ライフサイエンスコーパス: iodo

1 Here we report the synthesis of the 5-iodo-1,2,3-triazole (FITI) analog of the PET tracer [(18

2 5-Iodo-1,2,3-triazole (iodotriazole) can be prepared from

3 4-(1'-Cyclohexenyl)-5-iodo-1,2,3-triazole and 4-phenyl-1,2,4-triazoline-3,5-di

4 the amine compromises the selectivity for 5-iodo-1,2,3-triazole by promoting the formation of 5-prot

5 mechanistic model is formulated in which a 5-iodo-1,2,3-triazole is formed via iodination of a copper

6 iological evaluation suggests that 5-[(125)I]iodo-1,2,3-triazoles are resistant to deiodination in vi

7 cies and triiodide ion in the formation of 5-iodo-1,2,3-triazoles than that of the pure forms of copp

8 diated cyclization of sulfonamide-tethered 5-iodo-1,2,3-triazoles which are readily available via an

9 kynes, and [(125)I]iodide to yield 5-[(125)I]iodo-1,2,3-triazoles.

10 ing reaction of propargylic stannanes with 5-iodo-1,3-oxazoles to produce 1,1-disubstituted allenes (

11 , we accessed 1,4-disubstituted triazoles, 5-iodo-1,4,5-trisubstituted triazoles, and 5-alkynylated 1

12 rganic azide and terminal alkyne to afford 5-iodo-1,4-disubstituted-1,2,3-triazoles.

13 2,2-difluoro-1-iodoethene and 2,2-difluoro-1-iodo-1-(2'-methoxyethoxymethoxy)ethene.

14 regioselective annulation of allenes with 3-iodo-1-alkylindole-2-carboxylic acids is described.

15 g sequential arylation of 5-bromo-6-chloro-3-iodo-1-methyl-1H-pyrrolo[2,3-b] pyridine is established.

16 in good overall yield in three steps from 2-iodo-1-naphthoic acid and enantiopure beta-amino alcohol

17 ion of 4-methylanisole and alkylation with 5-iodo-1-pentene, followed by intramolecular Friedel-Craft

18 ereogenic cuprate reagent with (E)-4-bromo-1-iodo-1-trimethylsilyl-1-butene with retention of configu

19 sequential oxidation reaction of cyclized 7-iodo-12-phenylindeno[2,1-alpha]phenalene (ipp) with mole

20 nist (1-butylpiperidin-4-yl)methyl-8-amino-7-iodo[(123)I]-2,3-dihydrobenzo[b][1,4]diox ine-5-carboxyl

21 binding site or receptor, we synthesized 20-iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonami

22 amides by the aminocarbonylation of 5-aryl-4-iodo-1H-imidazoles using ex situ generation of CO from M

23 nterparts and allows the synthesis of both 3-iodo-1H-indenes (from beta-alkyl-beta-alkyl/aryl-o-(alky

24 2CO3 at room temperature to provide 1-acyl-4-iodo-1H-pyrazoles.

25 3-iodo-1H-pyrrolo[3',2':4,5]imidazo-[1,2-a]pyridines and [

26 ne (2a) and 3-N-benzoyl-3',5'-di-O-benzoyl-5-iodo-2'-deoxy-2'-fluoroarabinouridine (2b) with unactiva

27 coupling of 3-N-benzoyl-3',5'-di-O-benzoyl-5-iodo-2'-deoxyuridine (2a) and 3-N-benzoyl-3',5'-di-O-ben

28 ommitted, slowly cycling cells by tracking 5-iodo-2'-deoxyuridine (IdU) label-retaining cells (LRCs)

29 oduced with 5-azacytidine (AzaC) and with 5'-iodo-2'-deoxyuridine (IUdR); none was detected with sodi

30 nist (1-butylpiperidin-4-yl)methyl 8-amino-7-iodo-2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylate (1, S

31 ed by two sequential cross couplings using 4-iodo-2,3-dinitrophenyl trifluoromethanesulfonate as the

32 orophenoxy)propyl]-4-methyl-4-piperidinyl]-5-iodo-2- methoxybenzamide (123I-5-I-R91150).

33 nedioic acid (OPA) carbamate [(18)F]23 and 4-iodo-2-[(18)F]fluorobenzoyllysine OPA carbamate [(18)F]2

34 evaluation led to the identification of 4-[4-iodo-2-[(5-quinoxalinylsulfonyl)amino]benzoyl]-morpholin

35 In the presence of indium metal, 3-iodo-2-[(trimethylsilyl)methyl]propene (1) reacts with s

36 reacting (11)C-cyanide ion with protected 4-iodo-2-amino-butanoic ester, the key intermediate was ob

37 via a palladium-catalyzed dimerization of 1-iodo-2-arylethynyl-acenaphthylenes.

