ライフサイエンスコーパス: ion channel

1 ran system and a cytotoxic variant of the M2 ion channel.

2 ceptor (AChR), which is a well-characterized ion channel.

3 utation affects the TWO PORE CHANNEL1 (TPC1) ion channel.

4 the ring-shaped beta subunit of a vertebrate ion channel.

5 gulator (CFTR) gene, encoding for a chloride ion channel.

6 or (S4), and a gate (S1) and forming its own ion channel.

7 149 with reduced off-target affinity for the ion channel.

8 which are mediated via the activity of many ion channels.

9 d glutamate, respectively, to activate their ion channels.

10 P, which interacts with specific enzymes and ion channels.

11 igomerisation of the protein into functional ion channels.

12 neuronal responses via nonspecific gating of ion channels.

13 lling through the action of mechanosensitive ion channels.

14 y of synaptic neurotransmitter receptors and ion channels.

15 tors to the dynamics shaped by voltage-gated ion channels.

16 ture experimental and theoretical studies of ion channels.

17 because they are modulators of voltage-gated ion channels.

18 tle is known about their functional roles in ion channels.

19 the influx of extracellular calcium through ion channels.

20 and function of various proteins, including ion channels.

21 e many advances in the study of acid-sensing ion channels.

22 s the realistic noisy opening and closing of ion channels.

23 ilarity to those in other mechanically gated ion channels.

24 odels for the allosteric modulation of these ion channels.

25 ogical channels and in hydrophobic gating of ion channels.

26 s to control the properties and functions of ion channels.

27 f neurotransmitters to ligand-gated receptor ion channels.

28 skeletal scaffolding proteins, which cluster ion channels.

29 mediators influences the function of sensory ion channels.

30 chanosensors of this class are restricted to ion channels.

31 eletions or mutations that affect subsets of ion channels.

32 nism emerged to explain a membrane effect on ion channels.

33 pores, and a number of different classes of ion channels.

34 chemical signals via mechanically activated ion channels.

35 furan compounds as novel inhibitors of AQP1 ion channels.

36 o-chemical signals by mechanically activated ion channels.

37 g hypoxia provides the signal that regulates ion channels.

38 We reported previously that acid-sensing ion channel 1a (ASIC1a) mediates acidic neuronal necropt

39 radients across cells [2], voltage-dependent ion channels [3], molecular motors [4-7], and synaptic t

40 e to investigate if deletion of acid-sensing ion channel 5 (Asic5), which is richly expressed in type

41 amphiphilic peptides have been found to form ion channels(5,6), and there have been recent advances i

42 have become bona fide neurotransmitter-gated ion channels, activated by the smallest neurotransmitter

43 5NF), were analyzed for effects on water and ion channel activities of human AQP1 channels expressed

44 tigated the relationship between bioelectric ion channel activity and calcium, finding that cell hype

45 the emerging role for heme as a regulator of ion channel activity in cells.

46 e programs (neuronal, Wnt signaling, calcium/ion channel activity).

47 s in synaptic transmissions or by changes in ion channel activity.

48 viral-mediated gene delivery, and a specific ion channel agonist, we studied the role of dentate gyru

49 ss our current understanding of ligand-gated ion channel and G protein-coupled receptor complexes and

50 lts assess the functional relevance of GluD2 ion channel and introduce an optogenetic tool that will

51 selectivity is a defining feature of a given ion channel and is considered immutable.

52 nits form the extension of the transmembrane ion channel and shape what has been described as a "clos

53 ochondrial antioxidant therapy abrogated the ion channel and structural remodeling and reversed the o

54 channel/degenerin (ENaC/DEG) superfamily of ion channels and are expressed throughout the central an

55 2 is at least threefold lower than for other ion channels and clinically used serum levels, pointing

56 cial since Ca(2+) dynamics profoundly affect ion channels and electrogenic transporters and vice vers

57 d optically were confirmed to be mediated by ion channels and experimental data suggests an insignifi

58 ting receptor proteins, such as ligand-gated ion channels and G protein-coupled receptors, has direct

59 suggested that transient receptor potential ion channels and G-protein coupled receptors play import

60 ient Receptor Potential Melastatin family of ion channels and is a divalent cation-conducting ion cha

61 Sperm ion channels and membrane receptors are attractive targe

62 sion of specific neurotransmitter receptors, ion channels and neuropeptides.

