ライフサイエンスコーパス: iron uptake

1 bably targets the ESAT-6 protein to increase iron uptake.

2 P(C) to a detergent-insoluble form, limiting iron uptake.

3 egress from cells and thus limits intestinal iron uptake.

4 y repressing iron consumption and activating iron uptake.

5 ses such as oxidative stress, heat shock and iron uptake.

6 agreement with the need to prevent excessive iron uptake.

7 th other genes encoding proteins involved in iron uptake.

8 iently use iron, despite unimpaired cellular iron uptake.

9 um colony was designed to model whole colony iron uptake.

10 ght cell proteins loaded with iron following iron uptake.

11 gonist FPL 64176 was administered to promote iron uptake.

12 ereas FupA facilitates high affinity ferrous iron uptake.

13 s a co-repressor and inappropriately repress iron uptake.

14 ctive under high-iron conditions, repressing iron uptake.

15 e iron assimilation and siderophore-mediated iron uptake.

16 elative to hemophores and the Isd system, in iron uptake.

17 ng assumptions associated with phytoplankton iron uptake.

18 nickel ion homeostasis, acid adaptation, and iron uptake.

19 lipoprotein that increases the efficiency of iron uptake.

20 ple mutants showed a significant decrease in iron uptake.

21 in system incapable of obstructing bacterial iron uptake.

22 Arabidopsis root epidermal cells to optimize iron uptake.

23 represses transcription of genes involved in iron uptake.

24 as a negative regulator of genes involved in iron uptake.

25 ) is produced by enteric bacteria to mediate iron uptake.

26 nes required for ergosterol biosynthesis and iron uptake.

27 and show enhanced compensatory high affinity iron uptake.

28 porter FeuBC, which is involved in bacterial iron uptake.

29 efence system while concomitantly activating iron uptake.

30 te both recycling-dependent and -independent iron uptake.

31 presence of additional pathways involved in iron uptake.

32 ation of ferritin, leading to an increase in iron uptake.

33 mmation and were predicted to be involved in iron uptake.

34 treatment to chelation, reducing myocardial iron uptake.

35 ndent repression of FET3, a gene involved in iron-uptake.

36 oblasts (vs CV1 fibroblasts) showed enhanced iron uptake (1.8 mmol +/- 0.5 x 10(-8) vs 0.9 mmol +/- 0

37 ,6-biphosphate to the Caco-2 cells increased iron uptake 2-fold.

38 re type relying on a compatible receptor for iron uptake(8-12), our results suggest that pathogen-sup

39 3p turnover of Fe(II) supports high affinity iron uptake across the yeast plasma membrane, whereas it

40 on release and Mfrn2-dependent mitochondrial iron uptake act synergistically to induce PDT-mediated a

41 A feoA(E40K) mutant contained partial iron uptake activity in culture that supported normal gr

42 The feoA(E40K) strain had partial iron uptake activity in situ within nodules and in isola

43 t influence several central processes, e.g., iron uptake, adsorption/desorption of contaminants and n

44 led with group 3 and 5 media had the highest iron uptake after cells labeled with group 1 medium.

45 ng iron-scavenging siderophores that promote iron uptake and alleviate iron-regulated host immune res

46 These changes may increase dietary iron uptake and allow release of stored iron to ensure a

47 s allow a distinction to be made between its iron uptake and any putative cell signaling roles.

48 KCalpha deficiency did not show increases in iron uptake and BBM DMT1 expression.

49 embrane-associated glycoprotein critical for iron uptake and cell proliferation, are controlled by SI

50 The iron chelator desferoxamine reduced both iron uptake and colony formation.

51 ession of AtHSCB induced an increase in root iron uptake and content along with iron deficiency in sh

52 Hindering iron uptake and disrupting adhesins' function could be a

53 Thus, iron uptake and distribution in plants are controlled by

54 e components of transporters associated with iron uptake and DNA repair.

55 tinal HIF-2alpha that controls physiological iron uptake and drives iron hyperabsorption during iron

56 ted that HGA-melanin is able to both promote iron uptake and enhance growth under iron-limiting condi

57 unexpected role of ARHGEF3 in regulation of iron uptake and erythroid cell maturation.

