ライフサイエンスコーパス: iron deposition

1 ng a declining role of the peroxo complex in iron deposition.

2 acquired to derive estimates of hippocampal iron deposition.

3 y (chi) and T2*, measures used as indices of iron deposition.

4 lum; Cohen d >1) consistent with substantial iron deposition.

5 fective iron recycling and increased splenic iron deposition.

6 2G6 are inconsistently associated with brain iron deposition.

7 e on the follow-up scans, suggesting chronic iron deposition.

8 <0.001), and Perls stain confirmed localized iron deposition.

9 recruited macrophages at the site of chronic iron deposition.

10 her NAS, even among patients without hepatic iron deposition.

11 erapy and lead to severe consequences due to iron deposition.

12 xed HC/reticuloendothelial system cell (RES) iron deposition.

13 pcidin and ferritin and increased hepatocyte iron deposition.

14 odies and delineate histological features of iron deposition.

15 not sensitive enough to detect early cardiac iron deposition.

16 ng an environment favorable for extrahepatic iron deposition.

17 38 patients and in nine of 25 patients with iron deposition.

18 normal collagen accumulation, and remarkable iron deposition.

19 ers has been cardiac disease from myocardial iron deposition.

20 cession images within CMI likely result from iron depositions.

21 sistent with oxidative stress, HbG increased iron deposition, 4-hydroxynonenal and 8-hydroxydeoxyguan

22 A SF >1.5 x ULN is associated with hepatic iron deposition, a diagnosis of NASH, and worsened histo

23 e in vivo evidence of an association between iron deposition and both tau aggregation and neurodegene

24 an family with a pallido-pyramidal syndrome, iron deposition and cerebellar atrophy, we identified a

25 logic conditions suitable for future cardiac iron deposition and complementary information to liver a

26 ia major and sickle cell disease can lead to iron deposition and damage to the heart, liver, and endo

27 nts with NAFLD is associated with greater HC iron deposition and decreased serum hepcidin levels, and

28 The overall process of iron deposition and detoxification by LiDps is described

29 Increased iron deposition and evidence of oxidative damage have al

30 s examining the relationship between hepatic iron deposition and histological severity in nonalcoholi

31 ular renal injury was accompanied by nonheme iron deposition and hypoxia-inducible factor-1alpha upre

32 to examine the relationship between hepatic iron deposition and liver histology in 849 patients enro

33 To date, the link between the iron deposition and malignant ventricular arrhythmias in

34 utation type is associated with Kupffer-cell iron deposition and normal transferrin saturation in viv

35 Iron deposition and polymicrogyria were found in a subse

36 ggest that the CR-induced benefit of reduced iron deposition and preserved motor function may indicat

37 iated virus (AAV)-ADIPOQ ameliorated cardiac iron deposition and restored cardiac function in iron-ov

38 otein in Kupffer cells (proposed) facilitate iron deposition and retention in the liver.

39 quantitatively evaluated for diffuse hepatic iron deposition and siderotic regenerative nodules to as

40 elationship between the grade and pattern of iron deposition and the clinical, laboratory, and histol

41 ication of susceptibility changes related to iron deposition and the potential to identify lesions ha

42 Histology was used to assess iron deposition and to examine relationships between iro

43 f both the HEPH and CP genes leads to kidney iron deposition and toxicity, MCFs could protect kidney

44 Less iron deposition and ventricular enlargement, lower brain

45 resonance imaging can be used as a marker of iron deposition and yields incremental information towar

46 ht be attributable to microglial activation, iron deposition, and blood-brain barrier breakdown.

47 sonance imaging scans, measures sensitive to iron deposition, and clinical diagnosis of neurological

48 ttack of the epididymis leading to fibrosis, iron deposition, and copper, zinc, and selenium imbalanc

49 worsened neurological recovery, exacerbated iron deposition, and decreased alternative activation of

50 Massive ascites, iron deposition, and high body mass index were additiona

51 HFE genotype, serum hepcidin level, hepatic iron deposition, and histology in nonalcoholic fatty liv

52 rin bound iron (NTBI), produces acute tissue iron deposition, and initiates inflammation.

53 multi-organ dysfunction caused by increased iron deposition, and is treatable if detected early.

54 te that the pituitary gland is vulnerable to iron deposition, and it occurs regardless of other extra

55 We investigated the impact of iron deposition, and its topographical distribution acro

56 more severe neuroinflammation, brain edema, iron deposition, and neurologic deficits associated with

57 ithout reperfusion hemorrhage led to chronic iron deposition, and the extent of this deposition was s

58 relationship between the presence of hepatic iron deposition, apoptosis, histologic features, and ser

59 Iron deposition appeared on day 3 around the haematoma b

60 The presence and pattern of hepatic iron deposition are associated with distinct histologica

61 mus with signs of extensive phagocytosis and iron deposition around plaque-like amyloid deposition.

62 renal pathology and point to increased renal iron deposition as a putative underlying mechanism.

