ライフサイエンスコーパス: iron-regulatory protein

1 ranslation or stability; all IREs bind IRPs (iron regulatory proteins).

2 ated by iron-regulated RNA-binding proteins (iron regulatory proteins).

3 ystem, mediated through effects on the Aft1p iron-regulatory protein.

4 uster, to its apo-form which functions as an iron-regulatory protein.

5 r the physiological actions of this critical iron-regulatory protein.

6 xpression, intracellular oxidant levels, and iron regulatory proteins.

7 een proposed to make direct contact with the iron regulatory proteins.

8 wo homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1)

9 Patients with mutations in iron regulatory protein 1 (IRP1) also develop polycythem

10 ranscriptional control through the action of iron regulatory protein 1 (IRP1) and IRP2 coordinate the

11 at prioritizes placental iron is mediated by iron regulatory protein 1 (IRP1) and is important for th

12 -sulfur cluster-dependent interconversion of iron regulatory protein 1 (IRP1) between its RNA binding

13 Iron regulatory protein 1 (IRP1) binds iron-responsive e

14 respiratory function concurrent with reduced iron regulatory protein 1 (Irp1) expression as well as i

15 Iron regulatory protein 1 (IRP1) is a bi-functional prot

16 Iron regulatory protein 1 (IRP1) is regulated through th

17 man paralog Cia2a, proposed to act solely in iron regulatory protein 1 (IRP1) maturation.

18 Iron regulatory protein 1 (IRP1) modulates iron metaboli

19 In contrast to yeast, vertebrates use iron regulatory protein 1 (IRP1) to sense intracellular

20 As examples, we use the binding of the iron regulatory protein 1 (IRP1) to the iron response el

21 ve element-binding (IRE-binding) activity of iron regulatory protein 1 (IRP1) was activated, and incr

22 Interconversion of iron regulatory protein 1 (IRP1) with cytosolic aconitas

23 Knockdown of ISCU enhanced the binding of iron regulatory protein 1 (IRP1), a cytosolic Fe-S prote

24 plicated in Fe/S cluster repair of cytosolic iron regulatory protein 1 (IRP1), a key regulator of cel

25 ble of repairing oxidatively damaged Fe-S of iron regulatory protein 1 (IRP1), a master regulator of

26 the mammalian cytosolic aconitase, known as iron regulatory protein 1 (IRP1), led to the characteriz

27 by the binding of two cytoplasmic proteins, iron regulatory protein 1 and 2 (IRP1 and IRP2) to stem

28 o the bifunctional eukaryotic protein IRP-1 (iron regulatory protein 1).

29 In this situation, control of iron regulatory protein 1, a key cytosolic modulator of

30 omolog, cytoplasmic aconitase, also known as iron regulatory protein 1, a well-recognized RNA-binding

31 osolic aconitase is known to be converted to iron regulatory protein 1, and consistent with this, we

32 a domain not present in the closely related iron regulatory protein 1, and we found that this domain

33 When incubated with iron regulatory protein 1, cysteine, and iron, the cytos

34 iron-responsive element-binding activity of iron regulatory protein 1, increased protein levels of i

35 h the kidney and liver through the action of iron regulatory protein 1.

36 anslational regulation of its expression via iron regulatory proteins 1 and 2 (IRP1 and IRP2, respect

37 (IRE) sequence, and ferritin IRE repressors (iron regulatory proteins 1 and 2).

38 Iron-regulatory protein 1 (IRP1) belongs to a family of

39 The generally accepted role of iron-regulatory protein 1 (IRP1) in orchestrating the fa

40 Iron-regulatory protein 1 (IRP1) is a dual-function prot

41 ependent manner, by enhancing the binding of Iron-Regulatory Protein 1 (IRP1) to a recently reported

42 everal cytosolic Fe/S proteins, for example, iron-regulatory protein 1, a major component of posttran

43 Iron-regulatory proteins 1 and 2 (IRP1 and IRP2) are RNA

44 as well as subsequent reoxygenation, on the iron-regulatory proteins 1 and 2 (IRP1 and IRP2) in a ra

45 Iron regulatory protein-1 (IRP-1) is a cytosolic RNA-bin

46 , while heavy chain ferritin mRNA levels and iron regulatory protein-1 (IRP-1) RNA binding activity w

47 o provide in vitro and in vivo evidence that iron regulatory protein-1 (IRP1) inhibits protoporphyrin

48 We show that Drosophila iron regulatory protein-1 (IRP1) registers cytosolic iro

49 dependent manner by promoting the binding of iron regulatory protein-1 (IRP1) to a noncanonical iron

50 aconitase was responsible for activation of iron regulatory protein-1 and increased expression of Tf

51 g involvement of reactive oxygen species and iron regulatory protein-1 in this mechanism.

