ライフサイエンスコーパス: iron

1 fety to placebo with less toxicity than oral iron.

2 ease in hepcidin affinity in the presence of iron.

3 rfaces such as silicate radicals and ferrous iron.

4 cy virus (HIV) infection, and elevated serum iron.

5 and a decrease in the coordination number of iron.

6 e in the CSF by outcompeting macrophages for iron.

7 timation was greatest in women with low body iron.

8 ch could be rescued by chemical chelation of iron.

9 oxide and pyrite sinks for Neoarchean marine iron.

10 ern II early active lesions contain 64% more iron (95% confidence interval [CI] = 17-127%, p = 0.004)

11 Hepcidin regulates iron absorption and recycling by inducing the internaliz

12 d in the acquisition, storage, and efflux of iron accordingly.

13 Localized iron accumulation and callose deposition in the root elo

14 ; as well as to elucidate genes required for iron acquisition and a functional type 9 secretion syste

15 ion scales originated from Cr(0) in the cast iron alloy.

16 rystallization caused formation of nanophase iron along the surface, which was revealed by mapping of

17 l positively correlating with soil clay, and iron and aluminum oxide and hydroxide content.

18 uperstoichiometric concentrations of ferrous iron and anthrahydroquinone disulfonate within a pH rang

19 While some metals such as iron and copper are essential for cellular functions, ot

20 We measured iron and ferritin levels in the bronchoalveolar lavage f

21 cess requires the acquisition of nutritional iron and heme from the host as Leishmania lacks the capa

22 not reveal any significant correlation with iron and lipid parameters including neutral and polar li

23 bacterium Synechococcus that flourishes when iron and nitrogen resupply to surface waters are diminis

24 inear positive feedbacks within the internal iron and sulfur cycling of the ocean.

25 lly and astrobiologically important elements iron and sulfur.

26 However, the origin of low-oxidation-state iron and the pathways responsible for its formation and

27 ke MBDs, YecA and YchJ, also copurified with iron, and NMR spectroscopy experiments indicated that Ye

28 cteria in root nodules has a high demand for iron, and questions remain regarding which transporters

29 through a series of growth experiments under iron- and cobalt-limiting conditions.

30 Iron- and nitrogen-doped carbon (Fe-N-C) materials are l

31 ted hsCRP and ESR with low serum albumin and iron], and serum interleukin (IL) 1beta were positively

32 Whether the amount and distribution of iron are similar or different among different MS immunop

33 ng tunneling microscopy images of a Co-doped iron arsenide superconductor and prove that the applicat

34 Correct metalation of proteins requiring iron as a cofactor demands that such a readily accessibl

35 Accessibility of iron at the phagosomal surface inside macrophage is cruc

36 The iron atoms substitute molybdenum sites in MoS(2) crystal

37 in deficiency, other factors such as reduced iron availability contribute to the pathobiology.

38 mothers, which is thought to ensure adequate iron availability for transfer across placenta.

39 Additionally, restraining iron availability in vitro severely inhibited CD4 T cell

40 ndrial respiration by limiting intracellular iron availability through an oxidant-based mechanism.

41 ervoir to modulate lipid, catecholamine, and iron availability.

42 of Fe(III) phases is a key process in making iron available to biota and in the mobilization of assoc

43 rystallization in this spark plasma sintered iron based metallic glass was established to be from pre

44 The nematic phase in iron based superconductors (IBSs) has attracted attentio

45 l boronic esters using a rationally designed iron-based catalyst supported by beta-diketiminate ligan

46 tic amounts of an appropriate earth-abundant iron-based complex, a base and a boryl compound, promote

47 ltaneous carbonization and sulfidation of an iron-based metal-organic framework (MOF) yielded well-di

48 ucomannan, together with simple-to-fabricate iron-based metal-organic framework-derived photothermal

49 epcidin binding to ferroportin is coupled to iron binding, with an 80-fold increase in hepcidin affin

50 ion between M6A, an intrinsically disordered iron-binding domain, and an iron oxide particle was visu

51 Iron bioavailability was determined using an in vitro si

52 Changing ocean chemistries will alter the iron bioavailability when a decrease in pH shifts elemen

53 for our understanding of basic mechanisms of iron biology but also for the development of new pharmac

54 glycolato)diborane (B(2)neop(2)) mediated by iron-bis amide is described.

