ライフサイエンスコーパス: inward

1 ion site on the Pd(II) centers, which points inward.

2 il periphery, which extended several microns inward.

3 hibits a gradient of damage from the surface inward.

4 is transmitted from the extracellular domain inward.

5 omes with the unoccupied terminal end facing inward.

6 nd T cell differentiation from the periphery inward.

7 where one points outward and the other three inward.

8 es at the nuclear periphery before advancing inward.

9 ts formed farther from the star and migrated inwards.

10 projected outward (2,2'-biaceanthrylene) or inward (1,1'-biaceanthrylene), and the optical and elect

11 ased peer review tends to drive radiologists inward, against each other, and against practice leaders

12 G299A structure, the 30S shoulder is rotated inward and decoding nucleotide G530 flips into the anti

13 substrate are close to each other, but curl inward and do not pair.

14 G347U structure, the 30S shoulder is rotated inward and intersubunit bridge B8 is disrupted.

15 tabolic cost by altering the interactions of inward and outward currents on multiple timescales, but

16 overning the complex temporal progression of inward and outward gas fluxes to and from the silage int

17 MCT1 mediates bidirectional and simultaneous inward and outward lactate fluxes, which were required f

18 while initiating vergence eye movements, the inward and outward rotation of the eyes.

19 ession in Xenopus oocytes, and mediates both inward and outward transport of small dipolar amino acid

20 ard rectification, BM2 conducts protons both inward and outward.

21 anged with the hydrophobic portions oriented inward and the hydrophilic head groups positioned outwar

22 2 directed outwards, whereas A63 is directed inwards and anchored by stacking and hydrogen-bonding in

23 debris of rocky planets that were scattered inwards and tidally disrupted(13).

24 and biscoumarins that are differentiated by "inward" and "outward" disposition of the pyran-2-one moi

25 embrane domains (TMDs), which switch between inward- and outward-facing (IF, OF) orientations.

26 linkers, indicating that MurJ can adopt both inward- and outward-facing conformations in vivo Further

27 on the periplasm with those calculated using inward- and outward-facing crystal structures of MdfA, s

28 a central cavity in MurJ alternates between inward- and outward-open conformations to flip lipid II,

29 ir epithelial glandular architecture with an inward apical pole delineating a luminal cavity.

30 m the silyl ether group toward directing the inward approach of indoles, leading to nucleophilic atta

31 A drop in extracellular pH induces transient inward ASIC currents (IASICs) in postsynaptic MNTB neuro

32 energy reached approximately 60 meV and then inward at higher energies.

33 to the mature virions, with molecules pushed inwards at the icosahedral fivefolds by ~100 angstrom, r

34 ocations in the nucleosome linkers to induce inward (AT-IN) and outward (AT-OUT) bending of the linke

35 esis that Kir2 currents non-linearly balance inward background cation currents, accounting for two le

36 KEY POINTS: Outward and inward background currents across the cell membrane bala

37 Similarly, the inward bias of the turns is a result of the increase in

38 ne and no-light-zone and these turns have an inward bias.

39 postulates that ILVs form individually from inward budding of the endosomal limiting membrane, plant

40 Mineralization proceeds inwards by mineral deposition from this membrane, which

41 he inhibition of L-type VGCC, inhibiting the inward Ca(2+) current through these channels, but does n

42 ch-clamp experiments clearly showed that the inward Ca(2+) current was absent.

43 mediated activation of P2X(7) induces a fast-inward cation current in cells.

44 -canonical pore of TRPM3, resulting in large inward cation currents via the voltage sensor domain in

45 ls that divide by constriction of the cortex inward, cells of land plants divide by initiating a new

46 slow channel closing, involving outward and inward charge displacements.

47 ssumes a relatively flexible, outward-closed/inward-closed (O(c)/I(c)) conformation.

48 eport crystal structures of MurJ captured in inward-closed, inward-open, inward-occluded and outward-

49 teraction sites, whereas inward-occluded and inward conformations present only a single beta-d-glucos

50 itive and voltage-dependent Na(+) persistent inward current (NaPIC).

