ライフサイエンスコーパス: iodination

1 similar to that of the electronic effects in iodination.

2 C) lost its binding affinity to heparin upon iodination.

3 and tested for their heparin affinity after iodination.

4 F-1 retained its heparin affinity even after iodination.

5 is the first use of N-iodoamide for C-H bond iodination.

6 d intrinsic ability to form T3 upon in vitro iodination.

7 cinimide followed by the silver(I)-catalyzed iodination.

8 e UK, which has no programme of food or salt iodination.

9 iO(1.5)](n) (n = 8, 10, 12) via ICl-promoted iodination (-40 to -60 degrees C) with overall yields of

10 loped different protocols for the arylation, iodination, acetoxylation, and olefination of these subs

11 catalyst training set in the atropselective iodination across a variety 2-aminopyridine substrates a

12 9-dicarboxylates followed by decarboxylative iodination affords a 2,9-diiododipyrroketone which gives

13 The hydrogen-atom transfer mechanism for C-H iodination allows C-H oxidation to proceed with minimal

14 ne-directed, Pd(II)-catalyzed sp(3) C-H bond iodination and acetoxylation reactions as reported in pr

15 ituted the enzymatic activities required for iodination and all embellishments of the highly substitu

16 from TG occurs in the thyroid gland via the iodination and coupling of pairs of tyrosines, and is co

17 sists of two tyrosine residues which undergo iodination and coupling, resulting in the synthesis of t

18 A notable exception is the iodination and deiodination of thyroid hormones.

19 Site-selective iodination and enantioselective cycloiodoetherification

20 , we computationally modeled the reaction of iodination and iodotyrosine coupling giving rise to thyr

21 Surface iodination and Man-6-P/IGF-II receptor affinity chromato

22 r was achieved in one pot through sequential iodination and O-arylation of phenol under mild reaction

23 First, by its in vitro iodination and site-directed mutagenesis we show that th

24 ic C(sp(3))-H bond functionalization such as iodination and thiocyanation.

25 iiodopropenyl phosphonate, via electrophilic iodination, and alpha-fluoro-gamma-amino-alpha,beta-unsa

26 permeable to dye and accessible to tyrosine iodination, and have aberrant collagen protein expressio

27 Using surface iodination, anti-CD44 immunoprecipitation and immuno-bin

28 Plot shapes for iodination are compared to those of other reactions, suc

29 extremely rare, and enzymes responsible for iodination are even less well described.

30 trate flexibility and a clear preference for iodination, as illustrated by kinetic analysis.

31 close proximity, in which case the extent of iodination at each residue may be difficult to determine

32 uantitative evaluation of the likelihood for iodination at each site.

33 rosine residue, similar chemistry occurs via iodination at histidine.

34 f the 2-amino group of 10 and regioselective iodination at the 5-position followed by palladium-catal

35 A feasible route for radio-iodination at the p-position of a 4-phenylamino substitu

36 a strong Pd-DG interaction increases the EC iodination barrier and reduces the I-I oxidative additio

37 ion is believed to take place via an in situ iodination-based oxidative elimination of formaldehyde.

38 ollowed by sequential C-2 O-methylation, C-5 iodination, C-3 oxidation, and C-3 O-methylation.

39 ate for all known enediynes; and (3) cryptic iodination can be exploited to increase enediyne titers.

40 To distinguish their contributions to DM iodination, [Cl(-)] was added at constant pH and ionic s

41 nd sst(4)-selective ligands amenable to (125)iodination, could not be achieved satisfactorily.

42 lyl/crotyl/alkoxyallylboration-hydroboration-iodination-cyclization reaction sequence.

43 Pd-catalyzed ortho-C-H iodination directed by a weakly coordinating amide auxil

44 ch for the determination of chlorination and iodination disinfection byproducts based on solid-phase

45 echnique was applied to the determination of iodination disinfection byproducts from individual precu

46 fect VKOR's enzymatic function, and tyrosine iodination does not compromise protease digestion and th

47 doalkenes by diverting intermediates from an iodination-electrophilic-cyclization mechanism.

