ライフサイエンスコーパス: ion permeation

1 ate the molecular determinants of gating and ion permeation.

2 dynamics, and electrostatics calculations of ion permeation.

3 an important role in channel activation and ion permeation.

4 h stabilizes a hydrated K(+) and facilitates ion permeation.

5 id interface and allosterically modulate the ion permeation.

6 nnels vary significantly among their rate of ion permeation.

7 ntribution of individual charged residues to ion permeation.

8 arallels to membranes deformed by unassisted ion permeation.

9 and points to a role of the internal pore in ion permeation.

10 ergetics and electrostatics control membrane ion permeation.

11 of ligand-gating, allosteric modulation and ion permeation.

12 whether a mutation alters the energetics of ion permeation.

13 e charge and solvent philicity could enhance ion permeation.

14 ossibly be a temporary reservoir involved in ion permeation.

15 in channel gating in addition to its role in ion permeation.

16 cavity of the pore domain, directly blocking ion permeation.

17 also be generated in more detailed models of ion permeation.

18 e central hydrated cavity, a crucial step in ion permeation.

19 the microscopic details of the mechanism of ion permeation.

20 uggesting that these residues have a role in ion permeation.

21 imer assembly, in addition to any effects on ion permeation.

22 pore loop are crucial for pore structure and ion permeation.

23 and pose intriguing mechanistic questions of ion permeation.

24 egatively charged residues in the process of ion permeation.

25 and reversal potential consistent with mixed ion permeation.

26 nel pore formed by the pore domains mediates ion permeation.

27 undamental questions about the mechanisms of ion permeation.

28 persistent activation, dynamically altering ion permeation.

29 rbide (MXene) membranes and impact selective ion permeation.

30 , atomistic mechanisms of this sophisticated ion permeation.

31 nt and susceptible to inactivation by copper ion permeation.

32 cyclic nucleotide-dependent modulation, and ion permeation.

33 the selectivity filter where it would impede ion permeation.

34 lf-diffusion coefficients and more effective ion permeation.

35 ir hydrophobic tails in the cavity to impede ion permeation.

36 n active conformation of the pore yet blocks ion permeation.

37 nnel pore, where bound drug directly impedes ion permeation.

38 hydrophobic gating mechanism for control of ion permeation.

39 ations, reduced K(+) affinity, and increased ion permeation.

40 states, consistent with its explicit role in ion permeation.

41 e molecular mechanisms of channel gating and ion permeation.

42 osolic G loop) may serve as gates to control ion permeation.

43 isms of channel gating, desensitization, and ion permeation.

44 esize that membrane interactions also affect ion permeation.

45 onductance; thus, the TARP C-tail influences ion permeation.

46 -helices is a key determinant of the rate of ion permeation.

47 a single gate into a position that occludes ion permeation.

48 y filter are critical for pain behaviour and ion permeation.

49 inhibited CRAC channel activity by blocking ion permeation.

50 ty to modulate RyR1 gating without affecting ion permeation.

51 es) into a position that physically occludes ion permeation.

52 scanning to map the paracellular pathway of ion permeation across claudin-2-transfected Madin-Darby

53 c acid, significantly decreased paracellular ion permeation across I66C-transfected cells by a mechan

54 Understanding the mechanism of ion permeation across lipid bilayers is key to controlli

55 m and hydrazinium, consequently facilitating ion permeation across the NaChBac-like filter.

56 However, the relationship between ion permeation and animals' nocifensive behaviour is unk

57 rchitecture explains the crucial features of ion permeation and blockade, and gives some strong hints

58 ring models of the channel in the context of ion permeation and blocking agents.

59 sidue determines single-channel conductance, ion permeation and channel block in the NMDA receptor, t

60 These domains determine ion permeation and channel block processes and are exten

61 ses), revealing intriguing interplay between ion permeation and channel gating.

62 -wide oscillation caused by coupling between ion permeation and channel gating.