58 the induction of genes that are required for iron uptake and for the maintenance of cellular iron hom

59 100A9 or MRP8/MRP14 heterooligomer) inhibits iron uptake and induces an iron starvation response in P

60 ureus, and demonstrate that CP also inhibits iron uptake and induces iron-starvation responses by thi

61 anism, potentially including facilitation of iron uptake and induction of toxicity to other organisms

62 e to polystyrene nanoparticles can influence iron uptake and iron transport in an in vitro model of t

63 P. aeruginosa from CP-mediated inhibition of iron uptake and iron-starvation responses.

64 cts S. aureus from CP-mediated inhibition of iron uptake and iron-starvation responses.

65 Iron uptake and metabolism are tightly regulated in both

66 ndicated high level up-regulation of several iron uptake and metabolism genes that are part of the Af

67 regulon increases the cellular capacity for iron uptake and mobilizes an iron-sparing response media

68 iron excess, induction of hepcidin restricts iron uptake and movement within the body.

69 ust be strictly regulated to ensure adequate iron uptake and prevent toxic iron accumulation.

70 ays a central role in the diel regulation of iron uptake and recycling and that this regulation of ir

71 separated by a phospholipid bilayer, such as iron uptake and redox signaling.

72 hus plants have evolved a complex network of iron uptake and regulation mechanisms.

73 esses hepcidin, thereby enhancing intestinal iron uptake and release from internal stores.

74 acid binding sites whose occupancy modulates iron uptake and release.

75 lled by iron regulatory proteins to increase iron uptake and retention; at the systemic level, suppre

76 In C. elegans, iron uptake and sequestration are regulated by HIF-1.

77 ccharomyces pombe was known to use reductive iron uptake and siderophore-bound iron transport to scav

78 The transcription of iron uptake and storage genes in Saccharomyces cerevisia

79 r1 are critical proteins for early postnatal iron uptake and storage in SCs and, as a consequence, fo

80 ta herein provide evidence for regulation of iron uptake and storage within brain microvessels that c

81 which three essential proteins implicated in iron uptake and storage, the divalent metal transporter

82 They caused significant changes in iron uptake and storage, the rate of ferritin synthesis

83 We found that the regulation of iron uptake and TfR1 expression contribute to the tumor-

84 or TfR1, a housekeeping protein required for iron uptake and the cell surface receptor for at least t

85 ticle discusses the mechanisms implicated in iron uptake and the challenges associated with the desig

86 fucose bearing linker to interfere with both iron uptake and the glycan recognition process involving

87 Herein, we show that iron uptake and the mRNA expression of iron importer div

88 The mechanisms of root iron uptake and the transcriptional networks that contro

89 Continued HU stress activates iron uptake and toxins MazF and RelE, whose activity cau

90 Chromatin in the promoter regions of iron uptake and utilization genes showed repressed and a

91 In the Deltairr DeltarirA mutant, iron uptake and utilization genes were derepressed, roug

92 hat Steap4 is a critical enzyme for cellular iron uptake and utilization in osteoclasts and, thus, in

93 veloped and provide further insight into the iron uptake and/or release and mineralization mechanism

94 myces cerevisiae by activating expression of iron-uptake and -transport genes when intracellular iron

95 ulticopper oxidase involved in high-affinity iron uptake), and Aft1p (iron regulator) were also compa

96 This receptor is crucial for placental iron uptake, and its decrease was accompanied by decreas

97 rol and cell wall biosynthesis, cell growth, iron uptake, and known fungal virulence factors compared

98 e by P. aeruginosa to counteract the loss of iron uptake, and strong biofilm inhibition was observed

99 ly low levels of hepcidin, increased dietary iron uptake, and systemic iron accumulation, has been as

100 na may utilize both S1 and S2 strategies for iron uptake; and mimosine may play an important role in

101 ow that microbial genes involved in cellular iron uptake are highly expressed in the Guaymas Basin de

102 those involved in siderophore synthesis and iron uptake - are strongly induced during biofilm format

103 pounds synthesized by microbes to facilitate iron uptake, are a dynamic component of the marine ligan

104 and identified cholesterol biosynthesis and iron uptake as essential metabolic pathways when lysosom

105 cludes the known components of high-affinity iron uptake as well as candidates for distributive iron

106 iron demand from shoots to roots to regulate iron uptake as well as the transport systems mediating i

107 nstitutively high capacity for high affinity iron uptake associated with loss of the chromosomal copy

108 which it modulates holotransferrin-mediated iron uptake at the surface of macrophage is not well und

109 Deletion of hapX does not affect iron uptake but causes derepression of genes involved in

110 gen receptor signaling or increased cellular iron uptake, but was impaired by mutation of either BMP

111 e of attenuated sunlight increased bacterial iron uptake by 70% and algal uptake by >20-fold.

