ライフサイエンスコーパス: iron deficiency

1 preserve placental iron in the face of fetal iron deficiency.

2 articularly important for COX assembly under iron deficiency.

3 pulation is anaemic, half of which is due to iron deficiency.

4 o 24 weeks, dosed according to the extent of iron deficiency.

5 horylated form of URI only accumulates under iron deficiency.

6 bioavailable dietary iron sources to prevent iron deficiency.

7 root microbial community specifically under iron deficiency.

8 but less is known about how plants perceive iron deficiency.

9 ltered growth responses to copper excess and iron deficiency.

10 orphyria, for example, in liver diseases, or iron deficiency.

11 e is highly regulated and induced only under iron deficiency.

12 ociated with an increased subsequent risk of iron deficiency.

13 letion reduced cell viability in response to iron deficiency.

14 ng medication use and the subsequent risk of iron deficiency.

15 modifications during both erythropoiesis and iron deficiency.

16 ciated with an increased subsequent risk for iron deficiency.

17 re donation-related symptoms, deferrals, and iron deficiency.

18 exercise capacity in patients with HFrEF and iron deficiency.

19 patients with pre-existing risk factors for iron deficiency.

20 petrobactin (fpbNOPQ) are induced to prevent iron deficiency.

21 FRO2 locus associated with root length under iron deficiency.

22 se medications increase the risk of clinical iron deficiency.

23 ortening in high copper conditions and under iron deficiency.

24 ysfunction as a consequence of cardiomyocyte iron deficiency.

25 n content is an effective strategy to reduce iron deficiency.

26 distribution to the cytoplasm in response to iron deficiency.

27 esis, was also downregulated by hypoxia with iron deficiency.

28 n patients with HF and often associated with iron deficiency.

29 ange of pseudomonads to enhance growth under iron deficiency.

30 orld's population; half the cases are due to iron deficiency.

31 is a common strategy to prevent or overcome iron deficiency.

32 a in school girls should focus on correcting iron deficiency.

33 to erythropoietin resistance associated with iron deficiency.

34 e in patients with chronic heart failure and iron deficiency.

35 iCOX19 plants resembled those observed under iron deficiency.

36 entation must be prescribed to avoid chronic iron deficiency.

37 r (FIT) and bHLH38/39/100/101 in response to iron deficiency.

38 ed in a personalized therapeutic approach to iron deficiency.

39 otential adaptive role in protecting against iron deficiency.

40 y and synaptic function following early-life iron deficiency.

41 s for patients receiving ESA with or without iron deficiency.

42 In patients with iron deficiency, a left ventricular ejection fraction of

43 In patients with chronic HF and iron deficiency, a total repletion dose of iron isomalto

44 1, involved in iron uptake, caused neuronal iron deficiency, age-progressive degeneration of a subse

45 Our studies revealed functional iron deficiency, altered post-transcriptional regulation

46 Iron deficiency anaemia (IDA) is a common nutritional di

47 imtomax had excellent diagnostic accuracy in iron deficiency anaemia and was comparable to convention

48 ity from a vegetarian diet, meaning non-haem iron deficiency anaemia and zinc deficiency immune malfu

49 in 133 prospectively recruited patients with iron deficiency anaemia attending for a gastroscopy.

50 ogy of 153 patients presenting to a separate iron deficiency anaemia clinic were retrospectively revi

51 nifestation of the remaining three cases was iron deficiency anaemia, abdominal pain and acute intest

52 nal guidelines recommend coeliac serology in iron deficiency anaemia, and duodenal biopsy for those t

53 ysiology, diagnosis, and acute management of iron deficiency anaemia, and outstanding research questi

54 fy any causes other than coeliac disease for iron deficiency anaemia, suggesting that biopsy avoidanc

55 onic diseases are frequently associated with iron deficiency anaemia--notably chronic kidney disease,

56 ains well, asymptomatic, with no evidence of iron deficiency anaemia.

57 classic red cell indices in the diagnosis of iron deficiency anaemia.

58 ent who developed a CRVO secondary to severe iron-deficiency anaemia (IDA) attributable to menstrual

59 n-guided screen-and-treat approach to combat iron-deficiency anaemia could achieve equivalent efficac

60 non-compliance and ineffective correction of iron-deficiency anaemia.

