ライフサイエンスコーパス: iron metabolism

1 cell death termed ferroptosis, all depend on iron metabolism.

2 ducible factor-1alpha signaling pathways and iron metabolism.

3 suppressor, in part, by modulating cellular iron metabolism.

4 olA-like protein family has been involved in iron metabolism.

5 ferrireductase activity and modulates kidney iron metabolism.

6 chanism involving interference with cellular iron metabolism.

7 al peptide that is also the key regulator of iron metabolism.

8 nged our understanding of human disorders of iron metabolism.

9 d many cancer cells exhibit dysregulation in iron metabolism.

10 chanistic insight into how copper influences iron metabolism.

11 nal regulators, but they also participate in iron metabolism.

12 homeostasis by altering mitochondrial matrix iron metabolism.

13 tion of hepatic hepcidin gene expression and iron metabolism.

14 ffect of bdh2 deletion on erythropoiesis and iron metabolism.

15 mone hepcidin is a key regulator of systemic iron metabolism.

16 physiologically relevant whole-body model of iron metabolism.

17 al role in the transcriptional regulation of iron metabolism.

18 ing DNA, RNA, protein, ATP biosynthesis, and iron metabolism.

19 hesion, immune cell regulation, and systemic iron metabolism.

20 abnormalities in erythropoiesis and systemic iron metabolism.

21 poiesis (IE), leading to anemia and abnormal iron metabolism.

22 mone, has emerged as the master regulator of iron metabolism.

23 iron transport protein that may function in iron metabolism.

24 ional regulator of several genes involved in iron metabolism.

25 ant regulatory link between inflammation and iron metabolism.

26 being developed to investigate mitochondrial iron metabolism.

27 ression of hepcidin, the master regulator of iron metabolism.

28 luable contributions to our understanding of iron metabolism.

29 witching between white and opaque cells, and iron metabolism.

30 ffects on both inflammation and dysregulated iron metabolism.

31 n synthesis is involved in the regulation of iron metabolism.

32 levated cellular nickel levels) that disrupt iron metabolism.

33 mojuvelin (HJV) is an important regulator of iron metabolism.

34 ntifying a potentially new role for ZIP14 in iron metabolism.

35 gene symbol: Hfe2) plays a critical role in iron metabolism.

36 3 may exert its gain of function by altering iron metabolism.

37 pression in diseases associated with altered iron metabolism.

38 into the cytosol and is involved in cellular iron metabolism.

39 sed sensitivity to oxidants, and a change in iron metabolism.

40 BMP signals regulate hepcidin expression and iron metabolism.

41 nd class II di-iron proteins not involved in iron metabolism.

42 n patients with CHF and evidence of abnormal iron metabolism.

43 aling that regulates hepcidin expression and iron metabolism.

44 the IRE/IRP interaction could greatly affect iron metabolism.

45 -gallium (DFO-Ga) that targets P. aeruginosa iron metabolism.

46 at functions as a key regulator of mammalian iron metabolism.

47 loss-of-function phenotypes associated with iron metabolism.

48 own Fur-repressed genes that are involved in iron metabolism.

49 tosolic protein binding to mRNAs to regulate iron metabolism.

50 and mammals and that this function regulates iron metabolism.

51 cidin is considered the central regulator of iron metabolism.

52 and IRP2) are master regulators of cellular iron metabolism.

53 interrogate the genetic circuitry regulating iron metabolism.

54 nthesized in the liver, is a key mediator of iron metabolism.

55 ntributed to the dysregulation of hepatocyte iron metabolism.

56 ary hemochromatosis is a genetic disorder of iron metabolism.

57 f new therapeutic approaches to disorders of iron metabolism.

58 mitochondrial protein implicated in cellular iron metabolism.

59 ink between A. phagocytophilum infection and iron metabolism.

60 acquisition is integrated with mitochondrial iron metabolism.

61 of copper-containing proteins in eukaryotic iron metabolism.

62 lobe of hTF, thereby interfering with normal iron metabolism.