112 n BeWo cells, a placental cell line, reduced iron uptake by approximately 40%, suggesting that ZIP8 p

113 its [4Fe-4S] cluster-bound form it represses iron uptake by binding to IRO Box sequences upstream of

114 ations in mineral contents of sorghum on the iron uptake by Caco-2 cells.

115 ken sulfated GAG polysaccharides can enhance iron uptake by Caco-2 cells.

116 Iron uptake by diatoms is a biochemical process with glo

117 e of iron from endosomes and lysosomes after iron uptake by endocytosis of Fe(3+)-bound transferrin r

118 thropoiesis, and impairing transferrin-bound iron uptake by erythroid cells.

119 null mutant is due to elevated repression of iron uptake by Fur, exacerbated by heme sequestration by

120 addition, HFE potentially modulates cellular iron uptake by interacting with transferrin receptor, a

121 Iron uptake by osteoclast precursors via the transferrin

122 atocytes, plays a central role in regulating iron uptake by promoting internalization and degradation

123 Transferrin-mediated iron uptake by regenerating myofibers occurs independent

124 main transporter responsible for apoplastic iron uptake by rhizobia-infected cells in zone II.

125 se human pathogens revealed that CP inhibits iron uptake by several bacterial species under aerobic c

126 ic iron may not be the rate-limiting step in iron uptake by strategy I plants such as Arabidopsis.

127 ssible mechanism explaining how GAGs promote iron uptake by the Caco-2 cells.

128 tal-ion transporter-1 (DMT1) is required for iron uptake by the intestine and developing erythroid ce

129 ium uniporter, consistent with mitochondrial iron uptake by the uniporter.

130 By measuring radiolabelled iron uptake, by monitoring the levels of cytosolic and i

131 -NOX(Vf) and modulates the expression of its iron uptake capacity during the early stages of the ligh

132 loss of transferrin receptor 1, involved in iron uptake, caused neuronal iron deficiency, age-progre

133 corresponded to the 3 recognized siderophore iron uptake clusters, reflecting the iron-restrictive en

134 acquisition, given that mutants deficient in iron uptake colonize the intestine but do not reduce S.

135 We characterized the dynamics of the iron uptake complex and showed that FRO2 and AHA2 ubiqui

136 llus membrane DMT1 expression and intestinal iron uptake, contributing to diabetic iron loading.

137 Iron uptake decreased with increasing the affinity const

138 Direct interrogation of iron uptake demonstrated that CSCs potently extract iron

139 l ligands show they can facilitate or impede iron uptake depending on their identity.

140 mice, further supporting a critical role for iron uptake during leukemogenesis.

141 culature appears to mediate the compensatory iron uptake during postnatal development and iron conten

142 up-regulation of transcripts related to heme/iron uptake (e.g., isdA, isdB, and isdCDEFsrtBisdG), and

143 This form of iron uptake entails a close association between diatoms

144 ion of sreA in the DeltaacuM mutant restored iron uptake, extracellular siderophore production and vi

145 gens may rely on siderophore-mediated ferric iron uptake, ferrous iron uptake, or heme uptake at diff

146 The ferric iron uptake (Fiu) transporter from Escherichia coli func

147 ties of the mutant confirm the importance of iron uptake for cellular function, e.g. for the Krebs cy

148 rom the phenylpropanoid pathway, compromised iron uptake from an iron source of low bioavailability.

149 , except for baobab, significantly inhibited iron uptake from FeSO(4) and FAC, with fenugreek sprout

150 at mobilizing cellular (59)Fe and inhibiting iron uptake from human transferrin depending on the cell

151 es, both of which are critical for efficient iron uptake from human transferrin.