61 onditions, hepcidin production is reduced by iron deficiency and erythropoietic drive to increase the

62 late iron transport in the setting of severe iron deficiency and explored a potential marker of place

63 To date, clinical implications of iron deficiency and high EPO levels in the general popul

64 c kidney disease (CKD) patients suggest that iron deficiency and higher circulating levels of erythro

65 In this study, we found that functional iron deficiency and higher EPO levels were each associat

66 aimed to determine the associations between iron deficiency and higher EPO levels with mortality, an

67 ith thrombotic events in young patients with iron deficiency and hyperhomocysteinemia.

68 volved in the association between functional iron deficiency and increased EPO levels and death.

69 epcidin expression occurs physiologically in iron deficiency and increased erythropoiesis but is path

70 rt failure as a consequence of intracellular iron deficiency and increased expression of the vasocons

71 anemia-control programs should address both iron deficiency and infections.

72 t high intracellular Zn concentrations mimic iron deficiency and inhibit the activity of the oxygen s

73 n to be effective in preventing and treating iron deficiency and iron deficiency anemia in infants an

74 or the local absorptive response to systemic iron deficiency and iron overload.

75 h studies, particularly in the evaluation of iron deficiency and its associated anemia in pregnancy a

76 tment is the standard of care for concurrent iron deficiency and malaria.

77 Interestingly, iron deficiency and overload disorders do not result in

78 estigation of strategies aimed at correcting iron deficiency and reducing FGF23 levels is warranted.

79 regnant women are particularly vulnerable to iron deficiency and related adverse pregnancy outcomes a

80 mportant role during iron overload, systemic iron deficiency, and anemia.

81 vels at 12 months of age and ferritin level, iron deficiency, and iron deficiency anemia at 8 and 12

82 oncentration and reduced the risk of anemia, iron deficiency, and iron-deficiency anemia.

83 eling with LNSs reduced the risks of anemia, iron deficiency, and low vitamin B-12.

84 In multivariable pooled models, child age, iron deficiency, and stunting independently predicted an

85 kidney; reduced red blood cell survival and iron deficiency; and mineral bone disease caused by dist

86 n Southeast Asia, Thalassemia trait (TT) and iron deficiency anemia (IDA) are the two most common ane

87 Although the hazards associated with iron deficiency anemia (IDA) are well known, concerns ab

88 on between Helicobacter pylori infection and iron deficiency anemia (IDA) in humans.

89 gastritis-induced achlorhydria is a cause of iron deficiency anemia (IDA) in humans.

90 Preoperative iron deficiency anemia (IDA) occurs frequently; however

91 The prevalence of iron deficiency (ID) and iron deficiency anemia (IDA) was 10-32% and 2-5%, respec

92 than 1 billion people worldwide suffer from iron deficiency anemia (IDA), a state of systemic iron i

93 nemia at delivery, and 25% (n = 5) developed iron deficiency anemia (IDA).

94 Iron deficiency anemia affects >1.2 billions individuals

95 Nontransgenic mice with acquired iron deficiency anemia also show thrombocytosis and Mk-b

96 6 knockout (Tmprss6-/-) mice, which exhibit iron deficiency anemia and thrombocytosis, we observed a

97 age and ferritin level, iron deficiency, and iron deficiency anemia at 8 and 12 months of age.

98 preventing and treating iron deficiency and iron deficiency anemia in infants and young children.

99 for pregnant women or routine screening for iron deficiency anemia in pregnant women or young childr

100 In particular, iron deficiency anemia is a major global health issue, b

101 Iron deficiency anemia is common and consequential in no

102 Iron deficiency anemia is one of the most serious forms

103 s underlying thrombocytosis in patients with iron deficiency anemia remain unknown.