63 Hepcidin is the master regulator of iron metabolism.

64 ys involved in mitochondrial homeostasis and iron metabolism.

65 ereby contribute to the control of mammalian iron metabolism.

66 96 hours of age were analyzed for markers of iron metabolism.

67 n cancer exhibits a targetable alteration in iron metabolism.

68 ferritin and hepcidin, two major proteins of iron metabolism.

69 meostasis and was required for FDXR-mediated iron metabolism.

70 eracting transcript, and studied its role in iron metabolism.

71 RNA-binding proteins that modulate metazoan iron metabolism.

72 iology, six Minireviews deal with aspects of iron metabolism.

73 ion changes are often indicative of abnormal iron metabolism.

74 ts for the treatment of diseases of abnormal iron metabolism.

75 hyperosmotic stress and SchA was involved in iron metabolism.

76 stress genes, including several involved in iron metabolism.

77 plants indicate that AtHSCB plays a role in iron metabolism.

78 hepcidin gene, HAMP, is the master switch of iron metabolism.

79 epcidin is the central regulator of systemic iron metabolism.

80 s not affected by overt genetic disorders of iron metabolism, a genome-wide association study was con

81 ferritin inclusion bodies, misregulation of iron metabolism, accumulation of ubiquitinated proteins,

82 y or in combination with Darbepoetin alfa on iron metabolism and anemia resolution in 2 different, we

83 rt to better understand the linkages between iron metabolism and breast cancer, a predictive mathemat

84 enes, IRP2-/- mice significantly misregulate iron metabolism and develop neurodegeneration, whereas I

85 rythroid factor with the ability to modulate iron metabolism and dietary iron absorption.

86 bility of transferrin injections to modulate iron metabolism and erythropoiesis in Hbb(th1/th1) mice,

87 s will provide a deeper understanding of how iron metabolism and erythropoiesis intersect in MDSs and

88 ith hamp1 more involved in the regulation of iron metabolism and hamp2 mostly performing an antimicro

89 d proteins involved in systemic and cellular iron metabolism and heme syntheses.

90 crocytic anemias due to genetic disorders of iron metabolism and heme synthesis.

91 of mutations affecting conserved pathways in iron metabolism and heme synthesis.

92 tial importance of iron deficiency, abnormal iron metabolism and hemodilution.

93 been found to play an important role in the iron metabolism and hemogenesis.

94 We studied iron metabolism and hepcidin expression in mice constitu

95 ealing important links between the V-ATPase, iron metabolism and HIFs.

96 e that the mTORC1 pathway serves to modulate iron metabolism and homeostasis, and we speculate that i

97 a reveal the centrality of PI3K signaling in iron metabolism and host colonization.

98 Understanding the relationship between iron metabolism and IE could provide important insights

99 The distinct roles of iron metabolism and inflammation triggered by interleuki

100 Regulation of iron metabolism and innate immunity are tightly interlin

101 It also depends on a strict control of iron metabolism and intracellular iron levels to prevent

102 Ferritin plays a central role in iron metabolism and is made of 24 subunits of 2 types: h

103 ances that have changed our understanding of iron metabolism and its regulation.

104 system, little is known about intracellular iron metabolism and its relation to oxidative stress in

105 rthologues, MRS3 and MRS4, causes defects in iron metabolism and mitochondrial Fe-S cluster biogenesi

106 L5 and CIA acts through both IRPs to control iron metabolism and promote optimal cell growth.

107 These findings provide insights into the iron metabolism and the etiology of anemia in parasitic

108 These cells, which are involved in iron metabolism and the phagocytosis of erythrocytes and

109 Iron metabolism and the plant immune system are both cri

110 Iron metabolism and transport are severely deranged in A

111 uded those for lipopolysaccharide synthesis, iron metabolism and type III secretion.

112 we review the impact of macrophages on heme-iron metabolism and, reciprocally, how heme-iron modulat

113 ry, (3) immunohistochemistry for proteins of iron metabolism, and (4) quantitative analysis by digita

114 gradation, immune signaling, cell signaling, iron metabolism, and apoptosis.

