ライフサイエンスコーパス: irreversible

1 perature thresholds beyond which ice loss is irreversible.

2 ng further synaptic damage before it becomes irreversible.

3 This exchange is irreversible.

4 on, and 5) the evolution of ECM symbiosis is irreversible.

5 s, micronuclear envelope ruptures seem to be irreversible.

6 de effects such as xerostomia are severe and irreversible.

7 infinitely slow protocols are energetically irreversible.

8 degrees C, beyond which GIS decline becomes irreversible.

9 T cell identity and make the lineage choice irreversible.

10 he formation of a series of products through irreversible 1,3-dipolar cycloaddition reactions with th

11 acokinetic modeling with both reversible and irreversible 1- and 2-tissue-compartment models was perf

12 Data were analyzed using the validated irreversible 2-tissue compartment model with a metabolit

13 ) showed a near-perfect correlation with the irreversible 2-tissue-compartment model analysis and can

14 tion, 3) the evolution of gasteroid forms is irreversible, 4) the ectomycorrhizal (ECM) symbiosis pro

15 The mechanisms that drive irreversible acute liver failure remain poorly character

16 substrate zeta-potential that promoted their irreversible adsorption on the silica sensor.

17 Background Longitudinal progression to irreversible airflow limitation occurs in approximately

18 Irreversible allograft rejection and late endothelial fa

19 nation of trisubstituted alkenes by enabling irreversible alpha-boron-directed insertion pathways to

20 when a solid medium as NaCl is employed, an irreversible amorphization of the empty structure occurs

21 sequences of these changes are in many cases irreversible and are likely to be mirrored in nearby for

22 ts in the cDC2 and Tfh cell response are not irreversible and can be enhanced to improve vaccine resp

23 s, any loss of cardiomyocytes is essentially irreversible and can lead to or exaggerate heart failure

24 N-acylation is irreversible and enhanced if a nearby cysteine residue u

25 outcome, showing that C-H bond activation is irreversible and not the rate-determining step.

26 With irreversible and potentially severe forms of fluoride (F

27 This was associated with an irreversible and progressive drop of blood glucose level

28 Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disorder

29 studies indicate that Ni-allyl formation is irreversible and related to the nature of the arylborona

30 obal coronary reserve, may eventually become irreversible and result in ischemic cardiomyopathy.

31 his protocol, we describe a strategy for the irreversible and selective modification of cysteine resi

32 Irreversible and turnover-rate limiting reaction with pi

33 ntional maleimide technique; the reaction is irreversible and uses synthetically accessible reagents.

34 nanoparticles (Au-Pd NPs) in solution for an irreversible and visual response to H(2).

35 n land expansion is one of the most visible, irreversible, and rapid types of land cover/land use cha

36 e activity and G1-cyclin function, causes an irreversible arrest in G1, configuring a molecular pathw

37 YBL2 transcription factor on Ser241, causing irreversible arrest of leukemia and other cancer cells i

38 inally viewed as being solely repressive and irreversible, as observed at the homeotic loci in flies

39 otective immune responses indicate plausibly irreversible attenuation of the L. major strain and its

40 d with concentration and scan rate dependant irreversible behaviour evident at glassy carbon and gold

41 arming and drying concurrence is potentially irreversible beyond a tipping point in the East Asian cl

42 Among irreversible binders, methyl beta-(3,4-dihydroxyphenyl)-

43 roved potency toward LOXL2 inhibition via an irreversible binding mode of inhibition.

44 mal histidine of PD-L1 selectively, enabling irreversible binding of PD-1 to only PD-L1 in vitro and

45 targets is the use of electrophiles to allow irreversible binding to the target.

46 ently, myopic retinopathy is the most common irreversible blinding disease but its pathophysiology is

47 Early detection and treatment can prevent irreversible blindness from diabetic retinopathy (DR), w

48 lar degeneration (AMD), the leading cause of irreversible blindness in the elderly.

49 Most irreversible blindness results from retinal disease.

50 Optic neuropathy is a major cause of irreversible blindness worldwide, and no effective treat

51 ealth problem and it is the leading cause of irreversible blindness worldwide.

52 ganglion cells (RGCs), is a leading cause of irreversible blindness worldwide.

