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1 ins that form the capsid, and the right-hand inverted terminal repeat.
2 d polymerase to specific sequences in the Ad inverted terminal repeat.
3 ouble-stranded DNA (dsDNA) genome with large inverted terminal repeats.
4 he starting element, i.e., at the end of the inverted terminal repeats.
5 replication centers and recognize the viral inverted terminal repeats.
6 ial genes in a central region and in 6.5-kbp inverted terminal repeats.
7 A molecule of 16,687 nucleotides with 143-bp inverted terminal repeats.
8 thin the hairpin structure formed by the AAV inverted terminal repeats.
9 ette flanked by adeno-associated virus (AAV) inverted terminal repeats.
11 g adenovirus sequences adjacent to the right inverted terminal repeat and by incorporated a number of
12 rates: the Rep binding site within the viral inverted terminal repeat and one of the terminal hairpin
13 er form, and vectors were created with AAV-2 inverted terminal repeats and AAV-1 Rep and Cap function
14 us (CMV)-TNFR:Fc vector (containing the AAV2 inverted terminal repeats and AAV5 capsid) to the rat lu
15 l coding region bounded by identical 3.7-kbp inverted terminal repeats and contains 150 putative gene
16 l coding region bounded by identical 2.4 kbp-inverted terminal repeats and contains 156 putative gene
17 l coding region bounded by identical 9.5-kbp inverted terminal repeats and contains 260 open reading
18 of a central coding region bounded by 7-kbp inverted terminal repeats and contains 267 open reading
19 zation, including replichore structure, long inverted terminal repeats and genome-wide unique perfect
21 rus containing the Ad7 genome except for the inverted terminal repeats and packaging sequence from Ad
22 ition sequence (RRS) found in both the viral inverted terminal repeats and the AAVS1 integration locu
23 in vivo approach to address the role of the inverted terminal repeats and the covalently linked term
24 on their structures and the sequences of the inverted terminal repeats and the putative transposase p
25 report we identify a single AD domain of the inverted terminal repeat as a minimal origin of cAAV rep
26 to the rest of the genes, forming a part of inverted terminal repeat characteristic of linear mtDNA
28 d sequence features with the exception of an inverted-terminal-repeat consensus sequence that has sim
29 Sequence analysis reveals that the 145 bp inverted terminal repeats contain the 5'-TGellipsisCA-3'
30 tegration into chromosome 19 when present in inverted terminal repeat-containing recombinant AAV (rAA
32 Candida salmanticensis, is characterized by inverted terminal repeats each consisting of several tan
33 e placed between late region 5 and the right inverted terminal repeat, efficiently expressed fiber an
34 tion system triggered by the base-pairing of inverted terminal repeat elements, which are a defining
37 is demonstrated the presence of full-length, inverted terminal repeat-fused, circular episomal genome
38 including megabase-scale linear genomes with inverted terminal repeats, genomic repertoires for energ
39 A-mediated transposable elements with short, inverted terminal repeats, have been reported in a wide
40 m interacts with the D-sequence in the viral inverted terminal repeat, inhibits viral second strand D
41 he single-stranded D sequence within the AAV inverted terminal repeats, inhibits viral second-strand
42 palindrome (BB'), necessary for optimal Rep-inverted terminal repeat interaction, does not contribut
43 duction over phage and that incorporation of inverted terminal repeats is associated with improved fa
45 scAAV) vector that does not utilize a mutant inverted terminal repeat (ITR) for vector production.