51 Pinacidil failed to activate current and the inward current activated by elevated [K(+) ]o was insens

52 he injury sustains the bulk (~60-70%) of the inward current active at subthreshold voltages during th

53 active under basal conditions carrying tonic inward current and synaptic activation of alpha1-A(R)s a

54 henylglycine (3,5-DHPG; 200 mum) produced an inward current at -60 mV and increased spontaneous gluta

55 bagin and atovaquone inhibit outward and the inward current flowing through NKA in SKOV-3 and OVCAR-3

56 sinhibition) combined with an increase in an inward current from excitatory synapses.

57 currents in the hair cell, and a maintained inward current in the afferent.

58 respond to the application of glutamate with inward current mediated by Ca(2+)-permeable AMPARs.

59 so poorly coupled, enabling local Ca-induced inward current of sufficient source strength to overcome

60 sent in zebrafish sperm and carries a proton inward current that acidifies the cytosol.

61 ltage clamp experiments showed activation of inward current when extracellular K(+) ([K(+) ]o ) was i

62 Spontaneous Ca release activates inward current which depolarizes membrane potential (Vm)

63 nd that despite evoking a similar excitatory inward current, activation of NMDARs resulted in a large

64 longed, concentration- and voltage-dependent inward current, associated with an increase in membrane

65 ctivation of Ano1 channels and generation of inward current, cause net depolarization of colonic musc

66 contrast, M3 receptor activation elicits an inward current, increases rheobase, extends action poten

67 Capsaicin evoked inward currents (current density ~10% of sensory neurons

68 not known although activation of persistent inward currents (PICs) might be involved.

69 eration of extrasynaptic NMDAR-mediated slow inward currents (SICs) in neighboring neurons, which can

70 Both inward currents and 5-HT release were inhibited by Piezo

71 ith single-channel conductances of 20 pS for inward currents and 80 pS for outward currents.

72 We measured the major inward currents and their Ca(2+)- and beta-adrenergic de

73 Steady outward and inward currents could be detected at different positions

74 We demonstrated that ATP application induced inward currents in hDPSCs.

75 how that activation of NMDARs evoked similar inward currents in MNCs of sham and renovascular hyperte

76 BAB receptor agonist baclofen also inhibited inward currents induced by CIM0216 in DRG neurons, and n

77 ordings on Arabidopsis vacuoles, we observed inward currents upon P(i) application on the cytosolic s

78 that activation of Piezo2 by force leads to inward currents, 5-HT release and an increase in mucosal

79 tonucleotidase activity enhanced ATP-induced inward currents.

80 re involved in the generation of ATP-induced inward currents.

81 by enhancing subthreshold voltage-activated inward currents.

82 .5), encoded by the SCN5A gene, conducts the inward depolarizing cardiac Na(+) current (INa) and is v

83 ubstrate-type releaser at DAT that evoked an inward depolarizing current and calcium influx, whereas

84 d by the intermediate Ag20 shell, preventing inward diffusion of the surface Au atoms.

85 of palladium phosphide and consequently the inward diffusion of vacancies and their coalescence into

86 is particularly effective in stabilizing the inward facing conformation of ABCG2.

87 avoring outside facing sites and disfavoring inward facing sites.

88 sted to adopt different conformations in the inward facing, outward facing and amphetamine-bound stat

89 ilized by a Fab fragment, and a ligand-bound inward-facing (I(f)) conformation, possibly stabilized b

90 access conformational transitions between an inward-facing (IF) and an outward-facing (OF) conformati

91 used to resolve the backbone dynamics in the inward-facing (IF) and outward-facing (OF) states by ana

92 found that acidic pH favors formation of an inward-facing (IF) conformation, whereas elevated pH (>7

93 the structures of MRP1 were determined in an inward-facing (IF) or outward-facing (OF) conformation.

94 al states, i.e., the outward-facing (OF) and inward-facing (IF) states, as well as on the OF <-> IF s

95 has an enhanced solvent accessibility in the inward-facing (relative to the outward-facing) form.

96 istinct conformational states: predominantly inward-facing apo P-gp, pre-hydrolytic (E552Q/E1197Q) P-

97 the glucose EIIC superfamily, bcChbC in the inward-facing conformation and bcMalT in the outward-fac

98 or its environment must thus stabilize this inward-facing conformation for the transporter to functi

99 Next, starting from the inward-facing conformation of EcNhaA, we sample what cou

100 The SUR1-ABC core is found in an unusual inward-facing conformation whereby the two nucleotide bi

101 nd ADP reveal an unprecedented closed and an inward-facing conformation, respectively.