152 phytate, and calcium, had limited effect on iron uptake from intact ferritin by Caco-2 cells, which

153 n expression is reduced to promote increased iron uptake from the diet and release from cells, wherea

154 matosis (HH) because of inappropriately high iron uptake from the diet resulting from decreased hepat

155 The peptide hormone hepcidin (Hepc) limits iron uptake from the intestine by triggering degradation

156 factors in B. anthracis are responsible for iron uptake from the most abundant iron source for mamma

157 gh affinity iron transporter responsible for iron uptake from the soil in Arabidopsis (Arabidopsis th

158 In plants, iron uptake from the soil is tightly regulated to ensure

159 rategy I (S1) and strategy II (S2) genes for iron uptake from the soil was studied in leucaena plants

160 em of Neisseria gonorrhoeae is necessary for iron uptake from transferrin in the human host and requi

161 erizes a new B. bronchiseptica mechanism for iron uptake from transferrin that uses host stress hormo

162 decrease in transferrin receptor levels and iron uptake from transferrin.

163 ssion of genes encoding proteins involved in iron uptake (Frp1, Fip1, Fio1, Str3, Str1, Sib1), withou

164 xide production, together with the increased iron uptake, fuels the formation of hydroxyl radicals th

165 Our results indicate that, albeit its iron uptake function, TfR1 is a signaling molecule and t

166 ng through a role that is independent of its iron-uptake function.

167 virus entry while simultaneously preserving iron-uptake functionalities, both in rodent and human Tf

168 ficient to induce swarming, luminescence and iron uptake gene expression in multiple Vibrio species;

169 this mutant leads to increased expression of iron uptake genes accompanied by elevated levels of mito

170 and molecular bases are unclear, as very few iron uptake genes have been functionally characterized f

171 RNA sequencing results identified changes in iron uptake genes in Hst 5-treated C. albicans cells.

172 utant demonstrated up-regulation of multiple iron uptake genes under control of Aft1p (the iron regul

173 Iron uptake genes were derepressed in the DeltarirA muta

174 fur mutant confirmed previous findings that iron uptake genes were highly de-repressed in the mutant

175 or strains can be isolated with mutations in iron uptake genes.

176 was directly involved in SRE1 regulation of iron-uptake genes.

177 We also demonstrate that enhancing root iron uptake has an impact on the expression of genes tha

178 D and bfrE genes, the role of these genes in iron uptake has not been demonstrated.

179 tworks that control root-level regulation of iron uptake have been well studied, but the mechanisms b

180 P6 content of wholemeal bread, its impact on iron uptake in Caco-2 cells and the predicted bioavailab

181 Finally, structural analysis of iron uptake in crystallo suggests a possible pathway for

182 gulates TfR-dependent, recycling-independent iron uptake in hBMVECs by fine-tuning the endosomal pH i

183 testinal metal transporter SMF-3 to increase iron uptake in hif-1 mutants.

184 Hepcidin plays a key role in modulating iron uptake in iron-overload disorders and new studies e

185 mber of strategy I and strategy II genes for iron uptake in leucaena.

186 fluctuations in atmospheric CO2, may perturb iron uptake in many marine heterotrophic bacteria due to

187 r IdeR is a key transcriptional regulator of iron uptake in Mycobacterium tuberculosis.

188 ontribute substantially to the efficiency of iron uptake in natural conditions.

189 howed that JTR-009 did not indirectly change iron uptake in neuronal cells suggesting a direct intera

190 Recent studies revealed a novel role for iron uptake in orchestrating the differentiation of amas

191 The mechanisms of iron uptake in roots are well characterized, but less is

192 indicate that the shoot-directed control of iron uptake in roots functions properly in these lines,

193 tion in shoots despite the reduced levels of iron uptake in roots.

194 ased iron accumulation in shoots and reduced iron uptake in roots.

195 ofilm development and mediates intracellular iron uptake in the absence of TonB.

196 died homeostatic mechanism is the control of iron uptake in the roots by shoots.

197 ulting in increased holotransferrin-mediated iron uptake in these macrophages.

198 were defective for xenosiderophore-mediated iron uptake in vitro.