46 , we show that DNA-PKcs and Artemis open AAV inverted terminal repeat (ITR) hairpin loops in a tissue
47 protein to the rep-binding site (RBS) of AAV inverted terminal repeat (ITR) in males compared with fe
48 ind the hairpin structures formed by the AAV inverted terminal repeat (ITR) origins of replication, m
49 oss-packaged material, there was substantial inverted terminal repeat (ITR) promoter activity that co
51 therapy, about 40% carried mutations in the inverted terminal repeat (ITR) regions due to their inhe
53 e sought to evaluate the mechanisms by which inverted terminal repeat (ITR) sequences mediate intermo
54 majority of AAV2 breakpoints were within the inverted terminal repeat (ITR) sequences, which contain
55 vealed the ubiquitous presence of a double-D inverted terminal repeat (ITR) structure, which implied
56 ation is dependent on two copies of a 145-bp inverted terminal repeat (ITR) that flank the AAV genome
57 ranscription initiation site within the AAV5 inverted terminal repeat (ITR), and mapping of the AAV5
59 tein (GFP) transgene cassette flanked by AAV inverted terminal repeats (ITRs) (Ad.AAV-LCR-GFP), trans
60 enome regulation, with a particular focus on inverted terminal repeats (ITRs) and AAV capsid-genome i
61 ng showed bias for partial AAV fragments and inverted terminal repeats (ITRs) and failed to detect fu
63 concatemers with occasional deletions of the inverted terminal repeats (ITRs) and their flanking sequ
65 AV7 and AAV8 were generated by using rep and inverted terminal repeats (ITRs) from AAV2 and were comp
66 left-hand open reading frame (ORF) and both inverted terminal repeats (ITRs) have the highest homolo
67 ncluded a DNA element encompassing two viral inverted terminal repeats (ITRs) in a head-to-tail orien
68 termed the D sequence, from both ends of the inverted terminal repeats (ITRs) in the adeno-associated
69 s derived from recombination between (i) AAV inverted terminal repeats (ITRs) in the recombinant plas
71 pplication of AAV or electroporation of AAV2 inverted terminal repeats (ITRs) is sufficient to induce
72 ssociated virus type 2 (AAV) genome contains inverted terminal repeats (ITRs) of 145 nucleotides.
73 compromises large inverted repeats, such as inverted terminal repeats (ITRs) of adeno-associated vir
76 1287 base pairs (bp) long, has 30 bp perfect inverted terminal repeats (ITRs), and encodes a 343 amin
77 Rep recognition sequences (RRSs) in the AAV inverted terminal repeats (ITRs), the AAV p5 promoter, a
78 E3, and late genes, but containing the viral inverted terminal repeats (ITRs), transgene expression c
79 ing of the proviral genome played by the AAV inverted terminal repeats (ITRs), which consist of a pal
86 nced by using viral DNA packaging sequences (inverted terminal repeats [ITRs]) derived from AAV genot
88 taining the target sequence derived from the inverted terminal repeat; nontarget DNA stimulates ATPas
89 the integration of a plasmid containing AAV inverted terminal repeats occurred at high frequency, su
90 is evidence of genome recombination, as the inverted terminal repeat of HAdV-4vac is initially ident
92 with one breakpoint precisely located at an inverted terminal repeat of the retained starting elemen
94 heterologous DNA sequences cloned within the inverted terminal repeats of AAV and subsequently packag
95 he sequences of regulatory protein (rep) and inverted terminal repeats of AAV into an HSV amplicon ve
96 ella virus PBCV-1, the SC-1A genome contains inverted terminal repeats, one of which is adjacent to t
97 placement of the p5 RBE with either the AAV2 inverted terminal repeat or the AAVS1 RBE sequence eleme
98 mage to a lesser degree, suggesting that the inverted terminal repeat origins of replication were ins
99 quences derived from PER.C6 cells flanked by inverted terminal repeat, packaging signal, and transgen
104 , first-generation Ad vectors containing AAV inverted terminal repeat sequences (ITRs) flanking a rep
105 anking expression cassettes of interest with inverted terminal repeat sequences (ITRs) from adeno-ass
106 is approximately 3.1 kb in length with 19-bp inverted terminal repeat sequences having a single misma
107 showed that Himar1 transposase binds to the inverted terminal repeat sequences of its cognate transp
108 that was further increased by including the inverted terminal repeat sequences of the adeno-associat
109 r of AAV5, within viral constructs that lack inverted terminal repeat sequences, displays a high basa
112 th the single-stranded D sequence within the inverted terminal repeat structure of the AAV genome and
113 ind to imperfect palindromic elements in the inverted terminal repeat structures at the 3'- and 5'-en
115 ains a small single-stranded DNA genome with inverted terminal repeats that form hairpin structures.
117 and crystallography have deciphered several inverted terminal repeat-transposase complexes that are
118 g on itself and replication back through the inverted terminal repeat, using itself as a template.
120 omain, and specific DNA sequences containing inverted terminal repeats with similarity to piggyBac tr