53 on in glaucoma, the world's leading cause of irreversible blindness, and measured how metabolites mob

54 endpoint in most retinopathies that lead to irreversible blindness, and there are no effective treat

55 ive neurodegenerative disease which leads to irreversible blindness.

56 a hallmark of glaucoma, the leading cause of irreversible blindness.

57 tional treatment interruptions can result in irreversible blindness.

58 most common form of eye diseases that cause irreversible blindness.

59 Irreversible blockade of MORs in the VTA counteracted tw

60 s dependent on a Michael acceptor forming an irreversible bond with Cys 215 in the ATP-binding pocket

61 which were produced by reaction schemes with irreversible bonds (e.g. hydrosilylation), here we use a

62 rotect the synapse before the development of irreversible brain damage.

63 We showed that irreversible BTKis broadly prevented IgE-mediated degran

64 n thought to be relentlessly progressive and irreversible, but both preclinical models and clinical t

65 The irreversible C-H activation is observed and becomes turn

66 pa) = -1.47 V vs SHE) that is followed by an irreversible cathodic peak (E(pc) = -2.17 V vs SHE).

67 CITe-Id analysis of our irreversible CDK inhibitor THZ1 identified dose-dependen

68 mic and mitochondrial DNA damage, leading to irreversible cell cycle arrest, and secretion of proinfl

69 Lack of blood perfusion can cause irreversible cell damage.

70 d senescence are the two major outcomes upon irreversible cellular damage.

71 osure of PFA cells to ambient oxygen induces irreversible cellular toxicity.

72 the postfusion conformation, an essentially irreversible change, to drive membrane fusion.

73 dysphoria and provide additional time before irreversible changes in secondary sex characteristics ma

74 d to forecast impact thresholds beyond which irreversible changes may occur.

75 e azurin, WT Az, up to |1.2 V|, beyond which irreversible changes occur.

76 Very large, irreversible changes to ecosystem structure are expected

77 idespread trophic cascades and in some cases irreversible changes to ecosystem structure.

78 gical and clinical characteristics including irreversible changes to the optic nerve and visual field

79 This confirms the irreversible character of the inhibition process.

80 sent a common mechanism to spatially control irreversible chemical reactions in general.

81 the presence of Au-Pd NPs caused visual and irreversible color changes that were concluded to procee

82 e level of the GATA3-BMP4 axis induces fast, irreversible commitment to differentiation.

83 re of CLK1 in complex with AB1 show that the irreversible competitive inhibition of CLK1 is dependent

84 To avert irreversible complications in congenital disorders produ

85 Irreversible condensation between CBT derivatives and N-

86 nsition from a reversible intermediate to an irreversible conformation, suggestive of the postfusion

87 1 binding further promoted transition to the irreversible conformation.

88 f endosomes activates fusion by facilitating irreversible conformational changes in the glycoprotein.

89 ce) rate about 19.1 cm/year which could have irreversible consequences.

90 3alpha undergoes an irreversible conversion to 3beta on warming to 120 degre

91 tion approach, SnoopLigase, for specific and irreversible coupling of antigens onto an oligomerizatio

92 ovalent (RNC), reversible covalent (RC), and irreversible covalent (IRC) binders, affects the degrada

93 As an irreversible covalent inhibitor, compound 15a exhibited

94 trahydropyridopyrimidines were identified as irreversible covalent inhibitors of KRAS(G12C) that bind

95 Given the resurgence of irreversible covalent inhibitors, can they impair off-ta

96 eatment back and forth up to ~300 MPa causes irreversible covalent oligomerization of BLG.

97 suggest that part of the degradation by our irreversible covalent PROTACs is driven by reversible bi

98 ivity toward BTK compared to noncovalent and irreversible covalent PROTACs.

99 ts, has eluded chemists for decades until an irreversible covalent strategy targeting a specific muta

100 e show efficient degradation by noncovalent, irreversible covalent, and reversible covalent PROTACs,

101 tane, and pentane) are initially produced by irreversible cracking chemistry, but, as thermal maturit

102 mer architecture that specifically decouples irreversible creep from stress relaxation and modulus.