55 evation in the tissue, increases pro-oxidant iron burden in AD.

56 ally important Staphylococcus aureus obtains iron by extracting heme from hemoglobin (Hb) using the c

57 omyces cerevisiae) responds to low cytosolic iron by up-regulating the expression of iron import gene

58 omplex, where CO is photolyzed from the heme iron by X-rays at cryogenic temperatures (100 K).

59 Herein, studying the iron-catalyzed hydromagnesiation of styrene derivatives

60 Herein, we report an iron-catalyzed, convenient, and expedient strategy for t

61 Iron-chalcogenide superconductors have emerged as a prom

62 native receptor and BBB transporter for the iron chaperone transferrin.

63 unctional protein that serves as a cytosolic iron chaperone, binding and transferring iron to recipie

64 Hemolysis and iron overload improved upon iron chelation with full correction of anemia in CEP mic

65 Both iron chelators and LXR agonists improve the response of

66 talyzed by a biologically unique hexanuclear iron cofactor denoted the H-cluster.

67 hyde and phenol in the presence of molecular iron complexes in solution.

68 cades have seen an impressive development of iron complexes involving organophosphorus ligands applie

69 Therefore, in this study, the copper and iron complexes of COTI-2 were synthesized and evaluated

70 erize the developmental trajectory of tissue iron concentration across the basal ganglia during adole

71 tends into the mid-twenties, with diminished iron concentration associated with poorer cognitive abil

72 ve developmental trajectory of basal ganglia iron concentration during adolescence and its associatio

73 However, the normative development of brain iron concentration in adolescence and its relationship t

74 lity is increasingly associated with greater iron concentration through late adolescence and young-ad

75 cterial iron content depends on the external iron concentration, and reaches a maximum value of ~10(-

76 nation, providing clear evidence of a copper-iron connection in CZ-induced neurotoxicity.

77 A leading postulate is that the iron-containing active sites exist primarily in a pyridi

78 lts showed that lung IR increased the tissue iron content and lipid peroxidation accumulation, along

79 Bacterial iron content depends on the external iron concentration,

80 escence and provide evidence that diminished iron content is associated with poorer cognitive perform

81 eat genotypes characterized for the zinc and iron content, the most important micronutrients.

82 latency or by decreasing oxidative stress or iron content.

83 of, and variability in, their intracellular iron content.

84 The active site consists of a mononuclear iron coordinated by two Tyr side-chain phenolates and on

85 ch was to quantify essential trace elements (iron, copper, zinc and iodine) and establish their speci

86 gated mechanisms of Cr(VI) release from cast iron corrosion scales.

87 s but also provide catechol moieties for the iron cross-linkages.

88 Here, we present an iron-crosslinked rosmarinic liposome (Rososome) which ca

89 syngeneic mouse model of breast cancer, the iron-crosslinked Rososomes exhibit better anticancer eff

90 affected the embryo, causing anemia, tissue iron deficiency (including in the brain), and decreased

91 Iron deficiency anaemia (IDA) is a common nutritional di

92 uction is the major driver of anemia in CKD, iron deficiency stands out among the mechanisms contribu

93 entation must be prescribed to avoid chronic iron deficiency.

94 preserve placental iron in the face of fetal iron deficiency.

95 8, 245 patients aged 18 years and older with iron-deficiency anemia (hemoglobin level <=11 g/dL; seru

96 In 2 randomized trials of patients with iron-deficiency anemia who were intolerant of or unrespo

97 S2 genes were upregulated in leucaena under iron-deficiency condition or when Fe(III) was supplied a

98 ls have been linked to impaired cognition in iron deficient children and adults with neurodegenerativ

99 Although PCBP1-deleted livers were iron deficient, dietary iron supplementation did not pre

100 onditions in host macrophages to support the iron demands of the pathogen.

101 Mechanistically, neutrophils induce iron-dependent accumulation of lipid peroxides within tu

102 Ferroptosis is an iron-dependent form of nonapoptotic cell death associate

103 -mediated oxidative stress, bacteria utilize iron-dependent global regulators to sense the iron statu

104 aturated fatty acyl tails are oxidized in an iron-dependent manner.