63 sm to control the properties and function of ion channels and other polytopic transmembrane proteins.

64 affects the structure and hence activity of ion channels and pumps, and indirectly changes the ionic

65 We propose that remodeling of ion channels and receptors occurs in a concerted and cel

66 nderstanding the architecture of full-length ion channels and the structural and biophysical details

67 n excitation and the effects of gestation on ion channels and their relevance to labor.

68 s essential to determine their complement of ion channels and to understand the function of biologica

69 atment with antagonists of both acid-sensing ion channels and transient receptor potential vanilloid

70 y environmental inputs to regulate different ion channels and transporters involved in the control of

71 discovery of this target, properties of this ion channel, and remaining questions are reviewed.

72 ibility of our approach on receptive fields, ion channels, and Hodgkin-Huxley models.

73 ng a combination of transcriptional factors, ion channels, and key molecules involved in synaptic tra

74 ction as light-driven ion pumps, light-gated ion channels, and photosensors, with potential utility a

75 45 compounds against a panel of 130 enzymes, ion channels, and receptors to assess secondary pharmaco

76 among gating modifier toxins, voltage-gated ion channels, and the lipid membrane surrounding the cha

77 , including myelin, axonal cytoskeleton, and ion channel antigens, in individual patients.

78 sient receptor potential vanilloid 4 (TRPV4) ion channels are a major Ca(2+) influx pathway in endoth

79 Mechanosensitive ion channels are crucial for normal cell function and fa

80 The opening and closing of voltage-gated ion channels are regulated by voltage sensors coupled to

81 f circadian behaviors.SIGNIFICANCE STATEMENT Ion channels are transmembrane proteins with selective p

82 During prenatal brain development, ion channels are ubiquitous across several cell types, i

83 ed receptor 68 gene (Gpr68) and acid-sensing ion channel (ASIC) genes Asic1, Asic2, and Asic4 in ante

84 e the sequence homology between acid-sensing ion channels (ASICs) and epithelial sodium channel (ENaC

85 Acid-sensing ion channels (ASICs) are neuronal sodium-selective chann

86 Acid-sensing ion channels (ASICs) are proton-gated cation channels th

87 Acid-sensing ion channels (ASICs) are proton-gated members of the epi

88 ith amiloride (an antagonist of acid-sensing ion channels, ASICs) and AMG8910 (a selective antagonist

89 icacy is reminiscent of multisubunit protein ion channels assembled with incorrect monomer stoichiome

90 unexpected role for polyamines in regulating ion channel assembly, which provides a new avenue for nA

91 Clustered ion channels at nodes of Ranvier are critical for fast a

92 y treat acquired focal epilepsy, focusing on ion channels because their manipulation is known be effe

93 nvolved on the regulation of these important ion channels, but also providing information that could

94 can regulate neurotransmitter receptors and ion channels by controlling their trafficking and locali

95 strate that clusters of strongly cooperative ion channels can plausibly form bistable conductances.

96 e principal Ca(2+)-selective plasma membrane ion channel CatSper, for sperm activity.

97 builds a core 'active zone' structure, where ion channels cluster and synaptic vesicles release their

98 However, how nodal ion channel clusters are maintained is poorly understood

99 neurons express the cyclic nucleotide-gated ion channel CNGA3, and that mouse, but not squirrel, CNG

100 hondrial calcium uniporter is a Ca(2+)-gated ion channel complex that controls mitochondrial Ca(2+) e

101 where they are thought to form a heteromeric ion channel complex.

102 Ion channel complexes promote action potential initiatio

103 dissecting the phospholipid requirements of ion channel complexes.

104 V and p.T860M, lead to a marked reduction in ion channel conductance.

105 lcholine receptor, a pentameric ligand-gated ion channel, converts the free energy of binding of the

106 We therefore propose that ion channel cooperativity constitutes an efficient cell-

107 We propose that smaller ion channel currents that contribute to setting the rest

108 the acyl protein thioesterases that control ion channel deacylation are very poorly defined.