38 include the chemoselective lithiation of a 1-iodo-2-bromoolefin, the introduction of the side chains

39 nitrobenzene and a 4,5-trans-disubstituted 2-iodo-2-cyclohexen-1-one, engaged in a tandem reductive c

40 inistration of 5-chloro-2-deoxyuridine and 5-iodo-2-deoxyuridine indicated that all HSCs segregate th

41 uorophenyl)propyl]-4-methylpiperidin-4-yl]-5-iodo-2-methoxy benzamide) and the influence of ketamine

42 diethylamino-ethyl)-4-(4-fluoro-benzamido)-5-iodo-2-methoxy-benzamide (MIP-1145), was evaluated for i

43 completed via asymmetric allylation of (E)-3-iodo-2-methylprop-2-enal followed by oxidative cleavage

44 ygen derived from air, yielding 12-hydroxy-7-iodo-2-phenylindeno[2,1-alpha]phenalen-1(12H)-one (hipp)

45 ibitors exemplified by 2-amino-6-chloro-9-(4-iodo-3,5-dimethylpyridin-2-ylmethyl)purine (30).

46 esence of specific Raf-1 inhibitor GW5074 (5-iodo-3-[(3,5-dibromo-4-hydroxyphenyl) methylene]-2-indol

47 cetate (5) and p-methoxybenzyl 2,6-dideoxy-2-iodo-3-C-methyl-alpha-mannopyranoside (11).

48 -2(1H)-yl)butyl)-2-(2-[18F]-fluoroethox y)-5-iodo-3-methoxybenzamide ([18F]3f) are acceptable compoun

49 y of (bacterio)chlorophylls, two routes to 2-iodo-3-methyl-4-(3-methoxy-1,3-dioxopropyl)pyrrole, a pr

50 e 7-methylbenziodoxolone ring system using 2-iodo-3-methylbenzoic acid as starting compound.

51 nthesis of masked 2,3-diaminoindole 1 from 2-iodo-3-nitro-1-(phenylsulfonyl)indole (2) has been devel

52 cells was sensitive to inhibition by trans-4-iodo, 4'-boranyl-chalcone, consistent with HDM2-catalyzi

53 onyl]methyl reserpate (AIPPMER), 18-O-[N-(3'-iodo-4'-azidophenethyl)glycyl]methyl reserpate (IAPEGlyM

54 These compounds are 18-O-[3-(3'-iodo-4'-azidophenyl)-propionyl]methyl reserpate (AIPPMER

55 ]methyl reserpate (IAPEGlyMER), and 2-N-[(3'-iodo-4'-azidophenyl)-propionyl]tetrabenazine (TBZ-AIPP).

56 osure of the vinyllithium derived from (Z)-1-iodo-4,4,5-trimethyl-1,5-hexadiene by lithium-iodine exc

57 Diastereomers of N-(cyclohex-2-enyl)-N-(2-iodo-4,6-dimethylphenyl)acetamides with an additional or

58 ter-insoluble 2-(2'-hydroxyphenyl)-6-[(125)I]iodo-4-(3H)-quinazolinone ((125)IQ(2-OH)).

59 luble 2-(2',4'-dihydroxyphenyl)-6-[127I/125I]iodo-4-(3H)-quinazolinone (127IQ2-OH,4-OH (2)/125IQ2-OH,

60 rodrug ammonium 2-(2'-phosphoryloxyphenyl)-6-iodo-4-(3H)-quinazolinone (IQ(2-P)) was docked in silico

61 Ammonium 2-(2',4'-diphosphoryloxyphenyl)-6-iodo-4-(3H)-quinazolinone (IQ2-P,4-P), having the most f

62 analog 1-O-hexadecanoyl-2-O-[9-[[[2-[(125)I]iodo-4-(trifluoromethyl-3H-diazirin-3-yl)ben zyl]oxy]car

63 e probe 1-O-hexadecanoyl-2-O-[9-[[[2-[(125)I]iodo-4-(trifluoromethyl-3H-diazirin-3-yl)ben zyl]oxy]car

64 oxyphenyl)tropane-2beta-carboxylic acid 2-(3-iodo-4-aminophenyl)ethyl ester (8i) with an IC(50) value

65 cocaine derivative and photoprobe 3-[ (125)I]iodo-4-azidococaine ([ (125)I]IACoc) binds to the sigma-

66 The cocaine photoaffinity label 3-iodo-4-azidococaine ([125I]IACoc) binds to the sigma-1 r

67 The synthetic application of 5-iodo-4-ethynyl triazoles obtained was also evaluated: th

68 e an efficient one-step synthetic route to 5-iodo-4-ethynyltriazoles.