105 emoglobin allowed Spn to resume growth in an iron-deplete medium.

106 tion-adjusted Mueller-Hinton broth (BMD) and iron-depleted cation-adjusted Mueller-Hinton broth (ID-B

107 mmune activation, suggesting that sensing of iron depletion is a mechanism by which plants recognize

108 Iron deposition and polymicrogyria were found in a subse

109 Despite chelation therapy, diffuse iron deposition was occurring in multiple organs, marked

110 Iron deposits were typically micron sized and consisted

111 opsis thaliana and the root microbiota under iron deprivation that is dependent on the secretion of p

112 In the largest study of tissue iron development yet reported, we characterize the devel

113 donovani promastigotes and amastigotes, and iron did not play a significant role in their activation

114 Here, we evaluate the impact of high-iron diets or depletion of Gpx4, an antioxidant enzyme r

115 We find that either high-iron diets or Gpx4 depletion promotes 8-OHG release and

116 Iron disorders are associated with adverse pregnancy out

117 In adults, oral iron doses increase plasma hepcidin (PHep) for 24 h, but

118 Use of iron during chemotherapy was significantly associated wi

119 ed anorexia; and redefinition of the role of iron during infection.

120 ces demonstrate that FGF23 is also linked to iron economy, inflammation and erythropoiesis.

121 is why we studied the molecular features of iron effect and Deferasirox therapy on PI-PLCbeta1 inosi

122 Air cathode Assisted Iron Electrocoagulation (ACAIE) overcomes this limitatio

123 processing could contribute to the neuronal iron elevation and oxidative burden that feature in AD p

124 ocessing of APP, combined with age-dependent iron elevation in the tissue, increases pro-oxidant iron

125 suggest a prolonged period of basal ganglia iron enrichment that extends into the mid-twenties, with

126 re expand the documented constellation of di-iron enzyme catalysis to include a dioxygenase reactivit

127 ow levels of liver iron, reduced activity of iron enzymes, and misregulation of the cell-autonomous i

128 nds that such a readily accessible source of iron exist, but overaccumulation results in an oxidative

129 XRF) mapping brings to light the presence of iron (Fe) and lead (Pb) compounds in the majority of the

130 Phytoplankton are limited by iron (Fe) in ~40% of the world's oceans including high-n

131 a layered double hydroxide (LDH) containing iron (Fe).

132 Hemoglobin, iron, ferritin, folate and vitamin B(12), in addition to

133 Overall, these results support an iron-first model for Fe-S cluster synthesis and highligh

134 molecules called siderophores that scavenge iron from host proteins(1).

135 Streptococcus pneumoniae (Spn) must acquire iron from the host to establish infection.

136 stals are trapped into sediments that remove iron from the soluble pool.

137 damping comparable to, for example, yttrium iron garnet (YIG).

138 A 2D array of bismuth-substituted iron-garnet nanopillars on an ultrathin iron-garnet slab

139 uted iron-garnet nanopillars on an ultrathin iron-garnet slab forms a metasurface supporting quasi-wa

140 , we show that in perpendicularly-magnetized iron garnets, rare-earth orbital magnetism gives rise to

141 nificant difference between the high-dose IV iron group compared with the lose-dose group in event ra

142 II)(OH)(halide) intermediate in the non-heme iron halogenases were synthesized and examined for their

143 Cortical iron has been shown to be elevated in Alzheimer's diseas

144 Mechanistic studies of plant iron home-ostasis and plant immunity have traditionally

145 P1 in hepatocytes exhibited defects in liver iron homeostasis with low levels of liver iron, reduced

146 human innate immune system, and control its iron homeostasis.

147 oxicity necessitate the strict regulation of iron homeostasis.

148 mechanism involved in regulation of cellular iron homeostasis.

149 t also leads to changes in the expression of iron homeostatic machinery.