104 nd clinical trial in adults with NDD-CKD and iron deficiency anemia to compare the safety and efficac

105 pcidin levels for diagnosing iron-refractory iron deficiency anemia to global health applications suc

106 f iron status across the full continuum from iron deficiency anemia to iron deficiency to iron replet

107 cantly lower prevalences of iron deficiency, iron deficiency anemia, and low vitamin B-12 and, in Ken

108 ong-standing type II diabetes, hypertension, iron deficiency anemia, aortic stenosis, and prior baria

109 h outcomes that are associated with maternal iron deficiency anemia, both Canada and the United State

110 ytol is approved for use in the treatment of iron deficiency anemia, but it can serve as an alternati

111 ating our findings from the murine models of iron deficiency anemia, primary human MEPs exhibit decre

112 boratory evaluation was notable for profound iron deficiency anemia, thrombocytosis, and hyperhomocys

113 reditary hemochromatosis and iron-refractory iron deficiency anemia.

114 d finding of thrombocytosis in patients with iron deficiency anemia.

115 eople worldwide whose inadequate diet causes iron deficiency anemia.

116 12 months of age in infants at high risk for iron deficiency anemia.

117 e to be a safe and efficacious treatment for iron deficiency anemia.

118 PRSS6, whose mutations cause iron refractory iron deficiency anemia.

119 ation of iron in macrophages and symptoms of iron deficiency anemia.

120 decreasing risk of traits related to anemia (iron deficiency anemia: odds ratio [OR] scaled to a stan

121 8, 245 patients aged 18 years and older with iron-deficiency anemia (hemoglobin level <=11 g/dL; seru

122 Iron-deficiency anemia (IDA) affects millions of persons

123 itional biomarkers used for the diagnosis of iron-deficiency anemia (IDA) in patients with CKD have l

124 ts and young children in Sub-Saharan Africa, iron-deficiency anemia (IDA) is common, and many complem

125 India's high prevalence of iron-deficiency anemia has largely been attributed to th

126 kworm disease is among the leading causes of iron-deficiency anemia in the developing world and is as

127 In 2 randomized trials of patients with iron-deficiency anemia who were intolerant of or unrespo

128 Intravenous iron enables rapid correction of iron-deficiency anemia, but certain formulations induce

129 hildren aged 9 to 48 months with nutritional iron-deficiency anemia, ferrous sulfate compared with ir

130 theless, studies of a murine iron-refractory iron-deficiency anemia-causing mutant (Mt2I286F) in the

131 ced the risk of anemia, iron deficiency, and iron-deficiency anemia.

132 is, and it predisposes Tfrc(Alb-Cre) mice to iron-deficiency anemia.

133 ted patients with unexplained, mild, chronic iron-deficiency anemia.

134 be considered for children with nutritional iron-deficiency anemia.

135 rriers, 20%, p = 4e-7, OR = 5), particularly iron-deficiency anemia.

136 hepcidin regulated intestinal HIF-2alpha in iron deficiency, anemia, and iron overload.

137 dered iron metabolism, leading to functional iron deficiency, anemia, erythropoietic protoporphyria,

138 Both anemia and iron deficiency are associated with an increase in all-c

139 ssays and transcriptomics we discovered that iron deficiency arising from KCNE2-dependent achlorhydri

140 de nanoparticles have been used for treating iron deficiency, as contrast agents for magnetic resonan

141 Adaptation to iron deficiency at the tissue level is controlled by iro

142 Iron deficiency augments hypoxic pulmonary arterial pres

143 amatergic terminals in the rodent with brain iron deficiency (BID), a pathogenetic model of restless

144 y important in relation to the management of iron deficiency but should also inform dietary advice, e

145 arial treatment in children with malaria and iron deficiency, but iron may not be well absorbed or ut

146 vate RNR in response to genotoxic stress and iron deficiency by facilitating redistribution of its sm

147 ins is substantially repressed by HRI during iron deficiency, causing a decrease in cytosolic and mit

148 63 women, 403 children) to assess changes in iron deficiency (children only) and anemia.

149 ne for the genetic studies of abiotic stress iron deficiency chlorosis (IDC) of soybean is reported.