63 th mechanisms of demyelination and increased iron deposition as key hallmarks of the aging hippocampu

64 Hfe (-/-) mice had considerable parenchymal iron deposition as well, in a pattern similar to that ob

65 progressive MS is consistent with increased iron deposition, as corroborated by other techniques.

66 ubular brush border loss, diminished tubular iron deposition, blocked the development of interstitial

67 halassemia major (TM), suggesting myocardial iron deposition, but it is unknown at what age this occu

68 hepatic MRI, specifically involving fat and iron deposition, by demonstrating how they were iterativ

69 Iron deposition correlated with the degree of atrophy (r

70 pathology: decreased tissue death, decreased iron deposition, decrease in markers of oxidative damage

71 The extent of iron deposition ([Fe]) within each sample was measured u

72 that the assessment of dissolved atmospheric iron deposition fluxes and their effect on the biogeoche

73 Crystallized iron deposition from PMO is directly related to proinfla

74 Subjects with hepatic iron deposition had higher serum hepcidin levels than su

75 Brain iron deposition has been linked to several neurodegenera

76 The SMA liver is dark red, small and has: iron deposition; immature sinusoids congested with blood

77 We measured iron deposition in 180 cortical regions of 96 patients w

78 tion of dietary iron, and patterns of tissue iron deposition in agreement with clinical observations

79 id precursors with perinuclear mitochondrial iron deposition in bone marrow.

80 nd neurobehavioral comorbidities, along with iron deposition in deep brain nuclei, mild normocytic to

81 characterized by pathological mitochondrial iron deposition in erythroid precursors.

82 mochromatosis (GH) is associated with excess iron deposition in hepatocytes, which results in progres

83 our understanding of the natural history of iron deposition in hereditary hemochromatosis.

84 er transferrin saturation and more prominent iron deposition in liver parenchyma in vivo, retained ir

85 own that Hjv-/- mice have markedly increased iron deposition in liver, pancreas, and heart but decrea

86 ion of dietary iron absorption and excessive iron deposition in major organs of the body.

87 knock-in mice show a significant increase in iron deposition in microglia following intrastriatal LPS

88 In summary, the localization of iron deposition in MS and AD brains indicates potential

89 We report perivascular iron deposition in multiple sclerosis lesions that was m

90 HC iron deposition in NAFLD is also associated with OS and

91 lzheimer disease and amyloid angiopathy; and iron deposition in neurodegenerative diseases or abnorma

92 Previously, we found appreciable hepatic iron deposition in one third of our patients undergoing

93 icantly with the spatial pattern of cortical iron deposition in Parkinson's disease.

94 The frequency of HCC in patients with iron deposition in regenerative nodules (52% [37 of 71 p

95 MR imaging can enable detection of iron deposition in regenerative nodules as a possible ri

96 rence of HCC may be associated causally with iron deposition in regenerative nodules in patients with

97 eposition was seen in 79 (40%) patients, and iron deposition in regenerative nodules was seen in 71 (

98 he liver and increased serum iron levels and iron deposition in several organs similar to classic her

99 s absorption of dietary iron and progressive iron deposition in several tissues, particularly liver.

100 s absorption of dietary iron and progressive iron deposition in several tissues, particularly liver.

101 erized by excess dietary iron absorption and iron deposition in several tissues.

102 duced TLR4-dependent hepcidin expression and iron deposition in splenic macrophages, findings mirrore

103 g, evidence of both significant increases in iron deposition in subcortical GM and myelin degeneratio

104 ion of significant, voxel-level increases in iron deposition in subcortical gray matter (GM) of patie

105 These findings indicate increased iron deposition in subcortical motor circuits in p.C282Y

106 Susceptibility-weighted imaging confirmed iron deposition in the anteromedial putamen in patients.

107 eristic profile of layer-specific myelin and iron deposition in the BA 3b hand area, but revealed an

108 Elevated iron deposition in the brain has been observed in older

109 mutation in the iron-regulatory pathways and iron deposition in the brain resulting in neurodegenerat

110 Histologic studies showed marked iron deposition in the cortex and outer medulla accompan

111 athologically by neuronal loss, gliosis, and iron deposition in the globus pallidus, red nucleus, and

112 progressive movement disorder and prominent iron deposition in the globus pallidus.

113 although the CR group had significantly less iron deposition in the GP, SN, red nucleus, and temporal

114 tory mediators, macrophage accumulation, and iron deposition in the injured spinal cord.

115 We also detected significant iron deposition in the injury site, a known catalyst for

116 ides of Aire-deficient mice are required for iron deposition in the interstitium, which is brought on

117 scopic and microscopic findings of a massive iron deposition in the liver, heart, lungs, spleen, bone

118 The iron deposition in the mutant mice was predominantly hep

119 Iron deposition in the pancreas and heart occurred after

120 he subfields and segments investigated here, iron deposition in the posterior hippocampal CA1 was the

121 susceptibility mapping identified increased iron deposition in the putamen, cingulate and medial fro

122 ontaining dopaminergic neurons and increased iron deposition in the substantia nigra.