63 ning ligand recognition, heteromer assembly, ion permeation and desensitization in this prototypical

64 membrane channels both for basic studies of ion permeation and for applications in biotechnology.

65 e fundamental implications for understanding ion permeation and gating in P2X receptor channels, as w

66 We studied ion permeation and gating of an inwardly rectifying K+ c

67 ntributed profoundly to our understanding of ion permeation and gating, it remains unclear how much t

68 may stem from the closed interaction between ion permeation and gating.

69 uch a wide inner pore may greatly facilitate ion permeation and high-affinity binding of multiple por

70 The structural basis for ion permeation and ion channel block also remain areas o

71 these results and describe the energetics of ion permeation and ionic fluxes, continuum approaches (P

72 ng further support for separate pathways for ion permeation and lipid scrambling.

73 arge distribution of the channel that govern ion permeation and selectivity in OmpF.

74 ies that have increased our understanding of ion permeation and selectivity mechanisms.

75 We explored the contribution to ion permeation and selectivity of residues in the TM2 se

76 The ion permeation and selectivity properties of these nanop

77 nal DE motif that has a critical role in RyR ion permeation and selectivity.

78 asparagine and glutamine profoundly affected ion permeation and selectivity.

79 specific mechanisms of receptor activation, ion permeation and signal transduction, and maternal car

80 erpinnings of stimulus detection and gating, ion permeation, and allosteric mechanisms governing sign

81 els that underlie ligand binding, gating, or ion permeation, and have thus served as invaluable tools

82 domain, thereby determining channel gating, ion permeation, and single-channel conductance; (2) enab

83 the mechanisms of receptor desensitization, ion permeation, and structural basis of camlipixant bind

84 but transport models to accurately simulate ion permeation are currently lacking.

85 ior (gating kinetics, modal transitions, and ion permeation) are interrelated and are modulated by th

86 that quantitatively relates the spontaneous ion permeation at equilibrium to the stationary ionic fl

87 c binding mode, bound 4-AP prevents not only ion permeation but also water flow.

88 racts lipid molecules, which probably causes ion permeation, but no molecular leakage.

89 Light-gated ion permeation by channelrhodopsin-2 (ChR2) relies on th

90 ing medium is incorporated into the model of ion permeation by including the free energy of inserting

91 with creation of an electrostatic barrier to ion permeation by lidocaine's charge.

92 + channel subunits mediate rapid blockade of ion permeation by physical occlusion of the ion-conducti

93 e unmask coupling between channel gating and ion permeation by structural perturbation of a conserved

94 lectrophysiological experiments showing that ion permeation can be resumed in the kv1.2-kv2.1-3m chan

95 Q747A) predicted to increase the size of its ion permeation cavity enhanced the sensor response and a

96 Ion permeation-changing mutations along the length of TM

97 87 A resolution as a basis for understanding ion permeation, channel activation, the location of volt

98 (+) dynamics reveals a knock-on mechanism of ion permeation characterized by alternating occupancy of

99 segments are drawn tightly together to block ion permeation completely.

100 icated that the mutation selectively impacts ion permeation coupled to 5HT occupancy.

101 eration and migration through both canonical ion permeation-dependent and noncanonical ion permeation

102 The extent of pore formation and ion permeation depends on the insertion depth of hydroph

103 rporating intra- and extracellular geometry, ion permeation, diffusion, extrusion, and buffering sugg

104 (1) Presently, we consider ion permeation energetics in the gramicidin A channel us

105 g the OF to IF transitions and the favorable ion permeation energetics provides breast cancer cells w

106 te makes it feasible to simulate entire K(+) ion permeation events driven by a voltage bias and, ther

107 ry between S2 and S3 in the context of multi-ion permeation events.

108 t the GYG motif is a critical determinant of ion permeation for HCN channels, and that HCN1 and HCN2

109 the potential of mean force (PMF) governing ion permeation from molecular dynamics simulations (MD)

110 ate dependence, suggesting the absence of an ion permeation gate at the cytosolic side of BK channel.