48 Negishi carbometalation-iodination established the (E)-iodoalkene, and addition

49 nctionalized tetrasubstituted enol ethers by iodination followed by Suzuki coupling.

50 ly available 2-chlorobenzothiazole by direct iodination), followed by Pd-catalyzed cross-coupling rea

51 gioselective, iron(III) triflimide-catalyzed iodination, followed by a copper(I)-catalyzed intramolec

52 highly regioselective and metal-free in oxy-iodination following Markovnikov's rule.

53 n) is essential to deliver Tg to its site of iodination for thyroxine biosynthesis.

54 m 2-(benzyloxy)-5-deoxyascorbic acid (15) by iodination (I2, PPh3, Imd), iodo substitution with lithi

55 via a three-step protocol consisting of (i) iodination, (ii) zincation followed by Pd-catalyzed viny

56 d be prevented by pretreatment of cyt c with iodination, implying that the tyrosine residue of cyt c

57 ing dihydropyrazoles undergo dehydration and iodination in the presence of ICl and Li2CO3 at room tem

58 Apart from ubiquitous mammalian iodination in thyroxine biosynthesis, iodinated natural

59 avin-dependent halogenase that is capable of iodination in vitro had not been reported.

60 y of deiodination from T4 We found that upon iodination in vitro, de novo T3 formation in TG was decr

61 same glands and processed similarly, without iodination in vitro.

62 via palladium-catalyzed enantioselective C-H iodination in which one of the enantiomers of a racemic

63 n and mass spectrometry to localize sites of iodination in whole proteins.

64 Pathways for HA iodination include covalent modification of aromatic-typ

65 The decarboxylative iodination is effected with the dimethyl ether derivativ

66 Site specific identification of the sites of iodination is important for many of these uses.

67 The iodination is successful with just 0.55 equiv of iodine

68 S(N)2 pathway, in which blue light-promoted iodination is used to form alkyl iodide intermediates fr

69 The reaction proceeds through sequential iodination, Kornblum oxidation, and amidation in one pot

70 The reaction involves consecutive iodination, Kornblum oxidation, and intramolecular amida

71 The invertive desilylative iodination leads to the total synthesis of isodomoic aci

72 benzyl-1H-imidazole and a regioselective C-4 iodination method to acquire starting material for our a

73 n lead to inactive peptides due to excessive iodination, nonspecific iodination, or oxidative damage

74 nd environmentally benign regioselective oxy-iodination of 1-aryl/alkyl butadienes has been developed

75 The atropselective iodination of 2-amino-6-arylpyridines catalyzed by chira

76 pharmaceutical formulation demonstrated that iodination of a conserved tyrosine (Tyr(B26)) enhances k

77 which a 5-iodo-1,2,3-triazole is formed via iodination of a copper(I) triazolide intermediate by the

78 envisioned mechanistic rationale comprises N-iodination of a cyclic amine, followed by N-I bond homol

79 Iodination of a lone tyrosine residue in each sequence d

80 lysts which were effective in catalyzing the iodination of a variety of 2-amino-6-arylpyridines with

81 the palladium(II)-catalyzed bromination and iodination of a variety of alpha-hydrogen-containing car

82 etF catalyzes site-selective bromination and iodination of a variety of aromatic substrates and enant

83 ad proceeding by electrophilic selenation or iodination of a vinyl boronate complex followed by stere

84 e of palladium(II)-catalyzed beta-C(sp(3))-H iodination of a wide range of ketones using a commercial

85 C-H chlorination and bromination, the direct iodination of alkanes represents a great challenge.

86 Here, the aerobic iodination of alkanes, including methane, was performed

87 a I(2) complexation, and (iii) vicinal amino-iodination of an in situ generated allyl imidate.

88 Direct iodination of annexin V on tyrosine residues is a poor t

89 A mild and rapid method for the iodination of arenes that utilizes silver(I) triflimide

90 The facile iodination of aromatic compounds under mild conditions i

91 e monochloride (I-Cl) generation followed by iodination of aromatics using NCBSI/KI system has been d

92 Iodination of aryls with N-iodo sulfoximines, oxidation,

93 ted meta-C-H olefination, acetoxylation, and iodination of biaryl compounds is reported.