150 ociated with adverse pregnancy outcomes, yet iron homeostatic mechanisms during pregnancy are poorly

151 Here, we report a molecular iron(II) system that captures this design concept in a h

152 surface chemistry and nucleation behavior of iron(III) (hydr)oxides in subsurface and water treatment

153 In the presence of iron(III) chloride (1.5 equiv) and diorganyl diselenides

154 Iron-oxygen intermediates like iron(III)-hydroperoxo and high-valent iron-oxo species h

155 ulating the expression of iron import genes; iron import can reflect iron transport into the cytosol

156 olic iron by up-regulating the expression of iron import genes; iron import can reflect iron transpor

157 ing antioxidant pathways and the intertwined iron import pathway.

158 of ~40 kilograys already yields 50% ferrous iron in a heme protein crystal.

159 Although PCBP1 distributes iron in cells, its role in managing iron in mammalian ti

160 tributes iron in cells, its role in managing iron in mammalian tissues remains open for study.

161 Whether more iron in the extracellular milieu of the lung associates

162 surprisingly decreased to preserve placental iron in the face of fetal iron deficiency.

163 ration threshold that buffers the deep ocean iron inventory.

164 o a cascade among excited spin states of the iron ion, causing the ferric heme to undergo doming, whi

165 xidation of Remazol black B dye by employing iron ions catalyst based gas diffusion cathodes, (GDCs).

166 h proteins have two zinc ions instead of two iron ions in the catalytic center, and as a result, the

167 In the un-doped crystal all iron ions, sitting in five different crystallographic po

168 o were intolerant of or unresponsive to oral iron, iron isomaltoside (now called ferric derisomaltose

169 Next, either cobalt or iron is added, again from a large number of possible qua

170 Iron is an essential biometal that may have a pathologic

171 Iron is an essential nutrient for most organisms, but it

172 As over 99% of iron is complexed to organic ligands, which increase iro

173 lescence.SIGNIFICANCE STATEMENT Brain tissue iron is essential to healthy brain function.

174 n of heme to carbon monoxide, bilirubin, and iron, is an important regulator of inflammation and epit

175 intolerant of or unresponsive to oral iron, iron isomaltoside (now called ferric derisomaltose), com

176 [11.0] years; 95.9% women), including 62 to iron isomaltoside and 61 to ferric carboxymaltose; 95.1%

177 Factors associated with iron isotope partitioning between the maternal, neonatal

178 Iron status indicators and stable iron isotopic enrichment were measured in maternal blood

179 L/6 mice not only decreases total and labile iron levels but also leads to changes in the expression

180 Atypical basal ganglia tissue iron levels have been linked to impaired cognition in ir

181 Consistent with elevated iron levels in the hemolymph, Tsf1 mutants exhibited inc

182 iron overload, such as haemochromatosis, or iron limitation anaemias(2).

183 In addition to counteracting hepcidin-driven iron limitation for erythropoiesis, we found that the co

184 ptake, which affect the strength of regional iron limitation.

185 as more highly expressed under conditions of iron-limitation.

186 also displayed a decreased growth rate under iron-limited conditions created by dipyridyl added to LB

187 oes not produce siderophores but grows under iron-limiting conditions using enterobacterial sideropho

188 molecular bands of PO and NO as well as the iron lines with Se line at 196.026 were demonstrated.

189 Functional studies have revealed that iron-loaded carboxymycobactin is imported into the cytop

190 constitute a potential therapeutic tool for iron loading anemias.

191 g alkaline conditions favored dissolution of iron-manganese- (Fe-Mn-) oxyhydroxides (which adsorb (21

192 The ubiquitous iron/manganese superoxide dismutase (SOD) family exempli

193 We quantified the iron mass contained in single MTB cells of Magnetospiril

194 recognized form of cell death that relies on iron-mediated oxidative damage.

195 To avoid iron-mediated oxidative stress, bacteria utilize iron-de

196 nts regarding CDAs have been in the study of iron metabolism in CDAII.

197 e not largely endocytosed in response to non-iron metal excess, unlike IRT1.

198 ses from icy cometary bodies to fully melted iron meteorites with isotopic affinities to carbonaceous

199 Thus, cortical iron might act to propel cognitive deterioration upon th

200 transfusion and discuss using first-line IV iron monotherapy to treat anemic patients with cancer, w

201 ns with carbohydrate cores binding elemental iron more tightly allow complete iron replacement within

202 The application of nanoscale zerovalent iron (nano-ZVI) particles for groundwater remediation ha

203 veloping a selective biosensing system using iron nanoflorets graphene nickel (INFGN) as the transduc

204 NO and iron nitrosyl species (FeNOs), are relatively unstable i

205 matter regions to assess the effect of brain iron on cognitive functions.