69 lly available 4-methoxy-2-nitroaniline and 1-iodo-4-methoxy-2-nitrobenzene.

70 ylboron triflate catalyzed condensation of 3-iodo-4-methoxybenzaldehyde with an indene enamine afford

71 r induction using N,N-diethyl-2-(2-(3-(125)I-iodo-4-methoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrim i

72 anilides and alkyl-/arylthioanilides using 1-iodo-4-nitrobenzene as catalyst and oxone as an inexpens

73 fically labeled using (111)In-DOTA or (125)I-iodo-((4-hydroxyphenyl)ethyl) maleimide (HPEM).

74 produced by replacements at C7, including 3-iodo- (4az) and 3-trifluoromethyl- (4be), with IC(50) of

75 of GaI(3) + Bu(4)N(+)GaI(4)(-) results in 5-iodo-5-arylpent-2-enylmalonates as products of HI formal

76 Single-crystal X-ray analysis of 7-iodo-5-aza-7-deaza-2'-deoxyguanosine displayed intermole

77 d via palladium-catalyzed carbonylation of 2-iodo-5-methoxyaniline (4) with thiazolylacetylene 5.

78 mesylate [WIN 55,212-2 (WIN)] and (R,S)-3-(2-iodo-5-nitrobenzoyl)-1-(1-methyl-2-piperidinylmethyl)-1H

79 lated with IgE-ICs consisting of 4-hydroxy-3-iodo-5-nitrophenylacetyl (NIP)-specific IgE JW8 and NIP-

80 P2Y1 receptor antagonist (1R,2S,4S,5S)-4-[2-iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicy

81 phosphate (MRS 2179), and (1R,2S,4S,5S)-4-[2-Iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicy

82 potent of these compounds is ethyl 2-(N-((4-iodo-6-methoxypyrimidin-2-yl)carbamoyl)sulfamoyl)benzoat

83 ad led to the identification of N(4)-butyl-5-iodo-6-methylpyrimidine-2,4-diamine as a pure TLR8 agoni

84 mbination of GM-CSF plus the MIF inhibitor 4-iodo-6-phenyl-pyrimidine achieved the best reprogramming

85 ogue MIF are biophysically very different, 4-iodo-6-phenylpyrimidine (4-IPP) forms a covalent bond wi

86 studies further reveal that this compound, 4-iodo-6-phenylpyrimidine (4-IPP), is approximately 5x to

87 Notably, the small molecule MIF inhibitor 4-iodo-6-phenylpyrimidine inhibits MIF secretion by target

88 discovered MIF small molecule antagonist, 4-iodo-6-phenylpyrimidine, recapitulates MIF deficiency in

89 the photo-affinity ligand 2-azido-3-[(125)I]iodo-7,8-dibromodibenzo-p-dioxin and liver cytosol isola

90 l acrylate to 5-iodoracil, 5-iodocytosine, 7-iodo-7-deazaadenine, and 7-iodo-7-deazaguanine 2'-deoxyr

91 5-iodocytosine, 7-iodo-7-deazaadenine, and 7-iodo-7-deazaguanine 2'-deoxyribonucleoside 5'-O-monophos

92 ,5S)-tert-butyl 2-(benzyloxycarbonylamino)-4-iodo-7-oxo-6-azabicyclo[3.2.1]octane-6-carboxylate 11.

93 5-(123)I-iodo-85380 ((123)I-5-IA) is used to quantitate high-affi

94 t compound, were synthesized from 6-chloro-2-iodo-9-methyl-9H-purine (2) by selective C-C bond format

95 Conversely, 5-iodo-A-85380, sazetidine-A, varenicline, alpha-conotoxin

96 sidues with a novel reagent, 2,4-dibromo-(2'-iodo)acetanilide.

97 DI MS analysis kit containing N-succinimidyl iodo-acetate, suberic acid bis(3-sulfo-N-hydroxysuccinim

98 either novel alpha-iodo-N-Ts-imines or alpha-iodo-aldehydes in high yield.

