ライフサイエンスコーパス: ionone

1 ntified a set of antagonists, including beta-ionone.

2 no impact on other terpene alcohols or beta-ionone.

3 hibitor corallidictyal D starting from alpha-ionone.

4 DA): beta-damascenone, beta-ionone and alpha-ionone.

5 amine receptors, and the opsin agonist, beta-ionone.

6 O2), converts xanthophylls to rosafluene and ionones.

7 to verify the model: 1-phenylethanol, alpha-ionone, 3-methyl-1-indanone, o-(chloromethyl)phenyl sulf

8 latiles with multiple oxidation sites, i.e., ionone (4 oxidation sites), from the phytovolatile libra

9 beta-ionone, 4-oxoisophorone and dihydroactinidiolide were fo

10 analysis showed a > or =50% decrease in beta-ionone (a beta-carotene-derived C13 cyclohexone) and a >

11 (alpha-ionone, beta-ionone, and dehydro-beta-ionone), a class of compounds whose reactivities with Cl

12 the 9,10 (9',10') bonds and generating beta-ionone, although beta-cyclocitral resulting from a 7,8 (

13 , as well as the noncovalent binding of beta-ionone, an antagonist for G protein activation.

14 ation and minor quantities of 5,6-epoxy-beta-ionone and 5,6-epoxy-4-oxo-beta-apo-11-carotenal, no oth

15 ilution assay (SIDA): beta-damascenone, beta-ionone and alpha-ionone.

16 f carotenoids at the 9'-10' bond to yield an ionone and an apo-10'-carotenoid.

17 (E)-B-ionone and B-ocimene, which are important compounds in p

18 ninfected controls, and generated trans-beta-ionone and beta-cyclocitral, which were attributed to ca

19 e of ripening, whereas the changes for alpha-ionone and beta-ionone were not obvious.

20 (E)-beta-ionone and beta-ocimene, which are important compounds i

21 d with extremely high concentrations of beta-ionone and binding did not alter the structure of rhodop

22 ols, volatile phenols and pantolactone; beta-ionone and herbaceous nuances were in higher proportions

23 atrices OTs varied by factors of 2 for alpha-ionone and up to 23000 for ethyl 2-methylbutanoate.

24 ecificity and converted carotenoids into two ionones and a central C14-apocarotendial by oxidative cl

25 ection in both concentration (200 pM of beta-ionone) and in molecular weight of VOCs (100 g/mol for h

26 while diethyl succinate, decanoic acid, beta-ionone, and citronellol concentration were not changed w

27 cturally related alkenes (alpha-ionone, beta-ionone, and dehydro-beta-ionone), a class of compounds w

28 nzyl isothiocyanate, 1-hexen-3-one, (E)-beta-ionone, and methyl benzoate were the most odour-active c

29 quantification of beta-damascenone and beta-ionone, and the crucial influence of ethanol content of

30 rod rhodopsin is also expected to bind beta-ionone at sufficiently high concentrations because the b

31 For alpha-ionone, being most prone for carryover, the three times

32 rincipal Component Analysis showed that beta ionone, benzaldehyde, 6-methyl-5-hepten-2-one, together

33 of three structurally related alkenes (alpha-ionone, beta-ionone, and dehydro-beta-ionone), a class o

34 losteric binding site for retinoid, but beta-ionone binds to the latter type of rhodopsin with low af

35 angle down-apo-beta-carotenal (C27) and beta-ionone (C13).

36 , v/v) and of an apolar mixture made of beta-ionone, (+/-)-citronellal, (+)-limonene, and flavone dis

37 ate, beta-damascone, beta-damascenone, and a-ionone, contributing nutty, sweet floral attributes to t

38 sults indicate that PhCCD1 activity and beta-ionone emission are likely regulated at the level of tra

39 beta-Ionone emission by flowers occurred principally during d

40 nd alpha-terpineol) and norisoprenoids (beta-ionone), especially when the CIS temperature was set at

41 ne, and white wine for three lactones, alpha-ionone, ethyl 2-methylbutanoate, trans-cinnamaldehyde, a

42 ,6-nonadienal, geraniol, phenylethanol, beta-ionone, hotrienol and dihydroactinidiolide to be odour a

43 linalool oxides, (E)-2-hexenal, phytol, beta-ionone, hotrienol, methylpyrazine and methyl salicylate

44 Synthesis of beta-ionone in recombinant Saccharomyces cerevisiae is limite

45 an enzyme responsible for formation of beta-ionone in tomato.

46 ylate cyclase agonist), and conversely, beta-ionone-induced cell death could be blocked by cotreatmen

47 in (a G protein inhibitor) also blocked beta-ionone-induced cell death.

48 biosynthesis of the (+)-enantiomer of alpha-ionone is favoured equally, whichever MJ stereoisomer us

49 Ionone is one of the signature volatiles released by the

50 One such volatile, beta-ionone, is important to fragrance in many flowers, inclu

51 n of isorhodopsin or by incubation with beta-ionone (opsin agonist) killed 19-30% of rod cells.

52 ated that the truncated retinal analog, beta-ionone, partitioned into the membranes of green-sensitiv

53 was an enhanced uptake of four or more beta-ionones per rhodopsin.

54 h native PhCCD1 and further analyzed by beta-ionone quantification via RP-HPLC.