102 KCC1 adopts an inward-facing conformation, with the extracellular gate

103 transition state structurally resembles the inward-facing conformation.

104 ion of the nucleotide-binding domains in the inward-facing conformation.

105 inding site when the transporter rests in an inward-facing conformation.

106 ter adopts a LeuT fold and is captured in an inward-facing conformation.

107 cNhaA), alternate between their outward- and inward-facing conformations in the membrane.

108 Crystal structures in the outward- and inward-facing conformations of a glutamate transporter h

109 7, suggesting that Mhp1 adopts predominantly inward-facing conformations.

110 of human ZnT8 (HsZnT8) in both outward- and inward-facing conformations.

111 An inward-facing crystal structure and an outward-facing mo

112 SS member, LeuT, in a Na(+)/substrate-bound, inward-facing occluded conformation.

113 rd-facing occluded with substrate bound, and inward-facing open).

114 ased exchange to similar extents relative to inward-facing P-gp.

115 the interconversion from the outward- to the inward-facing state in the conformational ensemble under

116 nsition from the outward-facing state to the inward-facing state involves rigid body movements of tra

117 onal transition from an outward-facing to an inward-facing state of the transporter.

118 In our structure, TmrAB adopts an asymmetric inward-facing state, and we show that the C-terminal hel

119 mational transition from the outward- to the inward-facing state, when the bound substrate is translo

120 s furiosus (PfMATE) in the long-sought-after inward-facing state, which was obtained after crystalliz

121 odulating the stability of a partially open, inward-facing state.

122 cotransporter protein in a substrate-bound, inward-facing state.

123 sporter Can1 is promoted by transition to an inward-facing state.

124 ormational transition from outward-facing to inward-facing state.

125 erved N-terminal Trp8 to Ala both promote an inward-facing state.

126 lobal (transition between outward-facing and inward-facing states) scales.

127 t state with height between the outward- and inward-facing states.

128 The inward-facing structure of PfMATE in combination with th

129 Comparison with the previously determined inward-facing structure of SCL1A5 provides a basis for a

130 Comparison of these outward- and inward-facing structures reveal how the transport domain

131 A comparison of the outward- and inward-facing structures reveals that the TMD of each Hs

132 f IrtAB that result in a partially collapsed inward-facing substrate-binding cavity.

133 f this cavity during the transition from the inward-facing to outward-facing conformational states, a

134 sm on DAT by inducing a relative increase in inward-facing transporters.

135 It is defined by a "half-open and inward-facing" state (HOIF) of the intracellular gate th

136 an ionophore decreases the prevalence of the inward-facing, but not the outward-facing state.

137 Here we present crystal structures of the inward-facing, intermediate, and outward-facing states o

138 of the binding site to the cytoplasmic side (inward-facing, open NBD conformation).

139 ions indicate that when the protomers become inward-facing, they cause deep, long-ranged, and yet mut

140 e torque generator rotates in response to an inward flow of H(+) driven by the proton motive force, a

141 These findings lead to a new model where inward forces generated by endocytic machinery on the pl

142 ultaneously: The frozen phase boundary moves inward from the droplet free surface toward the droplet-

143 ward, outward-occluded, inward-occluded, and inward GLUT1 conformations.

144 ZnT10 is exploiting the transmembrane Ca(2+) inward gradient for active cellular exchange of Mn(2+) I

145 treadmilling, which guides and regulates the inward growth of the septal wall.

146 peptidoglycan synthesis and coordinating the inward growth of the septum to form the new poles of the

147 were categorized into three groups: routine inward hospitalization, intensive care unit admission, a

148 r compartments and subsequent attenuation of inward I(NaCa) and reduction of intracellular sodium.

149 vations in cytosolic free calcium and evoked inward ion current in HEK293 cells expressing the transi

150 Previous reports suggest that elevated inward ionic currents in HF promote action potential (AP

151 ier model in an outward (OWF) and develop an inward (IWF) facing model employing an integrated experi

152 rane resting potential, AP amplitude, or the inward K(+) current.

153 Both the outward and inward K(+) currents shifted Veq K(+) consistent with K(

154 membrane invagination, which grows radially inward like the shutter of a camera.

