenanthroline magnesium di
166 e LPCAT3 and CD4 genes induced an LPCAT3-CD4 inversion rearrangement resulting in CD4 expression.
167 tropic contrast-enhanced T2 fluid-attenuated inversion recovery (CE-T2-FLAIR) imaging with a 3T magne
168 with a three-dimensional double-echo sliding inversion recovery (DESIRE) UTE sequence.
169 rsignal in optic nerve segments on 3D double inversion recovery (DIR) MR sequence in 21 patients with
170  diffusion weighted imaging-fluid attenuated inversion recovery (DWI-FLAIR) mismatch were eligible.
171 ary analysis of T2-weighted fluid-attenuated inversion recovery (FLAIR) and T1-weighted postcontrast
172 -weighted imaging (DWI) and fluid-attenuated inversion recovery (FLAIR) estimates lesion age to guide
173 etermine the association of fluid-attenuated inversion recovery (FLAIR) hyperintense arteries (FLAIR-
174 -thick brain slices were T2/fluid-attenuated inversion recovery (FLAIR) hyperintense, T1-hypointense,
175 e patients screened for DWI-fluid-attenuated inversion recovery (FLAIR) mismatch in WAKE-UP who under
176 me, noncontrast-enhanced T2 fluid-attenuated inversion recovery (FLAIR) signal abnormality volume, Ga
177 RI sequences, which are T2, fluid-attenuated inversion recovery (FLAIR), double inversion recovery an
178 nted long T2 signals can be achieved with an inversion recovery (IR) preparation pulse to null long T
179 r of heartbeats [nHB])3 modified Look-Locker inversion recovery (MOLLI) sequence, where nHB was three
180 ce and literature-based modified Look-Locker inversion recovery (MOLLI) values.
181 rbo spin-echo (HASTE), spectrally attenuated inversion recovery (SPAIR), true fast imaging with stead
182 e a new short repetition time (TR) adiabatic inversion recovery (STAIR) prepared UTE (STAIR-UTE) sequ
183 tocol consisted of three sequences: Short-TI Inversion Recovery (STIR), precontrast, and postcontrast
184 -weighted, T2-weighted, and fluid-attenuated inversion recovery [FLAIR] images) were curated.
185 erintense lesions seen with fluid-attenuated inversion recovery and diffusion-weighted sequences with
186 rall sensitivity does not exceed 25%, double inversion recovery and phase-sensitive inversion recover
187 vity of T1, proton-density/T2, FLAIR, double inversion recovery and phase-sensitive inversion recover
188             We conclude that, at 3 T, double inversion recovery and phase-sensitive inversion recover
189  did not significantly differ between double inversion recovery and phase-sensitive inversion recover
190 ensity/T2-weighted, as well as FLAIR, double inversion recovery and phase-sensitive inversion recover
191 ttenuated inversion recovery (FLAIR), double inversion recovery and phase-sensitive inversion recover
192 ouble inversion recovery and phase-sensitive inversion recovery are highly pathologically specific wh
193                             Fluid-attenuated inversion recovery hyperintense areas were segmented and
194 nts, mostly white matter T2/fluid-attenuated inversion recovery hyperintensities.
195 ve inversion recovery, while phase-sensitive inversion recovery identified more lesions than double i
196 maging utilized a flow-sensitive alternating inversion recovery method for labeling and a single-shot
197          At clinical field strengths, double inversion recovery MRI is most sensitive, but still only
198  and a clinical T2-weighted fluid-attenuated inversion recovery sequence for assessment of MS lesions
199 ouble inversion recovery and phase-sensitive inversion recovery sequences outperform conventional seq
200 ouble inversion recovery and phase-sensitive inversion recovery sequences.
201  that the presence of elevated MRI short tau inversion recovery signal has substantial predictive val
202           Conclusion The double-echo sliding inversion recovery ultrashort echo time sequence can gen
203 recovery identified more lesions than double inversion recovery upon retrospective analysis (126 vers
204 ouble inversion recovery and phase-sensitive inversion recovery was 8.9%, 5.4%, 5.4%, 22.8% and 23.7%
205               More recently, phase-sensitive inversion recovery was suggested to have a higher sensit
206 hancement, T2 weighted, and fluid-attenuated inversion recovery) was performed.