199 sor cells possess an efficient mechanism for iron uptake in which iron loaded transferrin (Tf) binds

200 of autoptic MS tissue, an in vitro model of iron-uptake in human cultured macrophages and ultra-high

201 Increments in mitochondrial iron uptake induced stepwise assembly of Yfh1 species ra

202 Iron uptake into cells and incorporation into ferritin w

203 is the cell-surface receptor that regulates iron uptake into cells, a process that is fundamental to

204 Although iron uptake into the cytoplasm in the form of heme has b

205 Mtb iron uptake is a complex process, requiring biosynthesis

206 Our findings indicate that cellular iron uptake is a major process in plume microbial commun

207 Here we show that iron uptake is a major trigger for the differentiation o

208 t a plasma membrane-associated mechanism for iron uptake is essential for the establishment of infect

209 Thus, iron uptake is highly regulated and induced only under i

210 Because iron uptake is vital for almost all bacteria, expression

211 ve stress-induced vicious cycle of increased iron uptake leading to further oxidative stress was intr

212 tics that could directly target Mtb heme and iron uptake machineries.

213 we describe the E. ictaluri Fur protein, the iron uptake machinery controlled by Fur, and the effects

214 tivities due to their ability to exploit the iron uptake machinery of Gram-negative bacteria.

215 nd, thus, for modulating the activity of the iron uptake machinery.

216 res early signaling components with the root iron-uptake machinery.

217 Therefore, at least one step of the iron uptake mechanism involves a thermodynamically contr

218 significant role in the siderophore-mediated iron uptake mechanism of LVS whereas fslE appears to pla

219 We investigated iron uptake mechanisms in five marine microalgae from di

220 Iron uptake mechanisms probably involve very different c

221 M. tuberculosis has two iron uptake mechanisms, one that utilizes non-heme iron

222 pJ homolog, and genes encoding at least five iron uptake mechanisms, two potential type IV secretion

223 The use of bacterial ferric iron uptake mutants further showed that both the Fe(II)

224 thought to meet the increased requirement of iron uptake necessary for cell growth.

225 siderophore analogs, supplanting the natural iron uptake of most bacteria.

226 nd with the start of PS release a "window of iron uptake" opens.

227 responds to dynamic changes in mitochondrial iron uptake or stress exposure in a highly controlled fa

228 infection, but it is unclear whether ferric iron uptake or the ferric iron binding siderophores ente

229 rophore-mediated ferric iron uptake, ferrous iron uptake, or heme uptake at different points during i

230 rs a more comprehensive picture of microbial iron uptake pathways in the ocean.

231 tion of norA-lacZ, suggesting that bacterial iron uptake plays an important role in regulating norA t

232 a surface-exposed lipoprotein that makes the iron uptake process more efficient.

233 Second, deregulation of root iron uptake processes in opt3-2 roots resulted in the ac

234 Irp2 post-transcriptionally regulates the iron-uptake protein transferrin receptor 1 (TfR1) and th

235 fully functional in regulated genes encoding iron uptake proteins.

236 n the feoAB operon encoding ferrous (Fe(2+)) iron uptake proteins.

237 pression of schT and iutA2 as well as of the iron uptake rate to the degree of starvation, a model fo

238 , we found that HCV alters expression of the iron uptake receptor transferrin receptor 1 (TfR1).

239 Iron uptake-related TBDTs and siderophore biosynthesis g

240 iptional regulation of genes responsible for iron uptake, release, use, and storage through the actio

241 iron exit pore were found to be important in iron uptake/release kinetics.

242 Kinetics of iron uptake/release of the wild type and mutants were co

243 , heme biosynthesis enzymes (hemAXCDBL), the iron uptake repressor (fur), and perR itself.

244 and exhibits constitutive expression of its iron uptake responses.

245 ckdown of ISIP2a in P. tricornutum decreases iron uptake, resulting in impaired growth and chlorosis

246 This effect was most prominent in the iron uptake results.

247 results, at least in part, from insufficient iron uptake, since it can be corrected by iron supplemen

248 onally regulate genes required for balancing iron uptake, storage, and utilization.