52 ked by the antioxidant N-acetyl cysteine and iron regulatory protein-1 siRNA, suggesting involvement

53 n converting cytosolic aconitase (ACO1) into iron regulatory protein-1 to bind iron-responsive elemen

54 ugh disruption of the iron-sulfur complex of iron regulatory protein-1, a translational regulator.

55 lular iron ((55)Fe) uptake and activation of iron regulatory protein-1.

56 effect of NO on the RNA binding activity of iron regulatory protein-1.

57 se of repressor interaction of APP mRNA with iron-regulatory protein-1 (IRP1) whereas IRP2 controls t

58 protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2)

59 Three SNPs in the iron regulatory protein 2 (IREB2) gene met this stringen

60 Genetic ablation of iron regulatory protein 2 (IRP-2), a protein responsible

61 eficient cells revealed increased binding of iron regulatory protein 2 (IRP2) and decreased binding o

62 pletion, as indicated by increased levels of iron regulatory protein 2 (IRP2) and/or increased IRE-bi

63 Iron regulatory protein 2 (IRP2) controls the synthesis

64 The degradation of iron regulatory protein 2 (IRP2) in iron-replete cells i

65 Iron regulatory protein 2 (IRP2) is a central regulator

66 Iron regulatory protein 2 (IRP2) is a key iron sensor th

67 Iron regulatory protein 2 (IRP2) is an RNA-binding prote

68 Here, we demonstrate that iron regulatory protein 2 (IRP2) plays a key role in iro

69 The first is that overexpression of iron regulatory protein 2 (IRP2) recapitulates many aspe

70 lated tightly in mammalian cells, in part by iron regulatory protein 2 (IRP2), a protein that is degr

71 ate covalently modifies cysteine residues on iron regulatory protein 2 (IRP2), rendering it unable to

72 s dominated by FBXL5-mediated degradation of iron regulatory protein 2 (IRP2), which is dependent on

73 ter regulators of iron metabolism, including iron regulatory protein 2 (IRP2).

74 ional regulation of iron metabolism genes by iron regulatory protein 2 (IRP2).

75 quired for FDXR-mediated iron metabolism via iron regulatory protein 2 (IRP2).

76 /6 mice and mice with a targeted deletion of iron regulatory protein 2 (IRP2-/-) that have been repor

77 the expression of transferrin receptor 1 and iron regulatory protein 2 consistent with decreased iron

78 Iron regulatory protein 2 contains a domain not present

79 Iron regulatory protein 2 coordinates cellular regulatio

80 Iron regulatory protein 2 coordinates the cellular regul

81 eceptor-interacting protein 1, Hemo-oxidized iron regulatory protein 2 ligase 1 (HOIL-1), HOIL-1-inte

82 he catalytic core component is heme-oxidized iron regulatory protein 2 ubiquitin ligase-1-interacting

83 igase complex that mediates the stability of iron regulatory protein 2, an important posttranscriptio

84 atory protein 1, increased protein levels of iron regulatory protein 2, and resulted in abnormal punc

85 cient erythropoietic tissues of mice lacking iron regulatory protein 2, in iron-deficient murine eryt

86 lated neurodegeneration has been reported in iron regulatory protein 2-deficient (IRP2 -/-) mice coin

87 nism by which heme can regulate the level of iron regulatory protein 2.

88 Here we show that mice lacking iron-regulatory protein 2 (Irp2), a regulator of cellula

89 iron, and to stimulate the expression of the iron regulatory protein-2 (IRP2), which increases the in

90 es and controls iron homeostasis through the iron regulatory protein-2 in human cell lines.