150 S2 genes were upregulated in leucaena under iron-deficiency condition or when Fe(III) was supplied a

151 Iron deficiency conditions as well as iron supplied as a

152 iCOX19 plants than in wild-type plants under iron deficiency conditions, suggesting that COX19 functi

153 Although iron deficiency continues to pose a problem for pregnant

154 With maternal iron deficiency, critical transporters mediating placent

155 Maternal diet-induced mild iron deficiency decreased offspring peritoneal iron, dec

156 the immediate arm had a lower prevalence of iron deficiency defined by ZPP (29.4% compared with 65.6

157 ed the proportion of anemia with concomitant iron deficiency (defined as an inflammation-adjusted fer

158 sed for acute heart failure with concomitant iron deficiency (defined as ferritin <100 mug/L, or 100-

159 ical trial of patients with HFrEF (<40%) and iron deficiency, defined as a serum ferritin level of 15

160 Children with iron deficiency, defined as zinc protoporphyrin (ZPP) >=

161 It contrasted 77,046 patients with new iron deficiency diagnoses (January 1999-December 2013),

162 Clinical iron deficiency disturbs normal responses to hypoxia, as

163 regnant women are particularly vulnerable to iron deficiency due to the high iron demands of pregnanc

164 The absence of HRI during iron deficiency elicits a prominent cytoplasmic unfolded

165 Plant iron deficiency (-Fe) activates a complex regulatory net

166 and specificities of 97%, 100%, and 97% for iron deficiency (ferritin <15 ng/mL or 32 pmol/L), vitam

167 in non-anemic repeat adult blood donors with iron deficiency (ferritin <= 50 ug/L).

168 eft ventricular ejection fraction <=45%, and iron deficiency (ferritin<100 mug/L or 100-300 mug/L wit

169 ed that under physiological conditions or in iron deficiency, fetal and placental hepcidin did not re

170 mong patients without known risk factors for iron deficiency, gastric acid inhibitor use for >/=2 yea

171 Iron deficiency has negative effects on pregnancy outcom

172 r lack of iron, in part because detection of iron deficiency has required a blood sample.

173 Among participants with HFrEF with iron deficiency, high-dose oral iron did not improve exe

174 Individuals with absolute iron deficiency (ID) and an iron-replete (IR) control gr

175 Both iron deficiency (ID) and excess can lead to impaired hea

176 he distribution of TBI and the prevalence of iron deficiency (ID) and ID anemia (IDA) among toddlers,

177 The prevalence of iron deficiency (ID) and iron deficiency anemia (IDA) wa

178 Iron deficiency (ID) and vitamin D deficiency (VDD) are

179 Iron deficiency (ID) anemia is a prevalent disease, yet

180 Iron deficiency (ID) before the age of 3 y can lead to l

181 African Americans are at increased risk of iron deficiency (ID) but also have higher serum ferritin

182 irst and <10.5 g/dL in second trimester) and iron deficiency (ID) by the iron indicators serum ferrit

183 This merits attention because iron deficiency (ID) during pregnancy is associated with

184 s to adjust for inflammation on estimates of iron deficiency (ID) in low- and high-infection-burden s

185 Iron deficiency (ID) is an urgent public health problem

186 Iron deficiency (ID) is common in young children aged 6-

187 Iron deficiency (ID) is independently associated with an

188 Absolute or functional iron deficiency (ID) is seen in ~50% patients with HF.

189 Iron deficiency (ID) is the main cause for anemia and co

190 ambodian women, current reports suggest that iron deficiency (ID) prevalence is low.

191 Clinical diagnosis of iron deficiency (ID) through sampling of bone marrow to

192 The diagnosis of iron deficiency (ID) through SF concentration, the most

193 At baseline, the prevalence of iron deficiency (ID) was 36.9% and 34.6% in Kenyan and U

194 icant and its absorption may be increased in iron deficiency (ID).

195 Because iron deficiency impairs mitochondrial respiration/ATP pr

196 with intravenous FCM in patients with HF and iron deficiency improves iron stores.

197 proteins due to Irp2 loss causes functional iron deficiency in beta cells.