99 ents and other nucleophiles delivered (2Z)-2-iodo allylic alcohols.

100 ylation of phenylphosphine borane with gamma-iodo-alpha-amino ester reagents under phase-transfer cat

101 nation and diastereoselective intramolecular iodo-amination, led to highly convergent total syntheses

102 )boronatophenylphosphine with beta- or gamma-iodo amino acid derivatives which are prepared from L-se

103 of the phosphine was performed using either iodo amino ester or carboxylic acid derivatives.

104 methylpropa namide 11 or the corresponding 5-iodo analog 14 via Sonogashira couplings with appropriat

105 henols rather of the more expensive bromo or iodo analogues makes this procedure environmentally conv

106 ctivity, including ribose ring constraint, 5-iodo and 4-alkyloxyimino modifications, and phosphate mo

107 gations proved the structural equivalence of iodo and cyano Gilman cuprates and their subsequential i

108 ta-substitutions on the aniline ring such as iodo and cyano increased reactivity with dansyl-GCVLS an

109 NAr reactions with 6-(fluoro, chloro, bromo, iodo, and alkylsulfonyl)purine nucleosides and nitrogen,

110 Fluoro, chloro, bromo, iodo, and gem-dihaloalkenes are viable substrates for th

111 or lipophilic residues increased potency, 2-iodo- and 2-chloro-adenosine-5'-O-[(phosphonomethyl)phos

112 ddition of N-formyl derivatives of 2-amino-3-iodo- and 3-amino-4-iodopyridines to acetylenes activate

113 tter nucleophile than the corresponding beta-iodo- and beta-chloroenones 9a,c; (2) (Me)2Phen(OMe)2.Ni

114 tion of free (N-H)-indoles and pyrroles with iodo- and bromoarene donors.

115 are operonic and inducible with 4-chloro-, 4-iodo-, and 4-bromobenzoate.

116 shows significant inhibition by 4-bromo-, 4-iodo-, and 4-fluorobenzoate and mild inhibition by 3-chl

117 Aryl halides, such as chloro-, bromo-, iodo-, and fluorobenzene, behave differently under the s

118 situ with TBAF and coupled to the 3-bromo-5-iodo arene using the iodo selective Pd(tri-2-furylphosph

119 thynyl arene and the other being a 3-bromo-5-iodo arene.

120 Generation of a [hydroxy(tosyloxy)iodo]arene from a functionalized (diacetoxyiodo)arene in

121 rting from simple and commercially available iodo arenes and aldehydes, for the synthesis of a wide v

122 e synthesis of various [bis(trifluoroacetoxy)iodo]arenes, ArI(OCOCF(3))(2).

123 n transfer (SET) from 2-azaallyl anions to 2-iodo aryl allenyl ethers initiates a radical cyclization

124 l tertiary phosphines bearing an o-bromo (or iodo)aryl substituent is described.

125 activity, which is further enhanced when an iodo, aryl, heteroaryl, t-butyl, or cyclopentyl substitu

126 ontaining the molecular switch with terminal iodo atoms exhibits visible-light-driven reversible unwi

127 hemistry represents the first general use of iodo-BCPs as electrophiles in cross-coupling, and the fi

128 ted BCPs from 1-iodo-bicyclo[1.1.1]pentanes (iodo-BCPs) by direct iron-catalyzed cross-coupling with

129 vity of enol esters toward [hydroxy(tosyloxy)iodo]benzene (HTIB) was assessed.

130 alent iodine(III) reagent, [hydroxy(tosyloxy)iodo]benzene (Koser's reagent), has been developed.

131 emperature mediated by [bis(trifluoroacetoxy)iodo]benzene (PIFA) and N-bromosuccinimide (NBS) using c

132 azatriphenylene, using [bis(trifluoroacetoxy)iodo]benzene is reported.

133 further oxidized with [bis(trifluoroacetoxy)iodo]benzene to give stable benziporphyrin derivatives.