91 on 125 placentas and iron transport assays (iron regulatory protein-2, transferrin receptor-1, dival

92 We propose that iron regulatory protein activation could serve as a mark

93 The consistent finding of loss of iron regulatory protein activity in restless legs syndro

94 with relatively higher labile iron pool and iron regulatory protein activity than WT or H63D HFE.

95 ynthesis at the translational level and that iron regulatory proteins appear to differentially affect

96 RE RNA and in possible interactions with the iron regulatory protein are discussed.

97 Analysis reveals that ferritin and iron regulatory proteins are the main intracellular mech

98 onal mRNAs whose expression is controlled by iron regulatory proteins, as well as provide insight int

99 Iron regulatory protein bandshift and calcein fluorescen

100 ays revealed that induction of p53 decreased iron regulatory protein binding.

101 RNA using a poly(G) stretch or the mammalian iron regulatory protein bound to the iron responsive ele

102 in an oxidative process with disturbance of iron regulatory protein capacity.

103 expression of genes encoding Epo, EpoR, and iron regulatory proteins contributes to defective erythr

104 d cytosolic aconitase of the capacity of the iron regulatory protein controlling the translation of s

105 t excess H-ferritin generated as a result of iron-regulatory protein deactivation sequesters toxic ir

106 te immune protein, has emerged as a critical iron regulatory protein during physiological and inflamm

107 The iron-regulatory protein Fur has been implicated in the A

108 reased intracellular iron levels measured by iron regulatory protein gel-shift assays and ferritin le

109 A putative iron-regulatory protein has also been identified in cyto

110 reased tissue iron, in analogy to mRNA (IRE)/iron regulatory protein in animals.

111 s was examined by the level of activation of iron regulatory protein in band shift assays.

112 is analysis revealed that the basal level of iron regulatory protein in growth-arrested cells was 6-f

113 determined iron levels and the expression of iron regulatory proteins in the liver and gut of nonobes

114 [2Fe-2S]-coordinating complexes in vitro and iron-regulatory proteins in fungi, but it is not clear h

115 ficantly reduced the expression of CA IX and iron-regulatory proteins, inducing apoptosis via mitocho

116 tin-H, and increased iron-responsive element-iron regulatory protein interaction are also observed in

117 ion, and increases cellular iron through the iron regulatory protein-iron response element system.

118 pendent iron signaling via activation of the iron-regulatory protein/iron-responsive element interact

119 bution, and iron-decoupled activation of the iron regulatory protein (IRP) 1.

120 IRP1 [iron regulatory protein (IRP) 1] is a bifunctional prote

121 nganese (Mn) exposure alters the function of iron regulatory protein (IRP) and increases iron (Fe) co

122 t enhancing ferritin expression by targeting iron regulatory protein (IRP) binding activity reduces c

123 ithelial antigen of the prostate (STEAP) and iron regulatory protein (IRP) families in cancer have pr

124 o disrupt translation repression by altering iron regulatory protein (IRP) interactions with the FTL

125 The cytoplasmic iron regulatory protein (IRP) modulates iron homeostasis

126 Iron regulatory proteins (IRP) 1 and 2 are RNA-binding p

127 Iron regulatory proteins (IRP) 1 and 2 play crucial role

128 Iron regulatory proteins (IRP) are sequence-specific RNA

129 eimer brain might result from alterations in iron regulatory proteins (IRP) such as IRP-1 and IRP-2,

130 ), to which a transacting protein called the iron-regulatory protein (IRP) is bound.

131 ed its identity to the previously identified iron-regulatory protein (IRP)-like cDNA from Plasmodium

132 ng the IRE, bind specifically to recombinant iron-regulatory proteins (IRP) and to IRP from neuroblas

133 IRE-RNA riboregulators bind specifically to iron-regulatory proteins (IRP) proteins, inhibiting ribo

134 lls is orchestrated posttranscriptionally by iron-regulatory proteins (IRP)-1 and -2.

135 translational control through regulation of iron-regulatory proteins (IRP).

136 muscle was associated with a decrease in the iron regulatory protein IRP1 and intracellular iron over

137 The RNA-binding iron regulatory proteins IRP1 and IRP2 are inactivated b

138 The two iron regulatory proteins IRP1 and IRP2 bind to transcrip

139 use, and storage through the actions of the iron regulatory proteins IRP1 and IRP2.