111 cal conditions, although their mechanisms of ion permeation gating are not well understood.

112 cal conditions, although their mechanisms of ion permeation gating are not well understood.

113 ew framework for understanding mechanisms of ion permeation, gating and channelopathy of cyclic-nucle

114 Whether ion channel gating is independent of ion permeation has been an enduring, unresolved question

115 RPV6 channels open and close their pores for ion permeation has remained unclear.

116 new insight into the mechanism of selective ion permeation in bacterial Na(v) channels.

117 Understanding the mechanisms of gating and ion permeation in biological channels and receptors has

118 Here, we show that ion permeation in CNG channels is tightly regulated at t

119 ism to lower the free energy barrier for the ion permeation in disagreement with predictions from the

120 arge-ring amino acids affects gating but not ion permeation in HCN2 and CNG channels.

121 y simulation studies on the understanding of ion permeation in selective and nonselective ion channel

122 to involve two gates that appear to prevent ion permeation in the absence of activators: the ion sel

123 of the Abeta42 oligomer models to facilitate ion permeation in the bilayer center.

124 In this study, we investigate ion permeation in the context of multiple Ca(2+) binding

125 lations capture the essential nature of K(+) ion permeation in the KcsA channel and provide a proof-o

126 and CRAC the general property of monovalent ion permeation in the nominal absence of extracellular d

127 o study and compare monovalent (Na(+), K(+)) ion permeation in the open-activated TRP vanniloid-1 (TR

128 ide a framework for understanding gating and ion permeation in this superfamily.

129 rts of the subunits involved in ATP binding, ion permeation (including calcium permeability), and mem

130 ctions modulate two restrictions controlling ion permeation, including widening of the selectivity fi

131 al ion permeation-dependent and noncanonical ion permeation-independent functions.

132 Ion permeation involving TRPC5 is crucial because S1P-ev

133 eory indicated that the major barrier to Cl- ion permeation is at the intracellular side of the membr

134 Modulation of ion permeation is crucial for the physiological function

135 In this regime, ion permeation is found to be thermally activated with e

136 Ion permeation is influenced by the orientation of the s

137 As in standard PNP, ion permeation is modeled as a continuum drift-diffusion

138 nt implications for our understanding of how ion permeation may be controlled in similar ion channels

139 lectrophysiology studies, the details of the ion permeation mechanism have remained elusive.

140 The ion permeation mechanism in the transient receptor poten

141 g in fluid anisotropic media and details the ion permeation mechanism on atomic level.

142 barriers associated with the different multi-ion permeation mechanisms.

143 rophysiology on cloned channels to elucidate ion permeation mechanisms.

144 Here, we characterized their ion permeation, membrane interactions, and ligand bindin

145 work, we employed a simulation strategy for ion permeation (molecular-dynamics simulations with bias

146 d the location of two binding sites for K(+) ion permeation near the channel entrance--i.e., an inner

147 We found that pore formation and ion permeation occur via edge conductivity and exclusive

148 important implications for understanding how ion permeation occurs, and further how it may be control

149 opening of Slo2.1 or Slo2.2, suggesting that ion permeation of Slo2 channels is not predominantly gat

150 Here we explore ion permeation on multimicrosecond timescales using the

151 To understand ion permeation, one must assign correct ionization state

152 ieved through both direct obstruction of the ion permeation path and induced rotation of an invariant

153 reveals that opening the KCC1 extracellular ion permeation path does not involve hinge-bending motio

154 n with amiodarone and directly obstructs the ion permeation path.

155 )-ATPases (CopA) and deliver copper into the ion permeation path.

156 late about their mechanistic consequences on ion permeation, pathological mutations, as well as funct

157 The reentrant loop lines the lower ion permeation pathway and buttresses the 'Gly-Ala-Ser'

158 nner pore-forming domain, which contains the ion permeation pathway and elements of its gates, togeth

159 The PD contains the ion permeation pathway and the activation gate located o

160 l is thought to decay nonlinearly across the ion permeation pathway because of the irregular three-di

161 ivation particle, which is stabilized in the ion permeation pathway by the N(153)VHNL(157) residues.