134 methoxy, dimethoxy, benzyl ether-substituted iodo-benzenes, other iodoarenes, such as iodo-naphthalen

135 Thus, reaction of 2-bromo or 2-iodo benzoate esters with amdidines afforded substituted

136 h enantioselection is the finding that ortho-iodo benzoic acid salts of the chiral copper(II) bis(oxa

137 Coupling of 2-iodo benzoic acids with enolates that were produced in s

138 ng Auger emitter 2-[3-[1-carboxy-5-(4-(125)I-iodo-benzoylamino)-pentyl]-ureido]-pentanedioic acid ((1

139 We prepared 2-[3-[1-carboxy-5-(4-[(125)I]iodo-benzoylamino)-pentyl]-ureido]-pentanedioic acid ([(

140 The preparation of challenging 2-deoxy-2-iodo-beta-D-allo precursors of 2-deoxy-beta-D-ribo-hexop

141 Unexpectedly, all reactions provided 2-iodo-beta-D-ketopyranosides in high yields and excellent

142 beta-glycosidation reaction of 2,6-dideoxy-2-iodo-beta-glucopyranosyl acetate (5) and p-methoxybenzyl

143 od to access 1,3-C-disubstituted BCPs from 1-iodo-bicyclo[1.1.1]pentanes (iodo-BCPs) by direct iron-c

144 3-(4'-Azido-3'-iodo-biphenyl-4-yl)-8-methyl-8-aza-bicyclo[3.2.1]octane-

145 xide) diamond-like core complemented by a mu-iodo bridge between the two Ni centers, which remains st

146 s an efficient method for the preparation of iodo-, bromo-, and azido-derivatives via dediazoniation.

147 koxide followed by tandem diastereoselective iodo-, bromo-, or chlorocyclopropanation to furnish halo

148 e potential incorporation of alkyl copper in iodo but not in cyano Gilman cuprates during the reactio

149 oranes outperform the traditionally utilized iodo-carborane species.

150 in 100% iodine atom economy for the reported iodo-cofunctionalization of alkenes.

151 )CO(2)I is utilized for the synthesis of 1,2-iodo-cofunctionalized derivatives of a variety of alkene

152 of XeF(2) at the iodo ligand of Pt(II) aryl iodo complexes to generate I-F species can be operative

153 A series of diphosphine Pt(II) aryl iodo complexes were reacted with XeF(2) to cleanly produ

154 The iodo compound 9b has nanomolar affinity for mGlu(5) and

155 ction periods ( approximately 50 min for the iodo compound and approximately 6 h for the fluoro analo

156 ding interactions between electron-deficient iodo compounds and Lewis bases.

157 The solid state structures of the chloro and iodo congeners establish short Zr N and elongated N N bo

158 mino, ester, chloro, trifluoromethyl, bromo, iodo, cyano, and fluoro groups, are tolerated.

159 with nitromethane followed by electrophilic iodo cyclization of the resulting 2-nitro-1-(2-(alkynyl)

160 In a single manipulation, a gamma-iodo-delta-valerolactone is obtained through an atom tra

161 Nucleobase anion glycosylation of the iodo derivative of isobutyrylated 5-aza-7-deazaguanine w

162 ra, and Heck C-C cross-coupling reactions of iodo derivatives 1c, 1d, and 2d were also successful and

163 Chloro, bromo, and iodo derivatives can be obtained successfully.

164 The bromo and iodo derivatives of these molecules are useful tools for

165 nal and biological use, including fluoro and iodo derivatives with potential radiodiagnostic ((18)F)

166 nctional method support that, in the case of iodo derivatives, homolytic thienyl-I bond fragmentation

167 ed are four synthetically valuable bromo and iodo derivatives.

168 [(125)I]Iodo-DPA-713 accumulates specifically in tuberculosis-as

169 losis and evaluated using whole-body [(125)I]iodo-DPA-713 single-photon emission computed tomography

170 atios were significantly higher with [(125)I]iodo-DPA-713 SPECT (4.06 +/- 0.52) versus [(18)F]fluorod

171 [(125)I]Iodo-DPA-713 SPECT imaging clearly delineated tuberculos

172 [(125)I]Iodo-DPA-713 SPECT provides higher lesion-specific signa

173 data support the application of both (125)I-iodo-DPA-713 SPECT/CT and DPA-713-IRDye800CW near-infrar

174 Pancreatic (125)I-iodo-DPA-713 uptake was significantly higher in treated

175 The biodistribution of (125)I-iodo-DPA-713 was determined under the same conditions, a

176 zolo[1,5-a]pyrim idin-3-yl)acetamide ((125)I-iodo-DPA-713) SPECT/CT or (18)F-FDG PET/CT.

177 ic pancreatitis, we hypothesized that (125)I-iodo-DPA-713, a small-molecule radiotracer that specific

178 imaged using a fluorescent analog of (125)I-iodo-DPA-713, DPA-713-IRDye800CW, for correlative histol

179 Using photoreactive DNA containing 5-iodo-dUMP in defined positions, XPC/Rad4 location on dam

180 carboiodination affords persubstituted alpha-iodo-enamides in moderate to high yield.