155 leosome proximity in the AT-IN arrays due to inward linker DNA bending.

156 port still occurs in outward-locked (but not inward-locked) DraNramp.

157 This inward-looking threat from parochialism occurs just as t

158 This process induces cargo crowding and inward membrane buckling, followed by constriction of th

159 This inward migration of GJ 436b could have triggered the atm

160 eads to cellular Mn(2+) extrusion against an inward Mn(2+) gradient, and (c) the cellular transport o

161 Inward motion of Arg664 allows it to interact with the g

162 We show that phosphorylation favors inward motion of Arg664, while simultaneously favoring o

163 We interpret this as the inward motion of gases at velocities comparable to freef

164 ents of the thumb and fingers modules and an inward motion of the fingers subdomain-especially the O

165 ntally, and validate theoretically, that the inward motion of the phase boundary near the substrate d

166 We suggest that an inward motion of the S4 sensor helix of approximately 5-

167 nhibitory inputs directionally selective for inward motion opposing the excitation.

168 nelles exhibited a burst of dynein-dependent inward movement at the growing aster periphery, then mos

169 Inward movement is driven by the matrix-localized, Hsp70

170 with beta(1)AR coupled to Nb80, including an inward movement of extracellular loop 3 and the cytoplas

171 3 interacting protein, for the formation and inward movement of the macropinosome.

172 xial movement of transmembrane (TM) helix 3, inward movement of TM7, and outward movement of TM6.

173 he tops of transmembrane helices 6 and 7, an inward movement of transmembrane helix 1, reorganization

174 ting that outward K(+) current via I(Kr) and inward Na(+) current via I(NaL) are in balance during ph

175 Triggered Ca(2+) waves activate inward NCX and dramatically reduce atrial maximum diasto

176 Inward NCX current was upregulated at phase 3 of AP in H

177 LCR signal activating an earlier and larger inward NCX current.

178 protein, as well as a mechanically-sensitive inward non-selective cation current characteristic of Pi

179 ling to demonstrate that the transition from inward occluded to inward open is more energetically fav

180 d its structure in a novel conformation, apo inward-occluded and a new nucleotide-bound state, high-e

181 ucose and maltose interaction sites, whereas inward-occluded and inward conformations present only a

182 MurJ captured in inward-closed, inward-open, inward-occluded and outward-facing conformations.

183 eria, GkApcT, has recently been solved in an inward-occluded state and allows an opportunity to exami

184 That E115 is likely to be protonated in the inward-occluded state and deprotonated in the inward-ope

185 mulations, we observed a transition from the inward-occluded state captured in the crystal structure

186 llus halodurans, have been resolved in novel inward-occluded states, with the extracellular vestibule

187 , allowing the protein to transition from an inward-occluded to an inward-open conformation.

188 ns, the so-called outward, outward-occluded, inward-occluded, and inward GLUT1 conformations.

189 ryo-EM structure of the KimA homodimer in an inward-occluded, trans-inhibited conformation.

190 that the transition from inward occluded to inward open is more energetically favorable when E115 is

191 location pathway to interact with TM2a in an inward-open cavity.

192 to transition from an inward-occluded to an inward-open conformation.

193 or substrate translocation by stabilizing an inward-open conformation.

194 ngements that occur from the outward-open to inward-open conformations, and provide insight into the

195 lexes captured in outward-open, occluded and inward-open conformations.

196 ported here spontaneously adopt occluded and inward-open conformations.

197 consider likely to be representative of the inward-open state associated with substrate release.

198 nward-occluded state and deprotonated in the inward-open state is further confirmed via the use of ab

199 er the bulk rearrangement of DraNramp to the inward-open state upon metal binding and facilitate retu

200 ith the conformational transition toward the inward-open state, a role that is likely to be shared ac

201 oning of the N terminus and transition to an inward-open state.

202 human NKCC1 captured in a partially loaded, inward-open state.

203 transport requires cycling from outward- to inward-open states, efficient proton transport still occ

204 lized in outward-open, outward-occluded, and inward-open states.

205 ions match crystal structures, including our inward-open structure.

206 oton-coupling residue Asp309 by Asn, similar inward-open structures were captured.