162 s (VSDs), one from each subunit, control one ion permeation pathway formed by four pore domains.

163 ve recently been shown to define part of the ion permeation pathway in several closely related member

164 ng inner helix, creating an hourglass-shaped ion permeation pathway in the channel tetramer.

165 ure of the C1C2 chimera demonstrate that the ion permeation pathway includes residues on one face of

166 The PKD2 ion permeation pathway is constricted at the selectivity

167 cation of these mutations indicates that the ion permeation pathway lies between the core and gate ri

168 reveals similar constrictions in the central ion permeation pathway near the intracellular end of the

169 The ion permeation pathway of ASIC1a is defined by residues

170 microscopy structure of chicken Slo2.2, the ion permeation pathway of the channel is closed by a con

171 that ouabain is trapped within the external ion permeation pathway of the pump.

172 oscopy structure of Slo2.2 suggests that the ion permeation pathway of these channels is closed by a

173 t 1 (TM1) is involved in forming part of the ion permeation pathway, and a missense mutation S427L in

174 t lipids within the central pore lumen block ion permeation pathway, and their departure driven by la

175 potassium channels, a main component of the ion permeation pathway, configures a stack of binding si

176 ng an amino-acid residue thought to line the ion permeation pathway, identifying a region that govern

177 Analysis of the ion permeation pathway, in the case of a highly conducti

178 se chemical structures, and we delineate the ion permeation pathway, including the contribution of li

179 esence of a cytoplasmic cap over the central ion permeation pathway, leaving lateral fenestrations th

180 Along the ion permeation pathway, three relatively narrow regions

181 cGMP, and the tetrameric central pore is the ion permeation pathway.

182 s a homodimer, and each protomer contains an ion permeation pathway.

183 to form the entrance into the substrate and ion permeation pathway.

184 her spermine occludes the channel within the ion permeation pathway.

185 e domains of each subunit contributes to the ion permeation pathway.

186 ransporter is intimately associated with the ion permeation pathway.

187 distinct sites in the pore and occluding the ion permeation pathway.

188 inding sites, lead us to propose a plausible ion permeation pathway.

189 of the transmembrane helix S6 region of the ion permeation pathway.

190 s with the transmembrane helices to form the ion permeation pathway.

191 al N-terminal structure (ball) occluding the ion permeation pathway.

192 TTX occludes the ion-permeation pathway at the outer vestibule of the cha

193 rdly rectifying K (Kir) channels control the ion-permeation pathway through diverse interactions with

194 permeant ions via their binding sites in the ion-permeation pathway.

195 tivity filter within the external end of the ion-permeation pathway.

196 gh-affinity ATP analogues, suggesting intact ion permeation pathways and nucleotide binding domains (

197 its outward configuration with two potential ion permeation pathways exposed to the extracellular env

198 sient receptor potential (TRP) channels, the ion-permeation pathways have been proposed to dilate in

199 n the absence of PIP(2) show the cytoplasmic ion-permeation pathways occluded by four cytoplasmic loo

200 c-nucleotide binding site on these channels, ion permeation, pharmacological blockers, channel gating

201 These structures reveal the ion permeation pore and represent different functional s

202 indicated that the intracellular side of the ion permeation pore may be occupied by anions like ATP,

203 suggesting that all 3 TRPs contribute to the ion permeation pore of the channels.

204 a groove harboring a lipid trail outside the ion permeation pore.

205 he beam acts as a cytosolic plug that limits ion permeation possibly by clogging the inner vestibule

206 e mechanisms of receptor desensitization and ion permeation, principles of antagonism, and complete s

207 ctric (continuum lipid), we found reasonable ion permeation profiles; cations bind and permeate, wher

208 a focus on their subcellular localizations, ion permeation properties, gating mechanisms, cell biolo

209 h impedes detailed study of their gating and ion permeation properties.