206 AD), but the impact of the directly measured iron on the clinical syndrome has not been assessed.

207 hemoglobin but no effect on anthropometry or iron or vitamin A deficiencies.

208 However, iron overload can damage the organism through a variety

209 as effective and safe in inducing control of iron overload during 12 months of treatment.

210 Hemolysis and iron overload improved upon iron chelation with full cor

211 ferroportin activity can lead to diseases of iron overload, such as haemochromatosis, or iron limitat

212 nted cell survival under the condition of an iron overload.

213 lactic-co-glycolic acid) shell incorporating iron oxide nanocubes (IONCs).

214 se-dependent neurotoxicity of dextran-coated iron oxide nanoparticles (dIONPs), a common type of func

215 In this study, biocompatible magnetic iron oxide nanoparticles (IONPs) stabilized with trimeth

216 cally disordered iron-binding domain, and an iron oxide particle was visualized at high resolution by

217 In vivo measurements of collagen and iron oxide probes showed a significant correlation with

218 s like iron(III)-hydroperoxo and high-valent iron-oxo species have been trapped and identified in inv

219 Iron-oxygen intermediates like iron(III)-hydroperoxo and

220 e much more pronounced when Fe is present as iron oxyhydroxide compared to that observed when organic

221 s effect because of the strong dependency of iron oxyhydroxide solubility on pH.

222 study 2, PHep was increased 24 h after oral iron (P = 0.014), and mean FIA [+/-SD](%) from the basel

223 Hep was not increased 48 and 72 h after oral iron (P = 0.384), and the geometric mean FIA[-SD, +SD](%

224 f o-nitrobenzaldehydes with amines utilizing iron pentacarbonyl as a reducing agent followed by subse

225 and reaches a maximum value of ~10(-6) ng of iron per cell.

226 Reactive iron phases promote stabilizing interactions between OM

227 e findings, we create functional Li||lithium iron phosphate (LFP) batteries in which LFP cathodes wit

228 For example, iron plays a critical role in the generation of reactive

229 Iron porphyrin catalysts have long been studied for the

230 y groups are important in the performance of iron porphyrin ORR catalysts, we suggest that electrosta

231 isotope data indicate a biogenic origin for iron precipitation around chert granules on the shallow

232 erythrocyte homeostasis and are required for iron recycling.

233 er iron homeostasis with low levels of liver iron, reduced activity of iron enzymes, and misregulatio

234 and is an important focal point in systemic iron regulation.

235 es, and misregulation of the cell-autonomous iron regulatory system.

236 In humans and rodents, the iron-regulatory hormone hepcidin is profoundly decreased

237 ploit or target TMPRSS6 to treat anemias and iron-related diseases.

238 g elemental iron more tightly allow complete iron replacement within 15-60 min in one visit.

239 amined the impact of hemoglobin, the largest iron reservoir in the body, on pneumococcal physiology.

240 this issue, we postulated that some level of iron restriction (by targeting Tmprss6) would improve sp

241 did not prevent steatosis; instead, dietary iron restriction and antioxidant therapy with vitamin E

242 d human models, the therapeutic potential of iron restriction to modulate the phenotype in CEP.

243 arises from variations in the efficiency of iron retention in the upper ocean in the eastern equator

244 Mislocalization of APP can promote iron retention, thus we hypothesized that changes in end

245 , aldehydes, and diacetyl, we confirmed that iron salts are the most efficient catalysts.

246 In this work, for the first time we employ iron single-atom catalysts (Fe-N-C SACs) as an advanced

247 e activation of methane occurs at the single iron site, whereas the dissociated methyl disfavors deso

248 complexed to organic ligands, which increase iron solubility and microbial availability, understandin

249 Iron speciation and concentration measurements coupled t

250 ontrolled regulator that is upregulated upon iron starvation.

251 om CP-mediated inhibition of iron uptake and iron-starvation responses.