181 Silver-mediated annulation of 2-iodo enol esters leading to 4- and 3,4-substituted isoco

182 The resultant iodo-enol esters were subsequently coupled with boronic

183 lement of the approach entailed treatment of iodo-epoxide 7, prepared by N-alkylation of 6 with (S)-g

184 C2 analogues, including the chloro-, bromo-, iodo-, fluoro-, and methyl-substituted analogues, but do

185 uorophore dyads were synthesized by coupling iodo-functionalized dithiahomoporphyrin with an ethynyl-

186 BA and the Vasella-type fragmentation of a 5-iodo furanoside using chromium(II) chloride when zinc pr

187 g agent, and by direct radioiodination using IODO-GEN ((125)I-Nanobody).

188 NMR spectroscopic methods revealing extended iodo Gilman cuprates.

189 of allyl chloride into a THF-d8 solution of iodo-Gilman reagent, Me2CuLi.LiI (A), spinning in the pr

190 ical method for the synthesis of C-2 deoxy-2-iodo glycoconjugates in self-assembled structures was fo

191 2-Iodo glycoserinyl esters were intramolecularly converted

192 an S(N)2' solvolysis process to displace the iodo group affords a fused polycyclic compound.

193 species differing in the positioning of the iodo group relative to the hydroxyl which readily underg

194 t N(4) was optimal, and replacement of the 5-iodo group with chloro, bromo, or fluoro groups led to l

195 The iodo groups of diiodide 6 pass through the calixarene ma

196 The stereospecific alkylation of the iodo groups of the resulting di-O-alkylated anti-1,3-dii

197 ity increases across the dihalogenated HBQs: iodo- > bromo- > chloro-HBQs (P < 0.05).

198 A new and extensive set of 4-(6-iodo-H-imidazo[1,2-a]pyridin-2-yl)-N-dimethylbenzeneamin

199 f the kibdelones employing an intramolecular iodo halo-Michael aldol reaction and its merger with an

200 hat formation and occurrence of highly toxic iodo-HBQs and 2,5-HBQs warrant further investigation to

201 of pyrido[1,2-a]pyrimidin-4-ones with bromo/iodo-(hetero)arenes under aqueous conditions has been de

202 The hydroamidation and iodo-imidation of ynamides to trisubstituted and tetrasu

203 g agent, 2-(4'-dimethylaminophenyl)-6-(123)I-iodo-imidazo[1,2-a]pyridine ((123)I-IMPY), in adjacent b

204 The syn iodo-imidazoliophane isomer forms novel dimeric isostruc

205 The protic-, chloro-, and anti iodo-imidazoliophane receptors proved to be ineffectual

206 xperimental observations that bromo- and syn iodo-imidazoliophane XB receptors form stable cooperativ

207 vent mixture demonstrated the bromo- and syn iodo-imidazoliophane XB receptors to bind selectively io

208 isolation of anti and syn conformers of the iodo-imidazoliophane, whereas the chloro- and bromo-imid

209 The receptors contain chloro-, bromo-, and iodo-imidazolium motifs incorporated into a cyclic struc

210 -1-(2-(alkynyl)phenyl)ethanol (6) to furnish iodo isochromene derivatives.

211 aza-2'-deoxyguanosine affording the 7- and 8-iodo isomers.

212 cope of the radical precursor includes alpha-iodo ketones, esters, nitriles, primary amides, alpha-fl

213 , 3,3'-diiodo-l-thyronine (3,3'-T(2)), and 3-iodo-l-thyronine (3-T(1)), in the brain and thyroid glan

214 viously shown that the late-term rise in tri-iodo-l-thyronine (T(3) ) in fetal sheep leads to the inh

215 Tri-iodo-l-thyronine (T(3)) suppresses the proliferation of

216 Tri-iodo-L-thyronine (T3) treatment of cultured cardiomyocyt

217 Inhibiting 3,5,3'-tri-iodo-L-thyronine and 3,5,3',5'-tetra-iodo-L-thyronine se

218 ,3'-tri-iodo-L-thyronine and 3,5,3',5'-tetra-iodo-L-thyronine secretion did not alter isoform switchi

219 Plasma thyroid hormone (tri-iodo-l-thyronine; T(3) ) concentrations rise near the en

220 ructures of human IYD and its complex with 3-iodo-l-tyrosine illustrate the ability of the substrate

221 pathway involving an attack of XeF(2) at the iodo ligand of Pt(II) aryl iodo complexes to generate I-

222 tal-free, visible-light, radical (trifluoro)(iodo)methylations of alkenes, illustrated by their use a

223 esis and characterization of a suite of aryl-iodo monomers, which were used to prepare iodinated poly

224 chiral 2-aryl-ferroceneamides from chiral 2-iodo-N,N-diisopropylferrocencarboxamide, iodoarenes, and

225 l acrylates, and substituted styrenes with 2-iodo-N,N-diisopropylferrocencarboxamide.