210 eras between mPiezo1 and dPiezo to show that ion-permeation properties are conferred by C-terminal re

211 res as the dominant mechanism of uncatalyzed ion permeation, providing new understanding for the acti

212 mbrane Q(5%)-PEI(1.0)@ZIF#CEM shows that the ion permeation rates follow the order of K(+) ~ Li(+) >

213 of ion channels, including the mechanisms of ion permeation, selectivity, and gating.

214 pid-embedded alpha7-receptor structures with ion-permeation simulations.

215 y the introduction of two main mechanisms of ion permeation: soft and direct knock-on.

216 ium channels showed a sharp size cut-off for ion permeation, such that no ion possessing a methyl gro

217 actors give rise to energetic constraints on ion permeation that have important functional consequenc

218 To begin to understand ion permeation, the potential of mean force (PMF) was ca

219 We show that water and ion permeation through 1T' MoS(2) membranes follows a pH

220 illustrated using two biophysical examples: ion permeation through a phospholipid membrane and prote

221 ive molecular dynamics simulations, to study ion permeation through a potassium channel MthK, for var

222 A recent model of ion permeation through a single, open RyR channel is use

223 lter and supports a 'knock-off' mechanism of ion permeation through a stepwise-binding process.

224 ading to the opening of a gate that controls ion permeation through an integral transmembrane pore.

225 channels achieve highly selective and rapid ion permeation through an open pore, by restricting the

226 he context of electrostatics calculations of ion permeation through channels, and the effect of the l

227 ite and that alphaSer-583 may have a role in ion permeation through ENaC.

228 arizes the postsynaptic afferent by altering ion permeation through hyperpolarization-activated cycli

229 olarized the postsynaptic neuron by altering ion permeation through hyperpolarization-activated cycli

230 Our understanding of ion permeation through K(+) channels, and by extension t

231 tions are perhaps most obvious in studies of ion permeation through membrane channels.

232 racterized scorpion toxin Agitoxin2 inhibits ion permeation through Shaker K+ channels by binding to

233 and compared to refine our understanding of ion permeation through the channel formed by OmpF porin

234 However, the structural determinants of Cl- ion permeation through the channel pore are not known.

235 ies confirm that these changes inhibit rapid ion permeation through the channel.

236 Ion permeation through the extracellular vestibule and t

237 sed to compute current-voltage relations for ion permeation through the gramicidin A ion channel embe

238 Ion permeation through the gramicidin channel is studied

239 aluminal loop contribute to determination of ion permeation through the intracellular Ca(2+) release

240 dius of about 3-4 A is sufficient to prevent ion permeation through the pore.

241 that Piezo1 conformational changes, but not ion permeation through them, are required for modulating

242 lished and molecular dynamics simulations of ion permeation through these channels are consistent wit

243 perhaps also ring size and are important for ion permeation through these channels.

244 M2 "pore", Brownian dynamics simulations of ion permeation through this putative conducting open sta

245 Ion permeation through voltage-gated sodium channels is

246 powerful and general approaches to study of ion permeation through wide molecular pores.

247 However, the molecular mechanism of K(+) ions permeation through potassium channels remains uncle

248 els in the absence of ATP, or 2) coupling of ion permeation to gating, for which there is currently n

249 oscopy (EIS) that directly probes changes in ion permeation upon chlorination at different pH values,

250 lored the mechanisms of uncatalyzed membrane ion permeation using atomistic simulations and electroph

251 th negatively charged amino acids facing the ion permeation vestibule of the channel in question.

252 Inhibition of TRPC5 ion permeation was achieved by conditional transgenic ex

253 For these mutants, ion permeation was not a function of the diameter of the

254 the pore-lining helix in channel gating and ion permeation was probed by replacing them with amino a

255 olding, hydrogen bonding, ion solvation, and ion permeation, we replaced the peptide bond between Val

256 the peptide backbone and Trp side chains for ion permeation, we undertook an investigation of the two

257 will form an energetic barrier to water and ion permeation without steric occlusion of the pore.