252 Iron status indicators and stable iron isotopic enrichme

253 ron-dependent global regulators to sense the iron status of the cell and regulate the expression of p

254 The toxicity of iron stems from its potential to catalyze formation of r

255 l week significantly reduces oligodendrocyte iron storage and maturation.

256 eme synthesis and does not contain cytosolic iron-storage proteins.

257 etal liver but its role in controlling fetal iron stores is not understood.

258 es cell-autonomously to increase fetal liver iron stores.

259 Moreover, plant iron stress triggers immune activation, suggesting that

260 es a salicyl-capped peptide mycobactin under iron-stress conditions in host macrophages to support th

261 Extraterrestrial iron sulfide is a major mineral reservoir of the cosmoch

262 Naturally occurring minerals, such as the iron sulfide mackinawite, play a key role in the remedia

263 Pyrite is a ubiquitous iron sulfide mineral that is oxidized by trace oxygen.

264 To address this need, we have developed iron sulfide nanoclusters that catalyse nitric oxide gen

265 e pathways range from photosynthesis through iron sulfur metabolism to carbohydrate metabolism.

266 Iron-sulfur (Fe-S) clusters are inorganic cofactors that

267 lta cells, indicating that the role of CL in iron-sulfur biogenesis is highly conserved.

268 Yfh1/frataxin, an essential component of the iron-sulfur biogenesis machinery, in mitochondria from T

269 cal processes such as amino acid biogenesis, iron-sulfur cluster formation, and redox homeostasis.

270 Alkyl-ligated iron-sulfur clusters in the [Fe(4)S(4)](3+) charge state

271 -deleted livers were iron deficient, dietary iron supplementation did not prevent steatosis; instead,

272 10, primary outcome) were 3.9 +/- 1.8 in the iron supplementation group and 4.0 +/- 2.2 in the placeb

273 Iron supplementation must be prescribed to avoid chronic

274 The eddy-driven iron supply and consequently productivity increase with

275 umoxytol injection to discriminate exogenous iron susceptibility from other endogenous sources.

276 than immunopattern III lesions, and 30% more iron than the surrounding periplaque white matter (95% C

277 lic iron chaperone, binding and transferring iron to recipient proteins in mammalian cells.

278 ck nitrogen fixation in Ljsen1 plants reduce iron transport in yeast.

279 f iron import genes; iron import can reflect iron transport into the cytosol or mitochondria.

280 alkaline pH, and that mimosine can bind soil iron under alkaline pH; (ii) pole bean, common bean, and

281 cts S. aureus from CP-mediated inhibition of iron uptake and iron-starvation responses.

282 In plants, iron uptake from the soil is tightly regulated to ensure

283 o major crops, corn and soybean differing in iron uptake strategies, were grown in irrigated syntheti

284 fic across different scenarios of biological iron uptake, which affect the strength of regional iron

285 bably targets the ESAT-6 protein to increase iron uptake.

286 na may utilize both S1 and S2 strategies for iron uptake; and mimosine may play an important role in

287 oscopy experiments indicated that YecA binds iron via its MBD.

288 mpare adverse event rates associated with IV iron vs red cell transfusion and discuss using first-lin

289 Intravenous iron was administered as a single 1000 mg dose of ferric

290 Irrespective of crop type, reduced iron was detected in pore water and postexperiment rhizo

291 Iron was elevated (beta [SE] = 9.7 [2.6]; P = 3.0 x 10(-

292 Preoperative intravenous iron was not superior to placebo to reduce need for bloo

293 unresponsiveness to 1 month or more of oral iron were recruited from 30 outpatient clinic sites in t

294 tACB was found to be positively regulated by iron, whereas lldD was more highly expressed under condi

295 R2', an MR measure of tissue iron which co-localizes with DA vesicles and is necessar

296 This allows FADH(2) to reduce the ferric iron, which forms the stable ferric-superoxide-TyrB10/Gl

297 indicated that these metabolites bind ferric iron, which suppresses their production when added to th

298 eport the wide-spread occurrence of metallic iron whiskers as a decomposition product formed through

299 er a hypoferremic response in flies, namely, iron withdrawal from the hemolymph and accumulation in t

300 s study, we evaluated vitamin D and mineral (iron, zinc, magnesium) transfer to the bolus aqueous pha