226 The reactions of a wide range of 2-iodo-N-phenyl benzamides and acyclic diketones as starti

227 The preparation of C-iodo-N-Ts-aziridines with excellent cis-diastereoselecti

228 ed, selectively affording either novel alpha-iodo-N-Ts-imines or alpha-iodo-aldehydes in high yield.

229 ted iodo-benzenes, other iodoarenes, such as iodo-naphthalene, heteroarenes, such as iodothiophene, a

230 of melting triphenylphosphine with the gamma-iodo NHBoc-amino ester, derived from L-aspartic acid.

231 was prepared by reacting 2-trifluoromethyl-4-iodo-nicotinic acid (2) with amidine 9a catalyzed by Pd(

232 , which reacts with nitronates to form alpha-iodo nitroalkanes as precursors to the amides.

233 As key compounds, 7-iodo nucleosides were synthesized.

234 The 1-N-benzyl-5-iodo(or bromo)uracil undergoes Pd-catalyzed [Pd2(dba)3]

235 o 86% yield via the catalytic reduction of 1-iodo- or 1-bromo-5-decyne by [[2,2'-[1,2-ethanediylbis(n

236 ed by stannyldesulfonylations and subsequent iodo- or protiodestannylation gave 6-N-cyclopropyl-5'-de

237 a-2'-deoxyguanosine displayed intermolecular iodo-oxygen interactions in the crystal and channels fil

238 [Bis(trifluoroacetoxy)iodo]perfluoroalkanes C(n)F(2n+1)I(OCOCF(3))(2) (n = 4,

239 ly converted to the stable [hydroxy(tosyloxy)iodo]perfluoroalkanes, C(n)F(2n+1)I(OH)OTs, by treatment

240 The classic 4-azido-3-iodo-phenyl group was appended to either the C-1 or C-5

241 6'-dimethyl-morpholino)-3-(4-azido-3-[(125)I]iodo-phenyl)propane ([(125)I]IAF), which covalently deri

242 Commercially available 4-iodo-phenylalanine or 4-iodobenzyl bromide served as the

243 specificity in AcKRS and in a PylRS variant [iodo-phenylalanyl-tRNA synthetase (IFRS)] that displays

244 (N()-acetyllysyl-tRNA synthetase [AcKRS], 3-iodo-phenylalanyl-tRNA synthetase [IFRS], a broad specif

245 otic stress were attenuated by 2-(2-chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benz

246 '-methoxyflavone)-, PD184352- [2-(2-chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benz

247 ed with [3H]prazosin, [3H]RX21002 and [125I]-iodo-pindolol autoradiography, respectively.

248 ultraviolet photolysis of the corresponding iodo precursors in a mixture of water and methanol at va

249 Mono-iodo-ProTx-II ((125)I-ProTx-II) binds with high affinity

250 f pyrrolo[3,2,1-de]acridones 4a-v, 5a-h from iodo-pyranoquinolines 2a-i by the palladium-catalyzed re

251 ctionalized azido-pyranoquinolines and azido-iodo-pyranoquinolines via electrophilic cyclization of o

252 eds with excellent regiocontrol to provide 5-iodo pyrazoles.

253 ety of aryl iodides, including less reactive iodo pyridine derivatives to provide a library of highly

254 ing of acrylanilides with 4-bromo-2-chloro-3-iodo-pyridine using palladium acetate can produce bis-He

255 [(18)F]6), and 2-(3-[1-carboxy-5-[(5-[(125)I]iodo-pyridine-3-carbonyl)-amino]-pentyl]-ureido)-pe ntan

256 nd an iodolactonization reaction to form the iodo pyrrolizidinone fragment of the molecule is describ

257 Substitution of 2-Cl with iodo reduced protection in the CSQ model.

258 Likewise, the antagonist 5-iodo-resiniferatoxin (5-iodo-RTX) displayed a Ki of 4.2

259 itor ruthenium red, and the TRPV1 antagonist iodo-resiniferatoxin (I-RTX).