103 vironmental data suggests conditions causing irreversible damage are possible in the field at +0.5 de

104 Notably, GVHD caused irreversible damage to a population of tolerogenic strom

105 d are at risk of developing lung fibrosis or irreversible damage to other organs.

106 Combined HL+HS was accompanied by irreversible damage to PSII, decreased D1 (PsbA) protein

107 NAFLD is important, as this can help prevent irreversible damage to the liver and, ultimately, hepato

108 ctivity or, when released in excess, inflict irreversible damage.

109 hereas under strong fields, they suffer from irreversible damage.

110 denosine deaminase (mADA) that catalyzes the irreversible deamination of adenosine to inosine and amm

111 Aging entails an irreversible deceleration of physiological processes, al

112 ells with the means to produce reversible or irreversible decisions.

113 d how these changes are rectified to produce irreversible deformation, remains poorly understood.

114 not affected by mild drying, while nanoscale irreversible deformations still occur.

115 In contrast, the irreversible degradation of FePc is a consequence of FeP

116 ity being achieved in the subsequent slower, irreversible deprotonation.

117 nic demyelination leads to damaged axons and irreversible destruction of the central nervous system (

118 er pheromones that are capable of triggering irreversible developmental switches.

119 es with aging and disease course, leading to irreversible disability.

120 Fatigue damage in metals manifests itself as irreversible dislocation motion followed by crack initia

121 eatment protocol was optimized, resulting in irreversible dissociation of human antibodies-Ara h 6 im

122 ed on the strong belief that PD is caused by irreversible dopaminergic neuronal death.

123 ection for developing effective treatment of irreversible dry mouth, which is common after radiothera

124 therapeutic targets of radiotherapy-induced irreversible dry mouth.

125 ntrast, the conversion of trapped TOP2ccs to irreversible DSBs during DNA repair is accelerated 2-fol

126 plex [MHL(n)](+), the oxidation of MHL(n) is irreversible due to proton loss from the oxidized comple

127 nto the medium, the first peak for 1 becomes irreversible (E(pc) = -1.56 V vs SHE), and the second (i

128 e temperature challenge, both tissues showed irreversible effects, where both heart and RM increased

129 isoform-selective PI3K inhibitor HS-173 and irreversible EGFR/ERBB2 dual inhibitor afatinib in most

130 clinical oncology to treat solid tumors with irreversible electroporation (IRE) and electrochemothera

131 Irreversible electroporation (IRE) is a promising new no

132 te an effective modulation of that stroma by irreversible electroporation (IRE), a local ablation tec

133 Irreversible electroporation (IRE), a nonthermal ablativ

134 overall survival with CT-guided percutaneous irreversible electroporation was exceeded in participant

135 er drugs or genetic probes into cells, while irreversible electroporation with nanosecond pulses is e

136 ser ablation, cryoablation, hyperthermia, or irreversible electroporation) (n = 13).

137 cal stimulation, radiofrequency ablation and irreversible electroporation.

138 An irreversible EMT and the accumulation of AMCs characteri

139 chymal cell plasticity during reversible and irreversible EMT.

140 EMT and the fixed differentiation status of irreversible EMT.

141 wn into minimum energy of separation and the irreversible energy dissipation.

142 ition of the stored native silk molecules is irreversible, environmentally sound and remarkably energ

143 localization, dimensionality reduction, and irreversible enzymatic reactions are combined.

144 The irreversible ErbB family tyrosine kinase inhibitor (TKI)

145 Accordingly, although irreversible ERBB inhibitors showed strong synergistic a

146 Two irreversible events proceed in concert with turnover.

147 tion of the female genital tract can lead to irreversible fallopian tube scarring.

148 that the dagger-shaped polymorphs represent irreversible fibril structures, whereas the SegB polymor

149 morph may participate in both reversible and irreversible fibrils.

150 Chronic pancreatitis (CP) is considered an irreversible fibroinflammatory pancreatic disease.

151 ator with PDZ binding motif (TAZ)-dependent, irreversible fibrosis and inflammation, which was initia

152 rly intervention may be important to prevent irreversible fibrosis when AF intervenes in a patient wi

153 impose strong mutation pressure and risk of irreversible fitness decline in mitochondrial (mt)DNA-en

154 equences of biological annihilation would be irreversible for humankind(2-4).