198 actors contribute to absolute and functional iron deficiency in CKD, including blood losses, impaired

199 associations, and consequences of anemia and iron deficiency in epidemiologically representative outp

200 However, induction of more severe iron deficiency in human trophoblast in vitro resulted i

201 overy opens new avenues for the treatment of iron deficiency in humans, one of the most common and wi

202 weight (LBW) (</=2500 g) is associated with iron deficiency in infancy and high blood pressure (BP)

203 0%, 55%, and 58% of children had concomitant iron deficiency in low-, medium-, high-, and very high-i

204 rone's effects on erythropoiesis, we induced iron deficiency in mice by feeding low iron diet.

205 rect abnormally high hepcidin expression and iron deficiency in MT2(-/-) mice.

206 to use means for point-of-care screening for iron deficiency in resource-limited settings lacking lab

207 e in root iron uptake and content along with iron deficiency in shoots.

208 ron rather than oral iron as a treatment for iron deficiency in some of these clinical scenarios.

209 cts >1.2 billions individuals worldwide, and iron deficiency in the absence of anemia is even more fr

210 On the basis of these results, a status of iron deficiency in the human population might contribute

211 ion of integratedstressresponse mRNAs during iron deficiency in vivo.

212 affected the embryo, causing anemia, tissue iron deficiency (including in the brain), and decreased

213 rrying the deletion showed early evidence of iron deficiency, including a mild decrease in hemoglobin

214 double mutant does not up- and down-regulate iron deficiency-induced and -repressed genes.

215 s grafted to ysl1ysl3 shoots do not initiate iron deficiency-induced gene expression, indicating that

216 nd their transcriptional regulators FER-like iron deficiency-induced transcription factor (FIT) and b

217 lix-loop-helix transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (FIT).

218 hat mimic these genetic disorders, including iron deficiency, inflammation, treatment with ferric car

219 ch has lost the ability to properly regulate iron deficiency-influenced gene expression in both roots

220 also had significantly lower prevalences of iron deficiency, iron deficiency anemia, and low vitamin

221 emphasizes the complex relationship between iron deficiency, iron treatment, and malaria infection i

222 BRINDA findings confirm that iron deficiency is a common and consistent risk factor f

223 Iron deficiency is a major global public health problem

224 Iron deficiency is also among the most common nutritiona

225 Total-body (absolute) iron deficiency is caused by physiologically increased i

226 Iron deficiency is closely associated with altered GABA

227 Iron deficiency is common in obese subjects.

228 Iron deficiency is common in patients with heart failure

229 Iron deficiency is common worldwide and is associated wi

230 The diagnosis of absolute iron deficiency is easy unless the condition is masked b

231 The accurate estimation of iron deficiency is important in planning and implementin

232 odia or in countries where the prevalence of iron deficiency is low and genetic hemoglobin disorders

233 the diagnosis of AI patients with coexisting iron deficiency is more difficult.

234 Iron deficiency is present in approximately 50% of patie

235 Iron deficiency is present in approximately 50% of patie

236 Notably, iron deficiency is sufficient to trigger inflammatory si

237 Iron deficiency is the most common cause.

238 Iron deficiency is the most common micronutrient deficie

239 Iron deficiency is thought to be one of the most prevale

240 propose that a maternal Cd exposure-induced iron deficiency leads to altered cellular metabolic path

241 ession analysis was conducted for each group.Iron deficiency, malaria, breastfeeding, stunting, under

242 signaling provides a mechanism through which iron deficiency may be detrimental to human health.

243 ggest a novel mechanism by which hypoxia and iron deficiency may modulate NCOA4 expression to impact

244 ght Dystonia (BAD) scale, and no evidence of iron deficiency, neutropenia, or abnormal hepatic or ren

245 ss is known about the effects of hypoxia and iron deficiency on hepatic gluconeogenesis.

246 o be sensitive to the effects of gestational iron deficiency on memory function in infants and young

247 cord clamping has not been shown to prevent iron deficiency or anemia after 6 months of age.

248 its and may also cause clinical syndromes of iron deficiency or excess.

249 ) levels in live cells and mice experiencing iron deficiency or overload.