55 sory evaluation in humans revealed that beta-ionone reduced the odor intensity and unpleasantness of

56 ion of (13)C nuclei introduced into the beta-ionone ring (at the C16, C17, and C18 methyl groups) and

57 site and a specific orientation of the beta-ionone ring above the plane of the heme consistent with

58 ion in the dark, and that motion of the beta-ionone ring allows Trp265(6.48) and transmembrane helix

59 ening of the steric restraints near the beta-ionone ring and SB ends of the chromophore, (ii) displac

60 d 7',8' double bonds adjacent to a 3-OH-beta-ionone ring and that the conversion of zeaxanthin to cro

61 rds, indicating that the opening of the beta-ionone ring and the increase of chromophore extension in

62 termine the relative orientation of the beta-ionone ring and the polyene chain of the chromophore 11-

63 etinal C6-C7 single bond connecting the beta-ionone ring and the retinylidene chain is 6-s-cis in bot

64 strong steric interactions between its beta-ionone ring and transmembrane helices H5 and H6, while d

65 The beta-ionone ring can rotate relative to the polyene chain, th

66 these bleaching intermediates shows that the ionone ring cross-links to tryptophan-265 on helix F in

67 l's polyene chain and separation of its beta-ionone ring from Trp-265.

68 ggested that at least one unsubstituted beta-ionone ring half-site was imperative for efficient cleav

69 In particular, we find that the beta-ionone ring has a twisted 6-s-cis conformation, whereas

70 can infer whether or not the pigment's beta-ionone ring has left its binding site.

71 G identified recently encoding the 2,2'-beta-ionone ring hydroxylase that further hydroxylate astaxan

72 ase and the crtZ gene encoding the 3,3'-beta-ionone ring hydroxylase that were responsible for astaxa

73 strain, while torsional twisting of the beta-ionone ring is maintained.

74 Most surprisingly, the beta-ionone ring is mobile within its binding pocket; interac

75 tion to the crtW gene encoding the 4,4'-beta-ionone ring ketolase and the crtZ gene encoding the 3,3'

76 hat represent the polyene chain and the beta-ionone ring of retinal.

77 rise from weakened interaction with the beta-ionone ring of the chromophore following cis-to-trans is

78 on alters the interaction of Trp265 with the ionone ring of the retinal chromophore.

79 e protein at van der Waals distance from the ionone ring of the retinal.

80 In particular, the beta-ionone ring of the retinylidene inverse agonist is cruci

81 The current view that the beta-ionone ring of the rhodopsin chromophore vacates its bin

82 ps of either carbon C(1) or C(5) of the beta-ionone ring or carbon C(9) of the polyene chain.

83 e hydroxyl-bearing amino acids near the beta-ionone ring part of the retinal in opsin, A164S, F261Y,

84 nal; we find that Trp265 moves away from the ionone ring prior to any conformational transition.

85 rization, the (2)H NMR data suggest the beta-ionone ring remains in its hydrophobic binding pocket in

86 ds (Ser164, Tyr261, and Thr269) close to the ionone ring that lower the transition energy by interact

87 efining the relative orientation of the beta-ionone ring to the polyene chain has both modest barrier

88 tic changes along the retinal polyene chain, ionone ring, and within the binding pocket.

89 lices H3 and H5 by the C5-methyl of the beta-ionone ring.

90 l twisting of the polyene chain and the beta-ionone ring.

91 an ordered cholesterol molecule and the beta-ionone ring.

92 tenoids with at least one unsubstituted beta-ionone ring.

93 rms a cap on the pocket occupied by the beta-ionone ring.

94 roxylases attach hydroxyl groups to the beta-ionone rings (beta-rings) of carotenoid substrates, resu

95 bind, as do truncated retinoids in the beta-ionone series.

96 mary melanocytes with the OR51E2 ligand beta-ionone significantly inhibited melanocyte proliferation.

97 Assessing alpha-ionone spiked wines by descriptive analysis, significant

98 Our results further showed that beta-ionone stimulates melanogenesis and dendritogenesis.

99 flavor compounds (2-methyisoborneol and beta-ionone), suggesting a cyanobacterial origin.

100 plants led to a 58% to 76% decrease in beta-ionone synthesis in the corollas of selected petunia lin

101 Ds significantly increases the yield of beta-ionone synthesized by metabolically engineered yeast.

102 crystallography revealed binding of one beta-ionone to bovine green-sensitive rod rhodopsin.

103 Beta-ionone was easily identified by the high-throughput scre

104 was not observed when methanethiol and beta-ionone were introduced simultaneously to different nostr

105 hereas the changes for alpha-ionone and beta-ionone were not obvious.

106 4-Ethyguaiacol and trans-beta-ionone were positive towards aroma, flavor and overall l

107 ethyl-1-hexanol, linalool, a-terpineol and a-ionone were the major ones.

108 hexanol, linalool, alpha-terpineol and alpha-ionone were the major ones.

109 ral nuances (with the only exception of beta-ionone) were in higher proportions.

110 ase of certain odorants (e.g. linalool, beta-ionone), while flavonoids showed the opposite effect, de

111 prouting was significantly increased by beta-ionone with concomitant increases in cAMP, pCREB, and sy

112 Two single-point mutants increased beta-ionone yields almost 3-fold when compared to native PhCC

113 essing peptide-PhCCD1 constructs showed beta-ionone yields up to 4-fold higher than the strain carryi