115 volved in detoxifying aldehydes, controlling iron metabolism, and degrading toxic lipoproteins.

116 altered expression of redox-active proteins, iron metabolism, and DNA repair, as well as via biofilm

117 fect of these changes on ferritin synthesis, iron metabolism, and downstream effects on iron-responsi

118 recently defined pathways in RBC production, iron metabolism, and fetal globin-family gene expression

119 tosis including lipid peroxidation, abnormal iron metabolism, and hypersensitivity to free iron.

120 The peptide hormone hepcidin regulates iron metabolism, and insufficient hepcidin synthesis is

121 ks, including heme and hemoglobin digestion, iron metabolism, and reactive oxygen species, and unveil

122 monoxide (NO) markedly affects intracellular iron metabolism, and recent studies have shown that mole

123 Dysregulation of iron metabolism, and resultant cytotoxicity, has been im

124 s the synthesis of many proteins involved in iron metabolism, and the level of IRP2 itself is regulat

125 As a consequence of disturbed iron metabolism, archazolid caused S-phase arrest, doubl

126 tein expression suggested defective zinc and iron metabolism arising from altered ZnT protein express

127 s and underscores the importance of haem and iron metabolism as rational targets for anti-tick interv

128 ve to the dysregulation of the intracellular iron metabolism as suggested by reports on loss of iron

129 eins involved in amino acid biosynthesis and iron metabolism, as well as two so-called sulfur-induced

130 Furthermore, by mimicking the altered iron metabolism associated with Hfe deficiency, we found

131 f inflammatory, metabolic, liver injury, and iron metabolism biomarkers on the association between co

132 significantly alters hepcidin expression and iron metabolism both in vitro and in vivo Specifically,

133 s widely recognized as a crucial protein for iron metabolism, but may also bear possible implications

134 ein 2 coordinates the cellular regulation of iron metabolism by binding to iron-responsive elements i

135 Hepcidin regulates iron metabolism by down-regulating ferroportin-1 (Fpn1).

136 activity of cellular Fe-S proteins, affects iron metabolism by influencing the cytosolic aconitase-I

137 ted into the circulation, hepcidin regulates iron metabolism by inhibiting iron release from cells, i

138 that mitochondrial SIRT3 regulates cellular iron metabolism by modulating IRP1 activity.

139 ction as a facilitator of heme synthesis and iron metabolism by reducing ROS production.

140 levels of hepcidin, a peptide that regulates iron metabolism by triggering degradation of ferroportin

141 nown function, followed by genes involved in iron metabolism, cell communication, and intermediary me

142 and suggests a mechanism of how interphylum iron metabolism contributes to gut microbiota resilience

143 Defective systemic and local iron metabolism correlates with cardiac disorders.

144 Despite having dysregulated iron metabolism, critically ill patients may receive exo

145 echanistically, IFN-I signaling dysregulates iron metabolism, depolarizes mitochondrial membrane pote

146 on TBSV replication in yeast, while altered iron metabolism did not reduce TBSV replication.

147 Despite the fact that the mechanisms of iron metabolism differ drastically in fungi and higher e

148 de hormone hepcidin, a systemic regulator of iron metabolism, dramatically decreased FPN1 protein lev

149 report we investigate changes in proteins of iron metabolism during p53-mediated replicative arrest.

150 erstand stress erythropoiesis and changes in iron metabolism during pregnancy and development, especi

151 s) in mRNAs that encode proteins involved in iron metabolism (e.g. ferritin and transferrin receptor

152 re transcription factors controlling energy, iron metabolism, erythropoiesis, and development.

153 ophages to saturated fatty acids also alters iron metabolism gene expression.

154 Conservation of iron metabolism genes across Wolbachia suggests iron hom

155 requires post-transcriptional regulation of iron metabolism genes by iron regulatory protein 2 (IRP2

156 This study shows that FixK regulates key iron metabolism genes in an alpha-proteobacterium, point

157 s to the differential expression of specific iron metabolism genes in Brucella strains are unclear.