207 diffusion-weighted imaging+/fluid-attenuated inversion recovery+ asymptomatic lesions in 5 and 3 of 5
208 ted to have a higher sensitivity than double inversion recovery, although this claim was not histopat
209 d, T2-weighted, T2-weighted fluid-attenuated inversion recovery, and postcontrast T1-weighted MRI fro
210 nces such as fast grey matter acquisition T1 inversion recovery, quantitative susceptibility mapping,
211 ouble inversion recovery and phase-sensitive inversion recovery, while phase-sensitive inversion reco
212 diffusion-weighted imaging+/fluid-attenuated inversion recovery- and diffusion-weighted imaging+/flui
213 nclusion The short repetition time adiabatic inversion recovery-prepared ultrashort echo time sequenc
214 her reliance on T2-weighted fluid-attenuated inversion recovery.
215 ouble inversion recovery and phase-sensitive inversion recovery.
216 formed with 3D T1-weighted, fluid-attenuated inversion-recovery and T2-weighted sequences.
217 covery imaging; and axial 2D phase-sensitive inversion-recovery imaging at the C2-C3 level.
218 al two-dimensional (2D) short inversion time inversion-recovery imaging; and axial 2D phase-sensitive
219 wed diffuse myocardial edema on T2 short tau inversion-recovery sequences and native T1 mapping, with
220    Five 'stratification' events, most likely inversions, reduced the Y chromosome's ability to recomb
221      We find stepwise variations of Z-linked inversions, repeat and guanine-cytosine (GC) contents, a
222                   Among structural variants, inversions represent a driving force in speciation and p
223 rest in phase variation mediated through DNA inversion, revealing a high level of complexity beyond s
224 d T(1) of (2)H-lactate isotopomers indicates inversion/saturation recovery methods may be a simple me
225 allowed us to explore in depth the SOMO-HOMO inversion (SHI) in chiral radical molecular systems and
226       Furthermore, there is an enrichment of inversions showing signatures of positive or balancing s
227 editing has been shown capable of generating inversions similar to the chromosomal rearrangements pre
228           This is especially problematic for inversions, since there is typically no gain or loss of
229 e, we do not find these gaps to exhibit band inversion so that HoSb does not host a Dirac semimetal s
230 ion between regions (dipoles) in atmospheric inversion so that their estimates become more comparable
231 evolved by sequential incorporation of three inversions spanning half of a 'social chromosome'.
232 sence of MAD, leaflet redundancy, and T-wave inversion/ST-segment depression (all p < 0.0001) but not
233 entricular end-systolic diameter, and T-wave inversion/ST-segment depression (all p <= 0.001).
234             Recently, it has been shown that inversion-symmetric defects in diamond, such as the nega
235 ts to control the combined time-reversal and inversion symmetries to manipulate Raman optical selecti
236 ral semiconductor that lacks both mirror and inversion symmetries, resulting in complex band structur
237 e stabilized in magnetic systems with broken inversion symmetry and chiral interactions, such as Dzya
238 ative capacitance external circuits to break inversion symmetry and create nontrivial topologically p
239 s between R- and S-hybrids due to the broken inversion symmetry and strong spin-orbit coupling.
240 metal dichalcogenide multilayers with broken inversion symmetry and substantially enhanced nonlinear
241 bit divergent selection rules that depend on inversion symmetry and the underlying magnetic order.
242 been limited by their characteristic spatial inversion symmetry and time inversion antisymmetry.
243 ferromagnet/heavy-metal interfaces, owing to inversion symmetry breaking and spin-orbit coupling by a
244            We demonstrate the persistence of inversion symmetry breaking and spontaneous, switchable
245 riya interaction (DMI), originating from the inversion symmetry breaking combined with the strong spi
246 xtrema of 35+/-10 meV, and identify the main inversion symmetry breaking direction perpendicular to t
247 licity in all odd-layer-number crystals with inversion symmetry breaking is observed, indicating exci
248 semiconductors with distinct structural/bulk inversion symmetry breaking, when combined with colossal
249 of both geometrically frustrated lattice and inversion symmetry breaking.