94 henol derivatives and allowed the late-stage iodination of biologically active compounds such as PIMB

95 A copper-catalyzed iodination of carbazoles has been developed.

96 mpeting ortho sites, the site selectivity in iodination of chrysenyl amides by directed ortho metalat

97 Iodination of different aromatic compounds with this rea

98 We present a kinetic investigation of iodination of dimethenamid (DM), a model compound lackin

99 Iodination of either 2-(1'-hydroxy-6'-methylphen-2'-yl)-

100 Rh(III)-catalyzed selective bromination and iodination of electron-rich heterocycles is reported.

101 A halogen bond-assisted electron-catalyzed iodination of heteroarenes has been developed for the fi

102 A one-pot, high-yielding iodination of hydroxypyridines and hydroxyquinolines is

103 in the regioselective allylic alkylation and iodination of imidazoheterocycles employing the mixture

104 alcohol and I(2) could be beneficial for the iodination of imidazoheterocycles under room temperature

105 etected at the cell surface as determined by iodination of intact cells and the lack of susceptibilit

106 od has been developed for selective benzylic iodination of methylarenes.

107 We report a new strategy for the catalytic iodination of nonactivated C(sp(3))-H bonds.

108 An oxidative procedure for the electrophilic iodination of phenols was developed by using iodosylbenz

109 te ([*I]SGMIB), an agent useful in the radio-iodination of proteins, including monoclonal Abs, and pe

110 be delivered at the cell surface to catalyze iodination of secreted thyroglobulin.

111 3-alkylation, N3-borane complexation, and C4-iodination of some of these were investigated in order t

112 nversely, de novo T3 that can be formed upon iodination of TG secreted from PCCL3 (rat thyrocyte) cel

113 rene 6 has been achieved by copper-catalyzed iodination of the 1,3-bistriflate ester 2a of p-tert-but

114 ransformations was lithiation and subsequent iodination of the 4-(2,2,2-trifluoro-1-hydroxyethyl)pyra

115 eliminary mechanistic studies reveal in situ iodination of the amine as the putative mode of activati

116 soft electrophilic halonium species for the iodination of the carbazoles.

117 t, shown in Scheme 1, involves diazotization/iodination of the corresponding aminofluoresceins.

118 The electrophilic aromatic iodination of the corresponding trimethylstannyl interme

119 NOLs is accomplished through decarboxylative iodination of the dimethyl ether derivative of BINOL-3,3

120 An efficient regioselective iodination of the Fischer-Borsche ring has been achieved

121 estigated whether iodine replacement through iodination of the irrigation water would decrease infant

122 cyclic chelation in a nonpolar solvent, (3) iodination of the naphthyridine at C(3), and (4) CuI-med

123 chanistic pathway involves the initial alpha-iodination of the nucleophile, followed by anti-carbopal

124 If iodination of the protein is carried out under natively

125 low) up to 244), coupled with the subsequent iodination of the remaining enantiomerically enriched st

126 rior to the copper iodide catalyst, as ortho-iodination of the substrates could be prevented.

127 Thyroidal T4 production results from iodination of thyroglobulin (TG) at residues Tyr(5) and

128 Iodination of tyrosine residues in proteins has many use

129 iodination with IODO-BEADS, resulting in the iodination of tyrosine residues; and use of the Bolton-H

130 A palladium-catalyzed C-H iodination of unactivated alkenes is reported.

131 A simple method for the iodination of unsaturated sugars to form sugar vinyl iod

132 s capable of a direct and efficient C-H bond iodination of various cyclic and acyclic alkanes providi

133 Traditional methods of iodination often lead to inactive peptides due to excess

134 an betaPP-wt cells after either cell surface iodination or [35S]methionine labeling, indicating that

135 Electrophilic iodination or bromination of a 5,10-diaryl-substituted c

136 Iodination or bromination of a free base 5,10-diaryloxoc

137 des due to excessive iodination, nonspecific iodination, or oxidative damage to the peptide.