158 Renal iron levels and the expression of iron metabolism genes were examined.

159 , altered post-transcriptional regulation of iron metabolism genes, and mitochondrial dysfunction, as

160 on levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1

161 Hepatic and/or duodenal response patterns of iron metabolism genes, such as Trfr, cybrd1, and Slc11a2

162 rived Hif-2 is involved in the regulation of iron metabolism genes, supporting a role for HIF-2 in th

163 egulate mRNA stability or the translation of iron metabolism genes.

164 The transcription and translation of iron-metabolism genes (light polypeptide ferritin chain,

165 n (FXN), which is critical for mitochondrial iron metabolism, global cellular iron homeostasis, and a

166 s of genes that participate in angiogenesis, iron metabolism, glucose metabolism, and cell proliferat

167 rent degrees of severity of anemia, abnormal iron metabolism, growth retardation and shortened lifesp

168 The study of iron metabolism has advanced greatly with the identifica

169 Understanding iron metabolism has been enhanced by identification of g

170 regulatory component of extracellular iron, iron metabolism has yet to be characterized in human CF

171 side, hepcidin, a key regulator of mammalian iron metabolism, has emerged as an important mediator of

172 icate that physiologic changes in macrophage iron metabolism have an important effect on HIF hydroxyl

173 Alterations in iron metabolism have been described during fibrotic lung

174 New insights into cellular iron metabolism have been provided by the recognition th

175 Perturbations in iron metabolism have been shown to dramatically impact h

176 Recent advances in the study of iron metabolism have led to a better understanding of th

177 strategies designed to interfere with tumor iron metabolism have targeted TFRC1.

178 lude the discovery of a new gene involved in iron metabolism, hemojuvelin, and new data on the role o

179 As a central regulator of iron metabolism, hepcidin inhibits dietary iron absorpti

180 Iron metabolism impacts mitochondrial function and oxida

181 n many diseases, and as our understanding of iron metabolism improves, the list of iron-related disor

182 m of this study was to analyze parameters of iron metabolism in a multicenter cohort of adult patient

183 The regulation of iron metabolism in biological systems centers on providi

184 2 is an early nodal point underlying altered iron metabolism in breast cancer and may contribute to p

185 e model successfully captures key aspects of iron metabolism in breast cancer cells and provides a fr

186 Dysregulation of iron metabolism in cancer is well documented and it has

187 nts regarding CDAs have been in the study of iron metabolism in CDAII.

188 sis in roots, also play a role in regulating iron metabolism in developing leaves.

189 how the newer understanding of hepcidin and iron metabolism in general can lead to very practical im

190 ells and that it may play a role in zinc and iron metabolism in hepatocytes, where this transporter i

191 irm that IRP2 is essential for regulation of iron metabolism in humans, and reveal a previously unrec

192 The mechanisms of iron metabolism in insects are still poorly understood,

193 ry is an important step toward understanding iron metabolism in insects.

194 central nervous system, evidence of abnormal iron metabolism in IRP2-/- mice precedes the development

195 ase uniquely affects lipid, cholesterol, and iron metabolism in juvenile mice.

196 Iron metabolism in mammalian cells is orchestrated postt

197 Iron regulatory proteins (IRPs) regulate iron metabolism in mammalian cells.

198 tic peptide hepcidin is the key regulator of iron metabolism in mammals.

199 dominates post-transcriptional regulation of iron metabolism in mammals.

200 the Trojan horse approach adopted to impair iron metabolism in mycobacteria has also been included i

201 The role of abnormal brain iron metabolism in neurodegenerative diseases is still i

202 any fundamental cellular processes linked to iron metabolism in order to coordinate the overall respo

203 the molecular mechanisms regulating cellular iron metabolism in osteoclasts remain largely unknown.

204 sed mutant p53 expression along with altered iron metabolism in p53(R270H/-) MEFs and cancer cells ca

205 l measures of iron status accurately reflect iron metabolism in physically active, nonanemic women.