260 Subunit-specific antagonism (iodo-resiniferatoxin) and agonism (capsaicin) were used

261 030031), but unaffected by the TRPV1 blocker iodo-resiniferatoxin.

262 se, the antagonist 5-iodo-resiniferatoxin (5-iodo-RTX) displayed a Ki of 4.2 pM if incubated with CHO

263 oupled to the 3-bromo-5-iodo arene using the iodo selective Pd(tri-2-furylphosphine)4 catalyst in con

264 The best yields of 4-iodo-selenophenes were obtained with iodine as a halogen

265 sters were intramolecularly converted into 2-iodo serinyl glycosides which upon dehalogenation gave C

266 tion reaction to provide the corresponding 3-iodo spirocyclohexadienones.

267 he need for an electronically enriched ortho-iodo substituent in catalyst 4f supports a recent theore

268 The iodo substituent in fluorinated 4-iodofurans was utilize

269 ketone, nitriles, nitro groups, and an aryl iodo substituent or a benzyl ether.

270 (1)H NMR studies suggest that the bulky iodo-substituent packs within a nonpolar interchain crev

271 , hydroxy, azido, imidazole, thiophenyl, and iodo substituents.

272 of low-valent Ni(0/I) species with specific iodo substituted N^O (Ar-I) ligands were shown to initia

273 and 2 equiv of NIS at refluxing CH2Cl2 gave iodo-substituted benzo[b]naphtho[2,1-d]thiophene (6) in

274 collected on Br2B-PMHC and related bromo and iodo-substituted BODIPY dyes show that the trap segment

275 Iodo-substituted compounds generated by the electrophili

276 nase inhibition and enabled the design of 10-iodo-substituted derivatives as very potent DYRK1A inhib

277 A synthesis of iodo-substituted dibenzocyclohepten-5-ones by the iodine

278 thodology can also be extended to the use of iodo-substituted imines to produce novel spirocyclic bet

279 ocess can be directed towards either tin- or iodo-substituted product formation, giving complementary

280 Selected iodo-substituted tetrahydro-3H-cyclopenta[c]quinolines e

281 A series of iodo-substituted tetrahydro-3H-cyclopenta[c]quinolines w

282 cked architecture of the EtCN solvate of the iodo-substituted, oxobenzene-bridged bisdithiazolyl radi

283 bicyclo sugar intermediate, followed by an N-iodo-succinimide-induced stereoselective nucleosidation.

284 The 4-iodo-thiophenes were exclusively obtained by using dimet

285 sulin (-54%), adiponectin (-49%), 3,5,3'-tri-iodo-thyronine (T3) (-39%), and testosterone (-11%).

286 TPN-Y1/K12/Q13 and mono-iodo-TPN-Y1/K12/Q13 ([(127)I]TPN-Y1/K12/Q13) inhibit wit

287 ing [3]rotaxane host system containing a bis-iodo triazolium-bis-naphthalene diimide four station axl

288 y of the axle to the central halogen bonding iodo-triazolium station anion recognition sites to form

289 onia addition revealed that the formation of iodo-trihalomethanes (I-THMs), especially iodoform, was

290 e engineered sites in lispro (Tyr(B26)) by 3-iodo-Tyr (i) augments its thermodynamic stability (Delta

291 Remarkably, the 3-iodo-Tyr(B26) modification stabilizes an oligomeric form

292 By exploiting this allosteric switch, 3-iodo-Tyr(B26)-lispro thus illustrates how a nonstandard

293 re observed in the crystal structure of a 3-[iodo-Tyr(B26)]insulin analog (determined as an R6 zinc h

294 ook quantitative atomistic simulations of 3-[iodo-Tyr(B26)]insulin to predict its structural features

295 hyl-DOPA and 0.75 mg/g of the TH inhibitor 3-iodo-tyrosine (3-IT) resulted in 20% pupae with partiall

296 it is shown that modification of tyrosine to iodo-tyrosine followed by UV photodissociation of the ca

297 UVPD of iodo-tyrosine-modified peptides was used to generate loc

298 5-Iodo-UDP 32 (EC50 = 0.15 microM) was equipotent to UDP,

299 Two different scaffold types, one a bicyclic iodo-vinylidene tertiary amine/tertiary alcohol and the

300 ility of (111)In-PSMA-I&T ((111)In-DOTAGA-(3-iodo-y)-f-k-Sub(KuE)) (PSMA is prostate-specific membran