250 e to a true paucity of iron stores (absolute iron deficiency) or a relative (functional) deficiency w

251 Remarkably, apo-pyoverdine abolished the iron-deficiency phenotype and restored the growth of pla

252 Iron deficiency plays a significant role in anemia in CK

253 The BRINDA method-adjusted iron deficiency prevalence was linearly associated with

254 ibution of SF, yielding similar estimates of iron deficiency prevalence when evaluated in the BRINDA

255 he functional and prognostic significance of iron deficiency, randomized multicenter trials exploring

256 transplantation assays suggest that systemic iron deficiency, rather than a local role for Tmprss6-/-

257 Current guidelines to treat iron deficiency recommend daily provision of ferrous iro

258 oposed to help clinicians diagnose and treat iron deficiency, recommending oral iron in the first tri

259 eginning of peak dendritic growth/branching, iron deficiency reduces mitochondrial speed through incr

260 Most iron deficiency reflects an inadequate supply of iron in

261 Efforts to address the global burden of iron deficiency-related anemia have focused on classical

262 Despite its known detrimental effects, iron deficiency remains the most common micronutrient de

263 The iron deficiency response engages hormone signaling secto

264 ysosomal acidification, we observed a robust iron deficiency response in the brain, verified by in vi

265 e independent of the shoot control over root iron deficiency responses.

266 ur approach uncovered pCREs resembling IDE1 (iron deficiency-responsive element 1), a known grass -Fe

267 Hypoxia, and more so hypoxia with iron deficiency, results in hypoglycemia due to decrease

268 red and compared between infants with latent iron deficiency (serum ferritin </=75 ng/mL) and infants

269 All cases of iron deficiency should be assessed for treatment and und

270 IRT1 (URI) acts as an essential part of the iron deficiency signaling pathway in Arabidopsis thalian

271 During iron deficiency, SMAD3 and SMAD4 expression was signific

272 s study presents evidence that intracellular iron deficiency specifically within PASMCs alters pulmon

273 uction is the major driver of anemia in CKD, iron deficiency stands out among the mechanisms contribu

274 Erythropoiesis and iron deficiency suppress hepcidin via erythroferrone-dep

275 n human placentas from pregnancies with mild iron deficiency, TFR1 was increased, but there was no ch

276 ates hepcidin suppression by erythropoietin, iron deficiency, thalassemia, and hemochromatosis.

277 Worldwide, more individuals have iron deficiency than any other health problem.

278 link between insulin processing and cellular iron deficiency that may have relevance to type 2 diabet

279 Laboratory tests defining iron deficiency, the recognition of developmental delays

280 udy uses a primary neuronal culture model of iron deficiency to address a gap in understanding of how

281 te deficiencies were not.The contribution of iron deficiency to anemia varies according to a country'

282 ull continuum from iron deficiency anemia to iron deficiency to iron replete to iron excess, 3) the l

283 arget genes are most highly activated during iron deficiency to maintain mitochondrial function and r

284 ntly, ATF4 target genes are activated during iron deficiency to maintain mitochondrial function and t

285 Down-regulation of FPS also triggered an iron-deficiency transcriptional response that is consist

286 an FDA-approved iron oxide nanoparticle for iron deficiency treatment, demonstrates an anti-leukaemi

287 ron application, citrate supplementation and iron deficiency treatment, indicate that the shoot-direc

288 the search for and treatment of the cause of iron deficiency, treatment strategies encompass preventi

289 At baseline, prevalence of iron deficiency was 9% on the basis of a low serum ferri

290 Iron deficiency was consistently associated with anemia

291 Depending on the definition applied, iron deficiency was present in 270 (43.2%) to 425 (68.0%

292 At 8 months, the risk for iron deficiency was reduced in the delayed clamping grou

293 ificity of optical non-invasive detection of iron deficiency were 97% and 90%, respectively.

294 to the frontline in multiple disorders with iron deficiency, which include heart failure, chronic ki

295 The response to iron deficiency, which is known to strongly induce couma

296 A coordinate response to iron deficiency, which leads to dismantling of the photo

297 of lysosomal acidification triggers cellular iron deficiency, which results in impaired mitochondrial

298 Whether correction of iron deficiency with (intravenous) ferric carboxymaltose

299 We therefore hypothesized that clinical iron deficiency would disturb integrated human responses

300 reatment in children with severe malaria and iron deficiency would improve iron status and lower mala