109 fic combinations of dendritic morphology and ion channel densities.

110 isms, from aberrant synaptic development and ion channel deregulation of auditory brainstem circuits,

111 In the past, ion channel dysfunction has been primarily studied in th

112 molog, the Erwinia chrysanthemi ligand-gated ion channel (ELIC).

113 n the membrane protein, Erwinia ligand-gated ion channel (ELIC).

114 physiology measurements on gramicidin A (gA) ion channels embedded in planar suspended lipid bilayers

115 large-scale particle-in-cell simulations of ion channels emerging from broken wakes that electron bu

116 ry neurons through non-canonical coupling to ion channels, enabling rapid modulation of neuronal acti

117 Voltage-gated ion channels endow membranes with excitability and the m

118 s, including gap junctions, mechanosensitive ion channels, energy-consuming ion pumps, and the actomy

119 Aquaporin-1 (AQP1) dual water and ion channels enhance migration and invasion when upregul

120 ne protein 175 (TMEM175) is a K(+)-selective ion channel expressed in lysosomal membranes, where it e

121 P2X7 is an important ligand-gated ion channel expressed in multiple immune cell population

122 ally characterized prototypical ANO/SCN/TRPM ion channel-expressing pacemaker cells in the basal meta

123 PCR and western blotting were used to assess ion channel expression.

124 d structures of known mechanically activated ion channel families and discuss their implications for

125 y related receptor subtypes in the glutamate ion channel family.

126 ctin also acts as an allosteric modulator of ion channels found in host central nervous systems.

127 SthK, a cyclic nucleotide-modulated ion channel from Spirochaeta thermophila, activates slow

128 ic ion channel to broadly modulating cardiac ion channels from all three families (Na(V), Ca(V), and

129 Ion channel function additionally demands an auxiliary s

130 the full measure of complexity displayed by ion channel function and the lower dimensionality that c

131 ained stillbirth population adversely affect ion channel function and this may precipitate fatal arrh

132 h a mechanism in which anionic AuNPs disrupt ion channel function in an indirect manner by altering t

133 fect of the four stillbirth mutants on TRPM7 ion channel function in heterologous cells.

134 rchestrate the (de)acylation that fine-tunes ion channel function in physiology and disease.

135 e widespread distribution of these channels, ion channel function of GluD1(R) as a regulator of neuro

136 Progress in defining the ion channel function of GluDs in neurons has been hinder

137 powerful and reversible mechanism regulating ion channel function.

138 two drug classes targeting CFTR-one boosting ion-channel function (potentiators) and the other increa

139 Finally, CLIC1 ion channel functionality was assessed relative to alpha

140 mber 8 (TRPM8), which is a calcium-permeable ion channel, functions as the primary molecular sensor o

141 channels and is a divalent cation-conducting ion channel fused with a functional kinase.

142 ng from regulation of trafficking to shaping ion channel gating kinetics.

143 nes are classically studied as regulators of ion channel gating that engage the nAChR channel pore.

144 Five of the ion channel genes also showed strong circadian expressio

145 Variants in ion channel genes have classically been studied in low t

146 Despite a growing number of ion channel genes implicated in hereditary ataxia, it re

147 nown circadian clock genes and 19 additional ion channel genes plausibly important to electrophysiolo

148 ansposon-mediated library generation on four ion channel genes, we demonstrate that SPINE-generated l

149 A native calcium ion channel has been identified in bacteria for the firs

150 ient receptor potential (TRP) superfamily of ion channels has garnered significant attention by the p

151 sm by which changes in O(2) tension modulate ion channels has remained elusive.

152 olog ELIC (Erwinia chrysanthemi ligand-gated ion channel) has a similar lipid sensitivity.

153 ation and gating regions within this complex ion channel have implications in identifying small molec

154 electrical remodelling of the key pacemaking ion channel HCN4 in this process.

155 TrkH is a bacterial ion channel implicated in K(+) uptake and pH regulation.

156 critical role of the Piezo1 mechanosensitive ion channel in guiding vascular tip cells in pathfinding

157 calcium uniporter (MCU), a Ca(2+)-selective ion channel in the inner mitochondrial membrane.

158 on nanotubes to emulate the spike-generating ion channels in biological neurons.