140 In low-iron conditions, the cytosolic iron-regulatory protein IRP1 binds to iron-responsive el

141 Iron regulatory proteins (IRP1 and IRP2) are master regu

142 Iron regulatory proteins (IRP1 and IRP2) are RNA-binding

143 Iron regulatory proteins (IRP1 and IRP2) play a pivotal

144 Equal modulated interaction of the iron regulatory proteins (IRP1 and IRP2) with canonical

145 th transferrin receptor (TfR) expression and iron-regulatory protein (IRP1 and IRP2) activity.

146 Iron-regulatory proteins (IRP1 and IRP2) are RNA-binding

147 uctures (iron-responsive elements, IREs) and iron-regulatory proteins (IRP1 and IRP2), controlling ei

148 Iron is stringently regulated by the iron regulatory proteins, IRP1 and IRP2, which regulate

149 llular iron homeostasis is controlled by the iron regulatory proteins (IRPs) 1 and 2 that bind cis-re

150 Iron regulatory proteins (IRPs) are cytoplasmic RNA bind

151 Iron regulatory proteins (IRPs) are RNA-binding proteins

152 When cells are iron-depleted, iron regulatory proteins (IRPs) bind to IREs in the tran

153 tural group of mRNA-specific sequences, bind iron regulatory proteins (IRPs) differentially and fold

154 While iron regulatory proteins (IRPs) function as RNA-binding

155 lar iron concentrations are modulated by the iron regulatory proteins (IRPs) IRP1 and IRP2.

156 Iron regulatory proteins (IRPs) regulate iron metabolism

157 h iron regulation by altering the binding of iron regulatory proteins (IRPs) to their response elemen

158 metabolism is mediated by the interaction of iron regulatory proteins (IRPs) with RNA stem-loop seque

159 IREs serve as binding sites for iron regulatory proteins (IRPs), iron-sensing proteins t

160 of cellular iron homeostasis is regulated by iron regulatory proteins (IRPs), which control the expre

161 teractions of iron-sensing proteins known as iron regulatory proteins (IRPs), with transcripts that c

162 metabolism largely through the action of the iron regulatory proteins (IRPs).

163 binding a family of mRNA-specific proteins, iron regulatory proteins (IRPs).

164 m in the cell via their interaction with the iron regulatory proteins (IRPs).

165 expression post-transcriptionally by binding iron regulatory proteins (IRPs).

166 se complex that regulates the degradation of iron regulatory proteins (IRPs).

167 Iron-regulatory proteins (IRPs) 1 and 2 are cytosolic RN

168 Iron-regulatory proteins (IRPs) 1 and 2 posttranscriptio

169 involving hypoxia-inducible factor (HIF) and iron-regulatory proteins (IRPs) are responsive to both t

170 The iron-regulatory proteins (IRPs) posttranscriptionally re

171 Iron-regulatory proteins (IRPs) recognize and bind to sp

172 In mammals, two iron-regulatory proteins (IRPs) shape the expression of

173 Iron regulatory proteins play a principal role in mainta

174 ndocytosis, ferritin iron sequestration, and iron regulatory protein regulation of iron related prote

175 erritin mRNA model that is recognized by the iron-regulatory protein repressor, were identified by us

176 lso manifests as NDEV abnormalities in other iron regulatory proteins, specifically, decreased transf

177 Hemojuvelin is a recently identified iron-regulatory protein that plays an important role in

178 by NO into an mRNA binding protein (IRP, or iron-regulatory protein) that regulates iron homeostasis

179 The roles of proteins such as iron regulatory proteins, the hereditary hemochromatosis

180 iciency at the tissue level is controlled by iron regulatory proteins to increase iron uptake and ret

181 tal muscle cells by promoting the binding of iron regulatory proteins to iron-responsive elements pre

182 The presence of an iron regulatory protein was demonstrated in the brain mi

183 mer's amyloid precursor protein IRE mRNA and iron regulatory protein was examined by employing molecu

184 ation principally through the interaction of iron regulatory proteins with mRNAs that contain an iron