123 set of liver transplant patients with marked iron deposition in their cirrhotic liver who developed s

124 ferrioxamine does not prevent excess cardiac iron deposition in two-thirds of patients with thalassae

125 nd neurological severity was associated with iron deposition in widespread cortical regions in chroni

126 psy tissue have demonstrated the presence of iron depositions in white matter lesions.

127 ts of the HFE knockout mice showed increased iron deposition, increased content of reactive oxygen sp

128 Brain iron deposition increases normally with age, especially

129 New evidence also suggests that hepatic iron deposition increases the risk of HCC in NASH-derive

130 the spatiotemporal relationships among PMO, iron deposition, infarct resorption, and left ventricula

131 s studied to further define the mechanism of iron deposition inside the protein and the role of LiDps

132 d the iron deficiency response and increased iron deposition into ferritin.

133 e2+/HoSF ratio), H2O2 is not produced during iron deposition into HoSF using O2 as an oxidant.

134 in both DRG neurons and cardiomyocytes, and iron deposition is detected in cardiomyocytes after 1 ye

135 n rates are high but the rate of atmospheric iron deposition is low.

136 Both iron deposition levels as well as its spatial distributi

137 Patients with iron deposition limited to hepatocytes had a lower propo

138 ntional imaging corroborates the findings of iron deposition, magnetic susceptibility imaging has imp

139 riable analysis, only body mass index, liver iron deposition, massive ascites, and use of 3.0 T were

140 univariate analysis, body mass index, liver iron deposition, massive ascites, use of 3.0 T, presence

141 ormal excitability and heterogeneous cardiac iron deposition may cause the arrhythmogenesis of human

142 of aging, motor performance speed and brain iron deposition measured in vivo using magnetic resonanc

143 of aging, motor performance speed and brain iron deposition measured in vivo using MRI, to determine

144 del (hA53T transgenic line M83, A53T) and an iron deposition model (Tau knock out, TauKO).

145 n did not affect the mean change in lesional iron deposition on brain MRI over 2 years when compared

146 etrospectively determine the effect of liver iron deposition on the evaluation of liver fat by using

147 model, were used to determine the effect of iron deposition on the Spearman correlation coefficient

148 uctural changes occur such as demyelination, iron deposition, or subtle atrophy, which can be charact

149 ion, IgG extravasation, heme oxygenase (HO), iron deposition, oxidative end products (4-hydroxynonena

150 e was the percentage change in mean lesional iron deposition per year, measured by quantitative susce

151 such correlation was found in patients with iron deposition (r = 0.1 for reader 1, r = -0.31 for rea

152 ned liver fat percentage in patients without iron deposition (r = 0.7 for reader 1, r = 0.6 for reade

153 g that H2O2 is a quantitative product of the iron deposition reaction with O2 as an oxidant, even tho

154 8.0 to determine if H2O2 is a product of the iron deposition reaction.

155 l recessive disorder characterized by tissue iron deposition secondary to excessive dietary iron abso

156 We therefore demonstrate that iron deposition serves as an endogenous metabolic imagin

157 ineralization of iron granules occurs in the iron deposition vesicles of trophocytes and requires the

158 t as the adiponectin-mediated attenuation of iron deposition was abolished in PPARalpha-knockout mice

159 Iron deposition was accompanied by hepatocyte injury and

160 Liver iron deposition was found in 25 of 38 patients.

161 reased epithelium-lamina propria ratio while iron deposition was impaired.

162 Although iron deposition was observed in all iron-injected fish,

163 Despite chelation therapy, diffuse iron deposition was occurring in multiple organs, marked

164 Hepatic parenchymal iron deposition was seen in 79 (40%) patients, and iron

165 No iron deposition was seen in aortas of the wild-type nona

166 Increased iron deposition was seen in FRDA heart, liver and spleen

167 31 and inducible nitric oxide synthase while iron deposition was shown with Prussian blue reaction.

168 ratio of GRE images in patients with hepatic iron deposition was significantly lower than that in pat

169 steady-state free precession as a marker of iron deposition was validated in a canine MI model (n=18

170 Liver fat percentage and presence of iron deposition were independently recorded by a patholo

171 al transport of iron is impaired, leading to iron deposition which in the presence of reactive oxygen

172 of hepcidin signaling in ALD leads to liver iron deposition, which is a major contributing factor to

173 erve large glacial-interglacial contrasts in iron deposition, which we infer reflects strongly changi

174 Recent canines studies have shown that iron deposition within chronic myocardial infarction (CM

175 Iron deposition within the iron storage protein ferritin

176 emorrhagic myocardial infarction can lead to iron depositions within the infarct zones, which can be

177 We postulated that pancreatic iron deposition would precede cardiac iron loading, repr