155 tation converts the R-shaped polymorph to an irreversible form that enhances pathology.

156 ved in THF instead of Et(2)O under N(2), the irreversible formation of an (N(2))(3-) complex [K(crypt

157 ypodermic needles, biohazardous sharp waste, irreversible formulation with vaccine antigen, undesirab

158 known association between podocyte loss and irreversible FSGS and global glomerulosclerosis, this st

159 While the irreversible gelation of protein condensates is generall

160 istance in cancer is thought to be driven by irreversible genetic mutations, emerging evidence also i

161 anetary boundaries, risking catastrophic and irreversible global environmental change.

162 th their biosynthetic activity results in an irreversible growth arrest of CRC.

163 on of POLR1A-high cell population imposes an irreversible growth arrest on CRCs.

164 Cellular senescence entails an irreversible growth arrest that evolved in part to preve

165 tumor suppressive mechanism characterized by irreversible growth arrest, apoptosis resistance, produc

166 Irreversible HE mutations led to cooperativity in virus

167 negative infections, these drugs often cause irreversible hearing damage.

168 kill sensory hair cells in the ear, causing irreversible hearing loss and balance deficits for milli

169 me by combining ER-directed therapy with the irreversible HER2 kinase inhibitor neratinib.

170 rt/binding processes generate an essentially irreversible, hook-like assembly that constrains an impo

171 produce skin bearing striking resemblance to irreversible human alopecia, which also displays reduced

172 Irreversible hypofunction of salivary glands is a common

173 U(VI) reduction should be effectively irreversible in these anoxic environments, which differ

174 stigated battery chemistry previously deemed irreversible in which lithium oxide, a lithium-rich phas

175 for industrial hydrogen production is their irreversible inactivation by oxygen.

176 that chronic autophagy inhibition confers an irreversible increase in cancer risk and uncovers a biph

177 arily responsible for the observed long-term irreversible inhibition of ACETYL-COA CARBOXYLASE, and c

178 py for stomach acid suppression due to their irreversible inhibition of the hydrogen/potassium pump i

179 h IC(50) of 0.055 muM and K(i) = 0.0225 muM (irreversible inhibition).

180 e or SnapTag, with a linker terminated in an irreversible inhibitor for each enzyme.

181 The addition of the irreversible inhibitor moxalactam destabilized several m

182 rate) and a phosphate-glutathione analog (an irreversible inhibitor) bound in the active site.

183 eine proteases (CPs) were inhibited using an irreversible inhibitor, E-64d.

184 Herein, we present a strategy using irreversible inhibitors (E-64 derivative) of cysteine ca

185 sequential reactions of linkers that present irreversible inhibitors for enzymes and fusion proteins

186 are agents and drugs, are AChE reversible or irreversible inhibitors, thus their rapid on-site detect

187 This results in an irreversible inhibitory complex of the serpin with the p

188 ng a key Ni(III) species prior to undergoing irreversible inner-sphere reductive elimination.

189 nd tensions) can be partially compensated by irreversible interpillar adhesion that reduces their bac

190 pathic pulmonary fibrosis (IPF), a fatal and irreversible interstitial lung disease, is predicted by

191 l of inflammation results in higher rates of irreversible joint damage, increased disability, and poo

192 Thus, irreversible junction deformations are regulated by RhoA

193 on contractions, while longer pulses produce irreversible junction length changes that saturate with

194 t focused on the discovery of reversible and irreversible ketone-based inhibitors of SARS CoV-1 3CL(p

195 Another example of footprinting is slow irreversible labeling of functional groups on amino acid

196 printing approach is by reactions with fast, irreversible labeling species that are highly reactive a

197 ated liver disease is often undetected until irreversible late-stage decompensated disease manifests.

198 Furthermore, irreversible lattice oxygen loss and structure distortio

199 ersible, while stretching deformation may be irreversible, leading to membrane disruption when they e

200 rent 'mechanisms of action' that converge to irreversible lethal effects.