206 The peptide hormone hepcidin regulates iron metabolism in response to erythropoietic demand, ir

207 Regulation of iron metabolism in Saccharomyces cerevisiae is achieved

208 To study iron metabolism in Schwann cells (SCs), we have created

209 dispensable for SC maturation, understanding iron metabolism in SCs is an essential prerequisite for

210 IREs serve as the main control mechanism for iron metabolism in the cell via their interaction with t

211 ta also suggests that SMS deficiency affects iron metabolism in the cells, which we hypothesize is li

212 These results point to a critical role for iron metabolism in the regulation of intra-graft alloimm

213 In this review, we discuss regulation of iron metabolism in the setting of infection and delineat

214 obably due to a greater effect of ethanol on iron metabolism in the susceptible strain.

215 The ability to manipulate iron metabolism in vivo may also allow investigation of

216 ogenous regulator of hepcidin expression and iron metabolism in vivo.

217 ate metabolism, solute transport systems and iron metabolism, in addition to others.

218 n is due to the combined effects of abnormal iron metabolism, inappropriately low erythropoietin prod

219 r expression of several master regulators of iron metabolism, including iron regulatory protein 2 (IR

220 ing mice displayed signs of dysregulation in iron metabolism, including reduced serum iron and increa

221 Emerging evidence suggests that disordered iron metabolism is a risk factor for various types of di

222 ing the crosstalk between erythropoiesis and iron metabolism is an area of active investigation in wh

223 regulation by miR-210 perturbing trophoblast iron metabolism is associated with defective placentatio

224 The essential role of hepcidin in iron metabolism is being elucidated through mouse and hu

225 Iron metabolism is controlled by hepcidin, a 25-amino ac

226 Iron metabolism is controlled by hepcidin, a 25-amino-ac

227 neral regulatory mechanism for mitochondrial iron metabolism is described that defines frataxin invol

228 Iron metabolism is disturbed, and administration of iron

229 Iron metabolism is essential for many cellular processes

230 am signaling events affect genes involved in iron metabolism is incompletely understood.

231 vestigate how expression of genes related to iron metabolism is linked to breast cancer prognosis.

232 m by which hepatitis C virus (HCV) regulates iron metabolism is poorly understood.

233 atus and are increased in disorders in which iron metabolism is secondarily disregulated, such as the

234 or process of iron homeostasis in whole-body iron metabolism is the release of iron from the macropha

235 These biological properties demand that iron metabolism is tightly regulated such that iron is a

236 n a mouse model causes profoundly disordered iron metabolism, leading to functional iron deficiency,

237 Polymorphisms of genes linked to iron metabolism may account for individual variability i

238 Because aberrant iron metabolism may cause neural and retinal degeneratio

239 der-related disparities in the regulation of iron metabolism may contribute to the differences exhibi

240 Finally, Irr-mediated control of iron metabolism may reflect a cellular strategy that acc

241 tions in Alzheimer's disease (AD), including iron metabolism, mitochondrial complex IV, heme oxygenas

242 Iron metabolism, monooxygenases, and secondary metabolis

243 a critical role in two important aspects of iron metabolism, namely, maintenance of whole-plant iron

244 Defects in iron metabolism observed in this study may inform host-p

245 show an additional role for AhpC in cellular iron metabolism of E. coli.

246 ansporter FeoB is an important factor in the iron metabolism of many bacteria.

247 in were used to investigate the influence of iron metabolism on the release of nitric oxide (NO) in r

248 IRP1-/- mice misregulate iron metabolism only in the kidney and brown fat, two ti

249 genetic or pharmacological manipulations of iron metabolism or erythroid cell differentiation and su

250 es with repeated measurements of glucose and iron metabolism parameters are needed to establish the r

251 urcumin has the potential to affect systemic iron metabolism, particularly in a setting of subclinica

252 Our findings demonstrate that parameters of iron metabolism, particularly transferrin saturation, th

253 -)) animals do not significantly misregulate iron metabolism, partly because IRP1 is an iron-sulfur p

254 aem-bound iron, was utilized by the mosquito iron metabolism pathway to boost the activity of reactiv

255 othiol multidomain glutaredoxins in cellular iron metabolism pathways, including the biogenesis of Fe

256 s that dysregulation of proteins involved in iron metabolism plays a critical role in cancer.