250 ened in the surface states by breaking their inversion symmetry by applying a perpendicular electric
251  We also explore the possibility that broken inversion symmetry in beta-TaFeTe(4) produces Weyl point
252                               The absence of inversion symmetry in non-centrosymmetric materials has
253  a cylindrical sawtooth geometry with broken inversion symmetry on a nanometer-length scale.
254 spin relaxation for systems with and without inversion symmetry on an equal footing.
255 line pentacene thin films possessing spatial inversion symmetry that prohibited second-order, all-ele
256                            Upon breaking the inversion symmetry, a spin splitting ('Rashba splitting'
257 dless of whether the constituent layers have inversion symmetry, exhibit a mechanical response to out
258                          By breaking spatial inversion symmetry, the stator defines the unique sense
259 show that this system features broken mirror/inversion symmetry, with the AB and BA domains supportin
260 breaks time reversal symmetry, but preserves inversion symmetry.
261 mpounds are type-II multiferroics induced by inversion-symmetry-breaking of spin order.
262 ives, we propose here a mechanism for chiral inversion that does not require the breaking of a metal-
263 fferent among ruminants due to a chromosomal inversion that splits MHC type II genes into two subregi
264 earrangements, including large deletions and inversions that are associated with cancer development.
265 ion polymorphisms and analysed in detail two inversions that are frequently found in current elite ba
266        To explore this, we generated genomic inversions that swap the Xist/Tsix transcriptional unit
267                 With ensemble geostatistical inversions, the optimized annual emissions in DC/Baltimo
268                                  The optimal inversion time for nulling long T2 signal is determined
269 ion framework was used to obtain the optimal inversion time for nulling water signals using STAIR-UTE
270 imaging; sagittal two-dimensional (2D) short inversion time inversion-recovery imaging; and axial 2D
271 Dirac bands is protected by a combination of inversion, time-reversal, and an additional translation
272 nerates a series of IR images with different inversion times during a single scan.
273 ly by deletion and TRBV31 rearranges only by inversion to create VbetaDJCbeta genes.
274 on water, to explore the longevity of a soil inversion to reduce surface As.
275  mice that upstream Vbetas recombine through inversion to the DJCbeta2 cluster on alleles carrying a
276 gnaled feedback inhibition and recombines by inversion to the DJCbeta2 cluster, creating alphabeta T
277 al bromo atoms confers reversible handedness inversion to the helical superstructure upon irradiation
278  results highlight the sensitivity of chiral inversion to the size, structure, and metal composition
279 nisotropy model constructed by full waveform inversion, to infer deep subduction-induced mantle flows
280 ent a simple thermal-oxidative compositional inversion (TOCI) method to introduce fractal-like struct
281 ttribute this pattern to nightly atmospheric inversions trapping Hg in the valley and the subsequent
282  described as a simple combination of Walden-inversion "umbrella" bending and asymmetric stretching o
283   We investigated whether common polymorphic inversions underlie the shared genetic influence of thes
284                    Finally, the cost of body inversion (upside-down rotation) on body recognition, a
285  and a totally unexpected facial selectivity inversion was also noticed.
286                        Rapid double nitrogen inversion was found for the cycloaddition products with
287                              Anterior T-wave inversion was more common in females than males (P<0.05)
288                                        Seven inversions were associated with multiple diseases while
289                                         Four inversions were identified, two of which were sorghum-sp
290                                     Foldback inversions were mediated by formation of single-stranded
291 mplex count, and number of leads with T-wave inversion) were associated with LTVA.
292 airpin-forming sequences could form foldback inversions when proximal or distal to the DSB, whereas s
293 em hairpin-forming sequences formed foldback inversions when proximal to the DSB.
294 genomic rearrangements, including indels and inversions, which is a similar result to what was found
295  high rates of large (> 20 kb) excisions and inversions, while also revealing a surprisingly low depe
296 oes not degrade the fit to the observations, inversions with and without it both give variance reduct
297 rphic species studied harbour the same three inversions, with the single origin of the supergene in t
298  supports previous findings of a chromosomal inversion within the MHC type II gene region in ruminant
299 treptococcus pneumoniae have shown that hsdS inversions within clonal populations produce subpopulati
300                  We show that reversible DNA inversions within this R-M locus leads to the generation

 
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