138 functionalization via direct cross-coupling, iodination, or protodestannylation and increase solubili

139 1, upon oxidation to cysteic acid during the iodination procedures, would interact with lysine-126 an

140 The iodination proceeds under mild conditions, and the produ

141 Furthermore, the one-pot direct iodination process is extended to the concise synthesis

142 teps, a novel one-pot CuAAc "click" reaction-iodination process, an amidation and a copper-catalyzed

143 ationale for the highly regioselective arene iodination process.

144 zation of a wide array of olefins to furnish iodination products as single stereoisomers.

145 The oxy-iodination products were obtained in good to excellent y

146 To this end, regioselective iodination protocols were developed for 7-deaza-2'-deoxy

147 As pH increased (4-9), DM iodination rate decreased.

148 Although chloride addition did increase the iodination rate, the reaction order in [Cl(-)] was fract

149 general, and practical ortho bromination and iodination reaction of different classes of aromatic com

150 An efficient iodination reaction of electron-deficient heterocycles i

151 An enantioselective C-H iodination reaction using a mono-N-benzoyl-protected ami

152 A stereochemically divergent desilylative iodination reaction was developed to convert the cycliza

153 nylglycine-derived 1,6-enyne, a desilylative iodination reaction, as well as an alkenyl-alkenyl silic

154 guing double XAT process for the deacylative iodination reaction, which could have implications beyon

155 bstrate revealed important details about the iodination reaction.

156 ting the missing version of the Wohl-Ziegler iodination reaction.

157 tereospecific chlorination, bromination, and iodination reactions.

158 ues was either conjugated with (124)I via an iodination reagent or coupled with deferoxamine (Df) and

159 roiodate (1, TMADCI) as a mild and efficient iodination reagent was prepared.

160 d 65-98 MBq (1.7-2.6 mCi) of (124)I using an iodination reagent.

161 The contribution of ICl to DM iodination remained below 47% under typical drinking wat

162 The kinetic profile of cyclohexane iodination showed that aerobic oxidation of I(3)(-) to p

163 e, because they are the most prominent early iodination sites in this part of thyroglobulin, and beca

164 TG synthesis, iodination, storage in follicles, and degradation contro

165 lated thyrocytes alters the structure of the iodination substrate in a way that enhances de novo T3 f

166 Here we report a low-cost decarboxylative iodination that occurs simply from readily available ben

167 ves binding up to 1 order of magnitude after iodination through interactions that can be interpreted

168 followed by the reduction, deuteration, and iodination to afford functionalized 2-deoxy sugars.

169 atalyzes bromination but not fluorination or iodination; (v) SgcC3 can utilize both (S)- and (R)-beta

170 Distinctions between DM iodination versus chlorination or bromination include a

171 ntails the following key steps: (i) beta C-H iodination via 1,5-hydrogen atom transfer (HAT), (ii) de

172 n forming the chroman moiety, regioselective iodination/vinyl Suzuki cross-coupling reaction, and rin

173 The efficiency of IODO-BEADS iodination was just below 30%; with the Bolton-Hunter pr

174 iculum (ER) before its export to the site of iodination, where it serves as the precursor for thyroid

175 131S) was able to bind to heparin even after iodination while bovine FGF-1 (S131C) lost its binding a

176 (125)I using 2 different techniques: direct iodination with IODO-BEADS, resulting in the iodination

177 hanistic details of the Pd(II)-catalyzed C-H iodination with molecular I2 as the sole oxidant.

178 th olefins, hydroarylation with alkynes, and iodination with N-iodosuccinimide is reported here.

179 nate and (diacetoxyiodo)benzene, followed by iodination with N-iodosuccinimide or iodine in situ, in

180 g was with (125)I or (131)I, by conventional iodination; with (111)In using the chelator benzyl-dieth

181 In addition, the iodination works on both 2- and 4-hydroxypyridines and -

182 .d.) of 91%+/-8% was achieved, comparable to iodination yields.