201 that shear can play an important role in the irreversible liquid-to-solid transition of protein conde

202 pon inhibitor binding in vivo would cause an irreversible loss of a structurally aberrant enzyme thro

203 high foveal cone density protects cones from irreversible loss of function in RP making them more lik

204 ecause it poses a risk of renal scarring and irreversible loss of kidney function.

205 ices induced non-synaptic depolarisation and irreversible loss of membrane potential in CA1 neurons f

206 n expected, and could potentially lead to an irreversible loss of some ecosystem functions, especiall

207 The rest of the tumor cells undergo an irreversible loss of their biosynthetic capacities as a

208 th range from mild to severe, but many cause irreversible loss of viability.

209 e identification of the potent and selective irreversible MAGL inhibitor 7 (PF-06809247) as a suitabl

210 ative diseases, which tend to progress in an irreversible manner and are associated with large socioe

211 Irreversible MAOIs cause serious hypertensive crises owi

212 Our findings reveal an irreversible mechanism of heme-ART adduct inhibition of

213 gulator of meiotic gene expression to enable irreversible meiotic exit.

214 on neurodegenerative disorder that may cause irreversible memory loss.

215 ment reversible model than the 2-compartment irreversible model.

216 Fatal outcomes were associated with irreversible multiple organ dysfunction syndrome.

217 d blood flow to bowel loops rapidly leads to irreversible necrosis and death.

218 tibody-mediated rejection (CAMR), leading to irreversible necrosis of the tissue.

219 Relapses in multiple sclerosis can result in irreversible nervous system tissue injury.

220 s inflammatory reactions, the major cause of irreversible neuropathy in leprosy.

221 n transfer with O(2) and NO movements averts irreversible NO poisoning and reductive inactivation of

222 We find that irreversible, non-linear responses commonly occur where

223 HP-induced protein folding intermediates and irreversible oligomerization.

224 sion of fibrosis is very complex and reputed irreversible once established.

225 chemical measurements for redox couples with irreversible or distorted electrochemical responses by c

226 erize alternative electrophiles that exhibit irreversible or reversibly covalent binding mechanisms t

227 imertinib is a third-generation, CNS-active, irreversible, oral epidermal growth factor receptor tyro

228 ses, balancing rapid transient responses and irreversible outcomes.

229 rs reflective of oxidative stress, including irreversible oxidation of betaCys93 and ubiquitination o

230 Therefore, our results demonstrate irreversible oxidation of pollen proteins during SI and

231 Notably, SI-induced pollen had numerous irreversible oxidative modifications, while untreated po

232 k because currently there are few reports of irreversible oxPTMs in plants.

233 Because our previous work on the irreversible part of the oxidative pentose phosphate pat

234 ivity, although all subtypes are regarded as irreversible pathologic conditions.

235 capsules (20 x 10(6)), which has not lead to irreversible pathological changes in blood flow and kidn

236 , so far, dominantly focused on implementing irreversible patterning of the system, or interference t

237 le (E(pc) = -1.56 V vs SHE), and the second (irreversible) peak shifts to -2.07 V vs SHE.

238 me ratios, while spherical particles undergo irreversible phase transition with relatively low phase

239 ch protein condensates can undergo a further irreversible phase transition, forming solid nanoscale a

240 al [2 + 2] cycloadditions, displays a nearly irreversible photoswitching behaviour.

241 al trial of carfilzomib (a second-generation irreversible PI) demonstrated improved efficacy in elimi

242 a full EMT, is associated with complete and irreversible pluripotency loss.

243 discovered the first potent and cell-active irreversible PRMT6 inhibitor, 4 (MS117).

244 ) pathogenesis and is prone to glycation, an irreversible process where proteins accumulate advanced

245 electrochemical reactions from those due to irreversible processes, which do not give AC signals.

246 (OA) is a degenerative disease resulting in irreversible, progressive destruction of articular carti

247 Carfilzomib (Cfz), an irreversible proteasome inhibitor licensed for relapsed/

248 to interact directly and indirectly (through irreversible protein binding and processing to the deriv

249 otential therapeutic strategy to prevent the irreversible pulmonary failure threatening the life of C

250 est that WGD can be selected to mitigate the irreversible, ratchet-like, accumulation of deleterious

251 cy study indicated the adsorption controlled irreversible reaction mechanism.