249 o major crops, corn and soybean differing in iron uptake strategies, were grown in irrigated syntheti

250 Furthermore, iron uptake studies in hem6 reticulocytes demonstrate de

251 xpression of AtHSCB led to activation of the iron uptake system and iron accumulation in roots withou

252 The gonococcal transferrin-iron uptake system is composed of two transferrin bindin

253 The iron uptake system of Edwardsiella ictaluri, a host-rest

254 ort pseudogene efeU repair that restores the iron uptake system of Escherichia coli under a designed

255 ence traits in B. anthracis, the PB-mediated iron uptake system presents a potential target for antim

256 independent and thermodynamically controlled iron uptake system.

257 enhancing our understanding of this critical iron uptake system.

258 a mutant that also lacked the high-affinity iron uptake system.

259 n-bound Fur represses the genes encoding for iron uptake systems and stimulates the genes encoding fo

260 nal activator of multiple ferrous and ferric iron uptake systems in addition to a haem uptake system.

261 nfection, bacterial pathogens have developed iron uptake systems that are upregulated in the absence

262 icularly when cells expressing high affinity iron uptake systems transition to iron rich environments

263 Expression of genes that encode iron uptake systems was decreased in the Deltairr mutant

264 istant Proteus-like (MR/P) fimbriae, urease, iron uptake systems, amino acid and peptide transporters

265 disulfide oxidoreductases likely involved in iron uptake systems.

266 DNA binding protein that represses bacterial iron uptake systems.

267 ur mechanistic understanding of the multiple iron-uptake systems used by diatoms and help us better p

268 wed a significantly higher degree of cardiac iron uptake than wild-type littermates following iron de

269 e of receptor that participates in a form of iron uptake that is mechanistically distinct from the ex

270 porter-1 (DMT-1), indicating PrP(C)-mediated iron uptake through DMT-1.

271 The enhanced iron uptake through enzymatic GAG depolymerisation could

272 h the wild type, presumably due to the lower iron uptake through IRT1.

273 Here, we investigated whether mitochondrial iron uptake through mitoferrin-2 (Mfrn2) enhanced PDT-in

274 errin receptor 1 (Tfr1) facilitates cellular iron uptake through receptor-mediated endocytosis of iro

275 y, critical transporters mediating placental iron uptake (transferrin receptor 1 [TFR1]) and export (

276 d provides a viable alternative to inorganic iron uptake under certain conditions.

277 ptionally regulating factors responsible for iron uptake, utilization, and storage.

278 The liver is highly specialized for iron uptake, utilization, storage, and secretion.

279 ta indicate that VciB functions by promoting iron uptake via a ferrous, but not ferric, iron transpor

280 from impaired function of PrP(C) in neuronal iron uptake via its ferrireductase activity.

281 erythropoiesis depends on transferrin-bound iron uptake via the transferrin receptor.

282 Careful regulation of iron uptake, via the ferric uptake regulator Fur, is ess

283 Iron uptake was evaluated with 3,3'-diaminobenzidine-Pru

284 ected in unstressed cells when mitochondrial iron uptake was maintained at a steady, low nanomolar le

285 Iron uptake was minimal in myelin-laden macrophages and

286 Enhanced iron uptake was not observed with a ferrous iron transpo

287 an with others but no difference in cellular iron uptake was observed.

288 ron import, confirming that dysregulation of iron uptake was the root problem.

289 hypothesis that DMT1 is required for hepatic iron uptake, we examined mice with the Dmt1 gene selecti

290 on factors of unknown function and genes for iron uptake were differentially expressed in response to

291 cidification-reduction-transport strategy of iron uptake, were part of this interactome.

292 ke protein 14, which may also participate in iron uptake, were unaffected in Dmt1(liv/liv) mice.

293 s able to directly bind Fe(III) and increase iron uptake when heterologously expressed, whereas knock

294 E is involved in siderophore-mediated ferric iron uptake, whereas FupA facilitates high affinity ferr

295 is expressed in erythroid cells and impairs iron uptake, whereas its absence exclusively from the he

296 fecBCDE and an upstream regulator likely for iron uptake, whereas the other phylotype consistently ca

297 fic across different scenarios of biological iron uptake, which affect the strength of regional iron

298 n aerobic environments, and the mechanism of iron uptake within symbiotic soybean root nodules is unk

299 -throughput screens for chemicals that block iron uptake, without genetic manipulations of the virule

300 blem, as in iron-rich environments excessive iron uptake would endanger H(2)O(2)-stressed cells by ac