159 disruption of PIP(2) regulation of vascular ion channels in disease.

160 Ion channels in excitable cells function in macromolecul

161 scovery approaches have identified defective ion channels in individuals with cerebral cortex malform

162 n outstanding representative of ligand-gated ion channels in ligand selectivity and sensitivity.

163 d to continue to explore the native roles of ion channels in microbes.

164 ges in dendritic function, and voltage-gated ion channels in particular, are increasingly the focus o

165 d diverse regulatory mechanisms available to ion channels in pLGICs, particularly involving Ca(2+) mo

166 f numerous somatic and germline mutations in ion channels in primary hyperaldosteronism underscores t

167 review, we focus on PIP(2) as a regulator of ion channels in smooth muscle cells and endothelial cell

168 The activity of these ion channels in somatosensory neurons is tightly regulat

169 utamate receptors are essential ligand-gated ion channels in the central nervous system that mediate

170 reen through the downregulation of candidate ion channels in the lateral ventral neurons (LNvs) and s

171 We then review each of the ion channels in the myometrium: L- and T-type Ca(2+) cha

172 Passive ion channels in the thylakoid membrane dissipate the mem

173 ding TNNI3 [troponin I, cardiac muscle]) and ion channels (including Kir2.1) in a dose-dependent mann

174 n potential depends on several voltage-gated ion channels, including Na(V), Ca(V), and K(V) channels.

175 an genetics have confirmed the importance of ion channels, including the principal Ca(2+)-selective p

176 V) and identified the voltage-gated chloride ion channel inhibitor 4,4'-diisothiocyano-2,2'-stilbened

177 screened a panel of broadly acting cellular ion channel inhibitors for activity against human cytome

178 How this electrical network of ion channels initiates left-sided signalling cascades an

179 neuromodulation and the nature of ultrasound/ion channel interaction.

180 The capsaicin receptor, TRPV1, is a key ion channel involved in inflammatory pain signalling.

181 Our goal was to identify ion channels involved in mechanically induced myotonia a

182 tor-like (GLR) channels are amino acid-gated ion channels involved in physiological processes includi

183 in their selectivity for human voltage-gated ion channels involved in the ventricular action potentia

184 The TRPV1 ion channel is a well-studied heat-sensing receptor that

185 The TRPA1 ion channel is activated by electrophilic compounds thro

186 The altered function of these ion channels is one of the causes of the thick dehydrate

187 e evolutionary origin of this novel class of ion channels is unknown.

188 type 3A receptor, a pentameric ligand-gated ion channel, is crucial for regulating conductance.

189 the receptor potential by voltage-dependent ion channels, is ubiquitous in all non-mammals, but has

190 the MC4R crystallized construct to couple to ion channel Kir7.1, while lacking cyclic adenosine monop

191 lastatin 7 (TRPM7), a ubiquitously expressed ion channel known to regulate cardiac development and re

192 e mechanosensory neurons, with the potassium ion channel Kv3.3 emerging as one potential contributor

193 ates cytoskeletal dynamics, controls sensory ion channel localization, and is required to maintain so

194 The extracellular domain of the M2-ion channel (M2e) is an ideal antigenic target for a uni

195 complex mixture by conducting voltage-driven ion-channel measurements.

196 However, the underlying specific ion channel mechanisms remain largely unknown.

197 ey establish a new paradigm whereby a single ion channel mediates distinct, functionally-relevant ion

198 We show how changes in ion channels modify the general equilibrium, as shocks w

199 nd opens up an avenue for the development of ion-channel modulators.

200 l members of the differentially up-regulated ion channel module have well-known pathogenetic roles in

201 st the contributions of the mechanosensitive ion channel MscS-like10 (MSL10).

202 eurons that fire action potentials - notably ion channels mutated in the epilepsies - yet data now su

203 in hereditary ataxia, it remains unclear how ion channel mutations lead to loss-of-function or death

204 ult from mutations in several genes encoding ion channels or proteins involved in their regulation.

205 nt has been licensed targeting virus-encoded ion channels, or 'viroporins', contrasting the success o

206 dhesion are mediated by the mechanosensitive ion channel Piezo-1.