257 f and HFE, HIV-1 directly regulates cellular iron metabolism, possibly benefiting viral growth.

258 Moreover, ferritin, a key protein in iron metabolism, prevents excessive ALIS formation.

259 AtHSCB play a key role in iron metabolism, probably taking part in the control of

260 tion of putative virulence genes involved in iron metabolism, protein secretion, and glycosylation, w

261 t alteration in expression of genes encoding iron metabolism proteins.

262 nsferrin receptor (TfR), ferritin, and other iron metabolism proteins.

263 of transferrin receptor, ferritin, and other iron metabolism proteins.

264 proteins (IRPs) shape the expression of the iron metabolism proteome.

265 ngle hepcidin gene, with a dual role in both iron metabolism regulation and antimicrobial response, m

266 mainly by the liver, plays a central role in iron metabolism regulation.

267 Many aspects of plant iron metabolism remain obscure.

268 analyzed safety and effects on inflammation, iron metabolism, serum albumin, and anti-drug antibodies

269 n horse delivery system that interferes with iron metabolism shows promise as a treatment for P. aeru

270 thway are associated with human disorders of iron metabolism, such as hereditary hemochromatosis and

271 -surface and secreted molecules unrelated to iron metabolism, suggesting that it has a fundamental ro

272 improved mechanistic understanding of plant iron metabolism suggests that such alterations could pro

273 The information on iron metabolism that has become available in recent year

274 in Ex12 mutant mice is favored by changes in iron metabolism that optimize iron availability to allow

275 he current series deal with redox cycling in iron metabolism, the biogenesis and assembly of iron-sul

276 th the proposed role of the sufBCDS genes in iron metabolism, the growth rate of the null mutant was

277 ed in regulation of the master controller of iron metabolism, the hormone hepcidin, in malaria infect

278 contrast to previous mathematical models of iron metabolism, the liver is included as a key site of

279 oteins involved in coenzyme biosynthesis and iron metabolism, the pyruvate dehydrogenase kinase, and

280 idant defense and impairing Nrf2-coordinated iron metabolism, thereby leading to ferroptosis in cardi

281 H2O2 are capable of disrupting intracellular iron metabolism, thereby selectively sensitizing non-sma

282 ta uncover a novel role of SIRT3 in cellular iron metabolism through IRP1 regulation and suggest that

283 emojuvelin regulates hepcidin expression and iron metabolism through the BMP pathway, the role of the

284 Here, we report that p53 regulates iron metabolism through the transcriptional regulation o

285 loops in messenger RNAs encoding proteins of iron metabolism to control their rate of translation.

286 on during infection and inflammation couples iron metabolism to host defense and decreases iron avail

287 Connecting iron metabolism to innate immunity, hepcidin is a key me

288 technology for studying the contributions of iron metabolism to physiology and pathology.

289 , a model of the human inherited disorder of iron metabolism type I hemochromatosis.

290 omeostasis and is required for FDXR-mediated iron metabolism via iron regulatory protein 2 (IRP2).

291 ession was not generally apparent, genes for iron metabolism were strongly induced specifically on sw

292 lobin chains, possibly related to defects in iron metabolism, were enriched in PD brains.

293 We found that IRP2-/- cells misregulated iron metabolism when cultured in 3 to 6% oxygen, which i

294 embers in Saccharomyces cerevisiae influence iron metabolism, whereas the single protein expressed in

295 chanistic computational model of human liver iron metabolism, which includes the core regulatory comp

296 tory protein 1, a key cytosolic modulator of iron metabolism, which is responsive to the availability

297 is emerging as a novel mechanism to promote iron metabolism while also providing anti-oxidant protec

298 at MYC upregulates ADHFE1 through changes in iron metabolism while coexpression of both ADHFE1 and MY

299 his review we summarize current knowledge of iron metabolism with an emphasis on the sources and pote

300 ndings reveal an essential role for HSPB1 in iron metabolism with important effects on ferroptosis-me