207 tructures of MurJ captured in inward-closed, inward-open, inward-occluded and outward-facing conforma

208 modynamic coupling between Na(+) release and inward-opening, and identifies diverse, yet well-defined

209 ll four azaphosphatrane (+)P-H vectors point inward, or else where one points outward and the other t

210 g is sufficient to switch SUR1 alone between inward- or outward-facing conformations with low or high

211 Previous models proposed that dynein-based, inward organelle transport generates length-dependent pu

212 The tight polymer membranes and the inward oriented enzyme caused 1 pH unit difference in 30

213 chromatin domains frequently contain several inward-oriented CTCF motifs whose effects, described abo

214 sic deformations: bending (orally, aborally; inward, outward), torsion (clockwise, counter-clockwise)

215 proton dissociation from H19 to increase the inward proton conductance and causes the small reverse c

216 We first show that Otop1 is required for the inward proton current in type III TRCs from different pa

217 ces outward pushing forces to antagonize the inward pulling forces from kinesin-14 or dynein.

218 With more suberin, the inward radial transport of calcium and sodium decreases,

219 Less suberin also favors the inwards radial transport of calcium and sodium, but nega

220 ties of optic nerve axons, accommodation and inward rectification (I(h)), respond to temperature chan

221 yl)ethyl)propenamide (B-973B) showed reduced inward rectification and calcium-dependent reversal pote

222 matched healthy subjects, indicating greater inward rectification in iRLS.

223 clic nucleotide-gated (HCN) channel-mediated inward rectification in motor axons.

224 However, the impact of inward rectification in shaping action potentials (APs)

225 ur studies reveal an unexpected mechanism of inward rectification involving a linker sub-helix emergi

226 However, the inward rectification of GABA-induced transport currents

227 ased GIRK currents ( I(K,ACh)) and a reduced inward rectification which was not compensated by intrac

228 exhibits alterations in sensitivity to ATP, inward rectification, and ion selectivity.

229 M2 (AM2), which conducts protons with strong inward rectification, BM2 conducts protons both inward a

230 ium relative to monovalent cations and shows inward rectification.

231 ltage (I-V) relationships, no longer showing inward rectification.

232 Two processes underlie this inward rectification: an intrinsic rectification caused

233 eptor 1 (SUR1 or ABCC8) and a K(+)-selective inward rectifier (Kir6.2 or KCNJ11).

234 and p.P888L-SAP97 cardiomyocytes, while the inward rectifier current increased in WT-SAP97 but not i

235 zations from any cause by overexpressing the inward rectifier K channel Kir2.1 in stabilizer cells.

236 sm and K(ATP) channels and the minor role of inward rectifier K(+) (Kir2.1) channels in regulating bl

237 Here we use human Inward Rectifier K(+) Channel Kir2.1 to map site-specifi

238 Inward rectifier K(+) channel subfamily 2 (Kir2) channel

239 ABSTRACT: Inward rectifier K(+) channel subfamily 2 (Kir2) channel

240 In the present study, we show that inward rectifier K(+) channel subfamily 2 isoform 1 (Kir

241 gulated in homologs, such as G-protein-gated inward rectifier K(+) channels (GIRK), have differential

242 We explored the role of inward rectifier K(+) conductances in colonic ICC that m

243 Using the Inward Rectifier K+ channel Kir2.1, we validate the prac

244 ), twin-pore domain K channels (TASK, TREK), inward rectifier Kir7.1, Ca(2+)-activated K(+) channels

245 leads to the activation of G-protein-coupled inward rectifier potassium (GIRK) channels and hyperpola

246 G-protein-gated inward rectifier potassium (GIRK) channels are regulated

247 = 0.2 muM), small-molecule inhibitor of the inward rectifier potassium (Kir) channel and diuretic ta

248 Inward rectifier potassium channel (Kir) Kir2.2 has mult

249 nding partners, kainate receptor GluR6/7 and inward rectifier potassium channel Kir2.1, closely assoc

250 ed rectifier potassium current (IKr) and the inward rectifier potassium current (IK1) were also downr

251 nsitive K(+) channels (K(ATP)) comprise four inward rectifier subunits (Kir6.2), each associated with

252 Inward-rectifier K(+) (Kir) channels are often activated

253 quired for activation and K(+) conduction in inward-rectifier K(+) (Kir) channels are still debated.