207 he mechanically activated, calcium-permeable ion channel Piezo1 in the pancreatic acinar cell is the

208 f-function mutations in the mechanosensitive ion channel PIEZO1 were shown to ameliorate Plasmodium p

209 The ion channels Piezo1 and TRPV4 have both, independently,

210 identify expression of the mechanosensitive ion channel PIEZO2 in lower urinary tract tissues, where

211 Voltage-gated ion channels play important roles in physiological proce

212 The TRPV1 cation nonselective ion channel plays an essential role in thermosensation a

213 ective member of the pentameric ligand-gated ion channel (pLGIC) superfamily.

214 Pentameric ligand-gated ion channels (pLGICs) are allosteric receptors that medi

215 tion relationship of pentameric ligand-gated ion channels (pLGICs).

216 are anion-permeable pentameric ligand-gated ion channels (pLGICs).

217 ion in the cavity located above the putative ion channel pore, for site-specific conjugation with a p

218 Thus, even highly temperature-sensitive ion channel properties can support temperature-robust ti

219 This site is located on the outside of the ion channel protein at the lipid interface where the cho

220 e extent of deficits in sensory encoding and ion channel protein expression by single mechanosensory

221 Ion channel proteins form water-filled nanoscale pores w

222 ructurally similar to the PAS domains in non-ion channel proteins, where these domains frequently fun

223 ional properties of this important family of ion channel proteins.

224 y the absolute expression levels of specific ion channels provides a counterexample to the widely hel

225 Ca(2+) ([Ca(2+)]) is regulated primarily by ion channels, pumps (ATPases), exchangers and Ca(2+)-bin

226 Antagonists for the ATP-gated ion channel receptor P2X1 have potential as antithrombot

227 tial vanilloid 4 (TRPV4), a mechanosensitive ion channel/receptor, is required for FBGC formation and

228 nto the loops or termini of different GPCRs, ion channels, receptors and transporters without disrupt

229 Our findings uncover a role of DAGK in ion channel regulation.

230 g the actual set of parameters of biological ion channels remains a formidable theoretical challenge.

231 biquitously expressed Orai1 calcium (Ca(2+)) ion channels represents the activation of the Ca(2+)-sen

232 Despite this crucial role, the ion channels responsible for alpha1-A(R)-mediated depola

233 ory cell types, genes encoding voltage-gated ion channels responsible for depolarizing and repolarizi

234 protein transferases (zDHHC) in controlling ion channel S-acylation, the acyl protein thioesterases

235 Neurotransmitter receptors and ion channels shape the biophysical properties of neurons

236 At least 5 ion channels show a circadian expression pattern in the

237 ire of programs, including those involved in ion channel signaling, development, extracellular matrix

238 achieved via a vast combination of different ion channels.SIGNIFICANCE STATEMENT Although essential r

239 al function and monolayers' response to hERG ion channel specific blocker was Torsades de Pointes (Td

240 Ion channel structure is evolutionary conserved between

241 Orai1 is a critical ion channel subunit, best recognized as a mediator of st

242 rval chemotaxis toward host serum, and these ion channel subunits partially rescue sensory defects in

243 annels (VGCCs) and postsynaptic ligand-gated ion channels such as AMPA receptors (AMPARs) are organiz

244 fication of new families of mechanosensitive ion channels-such as PIEZO and OSCA/TMEM63 channels-alon

245 channel Hv1 is a member of the voltage-gated ion channel superfamily, which stands out in design: It

246 Ubiquitination limits ion channel surface density, but targeting this pathway

247 type 3 receptor (5-HT(3)) is a ligand-gated ion channel that converts the binding of the neurotransm

248 ently characterized mechanosensor Piezo2, an ion channel that endows cells with sensitivity to gentle

249 P2X7 is an ATP-gated membrane ion channel that is expressed by multiple cell types.

250 stress inhibits Na(+)/K(+)-ATPase (NKA), the ion channel that maintains membrane potential.

251 mitochondrial calcium uniporter (MCU) is the ion channel that mediates Ca(2+) uptake in mitochondria.

252 che et al. (2020) describe TACAN, a putative ion channel that mediates mechanical pain in mice.