252 This simple genetic encoding for rapid irreversible reaction should provide diverse opportuniti

253 with carbon monoxide or intercepted through irreversible reaction with dihydrogen, resulting in sele

254 ens into C(18) estrogens is thought to be an irreversible reaction.

255 cycles meant to provide replacements for the irreversible reactive "warheads" of vinyl sulfone inacti

256 A further strong, discontinuous, and irreversible reduction along the stacking direction at 2

257 ystemic lupus erythematosus that can lead to irreversible renal impairment.

258 increases the likelihood of the evolution of irreversible reproductive barriers (incompatibilities) t

259 number (CN) alterations are associated with irreversible-resistance to endocrine therapy and subsequ

260 gregation) and sticking to mineral surfaces (irreversible retention).

261 , the cycle of readvances stopped leading to irreversible retreat.

262 city (~329 mAh g(-1) ) be harvested but also irreversible/reversible anionic/cationic redox reactions

263 n, providing a mechanistically selective and irreversible scaffold for cysteine conjugation.

264 asting invasion could be responsible for the irreversible secondary liver changes such as cirrhosis a

265 Glaucoma is a leading cause of irreversible sight-loss and has been shown to affect nat

266 ocess is found to be compound-specific, with irreversible sorption observed for GA and prolonged tail

267 tected after bone damage has occurred, at an irreversible stage of the disease.

268 meabilization (MOMP), which is considered an irreversible step in apoptosis.

269 ss-strain behavior evolution and in terms of irreversible structural and load-bearing capacity change

270 eases of the retina at earlier stages before irreversible structural damage has occurred.

271 le nanocomponents where mechanically-induced irreversible structural damage should be largely prevent

272 that the Cu(68)Ag(32) nanowires underwent an irreversible structural reconstruction and well-stabiliz

273 f oxygen at highly charged states aggravates irreversible structure changes and deteriorates cycle pe

274 ns should also be considered in pathological irreversible swelling.

275 y strategy allowing a target to catalyze the irreversible synthesis of its own ligands from a pool of

276 however, have been limited in part by their irreversible target engagement.

277 solid-state FK A15 phase through a rapid and irreversible thermotropic order-order transition, which

278 gest two levels of CFTR regulation in cells: irreversible through phosphorylation, and reversible thr

279 es essential signaling in vivo but may cause irreversible tissue damage under dysregulated or acute e

280 lineage confinement that otherwise triggers irreversible tissue degeneration.

281 ntually leads to severe pain, pus discharge, irreversible tissue destruction and scar development.

282 e effects on pumping capacity, contribute to irreversible tissue withdrawal, and weaken skeletal stre

283 d trapping of TOP2ccs, their conversion into irreversible TOP2-linked DSBs, and their processing duri

284 as etoposide and subsequently converted into irreversible TOP2-linked DSBs.

285 Additionally, we report a second type of irreversible tPAINT probe that exposes its cryptic docki

286 inked feedback is the molecular basis for an irreversible transition from pluripotency to differentia

287 he dynamic states of initiation make a sharp irreversible transition to an unbent conformation with a

288 the phenol results in an overall chemically irreversible two-proton-coupled electron-transfer proces

289 recombination systems, which are inherently irreversible, un-physiologically restricted and difficul

290 as measured at 23 degrees C, consistent with irreversible unimolecular reductive elimination to form

291 r effective local accumulation but may cause irreversible vessel blockage.

292 cular degeneration (AMD), a leading cause of irreversible vision impairment in the United States and

293 To prevent irreversible vision loss in age-related macular degenera

294 Glaucoma is a leading cause of irreversible vision loss predicted to affect more than 1

295 cular degeneration (AMD), a leading cause of irreversible vision loss worldwide, are variants associa

296 , this synaptopathy is immediate and largely irreversible, whereas, in guinea pigs, counts of immunos

297 id sorption to GAC was extensive and largely irreversible, with significantly greater sorption of imi

298 after release of obstruction is often deemed irreversible without any systematic therapeutic approach

299 by reversible Schiff-base formation, before irreversible Wittig olefination provided the rigidified

300 However, their lifespan is limited by irreversible Zn anodes owing to water decomposition and