254 y-which activates capillary endothelial cell inward-rectifier K(+) (KIR2.1) channels to produce a rap

255 ankyrin domain in the cytosolic side of the inward-rectifier K(+) channel AKT1 regulates kinase dock

256 It shares the common inward-rectifier K(+) channel fold with eukaryotic chann

257 KirBac1.1 is a prokaryotic inward-rectifier K(+) channel from Burkholderia pseudoma

258 containing the ABC transporter SUR1 and the inward-rectifier K(+) channel Kir6.2, in the presence of

259 The defining structural feature of inward-rectifier potassium (Kir) channels is the unique

260 KAT1 and its homolog KAT2 are the main inward rectifying channels present in guard cells, media

261 ells of SUR1 null islets have an upregulated inward rectifying K+ current that helps to compensate fo

262 cAMP production and inhibition of G protein inward rectifying potassium (GIRK) channels.

263 G-protein-gated inward rectifying potassium channels (GIRKs) require G(b

264 nd function of tandem of P domains in a weak inward rectifying TASK-1 (K(+) channel-related acid-sens

265 miana cells, Ma1 mediates a malate-dependent inward-rectifying current, whereas the ma1-mediated tran

266 further found that blue light activation of inward-rectifying K(+) (K(+) (in) ) channels was impaire

267 The inward-rectifying K(+) channel AKT1 constitutes an impor

268 ility and a reduction of the glial-specific, inward-rectifying K(+) channel Kir4.1.

269 tant, indicating that ZxAKT1 functions as an inward-rectifying K(+) channel.

270 entrations, amantadine preferentially blocks inward-rectifying K+ channel type 2 (Kir2) channels in s

271 sal CA1 neurons and that a G-protein-coupled inward-rectifying potassium channel mediated regulation

272 ocytes have very low membrane resistance and inward-rectifying potassium channel-mediated current, an

273 wer, acts via 5HT2A receptors to suppress an inward-rectifying potassium conductance in FSIs.

274 hanism that couples the transport-associated inward release of the Na(+) ion from the Na2 site to int

275 rimary failure rate resulting from excessive inward remodeling, medial fibrosis, and thrombosis.

276 er induced by impact draws material radially inward, resulting in an azimuthal compression that is re

277 AMP-PNP binding induces an inward rotation and shift of the transmembrane helices o

278 ly the closure of the alpha4-beta4 hinge and inward rotation of Y- or W106 with W58.

279 an occur with even a small imbalance between inward sodium currents and outward potassium currents, b

280 ither in the peripheral region and propagate inward (soft substrate/low friction) or in the central r

281 s, and the asymmetric freezing dynamics with inward solidification causing not fully frozen mass to b

282 lular Cl(-) with gluconate(-) diminishes the inward tail current (Cl(-) efflux) at a membrane potenti

283 This moment of change-in which science turns inward to examine its methods and practices-provides an

284 the Ku inhibition, perhaps by pushing the Ku inward to expose the overhang for NHEJ synapsis.

285 l gates as the protein transitioned from the inward to outward facing state.

286 to completely flip the gating polarity from inward to outward-rectifying.

287 as the mutant proteins were driven from the inward to the outward open Na(+)-bound conformation.

288 om the duct and endophytic lesions that grew inwards to the ductal lumen.

289 nsporter facilitates a reorientation from an inward- to outward-facing state.

290 ly, with 5 degrees and 10 degrees LWIs, toes inward ('Toe in'), and toes outward ('Toe out wide').

291 classical K(+) channels are shown to produce inward TOK currents.

292 c and circumnuclear scales(4) that gas flows inwards towards accretion disks around black holes, and

293 a persistent rise in the radial component of inward traction force signifies successful actin-cable s

294 b activates the TRPM4 channel and results in inward transient cation currents that depolarize smooth

295 a common mechanism involving the outward or inward translocation of gating charges(1-3), the general

296 pumping of sodium ions competes with passive inward transport of potassium.

297 The third uridine is turned outwards or inward, wedging between the other uridines, thus filling

298 lished P- and L-rings, and bend the membrane inward while it remains apparently sealed.

299 r fully penetrated the sediment, progressing inward with time to a maximum depth of 10000 mum and ind

300 At these vertices proteins engage inwards with the internal membrane vesicle whilst 2-fold