253 N-methyl-d-aspartate receptor (NMDAR) is an ion channel that mediates the slow, Ca(2+)-permeable com

254 Piezos are ion channels that are activated by mechanical force.

255 emoreceptor complements and lineage-specific ion channels that are predicted to operate downstream of

256 lloid 4 (TRPV4) is one of the few identified ion channels that can directly cause inherited neurodege

257 In this review, we focus on the beta-cell ion channels that control Ca(2+) handling and how they i

258 PIEZO2 are newly identified mechanosensitive ion channels that exhibit a preference for calcium in re

259 ansmembrane domains of these closely related ion channels that may help explain some of their distinc

260 otropic glutamate receptors are ligand-gated ion channels that mediate excitatory synaptic transmissi

261 NMDA receptors (NMDARs) are glutamate-gated ion channels that mediate fast excitatory synaptic trans

262 -HT(3) receptors are pentameric ligand-gated ion channels that regulate synaptic activity in the cent

263 The ion channels that regulate the circadian pattern of SCN

264 he functional expression of disparate mutant ion channels that underlie long QT syndrome (LQT) and cy

265 stitutions do not affect the function of the ion channel, the full Neanderthal variant carrying all t

266 One such ligand-gated ion channel, the NMDAR, impacts nearly all forms of nerv

267 ither N-TRTX-Preg1a nor N-BUTX-Ptr1a affects ion channels, the known targets of their toxin scaffolds

268 nalogues range from selective for a specific ion channel to broadly modulating cardiac ion channels f

269 interact with the microbial environment and ion channels to generate rhythmic contractions.

270 e (PIP(2)) regulates the activity of diverse ion channels to include the epithelial Na(+) channel ENa

271 e show that ion selectivity of the lysosomal ion channel TPC2, which is hotly debated (Calcraft et al

272 corrects diverse diseases caused by impaired ion channel trafficking, but also introduces a new tool

273 s associated with selective dysregulation of ion channel transcripts and altered Purkinje neuron spik

274 en ATXN1 and Cic rescued the levels of these ion channel transcripts, and lentiviral overexpression o

275 Mechanosensitive ion channels transduce physical force into electrochemic

276 PC 18:1 contributes to the activation of the ion channels transient receptor potential vanilloid 1 an

277 The transient receptor potential ion channel TRPA1 is expressed by primary afferent nerve

278 Activation of mechanosensitive ion channels underlies a variety of fundamental physiolo

279 As various mechanisms for modulating ion-channels underlying DAPs exist, our results suggest

280 VGCCs occupy a special position among ion channels, uniquely able to translate membrane excita

281 on flux through human intracellular chloride ion channels using live-cell based techniques, such as p

282 e (FXS), yet the dysfunction of a particular ion channel varies with cell type.

283 affected as well, particularly voltage-gated ion channels (VGICs).

284 otein-coupled receptor, and activation of an ion channel voltage-sensor domain, unraveling features c

285 Recently, a schistosome ion channel was discovered that is activated by PZQ and

286 N3), a recently identified stretch-sensitive ion channel, was present at the vagus afferent nerve end

287 targeting extracellular sequences of cardiac ion channels were detected.

288 the gene encoding TRPM3, a calcium permeable ion channel, were identified as the cause of DEE in eigh

289 orces are detected by mechanically activated ion channels, which constitute the basis for hearing, to

290 and the expression of distinct receptors and ion channels, which together define their transcriptiona

291 or-neighbor activation of energy-dissipating ion channels, while hydrogen peroxide distributes oxidat

292 such mechanisms and we apply it to the HCN4 ion channel, whose cAMP-binding domain is an archetypal

293 Channelrhodopsins are light-gated ion channels widely used to control neuronal firing with

294 chanism of activation and inhibition of this ion channel will be critical to an improved understandin

295 G targeting epitopes from all known cardiac ion channels with extracellular domains.

296 NMDA receptors are excitatory ion channels with fundamental roles in synaptic transmis

297 its realization involves the integration of ion channels with newly designed gating properties into

298 Through a screen to uncover ion channels with roles in circadian rhythms, we have id

299 ts against trypanosome infections by forming ion channels within the parasite, causing lysis.

300 ized because heterologous expression of this ion channel yields only very low levels of functional ac